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The SIMPLE Way To Reverse Gray Hair (Science Backed) — Transcript

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0:00Well, then what's what's going on with
0:01aging? I've got two women in front of me
0:04and they have two different colors of
0:07hair. Now, let's just pretend for
0:09argument's sake and for the sake of this
0:12explanation that this is someone's hair
0:14that's gone gray because of stress.
0:17Um and this is what she used to look
0:20like or he used to look like in terms of
0:22the color of the hair. What I found
0:24really interesting cuz it kind of speaks
0:25to lots of things that are going on
0:27going on in the body is you're saying
0:30you can actually reverse
0:32gray hair.
0:35Without dying it. And if so, what does
0:37that tell us about what gray hair is,
0:39but more broadly about stress, energy,
0:42mitochondria, and everything in between?
0:43>> Yeah. Uh what we discovered is that hair
0:46graying is reversible. And and that was
0:49surprising because what I've learned and
0:52what most people learn is that when you
0:54age, it's kind of this linear
0:56progressive decline and and there's kind
0:58of nothing you can do about it. Uh but
1:00it turns out that if you look on most
1:01people's head,
1:03um
1:05you can see things like this. This is
1:07obviously, you know, this was dyed and
1:09all of the hairs were were white and
1:11then all the hairs are are or dark. And
1:14if you take a hair like this,
1:16uh the tip here, right, was inside the
1:18body long time ago. This is almost like
1:20if you look at tree rings, right, you
1:22take [clears throat] a tree and you cut
1:23it in cross section, you see like the
1:24rings and then you can see, "Ooh, this
1:26ring was uh 30 years ago, right? And
1:29this ring is today." Uh so, you can use
1:31that to kind of map the history of what
1:33happened in the environment of of the
1:35tree. You can do the same thing. We all
1:37walk around with biological history
1:40crystallized in in this hair. And that's
1:42why if you want to know if someone had a
1:44a drug, for example, like a month ago or
1:466 months ago or like 2 years ago,
1:48depending how long the hair is, you can
1:50actually use the hair and all along
1:52would be, you know, the chemical
1:53signature of what you took. So, you can
1:56find marijuana in in the hair, you know,
1:58here but not here. So, if you if you
2:00have marijuana
2:026 months ago, it's going to be in your
2:03hair and you're going to walk around uh
2:06with that trace, that physical trace in
2:08in your body.
2:08>> He's got hiccups.
2:10>> [laughter]
2:11>> And the idea was if we could find hairs
2:14on someone's head
2:15that the tip was uh dark, right? And
2:20then when you look closer to the body,
2:22it becomes white, right? And you would
2:23say the hair was young, it was young, it
2:25was young, and then boom, it became old,
2:27right? It It lost color. Hair graying is
2:30a a classic hallmark of aging.
2:32Um then we thought then you would know
2:34something that something was happening
2:36in this hair follicle, in this person's
2:37body, right? That made this young hair
2:40become old. And then maybe we could
2:42understand the mechanisms of the aging
2:44process. So, this became a kind of an
2:46interesting scenario. And through doing
2:49this, we found people started to send us
2:51hair samples in Ziploc bags, you know,
2:53over the mail. Uh and we were looking
2:55for two colored hairs. A single hair
2:58that has two colors, kind of like this.
3:00Uh and we found hairs that
3:02uh you know, head hair, beard hair,
3:04pubic hairs that showed the signature.
3:07The hair was dark and then it became
3:09white or the hair was white and it
3:11became dark again.
3:12>> Mhm.
3:12>> So, we had [clears throat] physical
3:14evidence from like multiple people that
3:16showed white hairs can go back to being
3:18dark. And this contradicted this idea
3:21that, you know, aging is this linear
3:23progressive process that we're kind of
3:25doomed to experience without any
3:27flexibility. I was one of the
3:28participants in that study. I ended up
3:30finding five hairs that had this
3:32pattern. And when we looked at when the
3:34reversal happened, we found that the
3:36reversal happened when I went on
3:38vacation.
3:39And I would go back in those days on
3:42annual
3:43uh cycling uh training camps. So, I
3:45would go for a week where all you do is
3:48you bike, you eat, you sleep. Uh energy
3:51started to move very differently in my
3:52body during that that time.
