Very strange white fibrous clots — Transcript

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1. 0:01You're very welcome to this talk. Now,
2. 0:02today we want to carry on thinking about
3. 0:04these anomalous white fibrous clots
4. 0:07that are being found by embalmers, not
5. 0:09really identified by pathologists yet as
6. 0:11far as I know, but the embalmers are
7. 0:13certainly flagging them up. They seem to
8. 0:15appear in 2021, different from clots
9. 0:17which occurred before 2021. So, just
10. 0:20what is going on here? Now, there's a
11. 0:22trickle of reports coming out on these
12. 0:24in the scientific literature.
13. 0:26Not a lot, but it is starting. So, we
14. 0:28are starting to learn a bit about them.
15. 0:30Now, just before we look at the content,
16. 0:31YouTube are quite happy for me to talk
17. 0:33about white fibrous clots, but they're
18. 0:35not so happy for me to show pictures of
19. 0:37them.
20. 0:38So, at the very top of the description
21. 0:40under this video, I'll put the link to
22. 0:41the Substack Substack article I've done
23. 0:43on this where there's a lots and lots of
24. 0:46high-resolution pictures that
25. 0:47definitively prove
26. 0:49uh the existence of these clots,
27. 0:51including some being withdrawn actively
28. 0:53from various blood vessels in the body
29. 0:55by embalmers. So, we know that these
30. 0:57things are real. That's how I was
31. 0:59convinced because of the photographic
32. 1:00evidence.
33. 1:02Check it out. Now, this video is about
34. 1:05the what what these clots are made of.
35. 1:07So, there's a some pharmacologists and
36. 1:09biochemists have analyzed these clots
37. 1:11and they've worked out partly what
38. 1:13they're made of. Not entirely, it's not
39. 1:15completely an exhaustive study,
40. 1:17but what are they actually made of?
41. 1:18Because this is the first point first
42. 1:21thing we need to know. We need to know
43. 1:22were these clots forming when people are
44. 1:24alive, were they forming during the
45. 1:26dying process, were they forming after
46. 1:27the people were dead?
47. 1:29We know they were there very shortly
48. 1:31after death and we're going to look at
49. 1:32evidence to show that they do actually
50. 1:33form in life today as well.
51. 1:36But, that's what this is about. Um
52. 1:38it turns out they're made of abnormal
53. 1:40proteins, very unusual proteins. So,
54. 1:43they're a bit like amyloid protein,
55. 1:45which is a pathological protein in the
56. 1:47body, although it can be part of normal
57. 1:48structures.
58. 1:49But, they're a bit like that, but not
59. 1:51quite like that. They're a bit
60. 1:52different. And they're a bit like the
61. 1:54clotting protein uh fibrinogen and
62. 1:56fibrin, the sticky strands that that
63. 1:58form blood clots, but not quite like
64. 2:00that either. So, not only are the
65. 2:02anomalous clots that made of anomalous
66. 2:04non-typical proteins. So, that's what
67. 2:06this is about if you haven't got time to
68. 2:08watch. But if you have, the detail
69. 2:10really is quite uh quite interesting,
70. 2:12really.
71. 2:13So, this is the first paper we're going
72. 2:15to be looking at here.
73. 2:17Um I'm not going to Yeah, I will read it
74. 2:19out now. Raman spectroscopic
75. 2:21characterization of characterization of
76. 2:23anomalous intravascular fibers discuss.
77. 2:26Evidence for stage-dependent beta sheet
78. 2:28enrichment protein maturation. Now,
79. 2:30that's pure gobbledygook, of course,
80. 2:32unless you're a biochemist, but we will
81. 2:34unpack that in a minute. Uh just to show
82. 2:37you the way this paper was done, it's
83. 2:39it's basically spectroscopic as it said.
84. 2:41You know what spectroscopy is. It's it's
85. 2:43analyzing light
86. 2:45to infer things about the nature of
87. 2:46matter. So, you can either shine a light
88. 2:48at it like these researchers did. They
89. 2:50They shone a laser light on the samples
90. 2:52and they looked at the way it bounced
91. 2:53back and did stuff.
