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Enclomiphene Vs. TRT - It's not EVEN Close! — Transcript

by Nicholas Trigili | Human Performance Specialist · 2,787 words · 428 segments · language en · Watch on YouTube

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  1. 0:00You're looking to raise your
  2. 0:00testosterone in 2026? TRT is no longer
  3. 0:03the only option. The closest thing that
  4. 0:05we ever had to rival TRT was in
  5. 0:07clomiphene. And I've had thousands of
  6. 0:09men ask me if it's actually the smarter
  7. 0:11move. After all, it's a pill. It's way
  8. 0:13more [music] convenient. But it doesn't
  9. 0:14shut your natural production down,
  10. 0:16either. Maybe it keeps your fertility
  11. 0:17fully intact. So it has to be better
  12. 0:19than TRT, right? As someone who's been
  13. 0:21on testosterone for the last 10 years
  14. 0:24and helping thousands of clients
  15. 0:25optimize their hormones, I can tell you
  16. 0:27this [music] debate isn't nearly as
  17. 0:28close as it looks. So in this video, I'm
  18. 0:31going to break down exactly what
  19. 0:32enclomiphene is, how it's actually used
  20. 0:34in the real-world protocols, and how it
  21. 0:36truly stacks up against the king of the
  22. 0:37hill, testosterone. Now before we dive
  23. 0:39in, everything on this channel is for
  24. 0:41education and entertainment purposes
  25. 0:42only. I'm not a medical doctor. So if
  26. 0:44you're going to start any of these
  27. 0:45treatments, do it under medical
  28. 0:47supervision, a licensed medical
  29. 0:49professional. Now we got that out of the
  30. 0:50way, let's dive in. To know exactly how
  31. 0:53enclomiphene helps increase your
  32. 0:54testosterone, you must understand how
  33. 0:56your body produces testosterone
  34. 0:57naturally in the first place. Because
  35. 0:59your testicles, I know, are actually the
  36. 1:01last stop in this whole chain of
  37. 1:02command. And that chain actually starts
  38. 1:04all the way up in your brain at the HPTA
  39. 1:07axis. The hypothalamus, this is sitting
  40. 1:09all the way up top, right here. It's
  41. 1:11constantly monitoring your hormone
  42. 1:12levels like a thermostat. When it senses
  43. 1:14your testosterone and estrogen are
  44. 1:16running low, it releases GnRH. GnRH is a
  45. 1:19signal which goes straight to your
  46. 1:21pituitary gland. Your pituitary gets
  47. 1:23that signal and responds by releasing
  48. 1:25two hormones you probably have ever
  49. 1:26gotten blood work done over. LH, FSH,
  50. 1:28ever hear of it? LH travels down to your
  51. 1:31testes and tells your Leydig cells to
  52. 1:33produce testosterone. FSH works
  53. 1:35alongside testosterone inside the
  54. 1:37testicles to keep the sperm production
  55. 1:39going and going. So the real chain looks
  56. 1:42just like this. Your brain senses low
  57. 1:44low hormones. Your hypothalamus fires
  58. 1:46the GnRH. Boom! Pituitary fires LH, FSH.
  59. 1:49Boom! Boom! Your testes now respond to
  60. 1:52them by producing testosterone and
  61. 1:54maintaining in sperm production. The
  62. 1:56whole system runs on this whole feedback
  63. 1:58loop. And the second your brain sees
  64. 2:00enough testosterone and estrogen
  65. 2:01circulating, pumps the brakes. It's the
  66. 2:03same logic as a thermostat shutting off
  67. 2:05when the heat in the room hits the right
  68. 2:07temperature. This feedback loop is
  69. 2:09exactly why TRT and clomiphene create
  70. 2:11two completely different outcomes in
  71. 2:13your body. Even though both of them
  72. 2:14raise your testosterone on paper, one of
  73. 2:16them works with the natural feedback,
  74. 2:18the natural loop. And the other one
  75. 2:20turns it off completely. The first one
  76. 2:22basically works with your body's natural
  77. 2:24feedback loop, which is enclomiphene,
  78. 2:26which is actually a piece of a much
  79. 2:28older drug called clomiphene citrate.