3:55Um, and then [clears throat] when we
3:57looked at the hair and we analyzed the
3:59the composition, the molecular
4:00composition, that's what scientists do.
4:02You can take a hair like this, snip the
4:04pieces, the white segment, the dark
4:06segment, it's all the same genome,
4:07right? Every hair has the same genome,
4:09the same genetic material, same food,
4:11uh, same physical activity, same
4:13everything. Why some hair is gray like
4:15this or like that uh,
4:17was an opportunity to understand the
4:18dynamics, the plasticity, like how life
4:21can go from being young to old or old
4:23back to young.
4:24Uh, and what we found was a domain
4:26signal was a mitochondrial signal.
4:28And in the white hair, I thought there's
4:30going to be less color, right?
4:32Obviously, but also probably less
4:34mitochondria, less, you know, some other
4:35things. We found that the white hairs
4:38have more mitochondria.
4:40And there was an upregulation of the
4:42body that the hair follicle where the
4:45hair was becoming old wasn't kind of
4:47letting go of things. It was doing more.
4:49>> So, that means during that period of
4:52time you were more stressed and using
4:56more energy?
4:56>> When cells become old instead of just
4:59dying, right? They struggle.
5:01And when a cell has damage in the DNA or
5:04the mitochondria not working properly or
5:06for some reason they accumulate damage
5:09and become old, the cell struggles to
5:11make more mitochondria and it it tries
5:14to kind of compensate and then ends up
5:16wasting a lot of energy in the process.
5:19>> So, in that hair what you looked at that
5:20was gray, let's call it, um, it had more
5:24mitochondria because it was struggling.
5:27And why was it struggling?
5:29>> It looks like stress hormones can, you
5:31know, make a cell struggle, for example,
5:33cortisol. Cortisol, yes. If you're a
5:35cell, right? And your perspective on the
5:37world is pretty simple.
5:39Uh,
5:40you don't have, you know, the senses
5:41that, you know, we we enjoy, but you do
5:44nevertheless, you you sense the
5:45environment. If cortisol comes and you
5:47get the signal
5:48uh it means there's something out there
5:50in the environment that's dangerous,
5:52right? You should be preparing for
5:53having to fight or to flight or there
5:55there there's something out there that's
5:56dangerous. Our cells evolved to
5:57interpret cortisol in that way.
5:59Um so we did an experiment in the dish.
6:02We wanted to know how much energy does
6:03it cost to worry about the future?
6:06Right? Or how much energy does it cost
6:08to ruminate about yesterday?
6:10>> Mhm.
6:10>> The thing you didn't do or the mistake
6:12you made at work or
6:13that conversation that went sideways,
6:16you know, with your partner.
6:17Uh how much energy does that cost to be
6:19thinking about this? To be, you know,
6:20engaging your stress system, to be
6:22releasing cortisol. Uh so two students
6:25in the lab, Gabriel and Natalia, did
6:27that experiment. They put you would put
6:28cells in a dish, you give them the
6:30equivalent of cortisol. How much energy
6:32is going to cost for these cells to
6:34prepare? There's nothing damaging
6:38to the cortisol itself, but the cortisol
6:39is a signal that there might be
6:40something dangerous outside. Right?
6:42That's like when you're sitting down,
6:43you get an email, you're like,
6:45"I might lose my job." Right? Or I might
6:48not get this contract. And then you you
6:49have this whole stress response. Your
6:51heart starts to beat faster. How much
6:53energy does that cost? Uh so in cells in
6:55a dish, we can isolate that question
6:57really well. We found that the stress
7:00hormone increased energy expenditure and
7:03the cost of life by 60%.
7:06>> So when I'm stressed, I'm using 60% more
7:09energy theoretically.
7:10>> I don't know about you, but cells in a
7:12dish.
7:12>> [laughter]
7:13>> Okay.
7:13>> So there the beauty about like bodies
7:16and you know, with the mind and you
7:18know, this complex organism, they're
7:19buffering systems, right? So you might I
7:21don't think your energy expenditure
7:22increased by 60% if you're stressed out,
7:25but it increases somewhat.
7:27>> What is that graph there?
