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How to Learn Faster by Using Failures, Movement & Balance | Huberman Lab Essentials — Transcript

by Andrew Huberman · 5,947 words · 949 segments · language en · Watch on YouTube

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  1. 0:00Welcome to Huberman Lab Essentials,
  2. 0:02where we revisit past episodes for the
  3. 0:04most potent and actionable science-based
  4. 0:06tools for mental health, physical
  5. 0:08health, and performance.
  6. 0:11My name is Andrew Huberman, and I'm a
  7. 0:13professor of neurobiology and
  8. 0:14ophthalmology at Stanford School of
  9. 0:16Medicine. Today, we're going to talk
  10. 0:18about how to change your nervous system
  11. 0:20for the better.
  12. 0:21As you recall, your nervous system
  13. 0:23includes your brain and your spinal
  14. 0:25cord, but also all the connections that
  15. 0:27your brain and spinal cord make with the
  16. 0:29organs of your body
  17. 0:31and all the connections that the organs
  18. 0:33of your body make with your brain and
  19. 0:34spinal cord.
  20. 0:36Now, this thing that we call the nervous
  21. 0:37system is responsible for everything we
  22. 0:39know,
  23. 0:40all our behavior, all our emotions,
  24. 0:43everything we feel about ourselves and
  25. 0:44the outside world, everything we think
  26. 0:46and believe. It's really at the center
  27. 0:48of our entire experience of life and who
  28. 0:51we are.
  29. 0:53Fortunately, in humans, unlike in other
  30. 0:55species,
  31. 0:57we can change our nervous system by
  32. 0:59taking some very specific and deliberate
  33. 1:01actions. And today, we're really going
  34. 1:03to focus on the actions, the motor
  35. 1:06commands, and the aspects of movement
  36. 1:09and balance
  37. 1:11that allow us to change our nervous
  38. 1:12system. It turns out that movement and
  39. 1:15balance actually provide windows or
  40. 1:17portals into our ability to change our
  41. 1:20nervous system the way we want, even if
  42. 1:23those changes are not about learning new
  43. 1:25movements or learning how to balance.
  44. 1:27And soon, you'll understand why. So,
  45. 1:29let's talk about the different kinds of
  46. 1:31plasticity that are available to us.
  47. 1:34Because those will point directly
  48. 1:36towards the type of protocols that we
  49. 1:38should engage in to change ourselves for
  50. 1:40the better.
  51. 1:41There is something called
  52. 1:42representational plasticity.
  53. 1:44Representational plasticity is just your
  54. 1:46internal representation of the outside
  55. 1:48world. We know that, for instance, if I
  56. 1:49want to reach out and grab the pen in
  57. 1:51front of me that I need to generate a
  58. 1:52certain amount of force, so I rarely
  59. 1:54overshoot. I rarely miss the pen, Okay?
  60. 1:58So, our maps of the motor world and our
  61. 2:01maps of the sensory world are merged.
  62. 2:04The way to create plasticity
  63. 2:08is to create mismatches or errors in how
  64. 2:12we perform things. And this I think is
  65. 2:14an amazing and important feature of
  66. 2:16neuroplasticity that is highly under
  67. 2:18appreciated. The way to create
  68. 2:21plasticity is to send signals to the
  69. 2:24brain that something is wrong, something
  70. 2:27is different, and something isn't being
  71. 2:29achieved. Errors.
  72. 2:31And making errors out of sync with what
  73. 2:34we would like to do is how our nervous
  74. 2:36system is cued through very distinct
  75. 2:39biological mechanisms that something
  76. 2:41isn't going right and therefore certain
  77. 2:44neurochemicals are deployed that will
  78. 2:47signal the neural circuits that they
  79. 2:48have to change. So, let's talk about
  80. 2:51errors and making errors and why and how
  81. 2:54that triggers of chemicals that then
  82. 2:56allow us to not just learn the thing
  83. 2:58that we're doing in the motor sense,
  84. 3:00play the piano, dance, etc., but it also
  85. 3:03creates an environment and milieu within
  86. 3:05the brain that allows us to then go
  87. 3:08learn how to couple or uncouple a
  88. 3:10particular emotion to an experience or
  89. 3:13better language learning or better
  90. 3:14mathematical learning. Last episode we
  91. 3:17discussed some of the basic principles
  92. 3:18of neuroplasticity.
  93. 3:20If you didn't hear that episode, no
  94. 3:22problem. I'll just review it quickly,
  95. 3:25which is that it's a falsehood that
  96. 3:28everything that we do and experience
  97. 3:30changes our brain. Brain changes when
  98. 3:32certain neurochemicals, namely
  99. 3:34acetylcholine, epinephrine, and dopamine
  100. 3:37are released in ways and in the specific
  101. 3:40times that allow for neural circuits to
  102. 3:42be marked for change and then the change
  103. 3:44occurs later during sleep. Basically,
  104. 3:46you need a certain cocktail of chemicals
  105. 3:48released in the brain in order for a
  106. 3:50particular behavior to reshape the way
  107. 3:52that our brain works.
  108. 3:54So, the question really is what allows
  109. 3:56those neurochemicals to be released? And
  110. 3:58last episode it talked all about focus.
  111. 4:00If you haven't seen or heard that
  112. 4:02episode, you might want to check it out
  113. 4:04about some specific tools and practices
  114. 4:07that can allow you to build up your
  115. 4:08capacity for focus and release certain
  116. 4:10chemicals in that cocktail. But today
  117. 4:12we're going to talk about the other
  118. 4:13chemicals in the cocktail, in particular
  119. 4:16dopamine.
