Exam 1 review — Transcript
Full transcript
- 0:02All right, guys. Hopefully this one
- 0:06works. And we have been having some
- 0:08technology issues, but hopefully this
- 0:09one works. We're going to do it again.
- 0:12Um, but this is just your exam review.
- 0:15Um, it is a supplemental help for your
- 0:17exam. So, please remember to review
- 0:20notes, look at those things that your
- 0:23professors have pointed out in class or
- 0:25on the slides, the things that are
- 0:26highlighted or bolded. um and concepts
- 0:30just in general, not just rope
- 0:32memorization. But I think you guys are
- 0:34going to do great and this is definitely
- 0:35going to help you a lot. So let's get
- 0:37started. So to begin, we're going to go
- 0:40through chapter one starting with macro
- 0:42versus micronutrients. So
- 0:44macronutrients, we need these in big
- 0:46amounts like grams. And these are going
- 0:49to be proteins, carbs, lipids, and
- 0:52water. Those are the things we need in
- 0:55larger amounts and are classified as
- 0:57macronutrients. Micronutrients on the
- 0:59other hand are smaller amounts. So we
- 1:03need them in smaller amounts like
- 1:04milligs, micrograms,
- 1:06etc. And they include vitamins and
- 1:08minerals.
- 1:12We have six classes of essential
- 1:13nutrients. Um these essential nutrients,
- 1:16they do a specific biological function.
- 1:18And when we don't have the minimum diet,
- 1:20we're going to see a decline in function
- 1:21in our body. Um, and typically we can
- 1:24add them back into our diet before real
- 1:27hardcore damage occurs. Um, as long as
- 1:30they haven't been too severely
- 1:32deficient. And these are going to
- 1:34include our vitamins, minerals, carbs,
- 1:36proteins, fats, or lipids, and water.
- 1:41So, here's just a big um table. You
- 1:45don't need to know it. You just need to
- 1:46know the different between energy
- 1:48yielding and non-energy yielding
- 1:49nutrients. So, our energy yielding
- 1:51nutrients, those are going to be our
- 1:53carbs, our fats or lipids, and our
- 1:56protein. They're actually giving us
- 1:57energy that our um bodies can use. Um
- 2:01and then our non-energy yielding
- 2:03nutrients. These are going to be
- 2:04vitamins and minerals. So our body's not
- 2:06taking these and converting them into
- 2:08ATP or energy for us, but they are being
- 2:11used in our body to perform various
- 2:13functions.
- 2:15All right, we'll keep going. So we have
- 2:17different functional categories for
- 2:19these nutrients. Um some provide energy,
- 2:23promote growth and development, and
- 2:25regulate body processes. A lot of these
- 2:27are going to do the same thing, but um
- 2:30the ones that provide energy, like we
- 2:32just talked about, carbs, proteins,
- 2:34lipids, um the ones that promote growth
- 2:37and development, proteins, lipids,
- 2:39vitamins, minerals, water, and the same
- 2:43ones regulate our body processes.
- 2:47All right, so we'll start with our
- 2:48macronutrient carbohydrates. And our
- 2:51carbohydrates are going to be made of
- 2:52carbon, oxygen, hydrogen. They provide
- 2:55four kal per gram. Know that. That's
- 2:58important to know. Um it's our major
- 3:00source of energy in most cells. Um we
- 3:02use carbohydrates the most for energy.
- 3:04And there's two types. There's simple
- 3:06and there's complex. Simple are readily
- 3:08usable forms of carbohydrates like table
- 3:11sugar, which is sucrose and blood
- 3:13glucose. And our complex carbohydrates
- 3:15are going to include starch, glycogen,
- 3:17and fiber. Our starch, it's a storage
- 3:20form of carb in foods. And our fiber is
- 3:22something we cannot digest and it forms
- 3:25structures in the plant cell walls.
- 3:28Great for our gut, but we can't really
- 3:30digest it.
- 3:34All righty. The next one we'll talk
- 3:35about is protein. Protein has a unique
- 3:38um difference between it and carbs and
- 3:41that is that it has nitrogen, the only
- 3:44macro nutrient um of the three that have
- 3:47nitrogen in it. Um, and it also provides
- 3:494 ks per gram similarly to carbs, but
- 3:53it's made of amino acids. There's 20
- 3:55amino acids, but nine are essential,
- 3:58which means we have to get them from
- 4:00food, from our diet. Our body does not
- 4:02make them. And protein is important in
- 4:05structural components in our body such
- 4:06as bone, muscle, blood, cell membranes,
- 4:10especially enzymes, and immune factors.
- 4:15All righty. Lipids, fats, our last
- 4:17energy yielding macronutrient. It's
- 4:20going to be carbon, oxygen, and hydrogen
- 4:22just like our carbs were made out of the
- 4:25same thing, but it provides 9 kals per
- 4:28gram, which is the most out of all our
- 4:30macronutrients. So, 9 kals. Keep that in
- 4:33mind for your exam. Um, there's two
- 4:36types of lipid categories. We have
- 4:38saturated fats and unsaturated.
- 4:41saturated I think like S for saturated
- 4:44means solid room temperature. Um they're
- 4:47mainly found in animal sources. They
- 4:49raise our blood cholesterol which can
- 4:51lead to cardiovascular disease. Um the
- 4:53ones that we really want to make a
- 4:54staple in our diet are unsaturated fats.
- 4:57They're liquid at room temperature and
- 4:59they're mainly found in plant sources
- 5:01like think olive oil, canola oil,
- 5:02vegetable oil and they're a lot better
- 5:04for us than saturated fats for our heart
- 5:06health.
