HY USMLE Q #498 – Diabetes pharm — Transcript

Full transcript

1. 0:00how's it going guys nearly identical
2. 0:01question shows up on one of the offline
3. 0:03nvme forms for step one no excuses you
4. 0:05need to know your diabetes meds i'll
5. 0:06keep this clip real [ __ ] clean and
6. 0:08concise not waste our time so before we
7. 0:10start please subscribe my channel i
8. 0:11really appreciate it give the video a
9. 0:12like i really appreciate it find me on
10. 0:14instagram at mailman underscore medical
11. 0:15mehla man underscore medical link is
12. 0:17down below find me on telegram the links
13. 0:19to the telegram group and channel are
14. 0:20down below not start the clip 59 year
15. 0:22old woman with type 2 diabetes mellitus
16. 0:24she's commencement thiazolidine dione
17. 0:26and the question response to the
18. 0:27mechanism of action let's just walk
19. 0:28through the answer choices here choice a
20. 0:30decreased absorption of glucose by the
21. 0:32intestine wrong [ __ ] answer this
22. 0:33refers to alpha glucose inhibitors i.e
23. 0:37miglital and the carbos they cause
24. 0:39diarrhea as a result wrong [ __ ]
25. 0:41answer
26. 0:42choice b decreased production glucose by
27. 0:44liver wrong answer this refers to
28. 0:46metformin which has a vague mechanism of
29. 0:48action quote
30. 0:50decreases gluconeogenesis increases
31. 0:52glycolysis that's what u.s similarly
32. 0:54wants you need to know metformin causes
33. 0:55lactic acidosis if you see low bicarb in
34. 0:58a question with patients on metformin
35. 0:59you're going to discontinue the drug
36. 1:01also don't give to patients who have
37. 1:03renal insufficiency slash increased
38. 1:04creatinine
39. 1:06wrong [ __ ] answer
40. 1:08should i see decreased absorption
41. 1:10glucose by the proximal convoluted
42. 1:11tubule wrong answer that's reversed the
43. 1:13sglt2 inhibitors i.e
44. 1:16dipagliflocin causes glucosuria as a
45. 1:19result increases risk of yeast
46. 1:21infections wrong answer
47. 1:23choice d increased insulin secretion by
48. 1:24the pancreas wrong answer this refers to
49. 1:26a myriad of agents the highest yield one
50. 1:28being the sulfonylurea class such as
51. 1:31glyburide also the maglitonides such as
52. 1:34rapaglinide
53. 1:36those are going to inhibit the atp gated
54. 1:38potassium channel in the beta islet cell
55. 1:41it keeps potassium within the cell
56. 1:43increase positive charge depolarization
57. 1:45calcium influxes into the cell insulin
58. 1:47effluxes the vesicles efflux as a result
59. 1:50so they're insulin secretogs you can
60. 1:52also know this refers to xenotide which
61. 1:56is a glp-1 analog just memorize it glp-1
62. 2:00will increase insulin secretion and also
63. 2:03can refer to the
64. 2:05glyptons such as
65. 2:07linogliptin okay which will
66. 2:10inhibit dpp4 which is an enzyme that
67. 2:13breaks down glp1 and as i just [ __ ]
68. 2:15said glp1 will increase insulin
69. 2:18secretion by the pancreas a myriad of
70. 2:20agents point is wrong [ __ ] answer
71. 2:23choice the increased uptake of glucose
72. 2:24and adipose tissue and squid of muscles
73. 2:26correct answer
74. 2:27thiazolidine dions quote
75. 2:30increase insulin sensitivity decrease
76. 2:32insulin resistance by agonizing ppar
77. 2:36gamma okay they can cause paratoxicity
78. 2:38cardiotoxicity weight gain edema nothing
79. 2:41dramatic nothing crazy okay we're just
80. 2:44whipping through slash regurgitating
81. 2:47mechanisms of action of various diabetes
82. 2:50myths you have to just
83. 2:52do your mileage put it in the clockwork
84. 2:54okay nothing crazy just memorize the
85. 2:56diabetes meds no [ __ ] excuses
86. 2:59you know the deal to make more content
87. 3:01if you like my stuff subscribe my
88. 3:02channel
89. 3:03i appreciate your time that's it