  120. 4:17And we're really going to center our
  121. 4:19discussion around this issue of making
  122. 4:23errors and why making errors is actually
  123. 4:25the signal that tells the brain, "Okay,
  124. 4:27it's time to change." Or, more
  125. 4:29generally,
  126. 4:31it's time to pay attention to things so
  127. 4:33that you change. And I really want to
  128. 4:36distinguish this
  129. 4:38point really clearly, which is that I'm
  130. 4:40going to talk today a lot about motor
  131. 4:42and vestibular, meaning balance,
  132. 4:44programs, but not just for learning
  133. 4:46motor commands and and balance, but also
  134. 4:49for setting a stage or a kind of
  135. 4:51conditioning your brain where you can go
  136. 4:52learn other things as well.
  137. 4:54So,
  138. 4:55let's talk about some classic
  139. 4:56experiments that really nail down
  140. 5:00what's most important in this discussion
  141. 5:01about plasticity.
  142. 5:03So, I mentioned last episode, and I'll
  143. 5:04just tell you right now again, the brain
  144. 5:06is incredibly plastic from about birth
  145. 5:10until about age 25. And then somewhere
  146. 5:12about 25, it's not like the day after
  147. 5:15your 26th birthday plasticity closes,
  148. 5:17there's a kind of tapering off of
  149. 5:19plasticity, and you need different
  150. 5:21mechanisms to engage plasticity as an
  151. 5:23adult. Knowing how to tap into these
  152. 5:25plasticity mechanisms is very powerful.
  153. 5:29The simplest example is if I hear
  154. 5:30something off to my right, I look to my
  155. 5:33right.
  156. 5:34If I hear it on the left, I look to my
  157. 5:36left. If I hear it right in front of me,
  158. 5:38I keep looking right in front of me, and
  159. 5:39that's because our maps of visual space
  160. 5:43and our maps of auditory space and our
  161. 5:46maps of motor space
  162. 5:48are aligned to one another in perfect
  163. 5:50register. It's an incredible feature of
  164. 5:53our nervous system. It takes place in a
  165. 5:54structure called the superior
  166. 5:55colliculus, although you don't need to
  167. 5:57know that name.
  168. 5:58Superior colliculus has a layers,
  169. 6:00literally stacks of neurons like in a
  170. 6:03sandwich, where the zero point right in
  171. 6:06front of me, or maybe, you know, 10 or
  172. 6:0815 degrees off to my right or 10 or 15
  173. 6:10degrees off to my left, are aligned so
  174. 6:13that the the auditory neurons, the ones
  175. 6:15that care about sounds at 15 degrees to
  176. 6:18my right, sit directly below the neurons
  177. 6:21that look at 15 degrees to my right in
  178. 6:23my visual system. And when I reach over
  179. 6:26to this direction, there's a signal
  180. 6:28that's that's sent down through those
  181. 6:30layers that says, "15 degrees off to the
  182. 6:32right is the direction to look. It's the
  183. 6:34direction to listen, and it's the
  184. 6:36direction to move if I need to move."
  185. 6:38So, there's an alignment. And this is
  186. 6:40really powerful, and this is what allows
  187. 6:42us to move through space and function in
  188. 6:44our lives in a really fluid way.
  189. 6:46It's set up during development,
  190. 6:48but there have been some important
  191. 6:50experiments that have revealed that this
  192. 6:53these maps are plastic, meaning they can
  193. 6:56shift. They're subject to
  194. 6:57neuroplasticity,
  195. 6:58and there are specific rules that allow
  196. 7:01us to shift them. So, here's the key
  197. 7:04experiment. The key experiment was done
  198. 7:06by a colleague of mine,
  199. 7:09who's now retired, but whose work is
  200. 7:10absolutely fundamental in the field of
  201. 7:12neuroplasticity, Eric Knudsen.
  202. 7:14The Knudsen lab, and many of the Knudsen
  203. 7:17lab scientific offspring,
  204. 7:19showed that if one
  205. 7:22is to wear prism glasses that shift the
  206. 7:24visual field,
  207. 7:26that eventually there'll be a shift in
  208. 7:29the representation of the auditory and
  209. 7:31motor maps, too. Now, what they
  210. 7:33initially did is they looked at young
  211. 7:35subjects.
  212. 7:37And what they did is they moved the
  213. 7:40visual world by making them wear prism
  214. 7:42glasses, so that for instance, if a if
  215. 7:44my pen is out in front of me at, you
  216. 7:46know, 5° off center, so just a little
  217. 7:48bit off center. If you're listening to
  218. 7:50this, this would be like just a little
  219. 7:51bit to my right.
  220. 7:52But in these prism glasses,
  221. 7:55I actually see that pen way over far on
  222. 7:58my right. So, it's actually here, but I
  223. 8:00see it over there because I'm wearing
  224. 8:03prisms on my eyes. What happens is in
  225. 8:05the first day or so, you ask people or
  226. 8:07you ask animal subjects or whatever to
  227. 8:10reach for this object, and they reach to
  228. 8:12the wrong place because they're seeing
  229. 8:15it where it isn't.
  230. 8:16But what you find is that in young
  231. 8:18individuals, within a day or two, they
  232. 8:21start adjusting their motor behavior
  233. 8:24in exactly the right way so that they
  234. 8:27always reach to the correct location.
