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Cancer Scientist: This Common Daily Diet May Be Feeding Cancer! - Thomas Seyfried — Transcript

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0:00You have an envelope in front of you
0:01there that says confidential on the
0:03front of it. What is in that envelope?
0:04>> It's a paper that's under embargo
0:06because the world thinks it's going to
0:07be very important and it's going to be a
0:09lead article in the frontiers in science
0:11because this is a strategy to manage
0:13cancer effectively and we have a lot of
0:15evidence to keep these people alive a
0:17hell of a lot longer. We have given hope
0:19to the hopeless
0:20>> and you have a perspective on treating
0:22cancer and other metabolic diseases that
0:24others don't have.
0:25>> Yes. But the problem is the field
0:27doesn't understand what I'm saying about
0:29the origin of cancer. So everything
0:31comes back to mitochondria and all
0:33chronic diseases in cancer are the
0:35result of damage to this and the science
0:37is telling us this. But the field of
0:38cancer has yet to accept it. That is a
0:42tragedy.
0:42>> Are you pissed off about this?
0:43>> Well, who wouldn't be? There's 1,700
0:46people a day in this country dying from
0:49cancer. That's 70 an hour. And it gets
0:51worse every single year. When is the
0:53people going to wake up? So give me a
0:55prescription of how I should live my
0:57life to keep my mitochondria healthy.
0:58>> So it all comes down to what you do to
1:01maintain the health and vitality of the
1:02mitochondria that reduce the risk. But
1:05we are now in a new environment where we
1:07have massive amounts of highly processed
1:08carbohydrates, inactivity, emotional
1:11stress, poor sleep habits and you
1:13chronically damage this organel. And
1:15then if you look at the domestic dog,
1:17cancer is the number one killer of the
1:18domestic dog. But wolves in the wild
1:20rarely have cancer. But the wolf is out
1:23running around eating natural foods. Yet
1:24the dog is in an apartment somewhere
1:26gets a dog walker once a day, right? And
1:28the next thing the dog is obese and full
1:30of cancer.
1:31>> And I want to give people actionable
1:32things that they can think about.
1:33>> So this is what's really important. This
1:35is a bioenergetic road map to health.
1:38This is what we call the zone of
1:39prevention. It's very hard to get cancer
1:41or chronic diseases when you're in these
1:43zones.
1:44>> So let's talk about that.
1:45>> So
1:48this is super interesting to me. My team
1:49given me this report to show me how many
1:51of you that watch this show subscribe.
1:52And some of you have told us according
1:54to this that you are unsubscribed from
1:56the channel randomly. So favor to ask
1:58all of you, please could you check right
1:59now if you've hit the subscribe button
2:01if you are a regular viewer of the show
2:02and you like what we do here. We're
2:04approaching quite a significant landmark
2:05on this show in terms of a subscriber
2:07number. So, if there was one simple free
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2:11team, everyone here, to keep this show
2:13free, to keep it improving year over
2:15year and week over week, it is just to
2:17hit that subscribe button and to double
2:18check if you've hit it. Only thing I'll
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2:23I'll make sure every single week, every
2:26single month, we fight harder and harder
2:27and harder and harder to bring you the
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2:31promise since the very beginning of the
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2:36help us. Really appreciate it. Let's get
2:37on with the show.
2:40[music]
2:41[singing]
2:42>> Professor Thomas Seaf Freed, what is it
2:45that you've committed your life to
2:46doing, Thomas?
2:47>> Well, we're right now committed our
2:50lives to managing cancer effectively
2:53uh without toxicity which is based on
2:56based on the science that I and other
2:59others have done in this field.
3:01>> You have a perspective on treating
3:02cancer and other metabolic diseases that
3:04others don't have. the mainstream should
3:07I say.
3:08>> Oh yeah. Well, mainstream doesn't have
3:09it for sure. But it's based on science.
3:11I mean I'm my work is based on what Otto
3:15Warberg the famous German scientist said
3:18from the 1920s30s and 40s. He clearly
3:21showed that cancer was a mitochondrial
3:23metabolic disease.
3:25>> What does that mean mitochondrial
3:27metabolic disease?
3:28>> Okay. It means that the origin of the
3:30disease resides in the organel called
3:33the mitochondrian. It's it's in the
3:36cytoplasm of the cell. It used to be
3:39called still is the the powerhouse of
3:42the cell. Gives the cell the energy.
3:44>> I think we have a mitochondria. Could
3:45one of my team bring in a mitochondria?
3:47>> Well, this is you have a a mitochondria
3:50in here. Oh, here we go.
3:51>> You got one each here.
3:52>> Yeah. Well, see, this is the little
3:53organel that you see. It looks like a
3:56bean shape, but it's actually a tubular
3:58network. These are tubes
4:01>> and they respond dynamically inside the
4:04cell to uh both internal uh activities
4:08as well as external activities. So you
4:11have to realize that at the time of
4:13conception
4:15uh all of the mitochondria for the
4:17developing embryo are in the cytoplasm
4:20from the mother.
4:21>> The cytoplasm
4:22>> the mitochondria are not in the nucleus.
4:24They're in the cytool. Oh, outside of
4:26the
4:26>> outside of the nuke, but in the cell
4:28body itself. So all of the mitochondria,
4:31they determine our destiny. They will
4:33determine how long you will live on the
4:35planet if if you don't have an
4:37unfortunate accident or something like
4:39this. They have an expiration date.
4:41Different species die at different
4:44times. You don't find people living 400
4:46years. Mice live about two and a half
4:48years. Elephants live, you know, as long
4:50as we do or whatever. But that's all
4:52determined by this organel. So you can
4:54see I have wrinkles and this kind of
4:56thing. This is from living on the planet
4:58and this is from wear and tear on this
5:00organel which allows us to make energy
5:04efficiently.
5:05>> So when this organel starts to falter
5:07with age uh you die you die from old
5:10age. This organel has to be protected
5:13and respected if you would like to live
5:15a normal lifespan. But in diets and
5:18lifestyles and way we are today we we we
5:21damage this organel and this organel
5:24then can present itself damage to this
5:26organel which is a tubular network
5:28inside the cell. But let me say
5:30something else. It not only controls the
5:33internal environment of the cell. It
5:35also controls the neighboring cells. The
5:38liver neighborhood the lung neighborhood
5:40the colon neighborhood the brain
5:41neighborhood the gal neighborhood the
5:43neuron neighborhood. But they're all
5:44come from the same origin in that
5:46cytoplasm and they determine the overall
5:50metabolic health of your body. It's a
5:52systemic they communicate
5:54uh with each other across cells across
5:56tissues. I'll tell you this organel
5:59controls [snorts] a lot of what goes
6:02what that nucleus does. It tells the
6:04cell when to divide. It tells the cell
6:08when to slow down.
6:09>> It's kind of like a brain but also like
6:10an engine room.
6:12>> It's kind of like that. Certainly
6:13certainly the brain part of it is really
6:16mysterious uh in the sense of of how it
6:20controls the destiny of the cell in the
6:22body. So sickness
6:25sickness disease cancer what do we know
6:28about the role that this little thing
6:30plays in these chronic diseases and
6:32illnesses and cancers that so many
6:33people suffer with?
6:34>> Yeah. Well, this is the organel that
6:36becomes damaged. Um and it can be
6:38damaged in many many different ways. uh
6:41for cancer is what [clears throat] we
6:43have spent a lot of our time on and now
6:46we've moved into the whole chronic
6:47disease issue because each each chronic
6:50disease can have different
6:52manifestations of ill health to the
6:55mitochondria in a particular population
6:57of cells. But in the case of cancer
6:59which is what we call the most serious
7:02of the chronic diseases creating the
7:05most trauma uh the most emotional
7:08distress but we have clearly shown based
7:12on on many many works that any multiple
7:17things from our environment can damage
7:19this organel in a particular population
7:22of cells in a particular organ. For
7:24example, when you talk about
7:26carcinogens,
7:27it's a chemical that causes cancer. How
7:30does that chemical cause cancer? It
7:32damages the proteins and the lipids.