92. 2:55Uh or or you can um look at stars, for
93. 2:58example, and do spectroscopic analysis
94. 3:00of stars, and that's
95. 3:02that's how we know what little stars are
96. 3:03made of. Um twinkle twinkle little star,
97. 3:06we now know exactly what you are.
98. 3:08But that's a separate topic. So, we know
99. 3:09what they are because of looking at the
100. 3:11light. It's analyzing matter from the
101. 3:13light.
102. 3:14That's what it means. Now, this is the
103. 3:16results from the paper here. Now, these
104. 3:18are the spectroscopic analyses. Now, I
105. 3:20do not pretend to understand these. Only
106. 3:22biochemists and
107. 3:24specialists do, really.
108. 3:25But all the data is there. It is a
109. 3:27peer-reviewed paper from the
110. 3:30one of the most reputable European
111. 3:31agencies
112. 3:33as we'll look at. So, basically, I'm
113. 3:35more than happy to trust what the
114. 3:37authors are telling me these things
115. 3:39mean. Although I don't fully Well, I
116. 3:42don't
117. 3:43hardly understand them at all.
118. 3:45Anyway, that that doesn't matter. We can
119. 3:47trust that it's a proper interpretation,
120. 3:49and it is peer-reviewed by other people
121. 3:50who know what they're talking about. So,
122. 3:52we can be pretty sure
123. 3:54this this is good scientific data. Now,
124. 3:56let's just unpack it a little bit.
125. 3:58That's the title there. Raman
126. 4:00spectroscopy um
127. 4:02what compounds are present by reading
128. 4:05the vibrational fingerprints of the
129. 4:07molecules in the sample. So, that's what
130. 4:08it is. Shining light, bouncing light,
131. 4:11non-destructive means of probing
132. 4:13molecular architecture of proteinaceous
133. 4:15materials. So, this is a way of
134. 4:17analyzing proteins by shining lasers on
135. 4:19it, looking at what comes back and what
136. 4:21happens to that light spectroscopically.
137. 4:24Just spectro- we've said what spectros-
138. 4:27spectroscopy is. So, next bit, what is a
139. 4:30beta sheet protein? Um
140. 4:32a protein where a lot of its structure
141. 4:34is made up of beta sheets.
142. 4:36And what are beta sheets? Uh flat
143. 4:38pleated segments form when strands of
144. 4:40the proteins line up
145. 4:44side by side. So, it's a secondary
146. 4:46structure of a protein, really.
147. 4:48And hydrogen bond together. So, we end
148. 4:49up with a sheet of these things.
149. 4:51And just to give an example, um silk
150. 4:55um it it is is a beta pleated sheet.
151. 4:58This is what gives uh silk its strength
152. 5:01and stability
153. 5:02and uh elasticity.
154. 5:04So,
155. 5:06the same thing the these beta pleated
156. 5:08sheets in these um anomalous white
157. 5:11fibrous clots giving them very unusual
158. 5:13characteristics.
159. 5:14What does the protein maturation bit of
160. 5:16the title mean? It means as proteins
161. 5:18progress through different stages of its
162. 5:19development or aggregation,
163. 5:21so I as they are clumping together, its
164. 5:23structure becomes increasingly rich in
165. 5:25in beta sheets.
166. 5:26So, these beta sheets become more
167. 5:28common,
168. 5:29basically replacing what's called the
169. 5:31alpha helical state,
170. 5:33which is the more normal native state of
171. 5:35proteins.
172. 5:37Um
173. 5:38Sorry if that's a bit of a stretch, but
174. 5:39you've just exhausted my knowledge of
175. 5:40biochemistry, so we won't be saying much
176. 5:43more about that in terms of protein
177. 5:44chemistry. But, the secondary structures
178. 5:46in proteins,
179. 5:48the first structure is the way the amino
180. 5:49acids come together and the way that
181. 5:51these fold into sheets and fold into
182. 5:53helices is the secondary structure of
183. 5:55the protein.