  235. 8:29So, they hear a sound at one location,
  236. 8:30they see the object that ought to make
  237. 8:32that sound at at a different location,
  238. 8:34and they somehow are able to adjust
  239. 8:36their motor behavior to reach to the
  240. 8:39correct location. It's incredible.
  241. 8:42And what it tells us is that these maps
  242. 8:44that are aligned to one another can move
  243. 8:46and shift, and it happens best in young
  244. 8:49individuals.
  245. 8:51If you do this in older individuals,
  246. 8:53in most cases, it takes a very long time
  247. 8:56for the maps to shift, and in some
  248. 8:58cases, they never shift. So, this is a
  249. 9:00very experimental scenario, but it's an
  250. 9:02important one to understand because it
  251. 9:04really tamps down the fact that we have
  252. 9:08the capacity to create dramatic shifts
  253. 9:11in our representation of the outside
  254. 9:12world.
  255. 9:15So, how can we get
  256. 9:17plasticity
  257. 9:18as adults that mimics the plasticity
  258. 9:21that we get when we are juveniles? Well,
  259. 9:23the Knudsen lab and other labs have
  260. 9:24looked at this,
  261. 9:26and it's really interesting. The signal
  262. 9:29that generates the plasticity
  263. 9:31is
  264. 9:33the making of errors. It's the reaches
  265. 9:36and failures that signal to these to the
  266. 9:39nervous system
  267. 9:41that this is not working and therefore
  268. 9:43the shifts start to take place.
  269. 9:46And this is so fundamentally important
  270. 9:48because I think most people
  271. 9:50understandably get frustrated like
  272. 9:51they're trying to learn a piece on the
  273. 9:53piano and they don't know they can't do
  274. 9:54it or they're trying to write a piece of
  275. 9:55code or they're trying to access some
  276. 9:57sort of motor behavior and they can't do
  277. 9:59it and the frustration drives them crazy
  278. 10:01and like I can't do it I can't do it
  279. 10:02when they don't realize that the the
  280. 10:04errors themselves are signaling to the
  281. 10:07brain and nervous system something's not
  282. 10:09working and of course the brain doesn't
  283. 10:11understand the words something isn't
  284. 10:13working. But the brain doesn't even
  285. 10:14understand frustration as an emotional
  286. 10:16state. The brain understands the
  287. 10:19neurochemicals that are released namely
  288. 10:22epinephrine
  289. 10:23and acetylcholine but also and we'll get
  290. 10:26into this the molecule dopamine when we
  291. 10:28start to approximate the correct
  292. 10:30behavior just a little bit. And we start
  293. 10:33getting it a little bit right. So what
  294. 10:35happens is when we make errors the
  295. 10:38nervous system starts releasing
  296. 10:39neurotransmitters and neuromodulators
  297. 10:42that say we better change something in
  298. 10:43the circuitry. And so errors are the
  299. 10:45basis for neuroplasticity and for
  300. 10:48learning and I wish that this was more
  301. 10:50prominent prominent out there. I guess
  302. 10:52this is why I'm saying it
  303. 10:54and humans do not like this feeling of
  304. 10:56frustration and and making errors. The
  305. 10:58few that do
  306. 11:00do exceedingly well in whatever pursuits
  307. 11:03they happen to be involved in. The ones
  308. 11:05that don't generally don't do well.
  309. 11:07They generally don't learn much and if
  310. 11:09you think about it why would your
  311. 11:10nervous system ever change? Why would it
  312. 11:13ever change unless there was something
  313. 11:14to be afraid of something that made us
  314. 11:16feel awful will signal that the nervous
  315. 11:18system needs to change or there's an
  316. 11:21error in our performance. So it turns
  317. 11:22out that the feedback of these errors
  318. 11:25the reaching to the wrong location
  319. 11:28starts to release a number of things and
  320. 11:30now you've heard about them many times
  321. 11:32but this would be epinephrine. It
  322. 11:33increases alertness.
  323. 11:35Acetylcholine, focus. Because if
  324. 11:37acetylcholine is released, it creates an
  325. 11:39opportunity to focus on
  326. 11:41the the error margin, the distance
  327. 11:43between what it is that you're doing and
  328. 11:45what it is that you would like to do.
  329. 11:47And then the nervous system
  330. 11:49starts to make changes almost
  331. 11:51immediately in order to try and get the
  332. 11:53behavior right. And when you start
  333. 11:55getting it even a little bit right, that
  334. 11:57third molecule comes online or is
  335. 11:59released, which is dopamine, which
  336. 12:01allows for the plastic changes to occur
  337. 12:03very fast. Now, this is what all happens
  338. 12:05very naturally in young brains, but in
  339. 12:07old brains
  340. 12:08it tends to be pretty slow, except for
  341. 12:10in two conditions.
  342. 12:13So, let me just pause and just say this.
  343. 12:14If you are uncomfortable making errors
  344. 12:17and you get frustrated easy
  345. 12:19easily
  346. 12:22if you leverage that frustration
  347. 12:25toward drilling deeper into the
  348. 12:27endeavor, you are setting yourself up
  349. 12:29for a terrific set of plasticity
  350. 12:32mechanisms to engage. But if you take
  351. 12:34that frustration and you walk away from
  352. 12:36the endeavor, you are essentially
  353. 12:38setting up plasticity to rewire you
  354. 12:41according to what happens afterwards,
  355. 12:43which is generally feeling pretty
  356. 12:44miserable. So, now you can kind of start
  357. 12:46to appreciate why it is that continuing
  358. 12:48to drill into a process to the point of
  359. 12:50frustration, but then staying with that
  360. 12:52process for a little bit longer, and
  361. 12:54I'll define exactly what I mean by a
  362. 12:55little bit, is
  363. 12:57the
  364. 12:58the most important thing for adult
  365. 13:01learning, as well as childhood learning,
  366. 13:03but adult learning in particular. Now,
  367. 13:05the Knutson lab did two very important
  368. 13:07sets of experiments.