7:36These little squiggles are delicate
7:39internal membranes. They they contain
7:42the proteins and the lipids that allows
7:44us to generate energy when we breathe.
7:47Okay, you're breathing. I'm breathing. I
7:49take in oxygen. Oxygen serves as a kind
7:53a a final acceptor for electrons that
7:56allows ATP uh to come out of this little
7:59and don't forget it's a tubular network
8:01>> and ATP is the energy currency.
8:03>> It's the chemical energy currency. It
8:05allows us to enzymes to work allow
8:08allows all the metabolic machinery
8:10inside of a cell to work optimally.
8:12>> So just to play this back to you so I
8:14know I'm clear. Oxygen comes in because
8:16I breathe in. I then eat food
8:18>> in in that mitochondria. It does a
8:20process and it spits out ATP as the
8:22energy.
8:23>> Well, and and the waste products of a
8:25good energy metabolism would be CO2 and
8:28water. So, when we burn gasoline in an
8:31engine of a car, we break down the
8:33octane, the carbon hydrogen bonds in an
8:35octane and and we have an internal
8:37explosion that drives pistons. Okay? The
8:40exhaust is a lot of waste products uh
8:42from breaking down the M that we're
8:44doing the same thing inside the cell.
8:46We're combusting carbon hydrogen bonds
8:49and that combustion of carbon hydrogen
8:51bonds is a graded process. So it's not
8:54an immediate explosion. It's a it's a
8:56you're you're breaking down the carbon
8:57hydrogen bonds in a very precise way
9:00producing ATP which then drives the
9:02entire machinery of the neurons and the
9:04rest of the body.
9:06>> It can respond dramatically to energetic
9:08stress, emotional stress. Anyway, I gave
9:11you an example of a carcinogen uh
9:13intermittent hypoxia like people who
9:16have sleep apnea. They stop breathing
9:18for 30 seconds or more in that general
9:20and then they that creates rust RO and
9:23that's what carcinogens do ROS. These
9:26are called reactive oxygen species. They
9:29damage those delicate membranes. And
9:32then what happens if it's too acute, too
9:36stressful, the whole cell will die. the
9:38cell loses its energy and we get uh
9:41apoptosis or necrosis cell death. But if
9:45it's gradual chronic over years, months,
9:48years, this organel
9:51loses its ability to produce sufficient
9:53energy. But the the cell compensates
9:58interestingly enough by using these
10:00ancient pathways heirlooms of our
10:03evolutionary past. So um because all
10:07life on the planet evolved in in oxygen
10:11but without oxygen in the dark uh these
10:14cells grew like crazy. There was no they
10:16were single cells. They unbridled
10:18proliferation and all this kind of
10:20stuff. They didn't have mitochondria.
10:22They had bacteria and the bacteria
10:25which this organel came from was a
10:27fusion between one cell uh that had a
10:31nucleus and and was was fermenting
10:35through the cytoplasm and this bacteria
10:37which is the mitochondria came in and
10:39now you have two different forms of
10:42energy. You have um the energy in the
10:44cytoplasm, the ancient fermentation, and
10:47then you have this new form which can
10:48take in oxygen and generate energy much
10:50much more efficiently than the airlumic.
10:53Listen, one of our big discoveries, if
10:56you can believe it. But you see that
10:58space in the middle there?
10:59>> Yeah.
11:00>> That's called the matrix. And that's
11:01where the KB cycle, the TCA cycle, which
11:04breaks down the food that we eat. But
11:07they have an ancient part of a
11:09fermentation mechanism inside because
11:11before oxygen came every all life forms
11:14were fermenttors. They they produced
11:16energy without oxygen because there was
11:18no oxygen. We had to wait for those
11:20bacteria to make oxygen through a
11:22photosynthetic process. But all
11:24organisms were fermenttors in the
11:26beginning after this organel came in and
11:28was able to take in oxygen make energy
11:30really really quick. But in that matrix
11:32they have a uh in the cycle there's a
11:34little pathway there that makes energy
11:37without oxygen from the evolutionary
11:39past. So we have it in the cytoplasm of
11:41the cell because they can use they can
11:43ferment in the cytoplasm. But this organ
11:46that our big discovery with the work of
11:48of Christounis from semlice university
11:51he's the world leader on that little
11:53pathway. When this organel becomes
11:57impaired,
11:58these ancient pathways of energy through
12:01fermentation arise. Okay, they they try
12:04to replace the lost energy from the
12:06efficiency of this organel. That space
12:09starts throwing out ATP
12:12from glutamine. It's another
12:14fermentation fuel and and it's making
12:18it's making ancient energy in the
12:20sophisticated organel that was that was
12:23that that evolved to make efficient
12:25energy. So let me let me tell you. So
12:28you get you asked me what about damaging
12:30this organel and what happens if the
12:33damage to oxidative phosphorilation
12:35>> what does that mean?
12:36>> Which means energy through oxygen
12:38[clears throat]
12:38>> is too acute the cell will die.
12:43Cyanide is a a perfect example of this.
12:46You take a mouse or a rat or a person
12:48and you drink Kool-Aid, the cyanide
12:50laced Kool-Aid, you die because what
12:52happens is that cyanide binds to the
12:55protein that's going to um um use oxygen
12:59for energy and the whole system shuts
13:01down.
13:02>> Suffocates you basically.
13:03>> Yeah. You die in instantly. Um and there
13:05are other things that can kill uh can
13:07kill uh quickly aid and a variety of
13:10other chemicals but for chronic diseases
13:12it's usually u not an acute stress on
13:16this organel it's a it's a chronic
13:18stress and in cancer what happens in a
13:21particular tissue whether it's bone lung
13:24bladder brain they gradually compensate
13:27with these ancient fermentation pathways
13:30so so this thing this organel cell
13:35signals to the nucleus I'm suffoc I'm
13:38not getting enough energy. Um so the
13:41nucleus turns on the transporters on the
13:44surface of the cell to bring in fuels
13:48that will elevate energy through what we
13:50call uh oxygen independent mechanisms.
13:53This is an oxygen dependent organel.
13:55This gets most of its energy because we
13:57breathe, all of our cells are using
13:59oxygen and the CO2 that we're blowing
14:01out and the water that will be collected
14:03in the form of urine when you might put
14:05uh other waste products in there. That's
14:08efficient metabolic homeostasis. This
14:10organel makes not only the cell but the
14:13whole body in a state of of metabolic
14:16homeostasis where all systems are
14:18working at optimal efficiency. But with
14:21chronic disruption, uh, smoking, uh,
14:25lack of exercise, you can go right down
14:26the list of all of the different things
14:28that can elicit cancer, any kind of
14:31carcinogens, microplastics, forever
14:33chemicals, uh, uh, uh, glyphosate and
14:37any of these kinds of things that would
14:39chronically damage uh, the ability of
14:41this organel to produce energy. Viruses,
14:44ankcoenic viruses, inflammation. you
14:46have chronic inflammation. Any of those
14:49things damage this the sophisticated
14:52ability of this organel to produce
14:53sufficient energy. That's why that's why
14:57um uh the ankcogenic paradox which we
14:59solved.
15:00>> What's the ankcogenic paradox?
15:01>> That was the paradox that was first put
15:03out by Albert St. Gorgi Hungarian
15:05[clears throat]
15:06uh scientist who received a Nobel Prize
15:08I think for vitamin C. He said he said
15:11he was very interested in cancer and
15:13living systems. He said there's a
15:15paradox. He said we know multiple things
15:19in the environment can elicit cancer.
