NMN Supplements: Hope vs Hype? (surprising conclusion) — Transcript

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1. 0:00this is the most comprehensive review of
2. 0:02the anime research that I've ever done
3. 0:03to answer the question will enemy
4. 0:06supplements radically improve our health
5. 0:07or is it just hype and I think most of
6. 0:10you will be surprised at the conclusion
7. 0:12at the end so nmn stands for
8. 0:14nicotinamide mononucleotide and it's a
9. 0:17form of vitamin B3 and there's a lot of
10. 0:19excitement about the potential that any
11. 0:21men may have on human health because of
12. 0:23papers such as this one in 2016 where
13. 0:26they gave any men to mice over a
14. 0:2712-month period and compared it to
15. 0:29Placebo and the mice who took in him in
16. 0:31they were protected against the
17. 0:33age-associated physiological declines so
18. 0:36they had enhanced energy metabolism
19. 0:38greater physical activity and improved
20. 0:40insulin sensitivity so the theory goes
21. 0:43that if we take nmn or other forms of
22. 0:45vitamin B3 we can support our NAD levels
23. 0:48and NAD is crucial to our metabolism it
24. 0:51influences many key cellular functions
25. 0:53including DNA repair cellulose
26. 0:56senescence and immune cell function the
27. 0:58trouble is many research papers they
28. 0:59postulate that aging is associated with
29. 1:02a gradual decline in NAD levels and this
30. 1:05decline is linked to numerous
31. 1:06age-associated diseases including
32. 1:08cognitive decline cancer metabolic
33. 1:11disease and Frailty so it's hoped that
34. 1:13many of these age-associated diseases
35. 1:15will be slowed down or even reversed by
36. 1:18restoring NAD that's the overall idea
37. 1:20but it raises even more questions do NAD
38. 1:23levels actually go down as we age does
39. 1:26this happen in all tissues is any men
40. 1:28directly absorbed and does it support
41. 1:30NAD levels in all tissues and what do
42. 1:33the current human clinical trials show
43. 1:35because here's the thing in February
44. 1:372022 a paper was published that took
45. 1:39muscle biopsies and compared them
46. 1:41between young and old patients what they
47. 1:44found is that older adults who didn't
48. 1:45exercise they had lower levels of muscle
49. 1:48NAD but the older adults who did
50. 1:50regularly exercise they had NAD levels
51. 1:53roughly the same compared to younger
52. 1:54people so it's not obvious that NAD
53. 1:56levels decline as we age it might be
54. 1:59that through a great lifestyle including
55. 2:01a good diet and regular exercise we can
56. 2:03maintain youthful NAD levels without
57. 2:05supplements particularly because in our
58. 2:07cells there's the Selvage pathway so as
59. 2:10our NAD is used up for all of those
60. 2:12different chemical reactions related to
61. 2:14our metabolism that used up NAD can then
62. 2:16be recycled so that's the first
63. 2:18important point the second one is are
64. 2:21any immune supplements actually absorbed
65. 2:23and can they help rebuild NAD now in the
66. 2:26literature there's a lot of controversy
67. 2:27where a fascinating twist has recently
68. 2:30been added to the story suggesting that
69. 2:32orally administered nicotinamide
70. 2:33riboside as well as nmin will almost be
71. 2:36fully transformed into nicotinic acid by
72. 2:39the gut microbiome so let's back up for
73. 2:41a second there are numerous different
74. 2:43forms of vitamin B3 so we've got NR
75. 2:46nimin nicotinamide and nicotinic acid or
76. 2:49niacin and multiple papers have now
77. 2:51suggested that if you take nmn
78. 2:53supplements or in our supplements
79. 2:54they're first converted into nicotinic
80. 2:57acid before they're absorbed into the
81. 2:59body but this is still extremely
82. 3:00controversial if the NR and any men
83. 3:03supplements were converted into
84. 3:04nicotinic acid we would expect to see
85. 3:07patients develop flushing because that's
86. 3:09one of the side effects of taking
87. 3:11nicotinic acid but this doesn't happen
88. 3:13with any men or NR even at doses four to
89. 3:16six-fold higher so there's still a lot
90. 3:18of unanswered questions about how
91. 3:20exactly inimin and in our supplements
92. 3:22are absorbed into the human body and
93. 3:24reach our cells it gets even murkier
94. 3:27when we look at this 2018 paper where
95. 3:29they isotopically labeled any Min and NR
96. 3:32to see exactly how these supplements are
97. 3:34absorbed what they found is that both of
98. 3:36these supplements are significantly
99. 3:37broken down before they reach our
100. 3:39bloodstream to sum up so far then it's
101. 3:42not obvious that NAD levels decline as
102. 3:44we age and it's not obvious that any men
103. 3:46or NR supplements are directly absorbed
104. 3:49by the body but moving on to the next
105. 3:51Point regardless if any mean is first
106. 3:54broken down into a different molecule
107. 3:55does it overall still result in Greater
108. 3:58NAD levels well with got overwhelming
109. 4:00human evidence that yes nmn supplements
110. 4:03they do Boost blood in A.D but it's not
111. 4:06so much blood in A.D that we're
112. 4:07interested in what we want to see is
113. 4:09Will these supplements increase muscle
114. 4:11NAD or the NAD levels in other tissues
115. 4:14in the body and unfortunately to my
116. 4:16knowledge we don't have any enemy in
117. 4:18human studies to answer this question so
118. 4:21we don't know whether nmn supplements
119. 4:22will boost muscle in ad but we do have
120. 4:25evidence from an NR or nicotinamide
121. 4:27riboside human study where over a
122. 4:2912-week period the muscle NAD levels
123. 4:32remained unchanged which is a very