- 5:09Water is another macronutrient that we
- 5:11need in the largest quantity. Although
- 5:14it doesn't produce um we our body
- 5:16doesn't use it to make ATP like the
- 5:19other ones, but we do need it for all
- 5:22sorts of functions. Um it's used for as
- 5:25a solvent, lubricant, a medium for
- 5:27nutrient transport to our cells and
- 5:29helps regulate our body temperature. And
- 5:31we get it from food and drink. And it
- 5:33actually is the byproduct of metabolism
- 5:36or byproducts of breaking down our
- 5:38lipids, proteins, and fat or carbs.
- 5:43And then this is just a note. We're made
- 5:45of of 60 to 70% water, which is probably
- 5:48why we need it in the largest quantity.
- 5:52All right, here's just a practice. Um,
- 5:54we won't I won't go through it totally,
- 5:56but um I'll just show you guys how you
- 6:00would go about solving this. Um,
- 6:04perfect. So, we know that
- 6:08our
- 6:11carbs, sorry. Okay, we know that our
- 6:13carbs produced four kals per gram. So
- 6:17you would just take however many grams
- 6:19of carbs we have and we would multiply
- 6:21that by the four because it produces or
- 6:24it gives us four cakeals per gram and
- 6:26then you would multiply that out to get
- 6:28the total cake. So again fat it's 9
- 6:31kowals per gram. So you multiply that by
- 6:349. Protein for
- 6:37alcohol is seven although it's not
- 6:39really considered an energy yielding
- 6:40nutrient just because of how it's
- 6:42metabolized in our body but it is seven.
- 6:45And then you would just multiply that
- 6:46out to get the total. So if that makes
- 6:49sense, we will just
- 6:52go ahead and get rid of these.
- 6:55All righty.
- 6:57Perfect. We'll keep going along.
- 7:00As long as that makes sense to everyone.
- 7:03Okay. So this is just a quick summary
- 7:04slide, but carbs produce 4k calories per
- 7:06gram. Protein 4k cows per gram. Alcohol
- 7:09again not a nutrient because it's not
- 7:10really producing um energy in our body
- 7:12like carbs, proteins, and fats does. but
- 7:14it's still considered one of these. Um,
- 7:17and then fats, 9 ks per gram. We use
- 7:21these energy producing nutrients um or
- 7:23energy yielding nutrients I should say
- 7:25to build new compounds in our body to
- 7:27perform movements with our muscles and
- 7:30to promote nerve transmission within our
- 7:32nervous system and also to maintain ion
- 7:35balance within cells like our blood
- 7:38cells um just different cells in our
- 7:40body. So we use energy to do work.
- 7:45Okay. So what influences our food
- 7:47choices? Well, there's two major
- 7:49factors. Um and it's hunger and versus
- 7:52appetite. So hunger is a physiological
- 7:55internal need for food. Like your body
- 7:57is telling you I need food to keep going
- 8:00to survive. So it's physiological. We
- 8:02really need it for um processes in our
- 8:04body to function. While appetite on the
- 8:06other hand is just a psychological
- 8:08desire to eat food. So, we may not need
- 8:12food, but our brain is telling us we
- 8:14want food. So, that's the main
- 8:16difference between hunger and appetite.
- 8:18Um, nutritional status, malnutrition, it
- 8:22can refer to over nutrition or under
- 8:24nutrition. So, it's just malnutrition is
- 8:26just meaning we're not in that just
- 8:28right desirable nutrition state.
- 8:32Under nutrition, this is when our
- 8:33nutrient intake is not meeting our
- 8:35needs. So it's less than what we need or
- 8:38our nutrient surplus stores are
- 8:40depleted. So the the energy um stores we
- 8:43have in our body are depleted. We really
- 8:45need that food. So we're under um we
- 8:48have under nutrition. Um over nutrition
- 8:51obviously the opposite. It's a
- 8:53consumption of more nutrients than the
- 8:55body needs. So more calories than we
- 8:56need, more energy than we need. So we're
- 8:58probably going to store it as fat which
- 9:00could lead and often does lead to
- 9:01obesity.
- 9:03All righty.
- 9:06the scientific method. You guys had some
- 9:11brief overview of this. So, we're just
- 9:12going to go through it again, but just
- 9:14make sure you kind of know what each of
- 9:16these do in maybe the step-wise order.
- 9:19But our first step, it's a little
- 9:20covered, but it's observation where
- 9:23we're seeing something, we're
- 9:24identifying a problem or a phenomenon.
- 9:26Then our second step is we're going to
- 9:28see that and then come up with an
- 9:30explanation for it. So, we're going to
- 9:32form our hypothesis.
- 9:34Then from that hypothesis we formed,
- 9:35we're going to experiment. We're going
- 9:37to design a study to test our
- 9:39hypothesis. From that experiment, we're
- 9:41going to collect data and analyze the
- 9:43results. We're going to use statistic
- 9:45methods, various methods to identify
- 9:48patterns, correlations, differences, and
- 9:50we're going to record those. Then we're
- 9:52going to conclude. We're going to either
- 9:54say, you know what, my guess, my
- 9:56hypothesis was correct, so we're going
- 9:57to accept it. Or we're going to say, you
- 9:59know what, my hypothesis was so wrong,
- 10:01and we're going to reject it. or maybe
- 10:03we just need to modify it. And finally,
- 10:06we're going to send it for peer review
- 10:07and ultimately publication. So many
- 10:10people are going to look through it to
- 10:11make sure that we did what we're
- 10:13supposed to and went through the right
- 10:14channels and then we would submit it for
- 10:16publication.