15:21We've identified these ankcogenic
15:23viruses, chronic inflammation,
15:25carcinogens, intermittent hypoxia, rare
15:29rare germline mutations. He said we
15:32don't understand
15:33the common pathophysiological
15:36mechanism by which any of those
15:39provocative agents would elicit
15:42disregulated cell growth which is
15:44cancer. When you talk about cancer, what
15:46do people say what is cancer? It's cell
15:48division out of control. It's
15:51disregulated cell growth. This organel
15:55determines when cells should divide and
15:57when they should not divide. It
15:59regulates the destiny of the cell. So
16:02what happens when this organel becomes
16:04chronically impaired? It falls back on
16:07these ancient pathways, these or or
16:10these or um uh pathways that existed
16:13before oxygen came into the environment
16:15where all the cells were disregulated in
16:17the growth because they didn't have this
16:19regulatory system which is the
16:21mitochondria coming from a from a
16:23bacteria.
16:23>> So let me play that back to you in a way
16:24just so I you know make sure I
16:25understand.
16:26>> I I know it can be kind of deep.
16:27>> Okay. So in this mitochondria here that
16:30I have in front of me, there is an
16:32ancient um because this came from the
16:36>> bacteria
16:36>> a fusion of bacteras a long long time
16:38ago.
16:39>> Yeah.
16:39>> The old bacteria
16:40>> about several billion years ago
16:42>> used to be very selfish and just think
16:44about itself. It used to grow on its own
16:45and didn't communicate with anybody. Had
16:47its own way of growing and multiplying
16:49that was really not um in cohesion with
16:51anything else. That is still in there
16:54somewhere. And although now in its
16:56modern form because there's been that
16:58fusion it grows thinking about the wider
17:01organism
17:02um when it becomes damaged
17:06it falls back on that old selfish way of
17:08growing and sometime and that's kind of
17:10what can cause cancers. So if you if
17:13there's stresses on this which could be
17:15all the car carogenic things you
17:17described then sometimes this falls back
17:20on that prehistoric selfish way of
17:22growing where it doesn't think about the
17:24wider organism.
17:25>> It's close um um in the sense of
17:29thinking we don't know about that we
17:31just know the consequences of what
17:33happens when it falls back on those
17:35ancient pathways. Now here's the
17:37situation.
17:39People knew from Otto Warberg said
17:42cancer is a energy problem in the cell.
17:46This why would the cells start to
17:49ferment and produce a massive amount of
17:52fermentation waste product which is
17:53lactic acid. Even in the presence of
17:57oxygen, 100% oxygen, they're still
17:59fermenting. Why? That shouldn't happen.
18:02Uh when you and I hold our breath or
18:04have a heart attack, let me tell you
18:05something. This is really remarkable and
18:07this is another piece of information
18:09that got us on this whole thing. When
18:11people have heart attacks, uh they stop
18:14breathing, the heart seizes, okay, the
18:16bloodstream immediately fills with these
18:19fermentation waste products which are
18:21lactic acid and the other one which we
18:25now know is suinic acid. Okay. Wow.
18:28These two waste products. Now, if you
18:30don't start breathing in a short period
18:33of time, you're going to be dead.
18:34>> Mhm. And you and what you die because
18:36the neurons in your brain cannot sustain
18:40this kind of fermentation energy for
18:42very long. As soon as you the heart you
18:44you give them cardiac massage and
18:46whatever the guy's heart starts beating
18:48again. The lac the waste products
18:51of lactic acid and suinic acid go away.
18:54They disappear because you're breathing
18:55now. You don't need to ferment when you
18:57have oxygen in the environment. And it's
18:59and the mitochondria can can utilize the
19:01oxygen in the environment. cancer cells
19:04to Warberg said it's the weirdest thing.
19:07These cancer cells um continue to
19:11ferment even in 100% of oxygen. Why are
19:14they doing that? And he speculated that
19:17this organel was damaged. Irre
19:20irreversible damage to the organel
19:23happened in these cancer cells. He
19:26didn't have an electron microscope at
19:28the time. He didn't have the
19:30sophisticated tools that we have today.
19:32So he projected that all on biochemistry
19:35at that time. He was a biochemist and he
19:37said you don't should not produce
19:39fermentation if you have ox oxygen
19:41should shut that off and these guys
19:43should return to a normal metabolic
19:44homeostasis. And he said that's because
19:46there's something irreplace irre
19:48irreversibly damaged in this organel. So
19:51a lot of people attacked him and they
19:52said oh we don't have any evidence for
19:54that. Here's the beautiful thing. Some
19:56cancer cells continue to take in oxygen
19:58and make ATP. Therefore Warberg must be
20:00wrong. Uhhuh. We showed that that we
20:04showed the cancer cell takes in oxygen,
20:06but it's not making energy through ATP
20:08in any great amount. It's using it for
20:10ROS react these radicals that further
20:13damage and cause the DNA mutations that
20:15everybody is chasing. It's all
20:17downstream effects of damage.
20:20>> So what does this what does this mean in
20:21simple terms? Because I'm aware a lot of
20:22my
20:22>> Well, it it means I say, okay, so so I
20:25have disregulated cell growth. That's
20:27ultimately what the problem we're
20:29dealing with. We can't control how these
20:31cells are dividing. We're throwing all
20:33kinds of crazy stuff at them. Trying to
20:34poison or radiate surgically remove
20:36them. We're trying to do everything to
20:38stop this disregulated cell growth.
20:40>> Mhm.
20:41>> So when we look at this organel under
20:43the micro under the electron microscope,
20:45we find these cry are often missing. You
20:47have what they call ghost mitochondria.
20:49You got the shell but nothing inside or
20:51if they're inside, they're all deformed.
20:53So we know there's a foundational
20:55principle in biology. Structure
20:57determines function. If the structure is
21:00abnormal, the function will be abnormal.
21:02This is known to all biologists except
21:05oncologists. They don't seem to
21:07understand it.
21:07>> What's an oncologist?
21:08>> Those are the people who study cancer.
21:11>> So, what are you then? [laughter]
21:12>> I'm a biologist.
21:14>> You're a biologist.
21:15>> Yeah. I mean, when we know that if the
21:17organel is damaged, you're not going to
21:18be able to produce energy efficiently by
21:20oxidative phosphorilation. Okay.
21:22>> I think you're a bit further down the
21:24road, Thomas, than a lot of my viewers
21:25are. for me hearing that there's this
21:27energy engine in my cells that and
21:30there's trillions of them or billions of
21:32them and they also communicate with each
21:34other and when this becomes stressed or
21:38hurt or damaged because of lifestyle
21:40choices that I make energy production
21:42and inefficiency will change and that
21:44could cause this to die or malfunction
21:46in some way that is as for me I go I've
21:49got it
21:49>> okay that's a major step forward now we
21:53build upon that yes now we build upon
21:55that okay so so here's the situation
21:58we've discussed cancer cells all of them
22:01that we have ever looked at have defects
22:04in the number structure and function of
22:07that organel okay I have looked at I
22:10published that big paper where I spent
22:13uh over a year of my time going through
22:16the ancient the well the early electron
22:18microscopy literature warberg didn't
22:20have that opportunity because that
22:22technology was not there for him. So he
22:25speculated that based on the
22:26biochemistry, but I went back and I
22:29looked at these um electron microraphs
22:31of mitochondria in various cancers and
22:33they're all damaged. There is few of
22:35them that risk Christ are gone. I work
22:38with some of the best like Aris Aris
22:40Mendy Marillo uh who is a world leader
22:42in beautiful electron microscopy of of
22:44cancer cells and you can see and and all
22:47the damage uh under his magnificently
22:49beautiful and one we have a couple of
22:51papers but let me tell you something
22:52else Stephen in the cytoplasm these
22:55organels are also in contact with other
22:58cellular membranes like the endopplasmic
23:00reticulum there's a lot of we call
23:01organels inside a cell you have the
23:04nucleus you have the mitochondrian
23:07you you you have loss. There's intimate
23:10contacts between some of the other
23:11membranes, mitochondrial associated
23:14membranes we see and they're also
23:16abnormal when you look at them under the
23:18electron microscope.