  369. 13:09The first one, which showed that
  370. 13:11juveniles can make these massive shifts
  371. 13:14in their map representations. They get a
  372. 13:16lot of plasticity
  373. 13:18all at once. It happens very fast in the
  374. 13:20period of just a a couple days.
  375. 13:23In adults it gen- tends to be very slow,
  376. 13:25and most individuals never actually
  377. 13:27accomplish the full map shift. They
  378. 13:30don't get the plasticity. Then what they
  379. 13:32did is they started making the increment
  380. 13:35of change smaller. So instead of
  381. 13:37shifting
  382. 13:38the world a huge amount by putting
  383. 13:40prisms that shifted the the visual world
  384. 13:43of you know, all the way over to the
  385. 13:44right, they did this incrementally. So
  386. 13:46the first they put on prisms that
  387. 13:48shifted it just a little bit, you know,
  388. 13:50and just like 7° I believe was the exact
  389. 13:52number. And then it was 14°. And then it
  390. 13:55was 28°. So what they found was that the
  391. 13:57adult nervous system can tolerate
  392. 13:59smaller and smaller errors over time,
  393. 14:03but that you can stack those errors so
  394. 14:05that you can get a lot of plasticity.
  395. 14:07Put simply,
  396. 14:08incremental learning as an adult is
  397. 14:10absolutely essential. You are not going
  398. 14:12to get massive shifts in your
  399. 14:14representations of the outside world. So
  400. 14:16how do you make small errors as opposed
  401. 14:18to big errors? Well,
  402. 14:20the key is
  403. 14:22smaller bouts of focused learning
  404. 14:25for smaller bits of information.
  405. 14:28It's a mistake to try and learn a lot of
  406. 14:32information in one learning bout as an
  407. 14:34adult. Now there is one way to get a lot
  408. 14:38of plasticity all at once as an adult.
  409. 14:40There is that kind of holy grail thing
  410. 14:42of
  411. 14:43you know, getting massive plasticity
  412. 14:46as you would when you were a a young
  413. 14:49person but as an adult. And the Knudsen
  414. 14:52lab revealed this
  415. 14:54by
  416. 14:55setting a very serious contingency on
  417. 14:58the learning.
  418. 15:00What they did was they had a situation
  419. 15:02where subjects had to find food that was
  420. 15:06displaced in their visual world again by
  421. 15:08putting prisms and they had to find the
  422. 15:10food and the food made a noise. There
  423. 15:12was a noise set kind of the location of
  424. 15:14the food through an array of speakers.
  425. 15:16Basically, in order to eat at all, they
  426. 15:20needed plasticity. And then what
  427. 15:23happened was remarkable. What they
  428. 15:25observed is that the plasticity as an
  429. 15:27adult can be as dramatic, as robust as
  430. 15:30it is in a young person
  431. 15:32or in a young animal subject provided
  432. 15:36that there's a serious incentive for the
  433. 15:38plasticity to occur. And this is
  434. 15:40absolutely important to understand,
  435. 15:42which is that
  436. 15:44how badly we need or want the plasticity
  437. 15:47determines how fast that plasticity will
  438. 15:50arrive. This means that the importance
  439. 15:52of something, how important something is
  440. 15:53to us, actually gates the rate of
  441. 15:56plasticity and the magnitude of
  442. 15:58plasticity. And this is why just
  443. 16:00passively going through most things,
  444. 16:03going through the motions as we say, or
  445. 16:05just getting our reps in, {quote}
  446. 16:07{unquote}, is not sufficient to get the
  447. 16:10nervous system to change.
  448. 16:12If we actually have to
  449. 16:14accomplish something in order to eat
  450. 16:16or in order to get our ration of
  451. 16:19income
  452. 16:20we will reshape our nervous system very,
  453. 16:22very quickly. And so, I think that the
  454. 16:25studies that Knudsen did showing that
  455. 16:27incremental learning can create a huge
  456. 16:30degree of plasticity as an adult, as
  457. 16:32well as when the contingency is very
  458. 16:34high
  459. 16:36meaning we need to eat or we need to
  460. 16:38make an income or we need to do
  461. 16:39something that's vitally important for
  462. 16:41us
  463. 16:42that plasticity can happen in these
  464. 16:45enormous leaps, just like they can in
  465. 16:48adolescence and young adulthood.
  466. 16:50That points to the fact that it has to
  467. 16:52be a neurochemical system. There has to
  468. 16:54be an underlying mechanism. All the
  469. 16:57chemicals that we're about to talk about
  470. 16:59are released from drug stores, if you
  471. 17:02will, chemical stores that already
  472. 17:04reside in all of our brains. And the key
  473. 17:06is
  474. 17:07how to tap into those stores. And so,
  475. 17:10we're going to next talk about what are
  476. 17:12the specific behaviors that liberate
  477. 17:15particular categories of chemicals
  478. 17:18that allow us to make the most of
  479. 17:19incremental learning and that set the
  480. 17:22stage for plasticity that is similar
  481. 17:25enough or mimics these high contingency
  482. 17:28states like the need to get food or
  483. 17:30really create a sense of internal
  484. 17:33urgency, chemical urgency if you will.
