Stop Quercetin Supplements (New Study) — Transcript

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1. 0:00about one week ago i made a video
2. 0:02explaining why i'd stopped taking
3. 0:03quercetin and physicism supplements it
4. 0:06was on the back of some disappointing
5. 0:08data that came out from the
6. 0:09interventions testing program they
7. 0:11trialled physician and there was no
8. 0:13health span or lifespan benefits scene
9. 0:16there was also no synalytic activity
10. 0:18generally people could understand why it
11. 0:20stopped taking physician but there was a
12. 0:22lot of confusion as to why it stopped
13. 0:24taking quercetin as well and i want to
14. 0:27address all of the main questions that
15. 0:29came up in the comments section
16. 0:30let's get into it i used to take both
17. 0:33quercetin and physician five days in a
18. 0:35row each month and this was for the
19. 0:37synalytic effect essentially what i was
20. 0:40trying to do is clear away my old
21. 0:42senescent cells cells that are no longer
22. 0:44dividing and potentially could be
23. 0:46damaging my surrounding tissues both
24. 0:48quercetin and physin they're molecules
25. 0:51called flavonoids and flavonoids are
26. 0:53found in fruits and vegetables and out
27. 0:55of all of the flavonoids that have been
28. 0:57tested it's physician that's the most
29. 0:59potent synalytic and that's why the
30. 1:01interventions testing program trialled
31. 1:03physcetin and not quercetin and
32. 1:05unfortunately there was no benefit seen
33. 1:08with physician supplementation so if
34. 1:10there's no benefit with physician and
35. 1:11even worse than that there's no
36. 1:13synalytic activity seen as in there was
37. 1:15no evidence of clearance of the
38. 1:17senescent cells why would i use a less
39. 1:20potent synalytic in quercetin if
40. 1:22physician doesn't work so i hope that
41. 1:24makes sense if the most potent synalytic
42. 1:27as in physatin doesn't appear to give
43. 1:29any benefits why would i take a less
44. 1:31potent synalytic as inquisitive it
45. 1:33doesn't make sense and that's why i
46. 1:35stopped both of them the next question
47. 1:37that came up was around absorption was
48. 1:40physician actually absorbed by these
49. 1:42mice because of course if the physician
50. 1:44isn't being absorbed we're not going to
51. 1:45see a benefit well before the
52. 1:47interventions testing program trials any
53. 1:49molecule they do make sure that it can
54. 1:52actually be absorbed so listen to what
55. 1:54dr richard miller the head of the
56. 1:56interventions testing program says about
57. 1:57spermadine and why they haven't tested
58. 2:00spermadine the other drug you mentioned
59. 2:02was spermatine
60. 2:04a very fine
61. 2:06scientist frank padeo
62. 2:08recommended that we try this
63. 2:10told us how much to use and whenever
64. 2:12before we start a lifespan experiment we
65. 2:13always give the mice the drug for eight
66. 2:15weeks just to see if it gets in
67. 2:18and we put them on spermadine and eight
68. 2:20weeks later we found no increase in
69. 2:22spermidine in the blood or the liver or
70. 2:25any of the other tissues so we were not
71. 2:27willing to test
72. 2:28a drug in mice unless we could prove
73. 2:32that it was
74. 2:33changing their intrinsic level of
75. 2:35spermity in at least one tissue so there
76. 2:37you go the interventions testing program
77. 2:39they do make sure that the molecules
78. 2:41that they're testing can actually be
79. 2:43absorbed by the mice and gives the
80. 2:44molecules a chance to work and in this
81. 2:47case then flycotin it was being absorbed
82. 2:49but there was no benefit seen and no
83. 2:51synalytic activity seen then in the
84. 2:54comments section people were mentioning
85. 2:55all sorts of other reasons for taking
86. 2:57quercetin so for example some people
87. 2:59were taking quercetin to lower their
88. 3:01uric acid levels and this idea of
89. 3:03lowering uric acid it really took off
90. 3:06after dr david perlmutter published his
91. 3:08book called acid drop now i have done a
92. 3:11separate in-depth video around the
93. 3:13research on lowering uric acid levels
94. 3:15and i'll link to it in the pinned
95. 3:17comment below but essentially lowering
96. 3:19uric acid levels for non-gout patients
97. 3:22it goes completely against the latest
98. 3:24clinical guidelines dr perlmutter talks
99. 3:27about how lowering uric acid levels may
100. 3:29prevent the chances of developing
101. 3:30dementia but actually the research
102. 3:33suggests the complete opposite two
103. 3:35separate meta-analyses which combined
104. 3:37all of the available data together both
105. 3:39concluded that uric acid might actually
106. 3:41protect against dementia and that lower
107. 3:44levels of uric acid is a potential risk
108. 3:46factor for developing dementia so using
109. 3:49quercetin to lower uric acid levels
110. 3:51makes no sense at all then other people
111. 3:54in the comments were mentioning about
112. 3:55how they were using quercetin for its
113. 3:57anti-inflammatory effect but arguably
114. 3:59the most famous anti-inflammatory
115. 4:01flavonoid is curcumin and that's found
116. 4:04in turmeric curcumin was trialled by the
117. 4:06interventions testing program in 2012
118. 4:09and no lifespan effects were seen so if
119. 4:11the most potent anti-inflammatory
120. 4:13flavonoid curcumin doesn't provide any
121. 4:16benefits why would i take a less potent
122. 4:18flavonoid as in quercetin it doesn't
123. 4:20make sense so i hope that by addressing
124. 4:23those points i've cleared up any
125. 4:24confusion as to why i've made the
126. 4:26decision to stop taking quercetin to
127. 4:28recap physatin is the most potent
128. 4:31flavonoid synalytic but there was no
129. 4:33synalytic activity seen with the
130. 4:35interventions testing program there was
131. 4:37also no other benefits or lifespan
132. 4:39extension seen so it doesn't make sense
133. 4:41to continue the less potent synalytic as
134. 4:43in quercetin that's why i stopped both
135. 4:45physician and quercetin the next
136. 4:48question was whether physician was
137. 4:49actually absorbed by the mice and we can
138. 4:51see quite clearly that during the
139. 4:53process of selecting molecules that the
140. 4:55interventions testing program trials
141. 4:57they first make sure that the molecules
142. 4:59are absorbed so the physician it was
143. 5:01absorbed but no benefit was seen the
144. 5:04research also doesn't support the idea
145. 5:06of using quercetin to lower uric acid
146. 5:08levels for non-gout patients and finally
147. 5:11the most potent flavonoid for
148. 5:13anti-inflammatory effects is curcumin
149. 5:15and that didn't produce any benefits
150. 5:17when it was tested in 2012 so why would
151. 5:20i take a less potent anti-inflammatory
152. 5:22as in quercetin so please let me know in
153. 5:25the comments section if i've missed any
154. 5:26of your queries or if there's any
155. 5:28remaining confusion because i do want to
156. 5:29try and clear things up a massive thank
157. 5:31you to all of the patrons who support
158. 5:33the channel and if you haven't already
159. 5:35please check out my clinical trial
160. 5:36fundraiser for rapamycin until next time
161. 5:39thanks very much