23:19>> The ones it's talking to are abnormal.
23:21>> Yeah. The ones you can see the the
23:22mitochondria are abnormal and the
23:24membranes that contact them are
23:25abnormal. Okay. And that intimate
23:27contact
23:28>> uh I'll get into the calcium signaling a
23:30little bit later which controls the
23:32destiny of the cell. Why the cell is
23:34growing out of control? Well, first of
23:36all, it's fermenting. Okay, that means
23:37it's getting energy from sources other
23:40than oxidative phosphorilation. You can
23:41take a cancer cell and and treat it with
23:44cyanide or aid or in absence of and it's
23:47still living. It's still growing because
23:49it's not using
23:50>> the oxygen path.
23:51>> They're not using the oxy falling back
23:53on on on oxygen independent mechanisms
23:56which are called fermentation. So I
23:58understand that to be that there's a
24:00malfunction in a mitochondria which
24:02means that it no longer uses its oxygen
24:04pathway
24:05>> as sufficiently as it should. There's
24:07always some residual level
24:08>> and it finds another way to make the
24:10energy which is how it survives.
24:11>> Yes.
24:11>> And then it stops communicating with the
24:13rest of the cell.
24:14>> Well, it actually communicates with the
24:15nucleus
24:16>> to open up the floodgates to bring in
24:18the fuels that drive this fermentation
24:20energy.
24:21>> It gets more and more greedy. It it has
24:23to because you're you're taking an
24:25organel that produces energy highly
24:27efficiently. Okay. Um like 34 to 36 ATPs
24:32>> with oxygen
24:33>> with oxygen. And now you're you're
24:35trying to replace that with fuels that
24:38give you two uh two moles of energy. Uh
24:42>> so it's inefficient
24:43>> very and then and then you get you get
24:45two out of the in so you're getting
24:46four. So you you you have to take in in
24:49order to make up the efficiency you must
24:52have a tremendous logistic you must have
24:54tremendous supply
24:56>> of
24:56>> of the fuels that will give us energy
24:58>> which are
24:59>> glucose the sugar
25:01>> and the amino acid glutamine
25:03>> okay
25:03>> okay our bodies are loaded with
25:05glutamine that's the most abundant amino
25:06acid in our bloodstream and evolution
25:08provided that for us because if we stop
25:11breathing we use that fuel to keep the
25:13cells alive we our gut is controlled by
25:16glutamine Our immune system uses
25:18glutamine.
25:19>> What is glutamine?
25:20>> It's an amino acid. Okay.
25:22>> Which we make from food.
25:23>> Yeah. Which we can make from food. True.
25:25Or they call essential and non-essential
25:27amino acids. Essentials are from that we
25:30must eat. We must have certain foods
25:31that provide these. Glutamine is
25:33considered a non-essential amino acid.
25:36It's an essential amino acid
25:37biochemically called non-essential
25:39because we can make it from sugar.
25:42>> But basically, it's the most abundant
25:44amino acid in our body. I think I get it
25:46now.
25:47>> Okay, feed me back. Tell me, let me let
25:49me test you. There should be a button
25:52just down below here. And if it says
25:53subscribed, you're already subscribed.
25:55If it says subscriber, that means you're
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25:59please could you do us a favor and hit
26:00that button? It helps the show more than
26:02you know. And according to the
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26:06button. Thank you so much.
26:08When we fall, the mitochondria falls to
26:11that prehistoric pathway where it starts
26:13making energy in a really really
26:14inefficient way without using oxygen in
26:17the same way. It starts relying now on
26:20glucose and glutamine um to produce that
26:22energy which is a much less efficient
26:24source of energy. So it gets a bit more
26:26greedy. It needs much more to make the
26:28same amount of ATP which is energy.
26:30>> Mh.
26:30>> So these a cancer cell can be very very
26:32greedy. It's not responding to oxygen in
26:34the same way and they they're a bit more
26:36selfish. they start they start sort of
26:38multiplying without thought of the
26:40broader organism.
26:41>> Yes. Yes.
26:43>> So the question I have is how does this
26:45happen?
26:46>> Malfunctioning of the m what is it that
26:48I've done? You know what I ask this
26:50question?
26:50>> Okay. Well, I Okay.
26:51>> It's because children can get these
26:53cancers
26:54>> or a 90-year-old can get the cancer. And
26:57it doesn't appear to me that a
26:58three-year-old
27:00has necessarily made life choices yet
27:02that could
27:02>> but as I said when you consider forever
27:05chemicals uh that are in the environment
27:08uh things that we have that we use in
27:11our technologically advanced societies
27:13can get through the placental wall and
27:16get these into the ch into these
27:17children's uh organs. Um you know you
27:21have to put it together. We usually it's
27:23a a constellation of things because
27:26don't forget I said carcinogens. Some of
27:27these carcinogens are fat soluble. Some
27:29of these carcinogens can get in and
27:31damage those during early stages of
27:33development. People always say how you
27:35explain brain cancer in in a in a
27:38six-month old baby. Okay. What what did
27:41he what what he he wasn't smoking and
27:43drinking and partying all the time, but
27:45but his the mitochondria and a
27:46population of cells in his brain became
27:49damaged. And that damage then led to
27:51this disregulated cell growth because
27:54the organel controls when cells should
27:56divide and not divide. And then and then
27:59where's the energy coming from? How do
28:01you how do you take a highly
28:03sophisticated piece of an organel and
28:05making energy so incredibly efficient
28:08and now we're using energy.
28:10So uh this organel signals to the
28:13nucleus called mitochondrial stress
28:15response retrograde signaling. The
28:17nucleus acts as a respondent to what
28:20this organel wants. So the nucleus then
28:22ankco genes which that you've heard a
28:25lot about. They open the floodgates to
28:27bring in the glucose and glutamine that
28:30allow the cell to grow in a disregulated
28:32way. So we've as you said they go back
28:35to these ancient fermentation pathways
28:37where there was no regulation because
28:39this organel was not part of the problem
28:41part of the situation the regulation. So
28:43is there what are the lifestyle factors
28:45that are causing this to were
28:46drastically increasing the probability
28:48of this happening.
28:49>> It's not necessarily what the person did
28:51or all cases it's what the person was
28:54exposed to uh that could have elicited
28:57this. That's the ankcoenic paradox. So
29:00uh we have shown uh that inflammation
29:04produces these cytoines when you have an
29:07inflammatory heat in inflammation they
29:10they damage the ability of this organel
29:12to make energy efficiently. Chronic
29:14inflammation is known to be a risk
29:17factor for cancer. Chronic inflammation
29:21intermittent hypoxia carcinogens.
29:23>> What's intermittent hypoxia?
29:25>> It's like the sleep apnea that kind of
29:27thing.
29:28Warberg had clearly shown that
29:30intermittent hypoxia on cells would
29:32damage the efficiency of oxidative
29:34phosphorilation leading to a
29:36compensatory fermentation. So you have
29:38to compensate because let me tell you if
29:40you don't compensate you're dead. The I
29:43mean the cell dies. When we look at the
29:45populations around the world that have
29:47the most prevalence of cancer, it
29:49doesn't appear to be
29:52some of the
29:54countries like Nijer, Gambia, Nepal
29:57consistently rank at the very bottom for
29:59cancer cancer incidents. Conversely,
30:02high-income countries like Australia,
30:03New Zealand, and the United States have
30:05the highest rates of cancer. Why is
30:08that?