  485. 17:35If you've heard previous episodes of
  486. 17:37this podcast
  487. 17:38you may have heard me talk about
  488. 17:39ultradian rhythms which are these
  489. 17:4190-minute rhythms
  490. 17:43that break up our 24-hour day they
  491. 17:47help break up our sleep into different
  492. 17:49cycles of sleep like REM sleep and
  493. 17:51non-REM sleep and in waking states they
  494. 17:52help us or I should say they
  495. 17:56break up our day in ways that allow us
  496. 17:58to learn best within 90-minute cycles
  497. 18:00etc. Today we're really talking about
  498. 18:02how to tap into plasticity through the
  499. 18:06completion of a task or or working
  500. 18:09towards something repetitively and
  501. 18:11making errors. The ultradian cycle says
  502. 18:13that for the first 5 to 10 minutes of
  503. 18:16doing that your mind is going to drift
  504. 18:18and your focus will probably kick in
  505. 18:20provided that you're visually you're
  506. 18:22restricting your visual world to the
  507. 18:24just the material in front of you,
  508. 18:26something we talked about last episode.
  509. 18:28Somewhere around the 10 or 15-minute
  510. 18:29mark and then at best you're probably
  511. 18:32going to get about an hour of
  512. 18:34uh deliberate kind of tunnel vision uh
  513. 18:36learning in there. Your mind will drift
  514. 18:39and then toward the end of that what is
  515. 18:41now an hour and 10 or hour and 20-minute
  516. 18:44um cycle
  517. 18:45your brain will start start to flicker
  518. 18:47in and out. You're trying your best to
  519. 18:48accomplish something and you're failing.
  520. 18:50You want to keep making errors for this
  521. 18:52period of time that I'm saying will last
  522. 18:55anywhere for about 7 to 30 minutes. It
  523. 18:57is exceedingly frustrating but that
  524. 19:00frustration it liberates the chemical
  525. 19:03cues that signal that plasticity needs
  526. 19:05to happen and it is the case that when
  527. 19:06we come back a day or two later in a
  528. 19:08learning bout after a nap or a night or
  529. 19:10two of deep rest then what we find is
  530. 19:13that we can remember certain things and
  531. 19:15the motor pathways work and we don't
  532. 19:17always get it perfectly, but we get a
  533. 19:18lot of it right, whereas we got it wrong
  534. 19:20before. So, that 7-30 minute intense
  535. 19:24learning bout, specifically about making
  536. 19:26errors. I want to really underscore
  537. 19:29that. And it's not about, uh, as I
  538. 19:31mentioned before, coming up with some
  539. 19:33little hack or trick or, um,
  540. 19:35or something of that sort. It's really
  541. 19:37about trying to cue the nervous system
  542. 19:40that something needs to change because
  543. 19:41otherwise it simply won't change.
  544. 19:43I think everyone could stand to enhance
  545. 19:46the rate of learning by doing the
  546. 19:47following.
  547. 19:49Learn to attach dopamine in a subjective
  548. 19:51way to this process of making errors
  549. 19:54because that's really combining two
  550. 19:56modes of plasticity in ways that
  551. 19:59together can accelerate the plasticity.
  552. 20:01So, in other words, making failures
  553. 20:03repe- if failing repetitively,
  554. 20:05provided we're engaged in a very
  555. 20:07specific set of behaviors when we do it,
  556. 20:09as well as telling ourselves that those
  557. 20:10failures are good for learning and good
  558. 20:12for us,
  559. 20:13creates an outsized effect on the rate
  560. 20:16of plasticity. It It accelerates
  561. 20:18plasticity.
  562. 20:19Now, some of you might be asking, and I
  563. 20:21get asked a lot, well, how do I get
  564. 20:23dopamine to be released? You know, can I
  565. 20:24just tell myself that something is good
  566. 20:26when it's bad? Well, actually, yes.
  567. 20:28Believe it or not, dopamine is one of
  568. 20:31these incredible molecules that both can
  569. 20:33be released
  570. 20:35according to things that are hardwired
  571. 20:37in us to release dopamine. Again, things
  572. 20:39like food, sex, warmth or cold, uh, cool
  573. 20:42environments when we're too warm. It's
  574. 20:44that kind of pleasure molecule, uh,
  575. 20:47overall,
  576. 20:48but
  577. 20:49it's also highly subjective
  578. 20:52what releases dopamine in one person
  579. 20:54versus the next. So, everyone releases
  580. 20:56dopamine in response to those very basic
  581. 20:58kind of behaviors and and activities,
  582. 21:00but dopamine is also released according
  583. 21:04to what we subjectively believe is good
  584. 21:06for us. And that's what's so powerful
  585. 21:08about it. In fact, a book that I highly
  586. 21:09recommend if you want to read more about
  587. 21:10dopamine, it's a book that frankly I
  588. 21:12wish I had written. It's such a
  589. 21:13wonderful book. It's called The Molecule
  590. 21:15of More, and it really talks about
  591. 21:17dopamine not just as a molecule
  592. 21:19associated with reward, but a molecule
  593. 21:21associated with motivation and pursuit
  594. 21:23and just how subjectively controlled
  595. 21:26dopamine can be. So, make lots of
  596. 21:28errors.