  80. 2:31And I probably know it by its brand name
  81. 2:33or when you hear it clomid. Now, clomid
  82. 2:35was synthesized all the way back in 19
  83. 2:3756, 55, somewhere around there. It
  84. 2:39wasn't even made for men. It was
  85. 2:41developed as a fertility drug for women.
  86. 2:43So I always hear like, I'm put on a
  87. 2:44hormone women's drug? No. The FDA
  88. 2:46approved this in 1967 to help induce
  89. 2:49ovulation. To this day, that's still the
  90. 2:51only thing clomid was actually FDA
  91. 2:52approved for. Clomid is actually a mix
  92. 2:54of two different isomers. Uh,
  93. 2:56zuclomiphene, which is the estrogenic
  94. 2:58half, and the other half is called uh,
  95. 3:00enclomiphene. Yeah, enclomiphene. Which
  96. 3:02is the anti-estrogen half-life or a half
  97. 3:05of the drug. It's the one blocking those
  98. 3:06receptors and driving the LH and FSH to
  99. 3:10increase. Eventually, a company isolated
  100. 3:12pure enclomiphene on its own. And they
  101. 3:14tried to bring it to the market under
  102. 3:16the name Androxal. The trials looked
  103. 3:18good on paper. It raised testosterone.
  104. 3:20It kept LH FSH in check, sperm
  105. 3:22production in check. But in 2015, the
  106. 3:24FDA they rejected it.
  107. 3:27Because nobody could prove that raising
  108. 3:28the number actually made guys feel
  109. 3:30better. Now, enclomiphene has never been
  110. 3:31approved as its own isolated drug. So
  111. 3:34how is a drug that actually failed
  112. 3:36suddenly everywhere? [music] Two words,
  113. 3:38supply economics. When clomid ran into
  114. 3:41supply shortages, prescribers pivoted
  115. 3:43right away and started compounding pure
  116. 3:45enclomiphene immediately. And that's
  117. 3:47when the telehealth companies noticed
  118. 3:48that enclomiphene isn't a controlled
  119. 3:50substance. Testosterone [music] is.
  120. 3:52Which means a telehealth company can
  121. 3:54mail to a man in all 50 states with
  122. 3:57almost none of the friction that comes
  123. 3:59with prescribing TRT. So, of course, it
  124. 4:01exploded. Not because it's the better
  125. 4:03tool for the job, [music] it's the
  126. 4:05easier one to prescribe. So, how does
  127. 4:06clomiphene actually raise your T levels?
  128. 4:08It goes straight to the top of the
  129. 4:10chain, hypothalamus and pituitary.
  130. 4:12Remember that thermostat we talked about
  131. 4:13earlier with the
  132. 4:14That one constantly scanning your
  133. 4:16bloodstream
  134. 4:18for estrogen, so it knows whether or not
  135. 4:20to keep producing or pump the brakes.
  136. 4:21And clomiphene goes in and blocks the
  137. 4:23estrogen receptors sitting [music] at
  138. 4:25the thermostat. So, even though your
  139. 4:27estrogen is still circulating completely
  140. 4:28normal in your body, your brain can no
  141. 4:31longer see it. As far as your
  142. 4:32hypothalamus goes, the room just went
  143. 4:35ice cold. Uh-oh, you know what that
  144. 4:37means, right? And a cold room means one
  145. 4:39thing, turn up the heat, baby. So, your
  146. 4:40hypothalamus panics a little bit and it
  147. 4:42fires off more GnRH.
  148. 4:46A lot more than normally would. And more
  149. 4:48GnRH means your pituitary responds by
  150. 4:51pumping out more LH and FSH. LH tells
  151. 4:54your Leydig cells to produce more
  152. 4:55testosterone. The FSH is going to keep
  153. 4:57your sperm production going all night
  154. 4:59long. And the entire system is going to
  155. 5:01speed up now. So, your body is still
  156. 5:03doing all the work. And clomiphene is
  157. 5:06just convincing your brain that it
  158. 5:07[music] needs to work more and harder.
  159. 5:10That's exactly why guys chasing
  160. 5:12fertility, where guys aren't ready to
  161. 5:13use like TRT, fully commit to that
  162. 5:15lifelong therapy, you know, they get
  163. 5:17pulled like a magnet towards this
  164. 5:18option. So, if you're looking to test
  165. 5:20clomiphene, this the protocol I would
  166. 5:22definitely suggest that works for a lot
  167. 5:24of my clients. You want to start at 25
  168. 5:27mg two to three times a week. [music] I
  169. 5:29mean, that's great. Then you're going to
  170. 5:31assess your results after 45 to 60 days.