- 10:19All right. So there's many experimental
- 10:21designs in nutrition research. Um
- 10:24various ways to experiment. In vitro
- 10:27means in glass. So like test tube
- 10:29experiments. While in vivo, vivo in life
- 10:32means that we're experimenting organisms
- 10:35in their natural habitat. So not
- 10:37isolated into a test tube or whatever.
- 10:40Um the gold standard for experimental
- 10:42designs is going to be a randomized
- 10:45control trial. And there's various kinds
- 10:47of these. We have a double blind where
- 10:49the participant nor the researcher knows
- 10:51what's going on um or which group is
- 10:53getting which um intervention. We have a
- 10:56crossover study where participants
- 10:59receive both the treatment and the
- 11:01placebo. So you're kind of each person
- 11:03is being their own tester. Um but it's a
- 11:07great way to do it. Or the placebo study
- 11:10which is fake treatment such as like a
- 11:12sham pill or just um not the real thing.
- 11:19All right. So that was chapter one and
- 11:21we're going to go into chapter two.
- 11:23So these ones can get confusing. the
- 11:25dietary reference intake. So, we're
- 11:27going to try to keep these straight
- 11:28together. And there's five standards of
- 11:30DRI. We have our estimated energy
- 11:32requirements, our ES. We have our
- 11:34recommended dietary allowance, our RDAs,
- 11:37adequate intakes, AIS, tolerable upper
- 11:40intake levels, ULS, and estimated energy
- 11:42requirements, EERS. Um, they differ by
- 11:45life stage. So, different life stages it
- 11:48may differ. But there's another one
- 11:50that's not technically a DRRi, but it's
- 11:53still one that we use and it's an
- 11:54acceptable macronutrient distribution
- 11:56range. So these are set for our
- 11:58macronutrients such as carbs, fats, and
- 12:00proteins and they're a percentage range
- 12:01that we can use for diets.
- 12:06All right, so our first one, ES, they
- 12:09meet the needs of half of the
- 12:11population. So their nutrient amounts
- 12:14are estimated to meet the needs for half
- 12:16of a population. So that's kind of what
- 12:18set this one apart. And Ess cannot be
- 12:20set without a functional um biioarker.
- 12:24So this means functional markers can
- 12:25include like enzymes, cells, organs, um
- 12:29just how your body is using these
- 12:31things. And this is for groups, not
- 12:33individualized. So that's something else
- 12:35to note. But know that ES meet needs for
- 12:39half of the population. It's not
- 12:41everybody.
- 12:43RDA's recommended dietary allowances.
- 12:45These meet the needs for nearly all
- 12:47individuals like in 98% of individuals.
- 12:50It's based on ERS, multiple ERS. And
- 12:54this nutrient is set to prevent disease,
- 12:57not to prevent deficiency, but it's
- 13:00going to be higher than what the average
- 13:01person needs. So know that this is going
- 13:04to meet the needs of nearly everybody
- 13:06and is based on ES. So those are just
- 13:09some things to note. Um, adequate
- 13:11intakes. These are set for nutrients
- 13:13where we don't have enough research of
- 13:15functional markers to have an E. So, we
- 13:19know we don't have enough research about
- 13:20this. So, we're just going to set an
- 13:21adequate intake. And these can be used
- 13:23for individuals. You know, our Esser
- 13:26more for groups, not individuals. AIS,
- 13:28they can be used for individuals. Um,
- 13:30these are based on experimental
- 13:31estimates. Um, and
- 13:35yeah, to maintain to find nutritional
- 13:37status. So, AI's target intake level for
- 13:40a nutrient based on people's estimated
- 13:42dietary intakes.
- 13:45All righty. Tolerable upper intake
- 13:47levels. So, these are the max daily
- 13:49intake you can um have without it
- 13:52causing adverse health effects. It's not
- 13:55really a nutrient goal cuz you do not
- 13:57want to be intaking the max amount you
- 14:00can every day. So, our nutrient intake
- 14:02should remain below this upper limit
- 14:05ceiling.
- 14:09And then we have estimated energy
- 14:10requirements, our last RDI. And these
- 14:13are our average daily energy needed for
- 14:16like for each life stage group. Um it
- 14:19depends on various things like how much
- 14:21we're exercising, how much energy we're
- 14:23expending, height, weight, gender, age,
- 14:27um and overall they're used the this um
- 14:29estimate is used to promote healthy body
- 14:32weight, quality of life, etc.
- 14:36Here's a great summary slide if you
- 14:37guys, this is in your notes, you can
- 14:39find it. Um, it's a great summary slide
- 14:41for all of these. But again, ES
- 14:44represent half of the population, more
- 14:47for groups, not individuals. RDAs used
- 14:50to evaluate current intake for specific
- 14:53nutrient. It can be more individualized.
- 14:56AIS when we don't have that E, we have
- 15:00we'll do experimental research to
- 15:02establish an AI. um an upper limit or
- 15:05upper level intake. This is the max
- 15:08amount. So, we usually want to stay
- 15:09under this ceiling. It's the max amount
- 15:11we can have before bad effects. ERS that
- 15:15estimated energy requirement. How many
- 15:18calories, how much energy are we needing
- 15:20according to various factors like
- 15:21exercise, height, weight, gender, etc.
- 15:24And then our AMDR nutrient range, that
- 15:27percentage of each macronutrient that we
- 15:28need.