124. 4:34disappointing finding but it's what we
125. 4:36would expect if NR and nmn supplements
126. 4:39are first broken down before they reach
127. 4:41the bloodstream and before they can
128. 4:43reach our muscles and it may explain why
129. 4:45these supplements have failed to provide
130. 4:47any major effect in skeletal muscle
131. 4:49metabolism in the different clinical
132. 4:51trials performed to the state on healthy
133. 4:53obese or elderly patients to make sure
134. 4:55that we're still all on the same page
135. 4:57it's not obvious that as we age our
136. 4:59inner ad levels decline it's not obvious
137. 5:02that nmn or NR is directly absorbed into
138. 5:04the body and it's unlikely that these
139. 5:06supplements directly reach our muscle or
140. 5:08boost muscle NAD last year there were a
141. 5:11lot of any men human clinical studies
142. 5:13that were published and I reviewed each
143. 5:15one on my channel as they came out and
144. 5:17if you just read the abstracts you'd
145. 5:19think that any Min was God's gift to the
146. 5:21world but as I went through in the
147. 5:23separate videos these studies are small
148. 5:25and many of them have got serious
149. 5:27methodological issues so it makes
150. 5:29drawing any definitive conclusions
151. 5:30difficult there's also no convincing
152. 5:32evidence for improvements in muscle
153. 5:34performance but if we expand our scope
154. 5:37and look at research on other forms of
155. 5:39vitamin B3 there are some very
156. 5:41interesting findings in multiple
157. 5:42clinical studies vitamin B3 has been
158. 5:45shown to improve signs of aging such as
159. 5:47fine lines and wrinkles and it's now
160. 5:49recognized in the clinical guidelines
161. 5:51for its skin anti-aging effect and given
162. 5:54that NAD is Central to our metabolism we
163. 5:56want to try and support it during times
164. 5:58of stress for example example when
165. 6:00vitamin B3 was given to covert patients
166. 6:02alongside other supplements the recovery
167. 6:04time was a whopping three days faster we
168. 6:07can also see that for patients with
169. 6:09damaged mitochondria which are the
170. 6:11powerhouses of our cells vitamin B3
171. 6:13improved muscle strength and helped grow
172. 6:15new mitochondria Plus in a large phase 3
173. 6:18study of nicotinamide which is also a
174. 6:20form of vitamin B3 we can see that it
175. 6:23reduced the rates of new non-melanoma
176. 6:25skin Cancers and high risk patients and
177. 6:28just on the point of cancers because
178. 6:29there's a lot of confusion about this on
179. 6:31social media it's highly likely based on
180. 6:33that paper that we've just gone through
181. 6:34that vitamin B3 is protected against new
182. 6:38cancers but there is a chance that
183. 6:39vitamin B3 may help fuel existing cancer
184. 6:42growth coming back to nmin it's highly
185. 6:45likely that any Min is not directly
186. 6:47absorbed by the body instead it's likely
187. 6:49that it's broken down first into
188. 6:51nicotinamide and nicotinic acid all of
189. 6:54which are forms of vitamin B3 and when
190. 6:56we look at the human data on vitamin B3
191. 6:58there seems to to be tangible benefits
192. 7:01and it's why vitamin B3 is the only
193. 7:03vitamin that I make a dose so
194. 7:05subscribers of this channel might think
195. 7:07that I'm against vitamin B3 because
196. 7:09whenever a new paper comes out generally
197. 7:11I tear it down because of the
198. 7:12methodological issues but I'm actually
199. 7:14very optimistic about the role that it
200. 7:16will have in human health span and again
201. 7:18this is why it's the only vitamin that I
202. 7:20make a dose and on the point of dosage
203. 7:23the recommended daily intake for vitamin
204. 7:25B3 is 16 milligrams and personally I
205. 7:28take 50 milligrams of nicotinic acid or
206. 7:31niacin so just over three times the
207. 7:33recommended daily intake and I use
208. 7:35nicotinic acid because it's far cheaper
209. 7:37compared to nmn or NR and again any Min
210. 7:39or NR they're most likely broken down
211. 7:42into nicotinic acid anyway supplement
212. 7:44companies who sell enemin they generally
213. 7:46sell it at a dose of one gram which is
214. 7:49just over 60 times the recommended daily
215. 7:51intake so again your health your
216. 7:53decision but that's not the dosage that
217. 7:55I take the other complicating factor is
218. 7:57that the FDA recently banned enemy in
219. 7:59supplements because of a company called
220. 8:01metrobiotech which Dr Davidson clay
221. 8:03co-founded they've developed their own
222. 8:05proprietary blend of any men called
223. 8:08mib626 now the supplement companies are
224. 8:10currently negotiating with the FDA and
225. 8:13while this process is ongoing many of
226. 8:15them are still selling any men if you do
227. 8:17choose to buy any mean I highly
228. 8:19recommend that you choose a brand that's
229. 8:21regularly third-party tested for Purity
230. 8:23for example I've previously done a
231. 8:25review of some of the enemy Brands sold
232. 8:27on Amazon and many of them don't have
233. 8:29any any men in their product at all the
234. 8:31three most recognized brands for pure
235. 8:33enemin is renewed by science Pro Health
236. 8:35and do not age but if you're interested
237. 8:37in a summary of all of the things that
238. 8:39you can do to lead a healthy long life
239. 8:41make sure to check out this video here a
240. 8:44massive thank you in particular to do
241. 8:45not age.org for their ten thousand
242. 8:47dollar donation to my rapamycin study
243. 8:49they are a health research organization
244. 8:51and to benefit from the ingredients as
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