‘Longevity’ Supplement FAILS In New Study — Transcript

Full transcript

1. 0:00important research has just been
2. 0:01published where a popular supplement
3. 0:03failed to show any benefit and I'd
4. 0:05highly recommend that you stop spending
5. 0:07your money on it to understand the hype
6. 0:09around the supplement and why this new
7. 0:11research is so critical we need to
8. 0:13understand what happens to our body as
9. 0:14we age so as we age the body builds up
10. 0:17with old cells that can no longer divide
11. 0:19and they make it difficult for our
12. 0:21organs to function correctly these cells
13. 0:23are called senent cells and there's an
14. 0:25idea that if we can clear away these old
15. 0:27senescent cells we can improve our
16. 0:29health so why do we collect senescent
17. 0:32cells as we age and how bad are they
18. 0:34well this 2019 review explains it
19. 0:36beautifully the first description of
20. 0:38this phenomenon dates back to the 1960s
21. 0:41when hayflick and Morhead observed that
22. 0:43human fiber blasts in a culture can only
23. 0:46achieve a maximum number of cell
24. 0:47divisions before they stop growing this
25. 0:50biological clock is known as the hay
26. 0:52flick limit it's caused by the
27. 0:54progressive shortening of telr upon each
28. 0:56cell division and it represents a
29. 0:58physiological response to prevent
30. 1:00genomic instability and therefore stop
31. 1:03the accumulation of DNA damage and
32. 1:05stopping old damaged cells from growing
33. 1:08and dividing plays a critical role it's
34. 1:10been demonstrated that sence occurs in
35. 1:12different tumors where it stops tumor
36. 1:15growth and development therefore because
37. 1:17of these effects sence also appears to
38. 1:19be a potent anti-tumor mechanism and
39. 1:21it's not just anti-cancer effects sence
40. 1:24is critical for wound healing this is
41. 1:26why we don't necessarily want to stop
42. 1:28ourselves from becoming Cent but once
43. 1:31they become ccent what effect do they
44. 1:33have on the body from a 2018 review
45. 1:35article it suggests that the
46. 1:37accumulation of senent cells drives
47. 1:39aging and age related diseases and sent
48. 1:42cells don't just remain dormant they
49. 1:44release a complex mixture of factors
50. 1:46called senance Associated secretory
51. 1:49phenotype or sasp and sesp contributes
52. 1:51to the age Associated increase that we
53. 1:53see in inflammation levels so as we get
54. 1:56older we can see that our inflammation
55. 1:58levels generally start to increase this
56. 2:00is known as inflammaging so while ccent
57. 2:02cells do have important roles to play in
58. 2:04our health if they start to build up
59. 2:07it's possible that they cause more harm
60. 2:08than good but it's really difficult to
61. 2:10know which senent cells are damaging and
62. 2:13which ccent cells we should keep to help
63. 2:15with other processes in the body my
64. 2:17point is that we don't want to try and
65. 2:18blanket remove all of the ccent cells
66. 2:21it's highly likely that a targeted
67. 2:23approach is needed but the idea of
68. 2:25clearing away these senescent cells has
69. 2:27led to a whole field called senolytics
70. 2:29which are molecules that flip the switch
71. 2:31and encourage these old ccent cells to
72. 2:33be cleared away so where has the hype
73. 2:36come from well in a landmark paper that
74. 2:38was published in 2018 it was found that
75. 2:40out of the 10 molecules tested fistin
76. 2:43was the most potent senolytic and when
77. 2:45fistin was given to inbred mice it
78. 2:48extended their median as well as maximum
79. 2:50lifespan so the hype has come from
80. 2:53single cell and M studies remember that
81. 2:55because it's important when we go
82. 2:56through the new study so what research
83. 2:58do we have in humans and then we'll go
84. 3:00through the new study in 2019 a study
85. 3:03was done using a combination of deatin
86. 3:05and quatin both of which are also
87. 3:07senolytics it was an open label pilot
88. 3:10study so it wasn't a randomized control
89. 3:12trial it was just giving these molecules
90. 3:14to one group of people to see what
91. 3:16effects there were and the headline
92. 3:18finding is that this combination of
93. 3:20senolytics reduced the ccent cell burden
