Omeprazole — Transcript

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1. 0:00the last new material that I'd like to
2. 0:03take in this chapter is to discuss some
3. 0:06of the important points about
4. 0:08omeprazole
5. 0:10Omeprazole is sold under a number of
6. 0:12different brand names around the world
7. 0:14some of which include Prilosec low SEC
8. 0:19and other names and it's made for the
9. 0:24treatment of gastroesophageal reflux
10. 0:27disease and peptic ulcer disease and
11. 0:31also in conditions where there's just
12. 0:33too much acid being formed in that
13. 0:36stomach
14. 0:37whenever you hear about a medication
15. 0:40that's indicated for something you
16. 0:43really do need to find out the safety
17. 0:46issues of that something that that
18. 0:49disorder that the person has
19. 0:52and find out you know quite a bit more
20. 0:55if possible
21. 0:56and I'll give you an example because
22. 1:00Omeprazole is oftentimes prescribed for
23. 1:04a condition called Barrett's disease and
24. 1:06Barrett's disease is a condition for the
25. 1:10esophagus is experiencing pre-cancerous
26. 1:14lesions it's actually going toward
27. 1:17cancer
28. 1:18and oftentimes the person describes
29. 1:22their disorder as being you know
30. 1:25gastroesophageal reflux disease and they
31. 1:27don't really know that it is Barrett's
32. 1:31disease they haven't been told uh enough
33. 1:34information or that maybe they forgot
34. 1:36that information and they just say oh
35. 1:38yeah I've got gastroesophageal reflux
36. 1:41disease and you might think well you
37. 1:43know if you just have gastroesophageal
38. 1:45reflux disease we'll just you know put
39. 1:47you on something else you're we've got
40. 1:49some natural things here that might be
41. 1:51better well that's extremely dangerous
42. 1:54because you know that could actually
43. 1:57result in the person progressing as the
44. 2:00acid continues to Splash on those cells
45. 2:03that are already changed and already
46. 2:06going toward the cancerous stage that
47. 2:10could actually develop into esophageal
48. 2:12cancer and another example is that the
49. 2:16Omeprazole is oftentimes per prescribed
50. 2:19for people who have peptic ulcer disease
51. 2:22sometimes those people who have peptic
52. 2:25ulcers will have an erosion all the way
53. 2:28down into the artery and then that
54. 2:31artery starts to spew blood into their
55. 2:35into their stomach so there's a couple
56. 2:38conditions where it's just really really
57. 2:41important that the person doesn't get a
58. 2:45suggestion for instance to go on some
59. 2:48alternative medication whenever you hear
60. 2:52that the person is having side effects
61. 2:55obviously you need to act act on that
62. 2:58but your action shouldn't be to just
63. 3:01withdraw that medication unless you're a
64. 3:03prescriber and unless you know the
65. 3:05entire situation of that individual
66. 3:08person
67. 3:10Omeprazole is on the World Health
68. 3:12organization's list of essential
69. 3:15medications and in some countries it's
70. 3:18available over the counter and the
71. 3:20common side effects include nausea
72. 3:23vomiting and increased intestinal gas
73. 3:27uh other side effects include an
74. 3:30increased risk of gastrointestinal tract
75. 3:33infections and also increased risk of
76. 3:36pneumonia so what's the reason why do
77. 3:39you think that the consumption of an
78. 3:44basically something that decreases acid
79. 3:46is going to result in an increase
80. 3:48incidence of infections well remember
81. 3:52that the acid is a protective mechanism
82. 3:55it's one of our protective mechanisms
83. 3:58for decreasing the proliferation of
84. 4:00bacteria for instance
85. 4:02so as we have
86. 4:04less of that protection or in some
87. 4:07instances
88. 4:09Omeprazole gives no protection allows no
89. 4:12acid in that stomach when we have that
90. 4:16condition there is going to be an
91. 4:18increased risk of infections
92. 4:23long-term
93. 4:24Omeprazole use also carries with it an
94. 4:27increased risk of bone fractures and
95. 4:30what did we say the reason for that was
96. 4:33remember that the acid in the stomach is
97. 4:37necessary for the absorption of some of
98. 4:40the nutrients and two specific nutrients
99. 4:43with respect to bone health have to do
100. 4:45with the calcium and the Magnesium when
101. 4:49you have a decrease in stomach acid
102. 4:51you'll have a decrease in absorption of
103. 4:54both magnesium and calcium
104. 4:58Omeprazole is considered a pregnancy
105. 5:00category B in Australia and a C class in
106. 5:06United States so what does that mean
107. 5:09well there's a slight difference in
108. 5:11categories in Australia and the United
109. 5:14States but in general for both
110. 5:16categorizations pregnancy category a is
111. 5:21the best class and you shouldn't expect
112. 5:24pregnancy category A drugs to have any
113. 5:28effects on the growing fetus any adverse
114. 5:31effects on the growing fetus
115. 5:34conversely pregnancy category D is the
116. 5:39worst class that's not definitively
117. 5:41associated with fetal abnormalities and
118. 5:45pregnancy category X is definitely
119. 5:48teratogenic in other words it definitely
120. 5:52causes abnormalities to The Unborn fetus
121. 5:55and different countries have different
122. 5:57classifications for instance in Germany
123. 5:59they have a completely different
124. 6:01classification so if you're working with
125. 6:04pregnant women you need to learn the
126. 6:06classifications that are relevant to the
127. 6:09country in which you're working the
128. 6:11bottom line for Omeprazole for instance
129. 6:14is that there are safety issues safety
130. 6:17questions about that medication that
131. 6:20should prompt you to go back to the
132. 6:22prescriber and say listen this person is
133. 6:26considering getting pregnant or this
134. 6:28person has become pregnant and they're
135. 6:31on this drug so do we want to do
136. 6:33something about it
137. 6:35and we've already taken quite a bit of
138. 6:38other information about Omeprazole
139. 6:40during the course of our discussions
140. 6:42about other things for instance we were
141. 6:44saying that
142. 6:46it did inhibit a couple of the liver
143. 6:49enzymes and as such there's going to be
144. 6:53an effect on certain drugs so
145. 6:56specifically for instance there's going
146. 6:58to be an increased action of the
147. 7:00benzodiazepines and then there will be
148. 7:03decreased action of other drugs
149. 7:07but the idea is not to memorize a long
150. 7:10list of drugs that every medication is
151. 7:13contraindicated in but rather to just
152. 7:16know that you need to research it as you
153. 7:19see that information pop up
154. 7:22and we already know that Omeprazole is
155. 7:25an irreversible inhibitor of the
156. 7:27hydrogen potassium atpase pump in the
157. 7:30stomach and that means that we're going
158. 7:33to have a decrease in stomach acid by
159. 7:35about 99 percent
160. 7:38and the fact that Omeprazole is an
161. 7:40irreversible inhibitor of that enzyme
162. 7:43means that the effects of the medication
163. 7:47are going to last a lot longer than the
164. 7:51medication is in the system in this case
165. 7:54the effects of the medication will last
166. 7:57you up to about 72 hours
167. 8:00and that wraps up the new material of
168. 8:03this chapter in the final lesson of this
169. 8:06chapter we're going to review what we've
170. 8:09learned and see how we can apply that
171. 8:12information to when we're studying other
172. 8:15medications