  597. 21:29Tell yourself that those errors are
  598. 21:31important and good for your overall
  599. 21:33learning goals. So, learn to attach
  600. 21:35dopamine, meaning release dopamine
  601. 21:38in your brain when you start to make
  602. 21:40errors. Once you're attaching dopamine
  603. 21:42to this process of making errors,
  604. 21:45then I start getting lots of questions
  605. 21:47that I really are the the right
  606. 21:48questions, which are, you know,
  607. 21:50"How often should I do this?" and "When
  608. 21:52should I be doing this?" and "At what
  609. 21:53time?" Well, I've talked a little bit
  610. 21:55about this in previous episodes, but as
  611. 21:56long as we're in a now kind of into the
  612. 21:58nitty-gritty of tools and application,
  613. 22:00each of us have some natural times
  614. 22:02throughout the day when we are going to
  615. 22:04be
  616. 22:05much better at tolerating these errors
  617. 22:08and much more focused on what it is that
  618. 22:10we're trying to do. Last episode was
  619. 22:12about focus, but chances are that you
  620. 22:14can't focus as well at 4:00 p.m. as you
  621. 22:17can at 10:00 a.m. It differs for
  622. 22:19everybody depending on when you're
  623. 22:20sleeping and your kind of natural
  624. 22:21chemistry and rhythms, but find the time
  625. 22:25or times of day when you naturally have
  626. 22:27the highest mental acuity, and that's
  627. 22:30really when you want to engage in these
  628. 22:32learning bouts. And then get to the
  629. 22:34point where you're making errors and
  630. 22:35then keep making errors for 7 to 30
  631. 22:38minutes. Just keep making those errors
  632. 22:39and drill through it, and you're almost
  633. 22:42seeking frustration, and if you can find
  634. 22:44some pleasure in the frustration, yes,
  635. 22:45that is a state that exists, you have
  636. 22:47created the optimal neurochemical milieu
  637. 22:50for learning that thing.
  638. 22:52But then here's the beauty of it. You
  639. 22:54also have created the optimal milieu for
  640. 22:57learning other things afterward. At
  641. 23:00least for an hour or so, I would say,
  642. 23:02you're going to be in a state of
  643. 23:03heightened learning. Again, these aren't
  644. 23:05gimmicks. These tap into these basic
  645. 23:07mechanisms of plasticity. And the three
  646. 23:10that I'd like to talk about next
  647. 23:13are
  648. 23:14balance,
  649. 23:15meaning the vestibular system, as well
  650. 23:17as the two sides of what I call limbic
  651. 23:21friction or autonomic arousal. And if
  652. 23:23none of that makes sense, I'm going to
  653. 23:25put a a fine point on each one of those
  654. 23:27and what it is and why it works for
  655. 23:30opening up neuroplasticity. Let's talk
  656. 23:32about limbic friction. Limbic friction,
  657. 23:35I realize, is not something you're going
  658. 23:36to find in any of the textbooks,
  659. 23:39but it is an important principle that
  660. 23:42captures a lot of information that is in
  661. 23:44textbooks, both neurobiology and
  662. 23:46psychology, and it has some really
  663. 23:48important implications.
  664. 23:52Limbic friction is my attempt to give a
  665. 23:54name to something that is more nuanced
  666. 23:57and mechanistic than stress. Because
  667. 24:00typically when we hear about stress, we
  668. 24:02think of heart rate heartbeat going too
  669. 24:04fast, breathing too fast, sweating, and
  670. 24:07not being in a state that we want. We're
  671. 24:08too alert and we want to be more calm.
  672. 24:11And indeed, that's one condition in
  673. 24:13which
  674. 24:14we have limbic friction, meaning our
  675. 24:16limbic system is taking control of a
  676. 24:19number of different aspects of our
  677. 24:21autonomic or auto- automatic biology,
  678. 24:24and we are struggling to control that
  679. 24:28through what we call top-down
  680. 24:29mechanisms. We're trying to calm down in
  681. 24:31order to reduce that level of arousal.
  682. 24:34We're all familiar with this. It's
  683. 24:35called the stress response. However,
  684. 24:37there's another aspect of stress that's
  685. 24:40just as important, which is when we're
  686. 24:42tired and we're fatigued and we need to
  687. 24:44engage, we need to be more alert than we
  688. 24:47are. And so, what I call limbic friction
  689. 24:50is really designed to describe the fact
  690. 24:52that when our autonomic nervous system
  691. 24:53isn't where we want it, meaning we're
  692. 24:55trying to be more alert or we're trying
  693. 24:57to be less alert, both of those feel
  694. 24:59stressful to people. But, the reason I'm
  695. 25:00bringing this up
  696. 25:02is that
  697. 25:03in order to access neural plasticity,
  698. 25:06you need these components of focus, you
  699. 25:08need the component of of
  700. 25:10attaching subjective reward, you need to
  701. 25:12make errors, all this stuff. And a lot
  702. 25:14of people find it difficult to just get
  703. 25:17into the overall state
  704. 25:19to access those things. Here's the the
  705. 25:21beauty of it.
  706. 25:23If you are too alert, meaning you're too
  707. 25:25you know, anxious,
  708. 25:27and you want to calm down in order to
  709. 25:29learn better, there are things that you
  710. 25:31can do. The two that I've spoken about
  711. 25:33previously
  712. 25:34on various podcasts, I'll just review
  713. 25:36them really quickly, are the double
  714. 25:37inhale exhale. So, inhaling twice
  715. 25:39through the nose and exhaling once
  716. 25:40through the mouth. This is what's called
  717. 25:42a physiological sigh. It offloads carbon
  718. 25:44dioxide from the lungs.