7:28>> So there two graphs here. Uh the top one
7:31is the color of the hair of a single
7:35hair from a young Asian woman who was
7:37part of the study. And what we see here,
7:39this is called a hair pigmentation
7:41pattern, the HPP. That was we we
7:43developed in the lab to understand
7:45quantitatively bring science to the to
7:47hair growing and and reversal.
7:49And so what you see here is this hair
7:51was dark
7:52and then it became white
7:54for
7:552 cm and then boom, completely regained
7:58color. Actually it regained it was
8:00darker here than it than it used to be,
8:02right? And then stayed dark afterwards.
8:04So this is a hair that we received uh in
8:06the mail as we were starting to to
8:08collect uh two-colored hairs. Um and
8:12then when we when we saw this we we had
8:14found from a few different people
8:16white hairs that had regained color.
8:18We'd never seen a hair like this. That's
8:20dark, white, and then dark, right? So I
8:22remember holding this hair I was like,
8:25"Oh my god.
8:26This is in the same hair. This is
8:28incontrovertible evidence that graying
8:31of hair is reversible and it can be
8:33pretty pretty fast. Like this transition
8:36here is just a few weeks. This is about
8:371 week.
8:39Right? So this white hair, completely
8:40white, regained color in just about a
8:42week.
8:42Um so then we developed an instrument
8:45which was a simple sheet. On the Y axis,
8:48the vertical, is most stressful thing
8:51that ever happened to you, no stress at
8:53all. 10 and 0. And then the X axis, the
8:56horizontal, was time. Yes.
8:59On the far right is now, right? This is
9:02now, this is a year ago. And then we
9:04labeled all the months.
9:06And then we asked people and we asked
9:08this uh lady put a dot on the graph that
9:11was the most stressful time in the past
9:12year. But anyone can do the exercise,
9:15past year, most stressful time.
9:18Okay, maybe last March. And then you put
9:20a dot, right? In March, number 10. And
9:23then least stressful part, uh zero. And
9:25then put other like meaningful things
9:27that happened that were challenging. So
9:28people put dots, you know, along the
9:30this last year, then connect the dots,
9:32right?
9:34The red graph is her dots connected.
9:38>> And it correlates perfectly to her hair
9:40going gray.
9:41>> Correct.
9:42And what happened to her life, she said
9:44she finished her PhD thesis and she was
9:47jobless, but she was fine. She was happy
9:49to be done with her studies and then
9:52broke up with her boyfriend.
9:54>> Oh, damn and her hair went gray.
9:55>> Yeah. Broke up with her boyfriend. She
9:58didn't know what was happening with her
9:59life. She had to travel to Europe. There
10:01was some family drama.
10:03Uh she said these were the last the most
10:04stressful 2 months of my life.
10:06>> There's a killer question here which is
10:09if that remains chronic, does that hair
10:12follicle go gray forever?
10:14>> Yeah.
10:15>> I.E. If I go through a a stressful
10:18period for 2 to 3 weeks and my hair goes
10:20a bit gray, as long as I get out of that
10:22stressful period as quick as possible,
10:24does that hair then return to to black
10:27or dark?
10:27>> Yeah.
10:28>> Do you see what I'm saying here?
10:29>> Yes. It seems like and we ran some like
10:31fancy mathematical model to understand
10:32why this would be possible,
10:34why it could happen like now for this
10:36hair and then be reversible, but we know
10:39it, you know, very well. If you have a
10:41full head of gray hair and you're 70
10:42years old, you're not going to regain
10:43your color. Yeah. So, there seems to
10:45what the model the mathematical model
10:47suggested is that there's a window
10:49opportunity. Right? Where a hair slowly
10:52accumulates damage, becomes more and
10:53more probably energetically inefficient.
10:56Right? So, there's more and more energy
10:57resistance and then there's a barrier.
10:59And then when the the hair hits that
11:01threshold, now it it loses color.
11:03>> It's done.
11:04>> Yeah. But then if something changes in
11:06the body, right? You go on a vacation or
11:09you start to do intermittent fasting and
11:11then there's more energy available for
11:13your dark hair, now it can be reversed,
11:15right? Because you can go back up
11:17against that threshold. But then
11:18eventually this hair is going to go gray
11:20again. And then if you're way way down,
11:22like this hair turned gray 10 years ago
11:24and you go back up, you're too far away
11:26from threshold to regain color.