- 15:31All right, guys, stick with me. So,
- 15:33nutrient density of food. You guys did
- 15:35this in your case study, so you should
- 15:36be good to go on this. But again, here's
- 15:39a reminder calculation. Um, to calculate
- 15:42nutrient density, we're going to divide
- 15:44the amount of nutrient in a serving,
- 15:45divided by our recommended daily intake,
- 15:47and get that value. And then we're going
- 15:49to divide our calories in a serving
- 15:50divided by our EER, our daily calorie
- 15:53need, and we're going to get that value.
- 15:55And then we're going to compare the two
- 15:57values. So the food is going to be
- 15:59nutrient dense if it if it provides a
- 16:01greater contribution to your nutrient
- 16:03need than your calorie need. So if this
- 16:05number is larger than this one, it's a
- 16:07nutrient-dense food. So here's an
- 16:09example problem you guys can do. Again,
- 16:10this is straight from your notes. So I
- 16:13you guys did this example in class. Um
- 16:16down here we can see that these produce
- 16:20similar calories. Actually, soda
- 16:22produces a lot more calories, but look
- 16:24at all the nutrients we're getting from
- 16:26milk.
- 16:27So, milk is clearly more nutrient-dense
- 16:29than soda.
- 16:32Okay, nutrition facts panels. There's so
- 16:34much on here, but we're going to try to
- 16:36simplify it. So, what I've highlighted
- 16:38here are all the things that are
- 16:39required on a nutrient fact label. Our
- 16:42serving size is required. Calories,
- 16:45fats, saturated fat, trans fats,
- 16:47cholesterol, sodium, potassium, carbs,
- 16:49dietary fiber, added sugars, and
- 16:52protein. Not to mention a few
- 16:55micronutrients like calcium, iron,
- 16:57vitamin D, which isn't on here. Those
- 17:00things are required. So, our DRRI,
- 17:03they're recommendations from the food
- 17:05and nutrition board. Um, again, we
- 17:09talked about all of those earlier, our
- 17:11ERS, AIS, all that. Um, our DRVs or
- 17:14daily recommended values are set for
- 17:17energy producing nutrients and
- 17:19cholesterol and sodium. And they're
- 17:21found over here. They're percent daily
- 17:22values. They're based on a 2,000 calorie
- 17:25per day diet. Um, so keep that in mind
- 17:28and you can see them over here. Um, and
- 17:31then RDI are set for vitamins and most
- 17:34minerals on a food label.
- 17:36So again, you can find that over there.
- 17:38Percentage value as well.
- 17:41All right. So just some brief overview
- 17:44of the dietary guidelines that we try to
- 17:46follow. Um, follow a healthy eating
- 17:48pattern across lifespan. Focus on
- 17:50variety and nutrient density and how
- 17:53much. Moderation is key on some things
- 17:56because every food has a place in our
- 17:58diet. No food is bad. Um, limit calories
- 18:02from added sugars and saturated fats and
- 18:04reduce sodium. Remember those three
- 18:05things that Mr. Hand is always talking
- 18:07about, but that we want to watch out for
- 18:09are added sugars, saturated fats, and
- 18:11and sodium. Those are the ones we want
- 18:13to limit and have in moderation. Um, and
- 18:17we should try to shift to healthier food
- 18:19and beverage choices, um, and support
- 18:21healthy eating patterns for all. And
- 18:23then these are just ways that we can put
- 18:24them into action, these dietary
- 18:26recommendations. Um, take into account
- 18:28your current health status, your family
- 18:30history. Maybe your family history has
- 18:32or maybe your family has history of
- 18:34heart disease. So maybe you need to be
- 18:35more cautious about certain foods. Um,
- 18:38identify specific changes you need to
- 18:39make. Develop a plan to achieve these
- 18:42changes and then see whether the changes
- 18:45are really effective. Are they helping
- 18:47you follow those dietary guidelines?
- 18:51Okay, my plate. This is a fun one and a
- 18:55really great tool for using in our daily
- 18:57life. Um, it helps us balance our
- 18:59calories. Um, basically
- 19:03avoid oversized portions when it comes
- 19:05to making your My Plate. Um, foods that
- 19:08you really don't have to worry about and
- 19:10you can increase a lot are your fruits
- 19:12and vegetables. You want to make half of
- 19:13your plate fruits and vegetables. make
- 19:15at least half of your grains whole
- 19:17grains and switch our milk from whole
- 19:21fat to low fat or fat-free option. Um,
- 19:24foods to reduce again those added
- 19:26sugars, sodiums, saturated fats. And
- 19:29then swap out water instead of high
- 19:32sugar drinks. Those are the main
- 19:34recommendations for my plate.
- 19:37All right, guys. We just made it through
- 19:38chapter 2. Last chapter to go. We get
- 19:41into digestion in this chapter. So our
- 19:44first we'll start with the organization
- 19:45of the human body. So how is the human
- 19:47body organized? Well, we start at a
- 19:48chemical level. Our atoms combine to
- 19:50form our cells. Cells combine to form
- 19:52tissue. Tissues combine to form organs.
- 19:55Organs work together to form an organ
- 19:58system. And then organ systems work
- 19:59together to make you and me organisms.
- 20:02So I think it makes pretty pretty good
- 20:03sense. But just keep those stepwise
- 20:06order in mind.
- 20:10major digestive organ system. The major
- 20:13organs, mouth, esophagus, stomach, small
- 20:16intestine, large intestines, and anus.