  719. 25:46The other thing is starting to remove
  720. 25:47your tunnel vision. You know, when you
  721. 25:49use tunnel vision, you're very focused,
  722. 25:51that epinephrine is released by dilating
  723. 25:53your your field of gaze, so-called
  724. 25:54panoramic vision. But, the other side of
  725. 25:56limbic friction is important, too. If
  726. 25:58you are too tired and you can't focus,
  727. 26:01well, then it's going to be impossible
  728. 26:02to even get to the starting line, so to
  729. 26:05speak, for engaging in neural plasticity
  730. 26:07through incremental learning, et cetera.
  731. 26:09So, in that case, there are other
  732. 26:10methods that you can do to wake yourself
  733. 26:12up. The best thing you should do is get
  734. 26:13a good night's sleep, but that's not
  735. 26:14always possible, or use a NSDR non-sleep
  736. 26:17deep rest protocol. But, if you've
  737. 26:19already done those things, or you're
  738. 26:21simply exhausted for whatever other
  739. 26:23reason, then there are other things that
  740. 26:27I often get asked about, like sure, a
  741. 26:28cup of coffee or super oxygenation
  742. 26:30breathing, which means inhaling more
  743. 26:31than exhaling on average in a in a
  744. 26:34breathing bout. Now, we're sort of
  745. 26:35getting toward the realm of like how you
  746. 26:36could trick your nervous system into
  747. 26:37waking up. And if you bring more oxygen
  748. 26:40in by making your inhales deeper and
  749. 26:41longer, you will become more alert.
  750. 26:43You'll start to actually deploy
  751. 26:44norepinephrine if you breathe very fast.
  752. 26:46So, there are things that you can do to
  753. 26:48move up or down this so-called autonomic
  754. 26:51arousal arc. And what you want to ask
  755. 26:54before you undergo any learning bout is
  756. 26:57how much limbic friction am I
  757. 26:58experiencing? Am I too alert and I want
  758. 27:01to be calmer, or am I too calm and too
  759. 27:03sleepy and I want to be more alert?
  760. 27:05You're going to need to
  761. 27:07engage in behaviors that bring you to
  762. 27:09the starting line in order to learn.
  763. 27:12There are other things that you can do
  764. 27:14in order to then learn better and faster
  765. 27:17besides incremental learning, and those
  766. 27:19center on the vestibular system. Why the
  767. 27:21vestibular system to access neural
  768. 27:23plasticity? Well, we have a hardwired
  769. 27:26system for balance,
  770. 27:28and here's how it works in as simple
  771. 27:30terms as I can possibly come up with.
  772. 27:33As we move through
  773. 27:36space,
  774. 27:37or even if we're stationary, your brain
  775. 27:39doesn't really know where your body is
  776. 27:41except when through that proprioceptive
  777. 27:43feedback. The main way it knows is
  778. 27:46through three planes of movement that we
  779. 27:48call pitch, which is like nodding. So,
  780. 27:51if I nod like this, that's pitch.
  781. 27:54Then there's yaw, which is like shaking
  782. 27:56my head no. And then there's roll from
  783. 27:58side to side, like when a puppy looks at
  784. 28:00you like
  785. 28:02that kind of thing, okay? So, pitch,
  786. 28:04yaw, and roll. Our ears have two main
  787. 28:07roles. One is to hear, right? To
  788. 28:10perceive sound waves, or taking sound
  789. 28:12waves for perception, so-called hearing,
  790. 28:14and the other is balance or vestibular
  791. 28:16function. So, sitting in our ears are
  792. 28:18these semicircular canals, and they're
  793. 28:20these little tubes where these little
  794. 28:21little stones, they're actually little
  795. 28:23bits of calcium, roll back and forth
  796. 28:24like little marbles. When we roll this
  797. 28:26way, they roll this way. When I pitch,
  798. 28:29when we go from side to side, there's
  799. 28:30some that sit flat like this and they go
  800. 28:31shh shh,
  801. 28:32like marbles inside of a hula hoop. And
  802. 28:34then we have roll. There's some that are
  803. 28:36kind of at 45° to those, and it's kind
  804. 28:38of pitch, yaw, and roll. So, you okay,
  805. 28:40great. That sends signals to the rest of
  806. 28:43our brain and body that tell us how to
  807. 28:44compensate for shifts relative to
  808. 28:46gravity.
  809. 28:48I say, "Okay, well, I thought we were
  810. 28:49talking about plasticity." But, this is
  811. 28:51where it gets really, really cool.
  812. 28:53Errors
  813. 28:55in vestibular motor sensory experience,
  814. 28:59meaning when we are off balance and we
  815. 29:01have to compensate by looking at,
  816. 29:04thinking about, or responding to the
  817. 29:06world differently,
  818. 29:08cause an area of our brain called the
  819. 29:09cerebellum, it actually means mini
  820. 29:11brain, it looks like a little mini brain
  821. 29:13stuck like tucked below our our cortex
  822. 29:15in the back,
  823. 29:16cause the cerebellum to signal some of
  824. 29:19these deeper brain centers that release
  825. 29:22dopamine, norepinephrine, and
  826. 29:23acetylcholine. And that's because
  827. 29:26these circuits in the inner ear, etc.,
  828. 29:31and the cerebellum,
  829. 29:32they were designed to recalibrate our
  830. 29:35motor movements when our relationship to
  831. 29:39gravity changes, something fundamental
  832. 29:40to survival. We can't afford to be
  833. 29:42falling down all the time or missing
  834. 29:44things that we grab for or running in
  835. 29:46the wrong direction when something is
  836. 29:48pursuing us. These are hardwired
  837. 29:50circuits that tap right into these
  838. 29:52chemical pathways.