  171. 5:33On paper, it sounds like the smarter
  172. 5:35move. You start to raise your
  173. 5:37testosterone without shutting it down
  174. 5:38and that system that's actually
  175. 5:40controlling it and working it. But, if
  176. 5:42reviving your engine harder was the
  177. 5:44superior right move, why does all the
  178. 5:47other side of this debate exist [music]
  179. 5:49at all then? That's where testosterone
  180. 5:50comes in and it plays a completely
  181. 5:52different game. TRT is not going to ask
  182. 5:55for permission at all. It skips the
  183. 5:57entire chain that we just talked about
  184. 5:59and goes directly to the end [music] of
  185. 6:01the road, the finish line, whatever you
  186. 6:02want to call it. Exogenous testosterone
  187. 6:04injected straight into your bloodstream,
  188. 6:05it's there immediately at whatever level
  189. 6:08your protocol is dosed for or based on.
  190. 6:10Remember that thermostat before? Then
  191. 6:12clomiphene tricked into thinking that
  192. 6:14the room was actually cold. TRT does the
  193. 6:16exact opposite. Your brain sees
  194. 6:19testosterone flooding into your
  195. 6:20bloodstream. As far as it's concerned,
  196. 6:22the room is plenty [music] warm. There's
  197. 6:24no reason to ask for more now. So, your
  198. 6:25hypothalamus stops firing GnRH, your
  199. 6:28pituitary stops firing LH and FSH, and
  200. 6:31your testes get the signal to power
  201. 6:33down. Turn right [music] off, boys, cuz
  202. 6:35the body doesn't waste energy on
  203. 6:36manufacturing something it's already
  204. 6:38getting handed. [music] This is why TRT
  205. 6:40by itself will shrink your testes and
  206. 6:42tank your natural sperm production over
  207. 6:44time, not immediately at all. Takes a
  208. 6:46long time to do that, if it ever
  209. 6:48happens. Cuz your body has been told to
  210. 6:50clock [music] out and someone else is
  211. 6:52taking over, baby. This is the exact
  212. 6:54fork in the road that separates these
  213. 6:55two compounds. And once you understand
  214. 6:57that distinction, the entire which one
  215. 7:00is better, this whole debate stops. It
  216. 7:02stops being about which one actually
  217. 7:03raises your testosterone number, because
  218. 7:05they both do that. What matters is which
  219. 7:08one actually delivers the final result
  220. 7:09that you want for performance. Is it
  221. 7:11body composition? Well, and how do you
  222. 7:13feel about taking testosterone? So,
  223. 7:15here's the problem that we have with
  224. 7:16clomiphene. Because here's what I've
  225. 7:18seen over the last 10 years on
  226. 7:19testosterone and helping thousands of
  227. 7:22clients with theirs. Remember, I was
  228. 7:24using testosterone all throughout my
  229. 7:25bodybuilding career since I was 15, 16
  230. 7:28years old. And clomiphene moves your
  231. 7:30testosterone number on your labs, on
  232. 7:32that piece of paper. But raising a
  233. 7:33number on a piece of paper is not the
  234. 7:34same and actually feeling like a
  235. 7:36different man on those numbers is
  236. 7:38completely different. [music] The
  237. 7:39symptoms data on the
  238. 7:41is so weak. Clients report that they're
  239. 7:43told their testosterone climbs into an
  240. 7:44amazing range. Then they tell me that
  241. 7:46they feel [music]
  242. 7:47nothing, or at best, a little bit
  243. 7:49better, but they really don't know. The
  244. 7:50reason is that your body still relies on
  245. 7:52your own natural production to work with
  246. 7:54that number and carry that number, which
  247. 7:56means every single variable that was
  248. 7:58tanking your testosterone in the first
  249. 8:00place is still fully there. The stress,
  250. 8:03the no sleep, the diet, the training,
  251. 8:05none of that gets fixed just because you
  252. 8:06tricked your brain into producing more.
  253. 8:08[music] TRT doesn't have that problem.