30:09>> It's because of our um technology. Uh we
30:12are still paleolithic man and uh our
30:16biology
30:18has allowed us to store energy
30:21efficiently
30:23uh because of times of famine. We are
30:25now in a new environment where we have
30:27massive amounts of highly processed
30:29carbohydrates, inactivity, emotional
30:31stress, we have poor sleep habits. You
30:34you pile all those together with availab
30:38the exposure to carcinogens and whatever
30:41and you chronically damage this organel
30:44and uh [clears throat] in some organs
30:46you can get breast cancer if it's a lung
30:48if it's a whatever it is that organel
30:51becomes chronically damaged in some
30:53populations of cells in a particular uh
30:56in a particular organ and and you can
30:58elicit disregulated cell growth as the
31:01result of that. You know what I find is
31:04in in that in the paper that we have
31:06with the chart uh if you can keep your
31:09mitochondria healthy because don't
31:11forget Paleolithic man our ancestors
31:13from 500,000 years ago uh or modern men
31:18like you said in these countries living
31:20according to traditional ways with
31:22minimal in interference from modern diet
31:25and lifestyle issues have lower amount
31:27of cancer in general and this is what
31:29Albert Schwitzer found the the famous
31:32humanitarian physician. He was
31:34specifically looking for cancer in
31:35African tribes and he said remarkably
31:38it's extremely low. What what are these
31:40guys doing where western society has has
31:43a lot of cancer and these Africans have
31:45living living according to the
31:47traditional ways. So they have a lot of
31:49exercise. They're eating all organic
31:50foods. Uh they're not under the same
31:52kind of stress or exposure to chemicals
31:54that modern societies have. And you find
31:57out you have very low cancer. Like for
31:59example, uh dogs are all evolved from
32:01the wolf. Uh wolves in the wild rarely
32:05have cancer. The domestic dog, cancer is
32:07the number one killer of the domestic
32:09dog. What is the dog doing that the
32:11wolf? The wolf is out running around
32:12eating natural foods. The dog the dog is
32:14in an apartment somewhere gets a dog
32:16walker once a day, right? And the next
32:19thing the dog dog is obese and full of
32:20cancer. So it all it all comes down to
32:24what what you do to maintain the health
32:26and vitality of the mitochondria that
32:28reduce the risk and that's what this
32:30chart I'll show you has reduce the risk
32:33of damaging this chronically. Okay. So
32:36that can explain in large part why
32:39modern societies are struggling with
32:42chronic diseases not only cancer we have
32:44diet type 2 diabetes we have obesity we
32:46high blood pressure we we have a whole
32:48even neuroscsychiatric problems. If you
32:51can protect and keep this organel
32:53healthy, you reduce risk. Now people
32:56say, well, cancer has to be genetic
32:58because we have inherited genes that put
33:01us at higher risk like the Bracka one
33:03for breast cancer and the leaf ramen for
33:05variety of other cancers. Our paper in
33:08this pile done by Bob Kaplan uh he went
33:11through uh and looked at all the genetic
33:14risk.
33:14>> Which paper is it?
33:15>> Um it's one of the ones published in
33:17oncology. But none of these mutations
33:20are 100% penetrant, meaning that they're
33:23secondary risk factors. A primary risk
33:25factor would be every time that mutation
33:27is there, 100% of the people because I
33:29work in Tesax's disease. I work in
33:31inborn errors of metabolism. Those
33:33mutations are 100% responsible for that
33:35condition. There's no gene mutation
33:37that's 100% pen. You have that gene,
33:39you're going to 100% get cancer. Uh most
33:41of them are are uh um are what they call
33:44incompletely penetrint. So what does
33:46that tell us about the nature of
33:47>> well it tell and then we went back what
33:48Bob did is he went back and he looked at
33:51what every one of those gene mutations
33:54in some way disturbs the efficiency of
33:57oxidative phosphorilation in that
33:59organel
34:00>> in the mitochondria
34:01>> in the mitochondria we we looked at we
34:02have all the evidence all the risk
34:04factor all the genetically just just the
34:07front page there I was going to show you
34:09the hard data but you got [laughter] so
34:11anyway that all of them damage this the
34:14efficiency of energy through through
34:15through this organel. So that's like
34:18carcinogens, that's like um viral
34:22infections. The viruses that like
34:24hepatoma and papilloma, they they their
34:27their products will go in here and
34:28damage it or they will replicate inside
34:30this organel, screwing up the
34:31efficiency, causing a compensatory
34:34fermentation, causing the disregulated
34:37cell growth through abnormal calcium
34:39signaling, causing cells to no longer uh
34:42be responsive to their neighbors. Is
34:44that clear? If I can make you understand
34:46this, we can make everybody understand
34:47this.
34:48>> Yeah. So, the the reason I uh spend a
34:50lot of time asking why and asking for
34:52clarification is because when I do the
34:55show, I then go out into the real world
34:56and I meet the people that listen.
34:57>> Yeah.
34:58>> And one of the groups of people that
34:59listens are young offenders. And when I
35:01went and visited them, I pointed at the
35:03episodes that I thought would help them.
35:04Yeah. And a young one of the young
35:05offenders said to me, "I can't listen to
35:07that episode because the words you used
35:08were too big."
35:09>> And I remember thinking to myself,
35:10>> "Okay, that I get that all the time, but
35:12guess what? Now we have AI and you can
35:15take this statements and put it into AI
35:19right on the and and it'll it'll it'll
35:22dumb it down for you.
35:23>> So So that's a tool that we previously
35:26did not have.
35:27>> So So I use that all the time. I said
35:30when you hear me speak like this, don't
35:31think I'm arrog
35:33I I I these are the terms that we use
35:35when you're part of the academy. Yeah.
35:37>> Okay. But we can take those terms now
35:39and AI can do a wonderful job in in in
35:41synthesizing. Oh yeah, I know what he's
35:43talking about now. But without that
35:45tool, then it becomes like you said,
35:47well, I can't understand anything.
35:49>> I've got 60 seconds and I'm going to
35:51show you how much I can get done because
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35:56for those of you that don't know what it
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36:51if you've listened to this podcast
36:52before, you'll know how obsessed I am
36:54with sleep. I've been on a bit of a
36:55journey with sleep. I see it as the
36:57single most important thing that I'm
36:58have the privilege of having control
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37:42Big opportunity. I am not kidding. Give
37:44it a try. I really want to just make
37:46sure I tick off the box of um cause
37:50factors. So you mentioned stress,
37:53>> you mentioned sleep.
37:55>> I currently don't have cancer as far as
37:57I'm aware. God forbid. Um but I but I
37:59want to do everything I can to prevent
38:00the probability. Yeah.
38:02>> And I from what I've understood that
38:03means protecting my mitochondrial
38:05function.
38:06>> Yes.
38:06>> By living a lifestyle where I'm not
38:08creating this sort of like crazy
38:09oxidative stress on the mitochondria.
38:12>> Right.
38:12>> So give me a prescription of how I
38:14should live my life to keep my
38:16mitochondria healthy.
38:17>> Well, that's why we developed the
38:18glucose ke ketone index calculator. the
38:20first biomarket tool that can allow
38:22people to know the level of health of
38:24their mitochondria because
38:27um when you shift from carbohydrate fuel
38:30to lip lipid fuel,
38:31>> what's lipid fuel?
38:32>> Fat.
38:34>> So ketones,
38:35>> ketones are a water- soluble breakdown
38:37product of fatty acids. [clears throat]
38:39>> Okay. So we store atapose tissue. We
38:42store fat
38:43>> which is the belly fat
38:45>> all over. We have fat on our
38:47>> on the outside.
38:48>> Yeah. So on the outside that was there
38:50because as a species we had to survive
38:54in the most harsh environments and we
38:57were um food was not always there. So we
39:00had to survive all kinds of famine all
39:02kinds of absence of food. Our bodies are
39:04so our it's a machine that was home over
39:09millions of years to be super efficient.