  839. 29:54And those chemical pathways are the
  840. 29:56gates to plasticity. So, I really want
  841. 29:59to spell this out clearly cuz I've given
  842. 30:00a lot of information today.
  843. 30:02The first thing is how are you arriving
  844. 30:04to the learning bout?
  845. 30:06You need to make sure your level of
  846. 30:08autonomic arousal is correct. The ideal
  847. 30:11state is going to be clear, calm, and
  848. 30:13focused, maybe a little bit more on the
  849. 30:14on the arousal level, like heightened
  850. 30:16arousal. So, understand limbic friction,
  851. 30:19understand that you can be too tired, in
  852. 30:20which case you're going to need to get
  853. 30:22yourself a little more alert, or you can
  854. 30:24be
  855. 30:25too alert and you're going to need to
  856. 30:26get yourself calmer.
  857. 30:28So, the first gate is to arrive at
  858. 30:30learning at the appropriate level of
  859. 30:32autonomic arousal.
  860. 30:33Clear and focused is best, but don't
  861. 30:36obsess over being right there. It's okay
  862. 30:38to be a little anxious or a little bit
  863. 30:39tired. Then, you want to make errors. We
  864. 30:42talked about that, and this vestibular
  865. 30:45motor sensory relationship is absolutely
  866. 30:47key
  867. 30:48if you want to get heightened or
  868. 30:50accelerated plasticity. And we talked
  869. 30:53about another feature, which is setting
  870. 30:55an a contingency. If there's a reason,
  871. 30:57an important reason for you to actually
  872. 30:59learn, even if you're making failures,
  873. 31:02the learning will be accelerated. So
  874. 31:04there's really four things that you
  875. 31:05really need to do for plasticity
  876. 31:08as an adult, and I would say that these
  877. 31:10also apply to young people,
  878. 31:12and there's an interesting kind of a
  879. 31:15thought experiment there as well, which
  880. 31:17is if you look at children,
  881. 31:20they are moving a lot in different
  882. 31:21dimensions. Whatever sport the kids are
  883. 31:23playing, or even if they don't play a
  884. 31:24sport, they tend to move in a lot of
  885. 31:27different relationships to gravity, more
  886. 31:30dimensionality to their movements, I
  887. 31:32should say, than adults. As we age, we
  888. 31:34get less good at engaging in neural
  889. 31:36plasticity. Part of that is because as
  890. 31:38we get older, we tend to get more linear
  891. 31:41and more regular about the specific
  892. 31:43kinds of movements. So you sort of have
  893. 31:45to wonder whether or not the lack of
  894. 31:46plasticity or the reduced plasticity in
  895. 31:49older individuals, which includes me,
  896. 31:53would reflect the fact that those
  897. 31:55chemicals aren't being deployed because
  898. 31:58we're not engaging in certain behaviors
  899. 32:00as opposed to we can't engage in the
  900. 32:02behaviors because the chemicals aren't
  901. 32:03being deployed. So
  902. 32:05I want to make sure that I I underscore
  903. 32:07the fact that this vestibular thing that
  904. 32:09I've been describing is a way to really
  905. 32:12accentuate plasticity. It's tapping into
  906. 32:15an inborn biological mechanism where the
  907. 32:18cerebellum has outputs to these deep
  908. 32:19brain nuclei associated with dopamine,
  909. 32:22acetylcholine, and norepinephrine.
  910. 32:24That's an kind of an amplifier on
  911. 32:26plasticity. As is high contingency. If
  912. 32:29you really need to learn conversational
  913. 32:30French to save your relationship,
  914. 32:33chances are you're going to learn it.
  915. 32:34Now, there are limits to this, of
  916. 32:35course, too. If someone puts a gun to my
  917. 32:37head and says, "Learn conversational
  918. 32:38French in the next 120 seconds."
  919. 32:41Um I think we would probably be my only
  920. 32:43response
  921. 32:44because I can't
  922. 32:46stuff in all the knowledge all at once.
  923. 32:48I mean, I think that's the dream of
  924. 32:50brain-machine interface that one will be
  925. 32:51able to download a chip into their
  926. 32:53hippocampus or cortex or some other
  927. 32:55brain structure that would allow them to
  928. 32:56download conversational French. And
  929. 32:59someday, uh we may get to that. And so,
  930. 33:02my overall goal here in this episode and
  931. 33:05with this podcast is to give you some
  932. 33:07understanding of the mechanisms and the
  933. 33:09insights into the underlying biology
  934. 33:11that allow you to tailor what these
  935. 33:15kind of foundational mechanisms are to
  936. 33:18suit your particular learning needs. So,
  937. 33:20I very much thank you for your time and
  938. 33:22attention. I know it's a lot of
  939. 33:24information, and it takes a bit of focus
  940. 33:26and attention, and certainly will
  941. 33:28trigger plasticity
  942. 33:30to learn all this information. Want to
  943. 33:32encourage you and just remind you that
  944. 33:34you don't have to grasp it all at once,
  945. 33:37that it is here archived, and that if
  946. 33:39you want to return to the information,
  947. 33:40it will still be here. And that I most
  948. 33:43of all really appreciate your interest
  949. 33:45in science. Thank you so much.

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