  254. 8:10It bypasses all of that, and your dose
  255. 8:13isn't at the mercy of how well you slept
  256. 8:15last night, or how well you ate
  257. 8:17yesterday. The second problem is the
  258. 8:18results from enclomiphene are not
  259. 8:21consistent from one guy to another. Two
  260. 8:22guys can walk into that room right now,
  261. 8:26get prescribed, have two identical labs,
  262. 8:29run the same exact dose of enclomiphene,
  263. 8:31and one of them is going to feel
  264. 8:32incredible, while the other one feels
  265. 8:34absolutely nothing. Now, some of that
  266. 8:37comes down to how your liver actually
  267. 8:38metabolizes it, which means you can't
  268. 8:40generally predict how your body's going
  269. 8:42to actually respond till you already
  270. 8:43spent months on this medication. TRT
  271. 8:46doesn't gamble like that with you. You
  272. 8:48dial in your dose, and the results are
  273. 8:50reliable 10 out of 10 times. The third
  274. 8:52problem is, this one barely ever gets
  275. 8:54talked about, enclomiphene has been
  276. 8:56shown to drop your IGF-1 levels in a
  277. 8:58very meaningful way. If your entire
  278. 9:00reason for chasing more testosterone is
  279. 9:02to build muscle and recover faster,
  280. 9:04tanking the hormone, well, the
  281. 9:05downstream of this hormone, of growth
  282. 9:07hormone, not a very smart move. And on
  283. 9:09top of that, enclomiphene was never
  284. 9:11built or designed for the guy who was
  285. 9:13chasing performance. It was designed to
  286. 9:14protect fertility and make your labs
  287. 9:17look incredible. It is not going to help
  288. 9:19you build more muscle. It is not going
  289. 9:20to help you drop more body fat. It is
  290. 9:22not going to make you feel like the
  291. 9:23anti-aging effects are happening like
  292. 9:26you do on synthetic testosterone. So,
  293. 9:27when you line up all these things, the
  294. 9:29inconsistent results, the weak symptom
  295. 9:31improvement, the no performance upside,
  296. 9:33possible IGF-1 getting hit, and zero
  297. 9:35long-term safety data against TRT, which
  298. 9:38bypasses every one of those variables
  299. 9:40and delivers an actual predictable,
  300. 9:42reliable result every single time. There
  301. 9:45is no version of this where enclomiphene
  302. 9:47is going to walk away as the best
  303. 9:49option. TRT is still and will be the
  304. 9:53king of the hill. Now you know why there
  305. 9:56is no discussion about whether or not
  306. 9:57TRT is the better option. Let's talk
  307. 9:59about how you actually start because two
  308. 10:01objections always come up before a guy
  309. 10:03even starts TRT. The first one is always
  310. 10:06about fertility. If you start TRT and do
  311. 10:08nothing else, yes, [music] your natural
  312. 10:11production will shut down eventually.
  313. 10:13Your sperm count will eventually drop
  314. 10:15with it. But that's not the full story
  315. 10:18though because that's not how you
  316. 10:19properly run TRT and how the protocol
  317. 10:21should look like. If fertility matters
  318. 10:23to you, you pair TRT, your testosterone,
  319. 10:26with hCG because hCG mimics LH, which
  320. 10:30means it keeps knocking on your testes
  321. 10:33to keep [music] them turned on and keep
  322. 10:35your brain on to communicating with
  323. 10:37them, so keeps the signal on. Your
  324. 10:39testes have to stay active, so the size
  325. 10:41needs to stay intact and your fertility
  326. 10:43is going to stay protected the entire
  327. 10:45time you're on testosterone. Any doctor
  328. 10:47actually knows what he's doing in this
  329. 10:49space does [music] this for their
  330. 10:50patients day one. Now there are other
  331. 10:52options like HMG, FSH, kisspeptin,
  332. 10:55gonadorelin. Now there's also a lot of
  333. 10:57other lifestyle factors that determine
  334. 10:59how much of your fertility is going to
  335. 11:00take a hit. The guys who lose their
  336. 11:02fertility on TRT are the guys just
  337. 11:04running [music] it blindfolded. They're
  338. 11:06not running it with hCG, they're running
  339. 11:08it with no hCG, [music] no blood work,
  340. 11:10and no one's there to help them. And
  341. 11:12even then, it takes a long time for you
  342. 11:14to run testosterone to completely shut
  343. 11:17down your fertility. I'm going to say it
  344. 11:18again. It takes a long time, if ever,
  345. 11:21but I've had hundreds, probably
  346. 11:23thousands at this point, clients restore
  347. 11:25their fertility and be able to conceive
  348. 11:27children even when it was zero for
  349. 11:28months. I got them they're to have kids.