- 20:18And these are in the order of which
- 20:20digestion occurs. Um, and then we have
- 20:22accessory organs that help out, but
- 20:24they're not main organs um that are a
- 20:27part of the digestive system, but still
- 20:28really important, and that's the liver,
- 20:30pancreas, and gallbladder, or in other
- 20:32words, llamas get pizza. A helpful way
- 20:34to remember if you need.
- 20:38All righty. So the functions of the
- 20:40digestive system
- 20:42main function is to absorb the nutrients
- 20:44that we're that we're intaking excreting
- 20:47waste making nutrients for cells out of
- 20:49the energy that we intake. Um it plays a
- 20:52role it plays a role in immune system
- 20:55and it houses the microbiota in our body
- 20:58and our gut which is really vital for so
- 21:01many things but especially digestion and
- 21:04a healthy gut. Um, our digestive system
- 21:07is controlled by hormones and the
- 21:09nervous system.
- 21:11All right. So, the GI tract, it's made
- 21:13of four layers and I have it organized
- 21:15as the very innermost layer to the
- 21:17outermost layer. So, we have the mucosa
- 21:20in the very innermost layer which is the
- 21:22epithelial cells and glands. Then we
- 21:24have one layer out is the sub mucosa
- 21:27that has the blood vessels and they and
- 21:29it carries nutrients in those. Um and
- 21:31then one more layer out we have muscle
- 21:34that is actually moving the food forward
- 21:36which we'll talk about later the
- 21:37difference between paristalsis and
- 21:39segmentation. Um and then we have the
- 21:41sarosa which is actually protecting the
- 21:43tract overall. And then just a little
- 21:45fun fact that you guys mentioned or that
- 21:47Mr. Hen mentioned in class but our GI
- 21:49tract is 15 ft long which is pretty wild
- 21:52that it fits inside of our body's
- 21:55sphincters. These are really important
- 21:57part of the digestive system. They're
- 21:59ringing like muscles and they open and
- 22:01they close to control the flow of the
- 22:03food that you're eating and the flow of
- 22:05the contents in the GI tract. Um the
- 22:08lower esophageal sphincter, again the
- 22:10numbers correlate to where they're
- 22:11located. Um and they do kind of what you
- 22:15think they do depending on where they're
- 22:17located, but the lower esophageal
- 22:19sphincter, it prevents backflow of the
- 22:22stomach back into the esophagus. Um,
- 22:24pyloric sphincter controls the flow of
- 22:26stomach contents into the small
- 22:27intestine so that it does not flow back
- 22:29into the stomach. The sphincter of odi
- 22:32it controls the flow of bile from the
- 22:33common bile duct into the small
- 22:35intestine. Ilioal valve prevents the
- 22:37contents of the large intestine from
- 22:39re-entering the small intestine and the
- 22:41anal sphincter prevents defecation until
- 22:43the person wants to do so. So all of
- 22:46these basically are preventing backflow
- 22:49and keeping the food moving forward
- 22:52which is essential for digestion.
- 22:54Okay. So speaking of food moving
- 22:56forward, how food is actually moving
- 22:58because without um segmentation
- 23:01paristalsis, our food is just going to
- 23:03be sitting in one spot which is not
- 23:06good. It might move a little because of
- 23:08gravity but overall it's not going to
- 23:09move very well. So parasolsis and
- 23:12segmentation great way to know the
- 23:14difference between these is paristelsis
- 23:16we're actually pushing forward. So
- 23:19parasolsis starts with a P. Pushing
- 23:21forward starts with a P. That's how I
- 23:22remember. So paristelsis we're actually
- 23:25moving forward. Segmentation on the
- 23:26other hand is just mixing back and
- 23:28forth. So it's mixing the food in with
- 23:30enzymes which is also great for our
- 23:32digestion. But so each are important but
- 23:35they're doing different things. So
- 23:36again, paristelsis food is mixing with
- 23:38digestive secretions, but it's actually
- 23:41getting propelled or pushed down the GI
- 23:43tract and it's waves of contractions
- 23:45because we do have that muscle layer on
- 23:48um in our GI tract that is actually
- 23:50doing the squeezing and shortening to
- 23:51push it. Segmentation, it's the back and
- 23:54forth movement, breaking apart context,
- 23:56make content, mixing with enzymes, and
- 23:58it's occurring in small intestine
- 24:00alongside of paristelsis.
- 24:03um mass movements, paraselsis over wides
- 24:06widespread area happening in the large
- 24:08intestines and then finally elimination,
- 24:11urine, feces, vomiting, all ways that we
- 24:13eliminate food or um excretions. Um a
- 24:17normal time for a meal to make it
- 24:21through your digestive system is 24 to
- 24:2260 hours, which is a really long time.
- 24:25Um so when you're eating something, it's
- 24:27going to be um working its way for a
- 24:30while.
- 24:32Wonderful. the wonderful world of
- 24:34enzymes or in other words aces. Most
- 24:36enzymes you see are going to end in aces
- 24:39or ACE which is super helpful. Not all
- 24:41of them but a lot of them. Um what are
- 24:43enzymes? They are proteins and they
- 24:45speed up reactions. That's their main
- 24:48function. That's what they're there for.
- 24:50They act on a specific substance. Um
- 24:52carbs, proteins, fats, whatever it may
- 24:54be. Most enzymes are going to be made in
- 24:57our pancreas and small intestine which
- 25:00our small intestine is essential for
- 25:02absorption. So it makes sense that the
- 25:03pancreas and small intestines are making
- 25:05our enzymes. But a small amount are made
- 25:07in our stomach and our salivary glands
- 25:09in our mouth. Um they the enzymes
- 25:12catalyze hydrarolysis reactions or we
- 25:14removing water to break um bonds or
- 25:17whatever it may be. And then inadequate
- 25:20enzyme production can lead to some
- 25:22issues like incompleted digestion or
- 25:25limited absorption. We're not getting
- 25:26all the nutrients we could. So it's
- 25:28important to have enzymes for digestion.
