Introduction to Chapter 2 — Transcript

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1. 0:03we've been talking about some of the
2. 0:05easier medications to understand because
3. 0:08first of all they worked by direct
4. 0:11actions and secondly they didn't get
5. 0:14absorbed normally as we said before our
6. 0:17medications work on cellular receptors
7. 0:21or by affecting enzymes
8. 0:24and now we're going to be talking about
9. 0:27a medication that works on cellular
10. 0:30receptors so this is going to be a
11. 0:33really interesting change this is going
12. 0:35to be an interesting discussion because
13. 0:38we get down to the cellular and
14. 0:41molecular level of the study of
15. 0:44medications and this is also where we
16. 0:47begin our discussions of pharmacology or
17. 0:51in other words this study of drugs and
18. 0:54toxins
19. 0:56the medication that we chose for
20. 0:58discussion is called loperamide and it's
21. 1:01also known as Imodium and it's also
22. 1:04known by other names as well
23. 1:06loperamide doesn't get absorbed to any
24. 1:09great extent and therefore I can
25. 1:11introduce to you the concepts of our
26. 1:14medications working on cellular
27. 1:16receptors without needing to discuss
28. 1:19absorption distribution metabolism and
29. 1:23excretion
30. 1:24only about one-third of one percent of
31. 1:27loperamide gets absorbed so we can
32. 1:32concentrate on what it does in the
33. 1:35receptors in the gastrointestinal tract
34. 1:39as a really broad overview loperamide is
35. 1:43a medication that's given to people to
36. 1:46relieve diarrhea
37. 1:48loperamide is from a group of
38. 1:50medications that's called opioids
39. 1:52but because of the fact that it doesn't
40. 1:55get absorbed to any great extent it's
41. 1:58normally not associated with the most
42. 2:00common and the most dangerous side
43. 2:03effects of opioids