184. 5:57So that's what we're talking about. Now,
185. 5:58what method was used in this paper? Now
186. 6:01this is the uh Wigner Research Center
187. 6:03for physics in Hungary. Now this is part
188. 6:07of the Hungarian National uh physical
189. 6:09network. In fact, it's probably the main
190. 6:11um research center in Hungary.
191. 6:14And it's got a very, very high
192. 6:15international reputation. So this is uh
193. 6:17absolutely definitive uh research
194. 6:20institute uh for physics.
195. 6:23Uh so
196. 6:24the the quality of the work there is is
197. 6:26uh is is second to none. It's absolutely
198. 6:28world-class.
199. 6:30So we can trust that.
200. 6:31Uh what did they do? White to pet what
201. 6:34white to pet rubbery intravascular from
202. 6:36within the blood vessels.
203. 6:38Uh fibrous casts Casts because they were
204. 6:41like molds on the inside of the blood
205. 6:43vessels.
206. 6:44Uh recovered during routine embalming
207. 6:47were analyzed during using
208. 6:49Raman spectrum.
209. 6:52Micro Raman microspectroscopy so it
210. 6:55shining a small laser beam at it and
211. 6:57looking at what came out.
212. 6:58Uh Raman spectra exhibited strong
213. 7:00protein signature. So these things are
214. 7:02full of proteins.
215. 7:03Lots and lots of proteins. We know that
216. 7:05bit.
217. 7:08Uh now they they look they did other
218. 7:09things as well as the spectroscopy.
219. 7:11Yeah, the cast made of from
220. 7:14atypical protein protein aggregates. So
221. 7:16different types of unusual proteins
222. 7:18clump together and they found 17
223. 7:20different amino acids and there's only
224. 7:2120 amino acids really present in the
225. 7:23human body. So um
226. 7:25they found quite a lot of them.
227. 7:27Uh the amino acid profile departs from
228. 7:29published composition of human fibrin
229. 7:31fibrinogen. Now
230. 7:34we had thought that these clots were
231. 7:36made of amyloid and and fibrin.
232. 7:38So fibrinogen clumps together to form
233. 7:40fibrin which is the sticky strands and
234. 7:42the red blood cells stick to that form a
235. 7:43blood clot. And that is kind of true.
236. 7:47But what what this is saying is um it's
237. 7:50like fibrin and fibrinogen, but not
238. 7:52quite. It's an abnormal type of fibrin
239. 7:54and fibrinogen.
240. 7:56>> [snorts]
241. 7:56>> It's a bit like amyloid protein, which
242. 7:57is a common pathological protein.
243. 8:00Causes an Alzheimer's disease, for
244. 8:01example, though probably not causal.
245. 8:03That's a separate matter. Um
246. 8:05so it's a well-known pathological
247. 8:07protein, although it does occur in
248. 8:09normal tissues as well.
249. 8:10Um but it's not quite normal amyloid
250. 8:12protein. So we've got to put it in the
251. 8:15way I understand it.
252. 8:17Uh kind of weird fibrin and kind of
253. 8:19weird amyloid. Atypical ones.
254. 8:22And uh
255. 8:23the authors say that this supports
256. 8:25interpretation of the non-canonical
257. 8:27protein aggregate. So a canonical
258. 8:29protein would be one which is
259. 8:30well-known, well-identified.
260. 8:32So healthy proteins would be a
261. 8:34canonical. Uh these aren't. They're a
262. 8:36bit weird. It's another way of saying
263. 8:38kind of
264. 8:39off-the-book or not quite off-the-shelf
265. 8:41proteins.
266. 8:42Exhibiting strong hetero-
267. 8:45genic
268. 8:47cons cons
269. 8:48exhibiting
270. 8:49exhibiting heterogeneous consistency
271. 8:52with state with stage-dependent beta
272. 8:55enhancement.
273. 8:57So in other in other words, it's
274. 8:58consistent with that. So in other words,
275. 9:01there's a mixture of proteins. So
276. 9:02there's some alpha helical ones.
