NAC & Glutathione Extend Mice Lifespan By 24% — Transcript

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1. 0:00a new paper published in march of this
2. 0:02year 2022 showed that the combination of
3. 0:05glycine and nac supplementation in mice
4. 0:08extended their lifespan by a whopping 24
5. 0:11percent so in this video we'll go
6. 0:13through the background research on
7. 0:14glycine and neck supplementation we'll
8. 0:17have a deep dive into this new paper and
9. 0:19then i'll share with you if it changes
10. 0:20anything for my supplement stack let's
11. 0:23get into it as we age our levels of a
12. 0:26powerful antioxidant called glutathione
13. 0:28appear to go down and this is a problem
14. 0:31because glutathione is a critical
15. 0:32regulator of oxidative stress and our
16. 0:35immune function but glycine and neck are
17. 0:38critical building blocks for glutathione
18. 0:41and we can see from a 2021 human pilot
19. 0:44study that the combination of neck and
20. 0:46glycine it can correct the glutathione
21. 0:49deficiency so after glycine and mac were
22. 0:52supplemented for 24 weeks in older
23. 0:54adults it corrected the lower levels of
24. 0:56glutathione in the blood this is
25. 0:58fantastic because we can see from the
26. 1:002002 paper that as we age the oxidative
27. 1:04stress it increases but our body it
28. 1:06seems to cope okay with it until we
29. 1:08reach 45 years old where we reach a
30. 1:11tipping point and the body can't cope
31. 1:13anymore our glutathione levels from that
32. 1:15stage decrease so by supplementing with
33. 1:18neck and glycine it looks like we can
34. 1:20support our glutathione levels and keep
35. 1:23them at a healthy level but that begs
36. 1:25the question if we're trying to boost
37. 1:27glutathione why not just take
38. 1:29glutathione supplements directly the
39. 1:31trouble is over-the-counter glutathione
40. 1:33supplements they are of limited value
41. 1:35because they're quickly broken down in
42. 1:37our environment so by the time that we
43. 1:39take the glutathione supplement in most
44. 1:42of it would have already broken down
45. 1:44this has led to some supplement
46. 1:45companies creating liposomal versions of
47. 1:48glutathione overall in the liposomal
48. 1:51form the glutathione it can be absorbed
49. 1:53but the trouble is it bypasses all of
50. 1:56the body's checks and balances and it
51. 1:58can directly get into our cells which
52. 2:00can be incredibly dangerous since the
53. 2:02body can't regulate the liposomal
54. 2:04glutathione in theory toxic levels can
55. 2:07build up instead what we're looking for
56. 2:09is a perfect balance between oxidants
57. 2:11and antioxidants this was highlighted in
58. 2:14the landmark 2009 paper titled the
59. 2:17hallmarks of aging in this paper the
60. 2:19authors say that oxidants they can be
61. 2:21regarded as a stress elicited survival
62. 2:24signal aimed at compensating for the
63. 2:26progressive deterioration associated
64. 2:29with aging however as our age advances
65. 2:32the levels of oxidants increase in an
66. 2:35attempt to maintain survival until they
67. 2:37betray the original purpose and
68. 2:39eventually make the whole situation
69. 2:41worse worsening the age-associated
70. 2:44damage so by supplementing with the
71. 2:46building blocks of glutathione we can
72. 2:48make sure that our glutathione levels
73. 2:50are well supported and importantly our
74. 2:52body can actually regulate the levels of
75. 2:54glutathione personally until there's
76. 2:56long-term human safety data on liposomal
77. 2:59glutathione i will not touch it so an
78. 3:03argument can be made that supporting our
79. 3:05levels of glutathione is a good idea
80. 3:07that it can possibly make us more
81. 3:09resilient against diseases so let's test
82. 3:12that idea in 2001 there was a paper
83. 3:15published on covert 19 patients it
84. 3:17wanted to see whether supporting our
85. 3:19metabolism would improve covert 19
86. 3:21recovery it gave half of the patients a
87. 3:24combination of supplements to support
88. 3:25their metabolism and this included the
89. 3:28building blocks of glutathione what they
90. 3:30found is that the patients that took the
91. 3:32combined metabolic activators recovered
92. 3:34from covert 19 are whopping three days
93. 3:37faster this is really exciting it backs
94. 3:40up the idea that if we support our
95. 3:42metabolism then hopefully we can be more
96. 3:44resilient against diseases and in terms
97. 3:47of lifespan extension we've got a robust
98. 3:49paper from the interventions testing
99. 3:51program showing that glycine
100. 3:53supplementation it increased lifespan by
101. 3:56four to six percent in both males and
102. 3:59female mice and that leads us onto this
103. 4:01new paper the new paper wanted to look
104. 4:03at the combination of both glycine and
105. 4:06neck not just glycine alone this study
106. 4:09gave half of the mice placebo and the
107. 4:11other half a combination of glycine and
108. 4:14neck and importantly the mice used here
109. 4:16were called black six mice this is
110. 4:19important because black six mice are the
111. 4:21most inbred strain of mice used in
112. 4:24research so this is important we are not
113. 4:27inbred so we can't always correlate
114. 4:29these findings to humans and in this
115. 4:31study only 32 mice were used so