- 25:31Some other secretions to know in our
- 25:33mouth we have saliva and there's enzymes
- 25:35in saliva that break down starch. In our
- 25:37stomach we have acid which activates um
- 25:41enzymes that break down protein. We have
- 25:43bile in our small intestines which help
- 25:45break down fat um through
- 25:47emulsification,
- 25:49but we'll talk more about that later.
- 25:51Okay, so moving through the GI tracts,
- 25:52we're going to start where digestion
- 25:54begins, the mouth and the esophagus. So
- 25:56digestion begins in the mouth, and we're
- 25:59going to chew food, mix it with enzymes,
- 26:01break it down mechanically by chewing,
- 26:04and our saliva is going to mix with the
- 26:06food, forming a bolus, which is like a
- 26:08big lump of food. And we're going to
- 26:11swallow that bolus and it's going to go
- 26:12through our esophagus and our epiglatus
- 26:14is going to cover the larynx so that
- 26:16that food is not going where it's not
- 26:18supposed to be. Um, and then what's in
- 26:20our saliva? Many things to help break
- 26:23down what we're eating, although we're
- 26:25not breaking down a lot in our mouth.
- 26:27Um, lizoomes to destroy bacteria, mucus
- 26:30to kind of lubricate and then like kind
- 26:32of like hold the bolus together because
- 26:34it's like slimy and gross. Um, it's like
- 26:37the slimy gross glue. And then
- 26:40amalayise, which breaks down a small
- 26:42portion of starch into simple sugars,
- 26:43not a lot, but a little bit. And then
- 26:45lipase, which begins fat digestion.
- 26:49All right, guys. We're doing great.
- 26:50Ramas there. Um, this is just a small
- 26:52caveat, but smell and taste. A lot of
- 26:55you are going to know this, but we have
- 26:56five um tastes. Salty, sour, sweet,
- 26:59bitter, unami, umami, excuse me. Um, and
- 27:02taste is enhanced by our oldactory cells
- 27:04in the nose. So a lot of times if you
- 27:06can't smell, you can't taste food very
- 27:08well because olfactory cells in our nose
- 27:10help us to taste better.
- 27:13Okay. Now that our food has moved
- 27:15through the mouth and esophagus, we get
- 27:17to the stomach. Food enters the stomach
- 27:20via that sphincter we talked about that
- 27:21lower esophageal sphincter and digestion
- 27:24continues to the stomach. But a small
- 27:26amount of digestion occurs here. really
- 27:28only protein gets digested here or
- 27:30broken down by enzymes because it's so
- 27:32acidic because gastric juices in our
- 27:34stomach contain HCL which is
- 27:37hydrochloric acid and intrinsic factor
- 27:40from parietal cells but we have a nice
- 27:43enzyme here that breaks down protein and
- 27:47pepsinogen this is the non-active form
- 27:50but it becomes activated by HCL
- 27:54into something that can digest the
- 27:56protein so pepsinogens is important for
- 27:58protein digestion and gastroglyphase
- 28:01from chief cells. So, a little bit of of
- 28:02fat breakdown occurs here. Gastrin, it's
- 28:05a hormone made in the stomach and it
- 28:07controls the release of HCL and
- 28:09pepsinogen.
- 28:11So, that's something to know. It's a
- 28:13hormone. Like we talked about, hormones
- 28:15do control our um or part of our reg
- 28:19regulation of our digestive system.
- 28:22All right, guys. We'll keep moving. So
- 28:23in our stomach, gastrin leads to the
- 28:26release of HCL and pepsinogen. And like
- 28:28I said, HCL, hydrochloric acid,
- 28:30activates our pepsinogen
- 28:33into pepsin. And our pepin breaks down
- 28:37proteins to small peptides, which are
- 28:39like smaller chains of amino acids.
- 28:44All righty.
- 28:47In the stomach, the bolus goes through
- 28:50the lower esophageal sphincter into the
- 28:52stomach. And in the stomach, secretions
- 28:56make the bolus become like a kim, which
- 28:59is like a more like liquid version of
- 29:01the food. It's just like a slushy slush.
- 29:03It's really nice picture. Um, and then
- 29:06once it's a kim in the stomach, it keeps
- 29:09going to the small intestine and the
- 29:11pyloric sphincter allows the kim to flow
- 29:13into the small intestine. um and it
- 29:15closes so that it doesn't go back up
- 29:17into the stomach. And then glucose
- 29:19depend dependent insulin tropic peptide
- 29:22slows the release into the small
- 29:24intestine. I don't this isn't really
- 29:26something you need to spend a lot of
- 29:28time memorizing at all, but it's just
- 29:30something to note. Um in our stomach
- 29:32expands a lot. It can expand from 2 oz
- 29:35to 16 cups when it's full. Um, and food
- 29:39typically stays in our stomach from like
- 29:401 to four hours
- 29:43or sorry, it's like takes about 1 to
- 29:45four hours from the stomach for the food
- 29:46to get from the stomach to our small
- 29:48intestine.
