How To REVERSE Skin Wrinkles Today — Transcript

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1. 0:00We have a proven strategy to reverse
2. 0:02skin aging today, and the evidence is so
3. 0:05strong that the strategy is recommended
4. 0:07in the clinical guidelines. Let's
5. 0:08explore what happens to the skin during
6. 0:10aging and how this treatment that's
7. 0:11available to you today can help reverse
8. 0:14that process. As we age, the skin
9. 0:16becomes progressively thinner. It has
10. 0:17decreased elasticity and impaired
11. 0:20metabolic responses. These changes are
12. 0:22separate to those caused by sun exposure
13. 0:24or photo aging. Instead, today we're
14. 0:27just going to focus on the normal aging
15. 0:29part. In a younger person, the skin is
16. 0:31fairly rapidly turned over where new
17. 0:33cells are formed in the deeper layers of
18. 0:35the skin and then eventually get pushed
19. 0:36out until they reach the surface and
20. 0:39that's the layer that we can actually
21. 0:40see. But in older adults, the skin
22. 0:42turnover is significantly slower. The
23. 0:44skin also has decreased blood supply and
24. 0:46nutrition. It loses about 75% of its
25. 0:49collagen. So collagen is there to help
26. 0:51keep everything together and the
27. 0:52collagen that remains is fragmented and
28. 0:54disarrayed. The chains of
29. 0:56glucosaminoglycans are disrupted leading
30. 0:58to a loss of hydration and decreased
31. 1:00resilience. Plus, since the skin
32. 1:02turnover is slower, that leads to an
33. 1:04accumulation of senescent cells. So
34. 1:06these are so-called zombie cells that no
35. 1:08longer divide and damage the surrounding
36. 1:10cells. What's really exciting though is
37. 1:12that in addition to a great diet,
38. 1:14regular exercise, and high-quality
39. 1:16sleep, we've now got a treatment to
40. 1:18reverse this process and this treatment
41. 1:20is called retinoid creams. Retinoids are
42. 1:23a class of naturally occurring compounds
43. 1:25that are related to vitamin A. They
44. 1:27exert their effects by binding and
45. 1:29activating two groups of receptors,
46. 1:31which causes significant increases in
47. 1:33collagen production, increased skin
48. 1:35turnover, and improved blood supply. And
49. 1:37here's what the human clinical studies
50. 1:39show. When these creams are used to
51. 1:41fight aging, a 2007 randomized clinical
52. 1:44study comparing 0.4% of retinol lotion
53. 1:47to a placebo found that there were
54. 1:49significant improvements in the
55. 1:50retinol-treated skin with decreased fine
56. 1:53lines and wrinkles. And when they looked
57. 1:55at the skin using a microscope. They
58. 1:56found significant increases in the
59. 1:58glucosaminoglycans, meaning that the
60. 2:00skin could actually hold on to water and
61. 2:02remain hydrated. They also found large
62. 2:05increases in collagen production, and
63. 2:07separate studies showed significant
64. 2:08improvements in blood supply, where they
65. 2:10could actually see growth of new blood
66. 2:12vessels, meaning that the skin could
67. 2:13actually get the nutrition that it
68. 2:15needs. All of these positive changes
69. 2:17that are seen in the clinical studies is
70. 2:18the reason why clinical guideline
71. 2:20databases such as UpToDate say that
72. 2:22these age-related changes now appear
73. 2:25mutable. So, we've talked about the
74. 2:26benefits of retinol creams, but what
75. 2:28about the side effects? Well, they can
76. 2:30cause photosensitivity, as in the skin
77. 2:33is more sensitive to sunlight. And when
78. 2:35you start using these creams, for the
79. 2:37first 3 months, they can irritate the
80. 2:39skin. And while the absorption of these
81. 2:41creams into our blood is very small,
82. 2:43women of childbearing age must use
83. 2:45effective contraception. The final
84. 2:47concern that I've seen online regarding
85. 2:49this treatment is that if this treatment
86. 2:50causes increased cell turnover, does
87. 2:53that mean that we're going to cause
88. 2:54aging? We're going to cause the skin to
89. 2:56become senescent. This is a concern for
90. 2:59some people because a cell can only
91. 3:00divide so many times before it has to
92. 3:03stop. So far though, from the decades of
93. 3:05use, this doesn't seem to be a problem
94. 3:07because remember, it's not only
95. 3:08increased skin turnover, it's also
96. 3:11improved blood supply, meaning that the
97. 3:12skin can actually get better nutrition.
98. 3:15We're also improving the extracellular
99. 3:16matrix, so we're improving the nutrition
100. 3:19and structure of the skin, meaning that
101. 3:21there's less stress to the skin cells.
102. 3:23So, which retinoid is best because
103. 3:25there's lots of different forms and
104. 3:26names? Well, tretinoin is the most
105. 3:28extensively investigated therapy for
106. 3:31aging, but there is a newer generation
107. 3:33called adapalene or Differin gel, and
108. 3:35this is more selective towards the
109. 3:37receptors, meaning that there's less
110. 3:38skin irritation. And we do have a 2018
111. 3:41randomized controlled study that was
112. 3:43published in the European Journal of
113. 3:45Dermatology. It compared the
114. 3:46medium-strength adapalene, so 0.3%, to
115. 3:50the medium-strength tretinoin, so the
116. 3:520.05% creams. What they found is that
117. 3:55both creams were effective without any
118. 3:57significant differences. So, based on
119. 3:59that study, you can use either adapalene
120. 4:01or tretinoin, but the adapalene it may
121. 4:04be less irritating to the skin. Overall,
122. 4:06for the patients that I see in the
123. 4:07clinic, if they're considering this
124. 4:09treatment, I always suggest to them to
125. 4:11use it at night and start using the
126. 4:13lowest strength. For tretinoin, that's
127. 4:15the 0.025%
128. 4:17and for adapalene, that's the 0.1% and
129. 4:19start by only using very small amounts
130. 4:22every second to third day and gradually
131. 4:24build that up to the point where you're
132. 4:25using it every day. And then for further
133. 4:28benefit, you can gradually increase the
134. 4:30strength. During this video, we've
135. 4:31talked a lot about collagen and how it
136. 4:33gets disrupted during aging. So, make
137. 4:35sure to check out this next video here
138. 4:37on collagen peptide supplements and how
139. 4:39that can help improve our collagen
140. 4:41structure. A massive thank you to do not
141. 4:44age.org for the $10,000 donation to my
142. 4:46rapamycin study. They are a health
143. 4:48research organization and to benefit
144. 4:50from the ingredients as well as a 10%
145. 4:53discount code, check out the pinned
146. 4:54comment.