277. 9:04But as time goes on, they think there's
278. 9:06more of these beta-pleated ones come up.
279. 9:09It's consistent with that. Now, they
280. 9:11don't know that for sure because they
281. 9:12didn't follow it through a pathway. This
282. 9:14is only based on
283. 9:16uh basically a snapshot in time, but
284. 9:17there's a mice from looking at two
285. 9:19different samples that they're
286. 9:20analyzing. That there was an evolution
287. 9:22in the way that these things uh that
288. 9:23these things develop.
289. 9:25With the normal um
290. 9:26alpha helical proteins being replaced by
291. 9:28these
292. 9:29uh
293. 9:31tough, stretchy, but abnormal beta-sheet
294. 9:33proteins, which is giving them the the
295. 9:35elastic uh calamari kind of
296. 9:38characteristics.
297. 9:41Right, so what? Well, it's distinct from
298. 9:43conventional postmortem thrombi. This is
299. 9:45not what we normally wash out of the
300. 9:47vasculature of dead bodies.
301. 9:50So, unusual.
302. 9:51The distinct physical and spectroscopic
303. 9:53features of these casts may aid in their
304. 9:55further recognition during embalming and
305. 9:57postmortem examinations. Hint hint,
306. 9:59pathologists, look out for these things.
307. 10:02Hint hint, pathologists, again.
308. 10:04This may aid pathologists in
309. 10:05distinguishing atypical intravascular
310. 10:07casts from conventional postmortem
311. 10:08thrombi. These are not the usual
312. 10:11postmortem thrombi.
313. 10:13So, this is now scientific validation
314. 10:17of what the undertakers were saying. The
315. 10:18undertakers were saying way back in
316. 10:202021, this is not what we normally see.
317. 10:24Undertakers with sometimes decades of
318. 10:26experience were saying, "No, we don't
319. 10:28normally see these. These are new." And
320. 10:30here we have the scientific confirmation
321. 10:32of that.
322. 10:34That these are not conventional
323. 10:36postmortem, after death, thrombus. Nor
324. 10:39is it similar to the thrombus that you
325. 10:42get in pathological situations such as
326. 10:44coronary arterial thrombosis formation
327. 10:47or deep venous thrombosis. These are
328. 10:49different.
329. 10:51They're essentially new
330. 10:52uh and they're not like all the other
331. 10:54ones.
332. 10:56What is causing these?
333. 10:59Uh no causal link to any exposure,
334. 11:02infectious agent, vaccine, or
335. 11:03therapeutic intervention can be inferred
336. 11:05from the present data. What they are
337. 11:07saying is because these samples were
338. 11:10given anonymously
339. 11:11to maintain confidentiality,
340. 11:14they don't know
341. 11:16whether the patients that these clots
342. 11:18from were vaccinated or not with COVID
343. 11:21vaccines, for example.
344. 11:22They don't know what their history is,
345. 11:24so they can't make any
346. 11:26uh intimation from that.
347. 11:28Clearly, this is research which urgently
348. 11:31needs to be done.
349. 11:33If it were that these clots are caused
350. 11:35by adverse reactions to some therapeutic
351. 11:37intervention, boy, do we need to know
352. 11:39about that quick.
353. 11:41Because there's a we're seeing a lot of
354. 11:42these clots.
355. 11:43There's a lot of them.
356. 11:46Sorry, that's the paper. We don't want
357. 11:47to see that. There we go.
358. 11:49Um these results underscore the need for
359. 11:52systematic multimodal investigation. So,
360. 11:54give it to the biochemists. Let them
361. 11:56think of any technique they can. As many
362. 11:58different modalities of investigation as
363. 12:00they can.
364. 12:01The clever people will think of dozens
365. 12:03of ways of doing it.
366. 12:05And we need further studies
367. 12:06incorporating incorporating proteomics.
368. 12:09That's analyzing the uh analyzing the
369. 12:11proteins.