- 29:50All righty. So, we've moved from the
- 29:52mouth, esophagus now to and the stomach
- 29:55to the small intestine. This is our
- 29:58major side of absorption um or digestion
- 30:00and absorption. Most of absorption
- 30:03occurs here. So on the exam if you'd
- 30:05asked like which organ does the most
- 30:08absorption in the digestive system you
- 30:10would say the small intestine. Um and
- 30:13it's divided into three sections. The
- 30:14dueum, the jugenum and the ilium.
- 30:19So here's all the things that kind of
- 30:21get absorbed and digested in the small
- 30:24intestine. We have glucose, minerals,
- 30:26amino acids, vitamins, alcohol, water,
- 30:28fat. So literally almost b everything
- 30:32does get absorbed here minus a few
- 30:36things.
- 30:38All right. In the small intestines we
- 30:39have small intestine villi which um
- 30:44circular folds and finger-like
- 30:45projections on the surface of our small
- 30:48intestine brush border. They their main
- 30:51goal is to increase the surface area and
- 30:54cause kime to like move slowly through a
- 30:57spiral path to allow for more absorption
- 31:00and it also helps mix the kim with more
- 31:03digestive juices and um again that
- 31:06surface area allows it to come into
- 31:07contact with even more villi.
- 31:10Um this process all is aided by
- 31:12segmentation too which again remember
- 31:14segmentation is not moving forward it's
- 31:16just like mixing.
- 31:19Villi are lined with interasittes and um
- 31:22they secrete enzymes which help absorb
- 31:25nutrients and other cells also secrete
- 31:28mucus and hormones. Um interosytes have
- 31:31a brush border. They're that are lined
- 31:33with microbilli and microbilli are
- 31:36another thing that are covered with
- 31:37digestive enzymes that help us to digest
- 31:40and absorb even more food. Okay, again
- 31:44our accessory organs, llamas get pizza,
- 31:46liver, gallbladder, pancreas. They work
- 31:49alongside of our small intestine to aid
- 31:51in digestion and absorption because
- 31:53again most of our enzymes are produced
- 31:56by our pancreas and our small
- 31:57intestines. Um but bile is produced by
- 32:00the liver, stored in the gallbladder and
- 32:02it helps us in fat digestion and
- 32:04absorption. Um by emulsifying fat which
- 32:07is basically just means breaking large
- 32:09fat into smaller tiny droplets. Um and
- 32:12then um bile is reabsorbed in the illium
- 32:16which is a portion of the small
- 32:17intestine and it can be returned to the
- 32:20liver. So we actually recycle the bile
- 32:22or interohypatic circulation. Fancy way
- 32:26of saying we recycle bile. a small
- 32:28amount of bile not reabsorbed and it's
- 32:30excreted in feces.
- 32:34Um our pancreas again pancreas produce a
- 32:37lot of those enzymes and juices that we
- 32:38need to digest food. Our sodium
- 32:41bicarbonate it helps neutralize acidic
- 32:43kime cuz remember kim is coming from the
- 32:45stomach where we had HCl and just a lot
- 32:47of acid gastrin like all that stuff
- 32:50that's just causes it to be a very
- 32:52acidic environment. So sodium
- 32:54bicarbonate helps neutralize the acidic
- 32:56kim when it gets to the small intestine.
- 32:58Pancreatic amalase helps digest starch
- 33:01in the small intestine. Pancreatic
- 33:03lipase digest fats and then proteases
- 33:06digest proteins. So these kind of um
- 33:08these words the names of the enzymes go
- 33:10with kind of what they digest
- 33:13which is helpful some of them.
- 33:16Okay. So we've moved from mouth,
- 33:17esophagus, stomach, small intestine, and
- 33:19now we're at the large intestine.
- 33:21There's three main parts of our large
- 33:23intestine. We have the colon, the anus,
- 33:24and the rectum. There's three main
- 33:26functions, but our large intestine
- 33:28houses our microbiota where live
- 33:30bacteria is living in our gut that helps
- 33:32us um to keep our GI tract healthy and
- 33:36helps us um just so there's so many
- 33:40benefits. Some it's even linked to
- 33:41mental health in some cases. Um some
- 33:43research suggests. So, it's really good
- 33:45to have healthy bacteria in our guts. Um
- 33:50it forms and expels feces our large
- 33:51intestines and then it also absorbs
- 33:53water and electrolytes.
- 33:55Um the large intestine is the main site
- 33:57where electrolytes are absorbed like
- 33:59sodium and potassium but essentially
- 34:01everything else is absorbed in our small
- 34:03intestine.
- 34:06our gut microbiota. Again, this live
- 34:08bacteria helps us control pathogenic
- 34:10bacteria, synthesize vitamin K, help
- 34:13with lactose digestion, and digesting
- 34:16and metabolizing complex carbs, fibers,
- 34:18and starches, and synthesized biotin.
- 34:21So, there's so many benefits to um our
- 34:24gut microbiota.
- 34:28Okay, so what the actual bacteria in our
- 34:32gut microbiota are called probiotics.
- 34:35They're the live bacteria. We can find
- 34:37these in food and supplements, but they
- 34:39colonize our large intestine and they
- 34:41provide health benefits. Like we just
- 34:42talked about all those health benefits.
- 34:44So, here's some foods they can be found
- 34:46in yogurt, kefir, miso, a lot of
- 34:48supplements you can get from the store.
- 34:50Um the prebiotics on the other hand,
- 34:53they're not the live bacteria. They're
- 34:55the food for the live bacteria to um use
- 34:59to grow. in um their various food
- 35:03ingredients, but they're non-digestible
- 35:05carbohydrates. Um they promote the
- 35:07growth of healthy bacteria. Again,
- 35:09prebiotics are the food for probiotics.