  350. 11:31Even after their
  351. 11:32steroid cycles or even on steroid
  352. 11:34cycles, you guys have no idea. It's
  353. 11:35going to be fine if you do this the
  354. 11:37right way. If you want the full protocol
  355. 11:39that I used to restore fertility, watch
  356. 11:41this video right here. It's absolutely
  357. 11:42amazing. You're going to learn so much
  358. 11:44about it. So, fertility isn't a reason
  359. 11:45to avoid TRT. Let's talk about the
  360. 11:48reason to make sure you're working with
  361. 11:49someone who actually knows what they're
  362. 11:51doing. Now, let's talk about this second
  363. 11:53objection, the stigma. Now, somewhere
  364. 11:55along the way, our society decided that
  365. 11:57a man optimized testosterone is the
  366. 11:59wrong move. You're the bad guy. But a
  367. 12:01guy walked around exhausted with man
  368. 12:03[music] boobs, with no libido, and
  369. 12:05drinking alcohol every weekend, oh, that
  370. 12:06guy is just getting older. [music] And
  371. 12:08it's totally normal for our society
  372. 12:11here. Meanwhile, you've got A-list
  373. 12:13celebrities who are completely open
  374. 12:14about being on TRT. [music] They're all
  375. 12:16showing up jacked and leaner in their
  376. 12:1750s, and no one cares. But the second
  377. 12:20the average guy says he's not on it,
  378. 12:22TRT, [music] suddenly he's cheating.
  379. 12:24Cheating at what? What is he cheating at
  380. 12:26exactly? Cuz life is not a drug-tested
  381. 12:29sport. There's no judge handing out
  382. 12:31medals for guys staying
  383. 12:33>> [music]
  384. 12:33>> natural. Nobody's checking your labs
  385. 12:35when they decide whether or not you get
  386. 12:36the promotion, or if they want to be
  387. 12:38your friend. How about if you want to
  388. 12:39queue up your wife? How about if you
  389. 12:40actually want to be present [music] to
  390. 12:41be around your family and your kids?
  391. 12:43You're not competing against a field of
  392. 12:45guys who actually all agreed to play by
  393. 12:48the same rules. You're competing against
  394. 12:49guys in their 30s and up who are already
  395. 12:51optimized. They're already dialed in.
  396. 12:53They're already using every legal or
  397. 12:56illegal tool to available to them to
  398. 12:58actually operate at that level. So,
  399. 13:00you're sitting on the sidelines refusing
  400. 13:02to use TRT [music]
  401. 13:03cuz you're worried about the society is
  402. 13:05going to judge you, or they're going to
  403. 13:07have a stigma attached to you, you're
  404. 13:09just choosing to compete with one
  405. 13:11[music] hand tied behind your back
  406. 13:12against men who are not tying theirs.
  407. 13:15So, being natural is not a badge of
  408. 13:17honor for people, but they convinced you
  409. 13:19it was. It's just a version of you
  410. 13:21that's leaving performance [music]
  411. 13:22on the table for absolutely no reason.
  412. 13:25So, there you have it. Complete
  413. 13:26breakdown on clomiphene, [music]
  414. 13:28testosterone, and why TRT is always
  415. 13:31going to be the superior option. If
  416. 13:32you're in your 30s, your 40s, or 50s, or
  417. 13:34older, and you want to optimize your
  418. 13:35testosterone and completely transform
  419. 13:37your body, working with someone who's
  420. 13:39done this with thousands of clients,
  421. 13:41click the first link in the description
  422. 13:42to schedule a call. It's the first one.
  423. 13:44Do not miss it. If you got value from
  424. 13:46this video, make sure you subscribe,
  425. 13:48drop a comment. Thanks for watching as
  426. 13:49always.
  427. 13:50>> [music]
  428. 13:50>> I'll see you in the next one.

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