11:28>> Okay.
11:28>> So, it suggests some threshold model
11:30that there's a window of opportunity for
11:33some something as binary as hair color.
11:36It's a black or it's white, right? So,
11:38there's kind of a window of opportunity
11:39there where
11:40>> where you can reverse gray hair.
11:42>> Yes.
11:42>> I I do want to come back to this hair
11:44thing, but it did make me think cuz you
11:45you added a layer of nuance there, which
11:47is about the mind.
11:48>> Mhm.
11:49>> Like if I go through my life
11:51um with a more resilient mind and you
11:54get that bad email and you go
11:56and I get the bad email and I go, "Fuck
11:57it. I I guess."
11:58>> Yeah.
11:59>> Am I then going to be a way more
12:00productive person throughout those 24
12:02hours because my mitochondria are using
12:04less energy because there's less
12:05cortisol?
12:05>> Yeah. Based on what we know, I think
12:07that's likely correct.
12:09So, it's not the stress that burns us
12:12down. It's the response to stress. And
12:15nothing is free in biology. And for your
12:16heart to beat a little faster, if you
12:18mount a response to that email, right?
12:21You're burning energy in your heart.
12:22>> Yeah.
12:23>> And then you're tensing your you know,
12:25your your shoulder. That's burning
12:26energy. Now your brain is going into
12:28like rumination mode and then this thing
12:30and then then it makes you think about
12:31your childhood and this and like and
12:33then the the anxiety that and then you
12:35start to sweat. Like everything costs
12:37energy.
12:38>> So, the chain of events is I get the
12:41email. It's a very bad email. Says,
12:43"You're fired, Steven, from the
12:44diversity here. We found a different
12:45host."
12:46>> Yeah.
12:46>> Um I look at the email.
12:48That goes into my psychology, my mind.
12:51I then have a story I tell myself about
12:54what that email means for me, my future,
12:55my children, whatever,
12:57which then causes a physiological
12:59response of like chemicals like
13:01cortisol.
13:02>> Yeah.
13:03>> Um which goes into my cells, my
13:05mitochondria, which then have to work a
13:07little bit harder or use more energy.
13:08>> Mhm.
13:09>> Which is ultimately then going to mean
13:10that I'm
13:12more tired because I have a finite
13:15amount of energy per day.
13:17>> Mhm.
13:17>> Is that is that sequence of events I ask
13:20about that sequence because it offers me
13:21an opportunity to intervene at some
13:23point?
13:23>> Yes. Yes. That's right way to think
13:25about it.
13:26>> Don't open the laptop.
13:26>> [laughter]
13:28>> Or I
13:29get a little bit better with bad news.
13:31>> Yeah, or you know, learn to be less
13:33reactive, right? Or learn to to feel and
13:36and
13:37um you know, sit with be aware of that
13:39reaction cuz the key solution to kind of
13:43to to cutting that
13:44sequence of event that ends up draining
13:46you is to become aware of it.
13:48>> Yeah, become aware of it. Yeah.
13:50>> Right? Uh so you can kind of interrupt
13:52this and people who study contemplative
13:55practices and and meditation and you
13:57know, mindfulness approaches,
13:59I think many of them think this is kind
14:01of the key, right? They the awareness,
14:03the somatic awareness or interoception.
14:06So if you feel into your your bodily
14:08responses, you become free of do I mount
14:11a response? Is that needed now or not?
14:13>> There's different types of stress,
14:14right? There's like the acute stress
14:16which is just you get the email, you
14:17feel a little bit of a spike, but 5
14:19minutes later you're fine.
14:20>> Yep.
14:21>> And then there's the more chronic type
14:23of stress where
14:24you wake up every day with the same
14:26feeling of stress deep inside you for
14:29many many days in a row, many weeks in a
14:30row.
14:30>> Yeah.
14:31>> Um I hear that acute stress isn't all
14:33that bad and it's very normal and
14:35useful, but it's this chronic stress
14:37that can cause a lot of damage.
14:38>> Yeah. And I think that brings us back to
14:40the concept of how is energy flowing
14:42through the body? And if it flows with
14:44not enough resistance, you can't
14:46survive, but if there's too much
14:47resistance, then you you get drained.