- 35:12Um some examples are inulin and
- 35:15resistant starches.
- 35:18So here again, probiotics are alive.
- 35:20Remember that they're the living ones.
- 35:22Prebiotics, they're just a form of fiber
- 35:24that serve as a food for probiotics. And
- 35:26here's some sources. Um, maybe just keep
- 35:29in mind a few of those in case you get a
- 35:32question.
- 35:35All right, foods that increase acid
- 35:36reflux. Not a fun condition to have. Um,
- 35:39but foods that increase it are typically
- 35:41more acidic. Um, obviously like citrus
- 35:44fruits, caffeine, chocolate even. You
- 35:47probably don't think that's acidic, but
- 35:48it actually is more acidic than others.
- 35:51um fatty foods, especially spicy foods,
- 35:54onions, tomatoes, all these things kind
- 35:56of have to watch out for if you have
- 35:58acid reflux.
- 36:01Intestinal gas. Intestinal gas, it's
- 36:03when um we have fermentation of those
- 36:05undigested carbohydrates or prebiotics
- 36:08that we intake by bacteria in large
- 36:11intestine. So if we don't digest the
- 36:14carbs and they make it to our large
- 36:15intestine, um fermentation happens and
- 36:18it builds up gas.
- 36:22We call it intestinal gas. Okay. The
- 36:24main difference between constipation and
- 36:25diarrhea. Some of this you'll probably
- 36:28just know from just common sense. Um but
- 36:31constipation is when we have difficult
- 36:33or infrequent bowel movements, um slow
- 36:35movement, fluid is absorbed in many
- 36:38cases or many causes, excuse me. um
- 36:41diabetes, IBS depression can cause this,
- 36:43pregnancy, anti-depressants can cause
- 36:45this, medication supplements and a low
- 36:48fiber diet. So, we can really help this
- 36:51um with a higher fiber diet. So, fiber
- 36:53is important. Um diarrhea on the other
- 36:56hand, it's very loose, watery stools
- 36:58like more than three times a day. Not a
- 37:00comfy situation to be in. Um, there's
- 37:03multiple causes for having diarrhea, but
- 37:05we could have bacterial or viral
- 37:07infections from maybe we had
- 37:09contaminated food or water, parasites,
- 37:11food intolerances, IBS, intestinal
- 37:14diseases, large amounts of unabsorbed
- 37:17substances. So, if we get too much of
- 37:18those unabsorbed carbs, complex carbs,
- 37:21that could be really not a good deal.
- 37:24Um, or other unabsorbed substances for
- 37:27that matter. Um, fluid secreted instead
- 37:30of absorbed. So yeah, we don't absorb
- 37:32the fluid that we should be. Um and it's
- 37:34secreted in diarrhea.
- 37:36Not fun. Um treatment for constipation.
- 37:40Again, high-fiber diets. So adding fiber
- 37:42to our diets is really important for um
- 37:46for constipation treatment and regular
- 37:48bowel movements in general. Um drinking
- 37:50more fluids, developing um more regular
- 37:54bowel habits, relaxing some also
- 37:57exercise. Exercise is really important.
- 37:59So, these are great ways um that we can
- 38:01actually um help with this versus we you
- 38:06can take some medications if it's
- 38:07serious like laxative stool softeners.
- 38:10Um but you might want to avoid lubricant
- 38:12laxatives like mineral oil cause some
- 38:15unforeseen side effects. Um so IBS
- 38:19versus IBD irrital bowel syndrome it's
- 38:22in 10 to 15% of the population
- 38:24unfortunately. Um, it's going to be
- 38:26characterized by irregular bowel
- 38:28function, abdominal pain, and
- 38:30distension.
- 38:32Treatment could be to watch trigger
- 38:34foods. You just have to keep an eye out
- 38:35for the foods that trigger you. A FODMAP
- 38:38diet, which we briefly talked about in
- 38:40class. Um, not a fun thing to have to
- 38:42follow. Smaller meals, peppermint oil,
- 38:45maybe have to go gluten-free. Just have
- 38:47to see what works for you. Um some
- 38:50causes abnormal abnormal intestinal
- 38:53motility, stress,
- 38:56altered gut immunity, intestinal
- 38:58dispiosis, many causes, not a fun thing.
- 39:01On the other side of it, we have
- 39:03inflammatory bowel disease. And this
- 39:05happens in one in every 225 people. So
- 39:08that's quite a few people um across the
- 39:11world. But it's it can be it's basically
- 39:15chronic intestinal disease um such as
- 39:17like ulcerative colitis, Crohn's
- 39:20disease. Um it's when reoccurring
- 39:23inflammation and ulceration of the large
- 39:25intestines. So this is not a fun um
- 39:27situation and could be really painful
- 39:29and uncomfortable. Um treatments
- 39:31typically it's medication, antibiot
- 39:34antibiotics and surgery. And we really
- 39:37don't know the cause, but it's an
- 39:39inflammatory response. Could be um or
- 39:42could be genetic. We don't really know.
- 39:46Okay guys, that is all I have for you
- 39:48tonight. Um but go crush your first
- 39:50exam. You guys are going to do great.
- 39:52And remember to
- 39:54review your notes. Um use this as a
- 39:57supplemental review guide, but review
- 40:00those notes. Look at those main bolded
- 40:02underlined highlighted things. things
- 40:04that maybe Professor Hand or Professor
- 40:06Mingi have pointed out to you. Um, yeah.
- 40:09And you're going to do great.
- 40:12All right, guys.
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