370. 12:12Uh histochemistry analyzing the
371. 12:14histology and the chemistry. Electron
372. 12:16microscopy, controlled comparisons, and
373. 12:19well-documented provenance will be
374. 12:20essential. So, the provenance means we
375. 12:23need to know the medical history of each
376. 12:24patient's clot.
377. 12:26The patient or the the corpse that the
378. 12:28body that the the clot was removed from,
379. 12:31we need to know their medical history.
380. 12:35That will be essential to uh clarify
381. 12:37biochemical
382. 12:39biochemi- biochemically identify
383. 12:41structural evolution, prevalence, and
384. 12:44potential clinical and postmortem
385. 12:46significance.
386. 12:48Um and as we've said, it may be that
387. 12:51these are forming in life.
388. 12:53Now, these huge clots
389. 12:55like like if you look on the Substack
390. 12:57Substack article, you'll see a clot that
391. 12:59um
392. 13:00>> [snorts]
393. 13:00>> basically would occlude all the bottom
394. 13:02of the aorta. Patients aren't going to
395. 13:03live with that. The question is did that
396. 13:05clot kill the individual or did the clot
397. 13:08form after death?
398. 13:10More on that in a minute.
399. 13:12Um anyway, let's look at the other
400. 13:14papers that we've got on few of the
401. 13:16papers I've got on this. We've got this
402. 13:17paper here
403. 13:20uh from uh New Zealand.
404. 13:22We've got this paper here also from the
405. 13:24same authors in New Zealand.
406. 13:25And this paper here. So, a trilogy of
407. 13:27papers. So, what are these papers got to
408. 13:30contribute to this is their consistency?
409. 13:32Yes, basically there is consistency.
410. 13:34So, if we take this first one,
411. 13:36morphological and histological
412. 13:37characterization of an
413. 13:40characterization of anomalous
414. 13:41intravascular casts, which are the white
415. 13:43fibrous clots.
416. 13:45Gross examination revealed elongating
417. 13:47lumen-filling casts up to 25 cm in
418. 13:49length, although on the
419. 13:51on the sub stack we have got a longer
420. 13:52one than that.
421. 13:54Um [snorts]
422. 13:55frequent branching as the blood vessels
423. 13:57do, demonstrating elasticity of
424. 13:58resistance atypical of conventional
425. 14:01thrombi, not like conventional clots.
426. 14:04These are different.
427. 14:06These are different to what
428. 14:08pathologists, doctors,
429. 14:10embalmers are used to seeing.
430. 14:13Histology demonstrates dense fibrous
431. 14:16lamination with intermittent lines of
432. 14:18Zahn. Now, these lines of Zahn
433. 14:22uh basically form
434. 14:26when there's a pulse.
435. 14:28They show
436. 14:29it's a bit it's a bit like the ripples
437. 14:30on a beach.
438. 14:32Uh the wave comes in and it forms a
439. 14:34ripple.
440. 14:36Comes in again, forms another ripple.
441. 14:37Lines of Zahn are like that. So, the
442. 14:39pulsatile nature of the blood forms
443. 14:41these lines of Zahn.
444. 14:43So, clearly
445. 14:45if these if these lines of Zahn are
446. 14:46confirmed and they're not they they
447. 14:47haven't been confirmed by other studies
448. 14:49yet, but if they're confirmed,
449. 14:51that means the lines of Zahn formed
450. 14:53during life. Therefore, at least part of
451. 14:55this white fibrous clot formed during
452. 14:58life and therefore was probably partly
453. 15:00responsible for killing the
454. 15:02individual. That means they're not
455. 15:05purely a postmortem phenomena.
456. 15:08That means they're an end-of-life or
457. 15:09perimortem phenomena.
458. 15:12We need that confirmed.
459. 15:14We have the labs to do that really
460. 15:15quickly and readily.
461. 15:17Uh pity none of them are chomping at the
462. 15:18bit to do it, but there you go.