116. 4:34relatively small numbers but what we can
117. 4:36see is that the mice who were receiving
118. 4:38the glycine and neck supplements they
119. 4:40increased their lifespan by 24
120. 4:43and importantly this happened in both
121. 4:45males and females we can see this
122. 4:48increase quite clearly here in the graph
123. 4:50now when i was reading the discussion of
124. 4:52this paper a few crucial things popped
125. 4:54out to me so from unpublished studies of
126. 4:57mice in our lab we found that
127. 4:58glutathione deficiency or lower levels
128. 5:00of glutathione it tends to occur in the
129. 5:03black six mice after approximately 65
130. 5:06weeks of age so remember in humans the
131. 5:09glutathione levels seemed to drop around
132. 5:1145 years old therefore this paper
133. 5:13supplemented the mice from the age of 65
134. 5:16weeks for the rest of their natural life
135. 5:18the other important point that popped
136. 5:20out to me is that no studies have
137. 5:22reported an increase of mammalian
138. 5:24lifespan by supplementing with
139. 5:26glutathione so again i don't want to be
140. 5:29supplementing with glutathione because
141. 5:30there's a lack of evidence that it
142. 5:32actually works on the contrary
143. 5:35supplementation of glutathione was
144. 5:37actually found to accelerate aging and
145. 5:39shorten lifespan in c elegans which is a
146. 5:41type of worm because different organisms
147. 5:44maintain different concentrations of
148. 5:46glutathione providing extra glutathione
149. 5:49is associated with risk of inducing
150. 5:51replicative stress this is what we were
151. 5:54talking about before we want to try and
152. 5:56aim for that balance between oxidants
153. 5:58and antioxidants so glycine and neck
154. 6:00supplementation it avoids this problem
155. 6:03because it allows the cells to auto
156. 6:05regulate as in to maintain those levels
157. 6:08to control the levels of glutathione
158. 6:10glycine and neck supplementation it
159. 6:12doesn't interfere with the cellular
160. 6:14autoregulation and this is an important
161. 6:17point to understand because the cellular
162. 6:19requirements of glutathione in each
163. 6:21organ is constantly and dynamically
164. 6:23changing so again we don't want to be
165. 6:26supplementing with liposomal glutathione
166. 6:28because we don't have long-term safety
167. 6:30data and there's no data so far that it
168. 6:33actually improves health span or life
169. 6:36span and the final thing that i want to
170. 6:37mention about this study is its
171. 6:39limitations so although this pilot
172. 6:41extrapolatory study provides proof of
173. 6:44concept that glycine and neck
174. 6:46supplementation from a younger age can
175. 6:48increase length of life this was done in
176. 6:50a relatively small number of mice and
177. 6:52the data is not reported in every organ
178. 6:55in the body essentially we need larger
179. 6:57trials and i'm really hoping that the
180. 6:59interventions testing program trials the
181. 7:01combination
182. 7:02of glycine and neck we can see from the
183. 7:04interventions testing program that
184. 7:06glycine alone does seem to extend
185. 7:08lifespan but maybe we'll get even
186. 7:10greater benefits if we combined glycine
187. 7:13and neck like this new paper is
188. 7:15suggesting so what am i going to do in
189. 7:17response to this new paper well to be
190. 7:19honest it doesn't change anything for me
191. 7:22i'm going to stick with my original plan
192. 7:24to add in neck and either glycine or
193. 7:27serine once i reach the age of 50 years
194. 7:29old because remember our glutathione
195. 7:31levels they appear to be fine up until
196. 7:34the age of around 45 years old in terms
197. 7:37of dosage i plan to take one and a half
198. 7:39grams of both serine and neck but why
199. 7:42did i choose serine instead of glycine
200. 7:45well the human combined metabolic
201. 7:47activator studies they used serine
202. 7:50instead of glycine so serine is
203. 7:52converted in the body to glycine but
204. 7:55during this conversion it may help drive
205. 7:57forward before late cycle so let's sum
206. 8:00things up glutathione is a powerful
207. 8:02antioxidant in the body but its levels
208. 8:04appear to decline around the age of 45
209. 8:07years old it looks like we can support
210. 8:09our glutathione levels by taking the
211. 8:11building blocks of glutathione so neck
212. 8:14and either serine or glycine personally
213. 8:17i will avoid liposomal glutathione
214. 8:19because we don't have much evidence that
215. 8:21it actually improves health and we don't
216. 8:23have long-term safety data and overall i
217. 8:26plan to take one and a half grams of
218. 8:28neck and serene twice a day when i reach
219. 8:31the age of 50 years old so please let me
220. 8:34know in the comments section what did
221. 8:36you think of this video and what are you
222. 8:37going to do about supporting your
223. 8:39glutathione levels are you going to wait
224. 8:41for more data or are you going to start
225. 8:43supplementing with neck and either
226. 8:45serine or glycine a massive thank you to
227. 8:47all of the patrons who support the
228. 8:49channel and if you haven't already
229. 8:51please check out my clinical trial
230. 8:52fundraiser for rapamycin until next time
231. 8:55thanks very much