39:11So glucose is gold sugar. Okay. You
39:16either burn it or you can store it as
39:18fat. Okay, that's that's the key. But
39:21when you have you're not bringing in
39:23sugar, that stored fat now moves into
39:25the bloodstream, goes to the liver, and
39:27it's like taking a branch and putting it
39:29in a chopper and you outcome these
39:32little soluble ketone bodies. They're
39:34breakdown products of longchain fatty
39:36acids. They can replace sugar for the
39:38brain, for the muscles, for most other
39:41cells in the body except ariththraittes,
39:43but they can replace they can replace
39:46the energy of glucose. Okay? So, uh, and
39:50that's how we evolved. But we're now in
39:52an environment where we have massive
39:54amounts of highly processed
39:56carbohydrates and we we don't want to
39:59pee them out unless you have diabetes or
40:01something. So, we store them as fat. So
40:03we have an obesity epidemic as the
40:06result of our evolutionary ability to
40:08store energy which kept us alive as a
40:10species because if we were unable to
40:12store the fat in 500,000 we would have
40:14all been extinct. You and I this
40:16conversation would never exist.
40:17>> We would never have existed as a species
40:19except for our ability to store energy
40:22and we burn energy efficiently in these
40:23organels. So this is all a very highly
40:27efficient machine. So when we lose that
40:29ability, uh when we have so much energy
40:32in the environment, stress, no exercise,
40:34all this, we store more and more fat, we
40:37produce an an environment that's very
40:40damaging to this organal.
40:41>> Well, say that again. So how does stress
40:43impact that?
40:44>> Stress elevates corticosteroids. When
40:46you're under stress, you get into a
40:47fight, you get into an argument, or
40:49you're stressed out by business deal
40:51going bad, whatever. uh corticosteroids
40:55elevate elevate blood sugar contributing
40:57to uh systemic inflammation. It's okay
41:01for a short period of time to be pissed
41:03off at something. But it's the chronic
41:04stress, the chronic like looking at the
41:07cell phone, doom scrolling, all this
41:08kind of crazy stuff while eating the big
41:10Twinkie, doom scrolling, eating
41:11Twinkies, not moving. All of this
41:13creates uh stress on this organel in
41:17some population of cells.
41:19>> It makes it work harder. It's damaging
41:21because you produce reactive species
41:23that damage the efficiency of this
41:25organel to produce energy effectively
41:28and that either will kill the cell
41:31gradually if it can't comp use
41:33compensatory fermentation or predispose
41:36you to cancer. So either way is
41:39unhealthy. So we have chronic disease.
41:41Cancer is the number one big dog in the
41:43chronic disease world. I mean it's the
41:44one that people fear the most. um type
41:47two diabetes, cardiovascular disease,
41:50you know, dementia, uh all of these are
41:53part of damage to this organel in one
41:55way or another. In like I said for
41:58Parkinson's disease, when that organel
42:00gets damaged, the cells of the
42:01substantion aigrate die. They are
42:03incapable of compensating with
42:05fermentation. So they up and die. Cancer
42:08is very rare in neurons of the brain.
42:10Neurons the gal cells of the brain form
42:13these brain tumors mostly but neurons
42:15[clears throat] can't compensate with
42:17fermentation so they die. So you you
42:19either get comp compensatory ancient
42:21fermentation leading to disregulated
42:23cell growth which we call cancer or we
42:25get cell death leading to chronic
42:27diseases.
42:27>> What about sleep then? What's going on
42:29with sleep that's causing
42:30>> sleep is a way we can restore the energy
42:32efficiency of the mitochondria
42:33>> if we're well slept.
42:34>> If we have good sleep. Yeah. You know
42:36everybody feels good when you have a
42:37good night's sleep. your body feels
42:38rejuvenated because you're not you're
42:40not stressing out. You're reducing the
42:43ability of this organel to manage the
42:46the the the metabolic uh environment. uh
42:49if you're up all night and you're and
42:50you're like stressed out and you're
42:52never given this uh organel in a
42:54particular cell in a particular part of
42:56the organ of the body, you know, you you
42:59get neuroscychiatric problems, you can
43:01get digestive problems, you can get
43:03cancer, you can get type 2 diabetes, you
43:06have a whole and we put it in the paper
43:08there, all the different stress, all the
43:09different things that can chronically uh
43:11or acutely damage oxidative
43:13phosphorilation.
43:14>> So sleep basically gives the
43:16mitochondria a little bit of a break.
43:17Yes. It's a it's it gives your whole
43:19body a break, let's be honest. So, so,
43:22but you you pile those things on
43:24together. Lack of exercise. Our
43:26ancestors, what do you think our
43:27ancestors, you know, how hard it is to
43:28run down and kill a big buffalo or a
43:30woolly mammoth? I mean, you're you're
43:32exhausted after doing something. As a
43:34matter of fact, you chase these animals,
43:37uh, you separate. And this is another
43:38thing that was really interesting. Came
43:39out of Israel. I think it was last year.
43:42They looked at the cavemen, what they
43:43were eating. they were eating the the
43:45strongest members of the herd uh leading
43:48to the indirect extinction of these
43:50animals. They found out that if you can
43:52eat the strongest member of the herd,
43:55you'll get the vitality of that uh of
43:57that or buffalo or elephant or whatever
44:00the hell they were eating because they
44:01knew the marrow and the and the the
44:04physiology of that of that organism at
44:07that point in its life could provide you
44:09with the strength that that had. Now,
44:11when you eat the strongest members of
44:13the herd because you want to be tough,
44:15you're putting the old and the young at
44:17vulnerable to predators leading to the
44:19extinction. Uh, and this is what a big
44:22paper came out of out of uh, Israel.
44:24They looked at these cavemen, what they
44:25were eating like 500,000 years ago or
44:27whatever they're doing. So, humans
44:28indirectly caused extinction of other
44:30species in part in not in part because
44:33they were eating the toughest guys in
44:34the herd. So, because they felt that if
44:37I eat those guys, I'm gonna be strong
44:39too. And in a way, they're right. But
44:41all of it has to do with the energy
44:43efficiency of your muscles, your brain,
44:45your ability to be resilient, endurance.
44:49I'm telling you, these guys were
44:52chiseled. They they weren't dying from
44:54type 2 diabetes, cancer, right?
44:57Dementia. They were dying from
44:58infections and injuries and child
45:01mortality. Uh we're mostly killing our
45:03paleolithic ancestors. But when you
45:06bring your body back into a low glucose
45:07ketone, you're actually going back like
45:09you were. This is why we developed the
45:11glucose ketone index.
45:13>> What is in that envelope in front of
45:14you?
45:15>> Well, this is um it's a paper that's
45:16under embargo because they they think
45:18it's going to be the world thinks it's
45:20going to be very important and um and it
45:23is.
45:24So, and what it is, this is a
45:28um a way to keep that organel healthy.
45:31So this is a way to manage uh um energy
45:36efficiency in the body.
45:37>> And this hasn't been released yet.
45:39>> It hasn't been released. Okay. It's
45:41coming out. It's a it's going to be a
45:42lead article in the frontiers in
45:44science. And not only that, we the paper
45:47the paper was written
45:50uh for the scientists and then the
45:53journal decided to make a second copy
45:55for they call young minds. So letting
45:58kids that are like 8 to 12 or 14 years
46:00old synthesize it down and and and one
46:04of my colleagues said that's probably
46:05what most people will be reading because
46:08they don't want to know about the
46:09bioenergetics that actually goes on
46:11inside this organel to explain why this
46:14chart means something.
46:15>> And you've been working on this for some
46:16time.