463. 15:21Um so, it did contain these lines of
464. 15:23Zahn according to this paper. Various
465. 15:25intracellular inclusion inclusions, so
466. 15:27you know, some white cells, some red
467. 15:28cells, things like that. Suggesting
468. 15:30antemortem, that means before death
469. 15:32formation
470. 15:34under atypical hemodynamic conditions.
471. 15:37So, suggesting they formed when the
472. 15:39patient was still alive
473. 15:41but in an abnormal circulatory
474. 15:44system
475. 15:45is what these lines of Zahn would
476. 15:47indicate.
477. 15:49These structures uh
478. 15:50features differ from
479. 15:52physiological thrombi and postmortem
480. 15:55clots. So, these these are different.
481. 15:56This is a new phenomenon. It's not like
482. 15:58normal blood clots.
483. 16:01Indicating a distinct pathological
484. 16:04phenomena in these white clots.
485. 16:06And then the last paper So, remember
486. 16:09that that was the first one. That was
487. 16:11the second of this trio of papers.
488. 16:13That was the third one there.
489. 16:15So, um
490. 16:19I've got those in the wrong order.
491. 16:20Anyway, there's three of them. Yep,
492. 16:22there's three of them anyway. Right, so
493. 16:24just to look at the last one.
494. 16:26Elemental characterization of anomalous
495. 16:28intravascular casts reveals an abnormal
496. 16:30biochemical matrix. So, everything about
497. 16:33these is abnormal.
498. 16:35The proteins, the biochemistry, all very
499. 16:37strange.
500. 16:38The elemental composition of anomalous
501. 16:41intravascular casts, which is what
502. 16:42they're calling the white clots,
503. 16:44is inconsistent with kinetical thrombus.
504. 16:47In other words, this is not like the
505. 16:49thrombus that's studied. It's not like
506. 16:51the thrombus that's in the book. It's
507. 16:53not like the biochemistry that's in the
508. 16:54book.
509. 16:55And supports the presence of a
510. 16:57non-kinetical
511. 16:58intravascular matrix. So, this
512. 17:04matrix structure within the blood
513. 17:06vessels is not
514. 17:08what we've seen before. We are dealing
515. 17:10with a new phenomenon.
516. 17:12So, uh thanks to those authors,
517. 17:14especially of ones from the this one we
518. 17:16haven't looked at before the Raman
519. 17:17spectroscopy.
520. 17:19Um we are hoping to talk to one or two
521. 17:21of the authors at some point
522. 17:23uh to get more detail and hopefully they
523. 17:25can
524. 17:26uh explain the biochemistry better than
525. 17:28I have.
526. 17:29But there we go. They are really weird.
527. 17:31New abnormalous uh
528. 17:34and clots very strange
529. 17:37very strange biochemistry, very strange
530. 17:40structures.
531. 17:41What is going on here? I would have
532. 17:43thought we need to find out fairly
533. 17:45desperately.
534. 17:47Big question of course remaining in my
535. 17:48mind, why these being identified in a
536. 17:50lot of patients, a lot of bodies
537. 17:53by undertakers
538. 17:55but it's not hitting
539. 17:56the mainstream
540. 17:59uh
541. 17:59pathology journals.
542. 18:01Uh these samples in this study here
543. 18:05were provided not by pathologists
544. 18:07but were provided by uh
545. 18:10embalmers
546. 18:12who anonymously donated these uh these
547. 18:14these white fibrous structures.
548. 18:17Why isn't this in the mainstream of uh
549. 18:19pathology? Why isn't it in the Lancet?
550. 18:21Why isn't it in Nature?
551. 18:23American Journal of Medicine, all those
552. 18:25other things.
553. 18:27Journal of the American Medical
554. 18:28Association, why is it not in there?
555. 18:30Because we're dealing with a truly
556. 18:31bizarre new phenomena that's relatively
557. 18:33widespread and yet
558. 18:35it [snorts] looks like the mainstream
559. 18:36doesn't want to touch it, which is just
560. 18:38really quite
561. 18:40I can't I can't explain it, maybe you
562. 18:42can.
563. 18:43For now as always, thank you for
564. 18:44watching.