14:49>> How do I think about this resistance
14:51thing cuz I'm really struggling with
14:52like understanding it?
14:54>> Maybe one good example to to frame this
14:56is exercise.
14:57>> Yeah.
14:57>> Right? When you start to exercise,
14:59there's increased resistance in your
15:02muscle, right? Your muscles are
15:04contracting. So there's a physical
15:05resistance there, but there's also
15:07energy resistance. So the the energy's
15:09trying to flow through the muscle and
15:10then there's you have mitochondria. If
15:12you have just a few mitochondria and the
15:14muscles are contracting really hard,
15:16like you're running, you're sprinting,
15:17right? You're doing interval training.
15:19Um now the mitochondria don't have the
15:21capacity to flow as much energy as the
15:23muscle is asking.
15:25Right? So, that imbalance of demand to
15:28flow capacity. Now, the the product of
15:31this, the demand divided by flow
15:32capacity, is resistance.
15:34>> Okay.
15:35>> So, if you demand a lot of your muscle
15:37because of your your your sprint, uh but
15:39you you don't have a lot of
15:40mitochondria, right? It's going to feel
15:42terrible. Uh and then because the
15:43resistance creeps up, and then your
15:45muscle, you know, becomes really hot,
15:47and then eventually there's
15:48inflammation, uh and then it it burns,
15:50and then then it's uncomfortable.
15:52Uh but then
15:54So, that's like an acute bout of of
15:56energy resistance. What happens with
15:58exercise is once you recover, right? The
16:01benefits of exercise don't happen during
16:03the exercise, they happen after, during
16:05the recovery. So, if you recover, now
16:07you're you're the muscles are relaxing,
16:09and you're resting, eventually you go,
16:11you know, for you go to sleep. Uh it's
16:14the And during the decrease in the
16:16resistance, now the cell says, "Next
16:18time this happens, I better be ready.
16:20Like, this was really uncomfortable.
16:21There was too much energy shoved into a
16:23system that couldn't take it." Right?
16:25So, I need next I'm going to make more
16:26mitochondria. So, that that's what
16:28happens if you go from being a sedentary
16:31couch potato, right? To training for a
16:33marathon. You can double the amount of
16:35mitochondria you have in your muscles.
16:38And that's the system feeling the the
16:40rise in resistance, like, "I don't have
16:41the capacity to flow that much energy."
16:43And then uh adapting for this for the
16:46next time. And said, "Next time, I'm
16:48going to be ready. Let's make more
16:49mitochondria." So, that's probably what
16:51where the benefits of exercise come
16:53from. This the spike in and and why
16:56stress is is not a bad thing
16:58intrinsically, right? If you have a
17:00spike of stress, it stimulates the
17:02process the the the it stimulates the
17:04body to put in place things that in the
17:07long run makes you more efficient,
17:09decreases your resistance. Then you can
17:10go through life with with less
17:13resistance.
17:14>> Coming back to this gray hair thing. So,
17:16if if we consider gray hair, my hair
17:19going gray, to be the last domino that
17:21fell, so like the symptom, yep, then
17:24what is what are the what is the first
17:26domino?
17:27And can you walk me through the sequence
17:28of events? Because one would assume that
17:31if I understand that sequence of events,
17:33I can also understand how to then
17:34reverse it. How to kind of take I've got
17:36a couple of gray hairs now. And I
17:37actually anecdotally do think, weirdly
17:39now you've said this,
17:41that I have like gray hair flare-ups.
17:44Where I'll go through I'll, you know, go
17:45through a couple of months of doing
17:46something and I look in the mirror and
17:48I'm like, "What? I have 12 now?"
17:50I'm being generous there, there's more
17:51like 25. [laughter]
17:52I have I have 25 now. In terms of those
17:54dominoes, the symptom is gray hair. What
17:56is the first domino that that falls? And
17:58what is the sequence of events that
17:59leads to the gray hair in the follicle?