46:17>> Well, I I I built the GKI. So let me
46:19tell you the story. There was a woman uh
46:21an American woman a lawyer Trudy Dupant
46:24who uh developed um a kind of a brain
46:27stem tumor and after I wrote my book
46:30that book there that's my only book
46:32anyway Trudy Trudy wanted to use this
46:35metabolic therapy she stayed alive much
46:37longer over 10 years with this we kept
46:40the she eventually passed away
46:41unfortunately but so I was measuring
46:44because we knew that the tumor cells
46:47needed sugar to grow out of Worberg
46:49showed that and many other people show
46:51that and they can't burn ketones because
46:54because the fatty you need a very
46:57efficient mitochondria to burn ketones
47:00for energy. Our normal cells can burn
47:03ketones for energy and that gives us
47:05tremendous uh uh we can actually breathe
47:08lower oxygen more energy if you have
47:10efficient if you can burn ketones
47:12efficiently in this organel. But if the
47:14organel is damaged, they can't use the
47:16ketones. They can't burn fatty acids or
47:18ketones, which stores lipid drops. It's
47:20one of these big papers here. These
47:24Stephen, you can't believe how people
47:25misinterpret information. They see
47:27droplets of fatty acids in the cytoplan
47:29say, you see the cancer cell needs all
47:30that fatty acid. No, they can't. It's
47:32there to protect them. If they try to
47:33burn it, they blow this up and die. So
47:35there is a storage of fat. They can't
47:37burn fatty acids or ketone bodies. So, I
47:39knew cancer needed glucose, and I knew
47:41cancer couldn't burn fatty acids or
47:43ketones because this organel is is
47:45broken.
47:47So, I'm measuring glucose and ketones
47:50independently in Trudy. She's doing the
47:53finger prick thing, sending me the
47:56information back and saying, "Oh, here's
47:58my glucose. Here's my ketones."
48:00>> Okay, so I have a a ketone glucose
48:02reader in front of me.
48:03>> Right. Right.
48:04>> If I put my blood on this strip, it
48:06tells me my glucose levels. If I put my
48:08blood on this strip, yeah, it tells me
48:09my ketone levels.
48:10>> Right. Right. But if you if you look at
48:12them independently,
48:14>> glucose is very volatile, very variable.
48:17>> And this is why I developed the glucose
48:19ketone ratio because Trudy had a parking
48:22spot that was for handicapped because
48:25she had a cane. Her brain stem gloma was
48:28preventing her from walking as
48:30effectively as normal people. So she
48:32somebody took her parking spot. She was
48:35So she ran upstairs and took
48:39her blood sugar and it was 186 milligram
48:42per deciliter. It was very very high. So
48:45and I know she was on a ke ketoic diet
48:48and and she emails me and says I'm going
48:50to die. My cancer is going to grow fast.
48:51What's going on? She said my blood sugar
48:53is like 186 and you know it's supposed
48:55to be you told me it was supposed to be
48:5660 or you know 50 65 or in that zone.
48:59She says so I said what's your ketone
49:00level? Oh, it's still, you know, like
49:02you just had point4 millmer or I think
49:05it was 0.9 millmer. I said, well, that
49:07didn't change, right? No, just the sugar
49:09changed. So, I said to the students that
49:12were working with Josh Fidenbower, I
49:13said, Josh, this this trying to measure
49:16these two independently is a
49:18You can't this is hard to figure out.
49:19So, what we decided to do in miller
49:21because glucose comes out in milligram
49:23per deciliter whereas ketones come out
49:25in millimmer. So we had to convert
49:27glucose to millimmer and divide it by
49:29the ketone in millimmer and then you get
49:31a number that's not all over the world.
49:34It's very stable. So so we were able to
49:38because of Trudy that one cancer patient
49:41we developed the ratio of of this. Then
49:44later on we realized that this ratio is
49:47a statement of how healthy your
49:49mitochondria actually are. So when you
49:52when you have these low ratio you're in
49:53paleolithic man. you're back in the zone
49:56where we didn't have chronic diseases
49:58because we didn't have damage to the
50:00organel that would cause those diseases.
50:02So, paleolithic men think where are they
50:04getting their pastries? Where where are
50:06they getting their cakes and sweets and
50:08all this other they didn't have it. They
50:10weren't there because of of choice. They
50:12were there because of circumstance. So,
50:14our new and we learned paleolithic man
50:17was always in some sort of a state of
50:20some ketosis because they wouldn't have
50:21food for periods. They were very active
50:24in their exercise. They had they didn't
50:26have chronic diseases, but they had
50:27other kinds of diseases. So, so then um
50:31my my my my student um Derek Lee, myself
50:35and Christo Shinopoulos, we started to
50:38make a ratio chart. Now, these are the
50:40numbers that you get when you divide
50:41your sugar by your ketones.
50:43>> Okay. So, my sugar by my ketones. So, if
50:45I did my glucose measure now on this
50:47little
50:47>> Okay, let's see what your GKI is.
50:49>> Oh, you want me to do it? Okay.
50:50>> Okay. What? You had a glucose. You had a
50:52a ketone was 0.4 millmer.
50:54>> Yeah.
50:54>> Okay. What was your sugar?
50:56>> I haven't.
50:56>> So, we can divide. We can do the divi
50:58division right now and tell you what you
51:00have.
51:00>> You can get these little uh ketone
51:02>> Oh, yeah. It's a keto mojo. And you can
51:03also get them now for for uh
51:06>> Wow, these guys skilled at doing this.
51:08>> I travel with one of these, [laughter]
51:10believe it or not.
51:11>> Yeah.
51:11>> So, I I have one all the time.
51:13>> Wow.
51:15>> 90.
51:15>> 90. Okay. So, you have to you have to
51:18divide. You have to divide. You're not
51:19getting the Doesn't this give you the
51:20push button and give you the GKI right
51:22away? Cuz the new ones have it. So, you
51:24have to divide 90 by 18 and you get a
51:27number.
51:28>> Uh, five.
51:29>> Five. So, divide five by 0.4.
51:32>> 12.5.
51:33>> Okay. So, here you are.
51:3612.5. You're down here in the in the in
51:39the prevention zone.
51:40>> Ah, nice.
51:41>> Okay. So, so you This is where
51:44Paleolithic man mostly lived.
51:46Paleolithic man lived in the yellow
51:49green zones because they didn't have
51:51access to all of the things that would
51:53drive up your blue blood sugar and keep
51:56your key when your blood sugar goes
51:58through the roof your ketones are really
51:59low because insulin is now driving it
52:01up. So So that's good. Um 12, huh?
52:05>> So I I did the I did the carnivore diet
52:08for a week.
52:09>> Uh eating big ribe eyes. You like ribeye
52:11steak?
52:12>> Yes, of course. [laughter]
52:15ribe eyes, bacon and eggs, lamb. I I so
52:18I did it for a week and um I was able to
52:21get down to 10.
52:23>> Okay.
52:24>> Okay. And I could get lower, but I was
52:25loving the ribeye so much I ate a little
52:27too much of it. Right. You have to
52:28[laughter] be have some level of
52:29discipline. Yeah.
52:30>> So, [clears throat] uh so so but people
52:33people this is what we call the zone of
52:35prevention. It's very hard to get cancer
52:38or chronic diseases when you're in these
52:40zones because you're keeping this
52:41organel quite healthy. When you live in
52:43these zones consistently,
52:45>> you you don't have to live consistently
52:47because humans, we we evolved as a
52:49scavenger species. We would engorgorge
52:51ourselves because we knew it wasn't
52:53happening every day.
52:54>> Modern man is live is living in the
52:57feast every single day. And that's why
52:59we're are we have an out all the chronic
53:02diseases. This is the red zone is the
53:06zone of risk for chronic diseases and
53:08cancer. And when you look at the obesity
53:11epidemic, you look at all these things,
53:13these guys are and it's it's like we can
53:16visit the red zone. We don't want to
53:18live in the red zone.
53:20>> So if I was to visit the red zone, it
53:22would look like meeting high
53:24carbohydrate diets, lots of sugar.
53:26>> Yeah. No exercise.
53:28>> No exercise.
53:29>> Yeah. And basically modern man.
53:31>> And also eating five meals a day, like
53:33snacking all the time.