94. 3:23within 11 days a separate study also
95. 3:25published in 2019 gave datinb and quatin
96. 3:29to patients with idiopathic pulmonary
97. 3:31fibrosis basically these are patients
98. 3:33that have got lung scarring it was also
99. 3:35a single group study and what they found
100. 3:37is that these patients could walk
101. 3:38further and faster after giving the
102. 3:41senolytic treatment but again neither of
103. 3:43these studies were randomized control
104. 3:45trials so it's really difficult to know
105. 3:47was it the senolytics that were causing
106. 3:48these effects or was it something else
107. 3:51there was no comparison group but those
108. 3:53types of studies continued to feel the
109. 3:55hype in this field the only human
110. 3:57randomized control trial that I could
111. 3:59find was was published in 2018 it
112. 4:01included 37 patients with coloral cancer
113. 4:04and the only statistically significant
114. 4:06difference that was found was a small
115. 4:08decrease in one inflammation marker so
116. 4:10you can see that the evidence isn't
117. 4:12exactly robust for using fistin
118. 4:14supplements but now though let's go
119. 4:16through this new trial and then what the
120. 4:18future of this field holds because it's
121. 4:20definitely not all doom and gloom
122. 4:22there's a lot to be hopeful about this
123. 4:24study was published by the interventions
124. 4:26testing program this is a study that
125. 4:28uses genetically diverse mice as opposed
126. 4:30to the other trial that we talked about
127. 4:32which used inbred mice the experiments
128. 4:35are also conducted at the same time in
129. 4:36three separate labs this way we can
130. 4:38figure out if the results are true and
131. 4:40reproducible or if it's just a quirk of
132. 4:42one particular lab and there were two
133. 4:44different dosing protocols that were
134. 4:46tried either where the fistin was given
135. 4:48continuously or it was only given for 3
136. 4:51Days Every 2 weeks and that strategy is
137. 4:54known as the hit and run method first
138. 4:56the authors wanted to figure out was
139. 4:58fistin removing old senent cells but
140. 5:01unfortunately there was no significant
141. 5:02difference between the Matched group and
142. 5:05the fistin group so there was no
143. 5:07difference in the ccent cells in either
144. 5:09the liver kidney or brain and for both
145. 5:12dosing protocols fistin did not affect
146. 5:14lifespan this is a big deal because
147. 5:17remember the initial hype around fistin
148. 5:19was based on the single cell and mice
149. 5:21studies but here neither a senolytic
150. 5:24effect or a lifespan effect was seen and
151. 5:26the basis for the discrepancy between
152. 5:28this study from the interventions
153. 5:30testing program and the study that
154. 5:32generated all of the hype is probably
155. 5:34due to the number of mice that were used
156. 5:36so in the interventions testing program
157. 5:38they used over 30 times the number of
158. 5:40mice compared to that other trial that
159. 5:42generated all of the hype so fistin is a
160. 5:44classic case of hype far exceeding the
161. 5:47scientific reality but with regards to
162. 5:49the analytic field there's a lot to be
163. 5:51hopeful about let me explain a lot of
164. 5:53research is going on right now to figure
165. 5:56out which individual senescent cell
166. 5:57types contribute to tissue dysfunction
167. 6:00as in which ccent cells are actually
168. 6:02contributing to aging once that's
169. 6:04figured out it's hoped that targeted
170. 6:06therapies can be used to make sure that
171. 6:08we remove the damaging senent cells and
172. 6:10leave the otherwise healthy cells
173. 6:12there's a long way to go but I'm very
174. 6:14hopeful about the senolytic field as for
175. 6:17fistin the mice research doesn't support
176. 6:19the idea of using supplements and
177. 6:21there's a lack of human randomized
178. 6:22clinical trials so my advice is to stop
179. 6:25spending your money on fistin and this
180. 6:27is why I didn't include atin or any
181. 6:30other senolytics in microvi instead
182. 6:33focus on diet exercise and sleep and if
183. 6:36you're interested in the supplement that
184. 6:37virtually everyone should take make sure
185. 6:39to check out this next video here