18:02>> So, there is a finite energy budget and
18:04then what the organism does is it
18:06allocates energy in different places,
18:07like a business, right? You have this
18:09budget, do I put more energy here? If do
18:11I put, you know, more resources here? If
18:13so, I need to take resources away from
18:14here, right? So, as stress happens in
18:17your life, it pulls energy away from
18:19some of the things that keep you young,
18:21right? So, there's
18:23there's a kind of a hierarchy of energy
18:25needs in the body. Not everything can be
18:26prioritized the same way. You know
18:28Maslow's hierarchy of human needs? Yeah.
18:31So, Maslow's insight was uh
18:33>> Oh my god, I just freaked out. My hand
18:35reached down and I just felt someone's
18:36head.
18:37It was just
18:40>> Acute stress response.
18:41>> Yeah, I just got Yeah, caught us off
18:43guard. Sorry. Maslow's hierarchy of
18:44needs.
18:45>> Yeah.
18:46So, there's there's a hierarchy of
18:48energy needs in the body that's works
18:50similarly to Maslow's hierarchy of
18:52needs. Maslow said, for a human being to
18:55be fully realized, first you need to
18:57have safety and food and shelter
18:59secured, right? Once you have this and
19:01you feel this is kind of covered in your
19:03life, then you can start to think about
19:04building relationships with other
19:06people, right? Loving relationships.
19:08Once you have this settled, now you can
19:10and to think about building your skills,
19:12right? Like becoming really good at
19:13something. Uh and then once you have
19:15this covered, now you can devote energy
19:18to the more frivolous things like
19:19spirituality, what do you call
19:21self-actualization, and kind of becoming
19:23your best self, flourishing. Uh so he
19:25saw this very much as a this is this
19:28needs to be covered uh and when things
19:31get really hard and there are
19:32constraints on your life, the first
19:34thing to go is the top of the pyramid,
19:35right? Your meditation practice or
19:37long-term type like I'm going to be a
19:39better person now like make sure we can
19:42put food on the table next week, right?
19:45Um so this hierarchy of of human needs,
19:48I think aligns with hierarchy of
19:51uh of energy needs in the body. And as
19:53far as the importance of hair color
19:56goes, it's pretty low on the hierarchy.
19:59So as the body gets older and you have
20:02more and more cells in the body that
20:04start to
20:06uh be less efficient, right? Their
20:07mitochondria working a little, you know,
20:10less efficiently and
20:12uh and then there there's more
20:13inflammation in the body that's costing
20:14energy and uh there's
20:18more worries about, you know,
20:20professional obligations and all these
20:21things kind of stack up and steal energy
20:23away from the things that are there, we
20:25call them growth, maintenance, and
20:27repair. These are like the anti-aging
20:30processes in in the body. And those need
20:32energy, but they're not as important as
20:35you know, facing the stressor that you
20:37think is life-threatening now.
20:38>> So if there's a lion chasing me, my
20:40body's going to commit all the the
20:42energy I have to getting away from this
20:44lion and it might say, "Listen, Stephen,
20:46we're not going to repair the skin next
20:49to your eyes. You're going to get a
20:51couple more wrinkles and we're not going
20:52to make your we're not going to commit
20:54energy to making sure your follicles in
20:56your hair produce black pigment or
20:58whatever."
20:59>> Exactly.
20:59>> So I would then look aged, I would look
21:01old older.
21:03>> But that's because all of my energy's
21:04been going to something else which my
21:05body considered to be a high priority.
21:07>> Right. Which also brings me to, I guess,
21:09the famous
21:11>> [laughter]
21:11>> what we always talk about with
21:12presidents because presidents go into
21:14office often with dark hair
21:16and they come out with gray hair. And
21:18usually one does not age that quickly in
21:208 years. We see the same in the Premier
21:21League with football managers. They walk
21:23in on that first day, they look very
21:24sprightly and energetic and 2 years
21:27later they have gray hair, bags under
21:29their eyes, wrinkles, and they look like
21:30they've aged 10 years.
21:32>> Yeah.
21:32>> So, you're telling me actually that the
21:34the real secret to anti-aging, if there
21:36was one,
21:37is this?
21:38>> Is the proper allocation of energy.
21:41>> If you love The Diary of a CEO brand and
21:42you watch this channel, please do me a
21:44huge favor, become part of the 15% of
21:47the viewers on this channel that have
21:49hit the subscribe button. It helps us
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