53:34>> Yeah. Oh, then you'd be, you know, we
53:36have uh there's document cases. We have
53:38them up to 500.
53:40>> You can get GKIS of 500.
53:42>> You have people with, you know, blood
53:44sugars about 4 or 500 milligram per
53:46deciliter. I mean, you could do the and
53:48zero ketones. I mean, you you do the you
53:51do the math. It's it's unbelievable.
53:52>> You're basically saying, I want to keep
53:54my my blood glucose levels
53:55>> and you want to you want to have some
53:57level of ketones
53:58>> and high and my ketone levels somewhat
53:59as high as I can.
54:00>> Well, it's you don't want to go because
54:02people then have the physicians
54:03listening. They go, "Oh, he's going to
54:04go with the keto acidosis." People give
54:06me a break. Keto acidosis is like when
54:09you have ketone levels of 15 to 20
54:11millmer. Are you kidding me? What is
54:13yours? 0.4. That's called nutritional
54:15ketosis. That's how we evolved. When you
54:18have type 1 diabetes where you can't
54:20control sugar or or or insulin, you have
54:23no insulin responsive. You're going to
54:25get high levels of sugar and ketones.
54:27This is this is a pathological
54:29condition. Most of type two diabetes,
54:32these are all pathologies based on
54:34damaging oxidative phosphorilation. So
54:37what this chart does is for the first
54:40time and we put it together because we
54:42did all the B in the paper discusses the
54:44bioenergetics. What we're finding in
54:46cancer is that if you can get into the
54:49green zones where your blood sugar is
54:51low and your ketones are elevated, you
54:53hammer the hell out of these tumor cells
54:56because they they they you're taking
54:58away one of their two primary fuels
55:02driving disregulated cell growth. Okay?
55:05And as the and as the and as the ketones
55:08go up, the rest of your cells in the
55:10body are getting super healthy. The
55:13tumor cells can't tap into the value of
55:16a ketone because the organel needed in
55:19the tumor cell to do that is corrupted
55:22structurally and functionally is am I
55:26clear about that?
55:27>> Yes.
55:27>> Okay. So ketones will make you healthy,
55:30the normal cells of your body, but
55:32cannot be used to help the cancer cell
55:35because you need a good structural
55:37functional organel to burn them. So they
55:39become marginalized and if the ketones
55:42go up, they're actually toxic to that to
55:44that cell to some extent. So but they're
55:47still alive. Uh the cancer cells are now
55:51incapacitated.
55:52there. Uh we we showed you get rid of
55:54the abnormal inflammation, you get rid
55:56of the angioen, the abnormal blood
55:57vessels. You're taking an angry tumor
56:00and making it much less angry, much less
56:03inflamed, uh uh more indolent uh kind of
56:07a tumor, but it's still there. It's not
56:09because the other fuel that's keeping
56:12this cancer cell going is the glutamine.
56:14Okay. So now when you have the patient
56:18in this green zone, this is for
56:20management. Now, Stephen, this is
56:22prevention is is never having to deal
56:25with what I'm talking about. If you're
56:27living in the yellow zone, the
56:28probability of getting cancer or chronic
56:31diseases is already reduced. Okay? But
56:35now you have some poor guy out there.
56:37He's living in the red zone his whole
56:38life. He wants to manage the cancer that
56:40he has. He he has to get down in the
56:42green zone and try to stay there as long
56:44as he can. But the cancer will still
56:46grow because it has access to glutamine.
56:48Okay? And glutamine is always here's the
56:50bloodstream. Look at look at you have
56:52this much blood. Cancer needs that. So
56:54you always have a surfitit of glutamine.
56:57So you have to come in now with drugs
56:59and the drugs like repurposed drugs to
57:02target the the glutaminolysis
57:04with this one here this BMC big paper
57:07here.
57:07>> Mhm.
57:08>> Okay. This paper and the new one we have
57:10with the ketogenic for the high
57:12childhood um high-grade gloma for kids.
57:15So once once you get down here, you come
57:19in with drugs that target glutamine.
57:21I've looked at one and that's Mbendazol.
57:24Okay. How did I come to that
57:25realization? People knew that embendazol
57:27had some therapeutic benefit about
57:29cancer, but they don't believe it until
57:30you show the mechanism. That paper shows
57:32the mechanism. It targets glucose and
57:34glutamine. That was this one targets
57:36glucose and glutamine, the two fuels
57:38driving the disregulated growth of the
57:40tumor. Okay. So here's the here's the
57:43mitochondria.
57:45So it's getting the glucose and the
57:47cytoplasm from the sugar uh and making
57:50and it's fermenting that and then also
57:52the the amino acid glutamine comes in.
57:55You have to block the glycolysis and the
57:57gluc these two pathways. You have to
57:59restrict availability of glucose and
58:01glutamine together at the same time.
58:04Yeah.
58:04>> I speak only about things that I have
58:06tested in my lab and published papers on
58:09like this. So you have to real the
58:11cancer field doesn't understand that the
58:14cancer can't grow without glucose and
58:17glutamine and can't switch to fatty
58:19acids or ketone bodies.
58:21>> That's still not going to kill the
58:22cancer though, is it? It's just going to
58:23>> Yeah, we don't ever use the term cure
58:25because some of these tumors, now let me
58:26tell you, we have people like Pablo
58:29Kelly from Devon, England, he had the
58:31glyobblasto
58:33uh he didn't take any radiation or
58:35chemo. He just did metabolic therapy. He
58:37lived for 10 years. He was diagnosed
58:39with an inoperable glyopblast. They
58:42wanted to irdiate and poison him with
58:44the drugs. He said no. He was one of
58:45these naturalistic kind of guys. And um
58:49he he lived for 10 years and the tumor
58:52became operable. He had four debulking
58:54surgeries on an originally described
58:56inoperable cancer cut out four times
58:59because once we put the metabolic
59:00therapy the circle the demarcation of
59:02the tumor. Whoa. A neurosurgeon says I
59:04think I can get this out. But he never
59:06never got rid he lived with it for 10
59:08years. Had a couple of kids. He died
59:10from a cerebral hemorrhage on the last
59:11debulking surgery. He never died from
59:13the tumor.
59:13>> But you're saying you're saying that the
59:15two work together in in tandem. You're
59:17saying that the chemotherapy works in
59:20>> the Now that's where that's another
59:21thing. So what we do u this is very
59:24interesting. So if you put the patient
59:27in nutritional ketosis, the the
59:29ketogenic
59:31state of nutritional ketosis facilitates
59:34the delivery of drugs to the tumor cell.
59:37It actually makes you can use lower
59:39doses of drugs and you and and and you
59:43get bigger effect. The therapeutic
59:44benefit increases with lower dosing.
59:47>> So you want to be in ketosis when you do
59:48these chemotherapy, radiation therapy.
59:50>> Yeah. And then you use much lower doses.
59:52This is what we're doing in a stimul
59:54clinic. We're taking pancreatic cancers.
59:56These guys live in four and five years.
59:58What are we doing? And advanced breast
1:00:00cancer and all these terminal cancers.
1:00:02We put them into some level of ketosis
1:00:04and then you come in with the standard
1:00:06drugs, cis platin, carboplatin, whatever
1:00:09you want to do, but you cut the dosages
1:00:11down big time and then they have tremend
1:00:15the the uh and this is what the title of
1:00:17the paper is ketogenic diet uh as a
1:00:22metabolic vehicle
1:00:24uh for enhancing therapeutic efficacy.
1:00:28The current body of research suggests
1:00:29that being in a state of ketosis can act
1:00:31as a helper therapy, enhancing the
1:00:33cancer killing effects of chemotherapy
1:00:34while simultaneously protecting healthy
1:00:36cells.
1:00:36>> Yeah. Yeah. Right. Right.
1:00:39>> Progressive oncologists are currently
1:00:40using ketogenic diets alongside standard
1:00:42chemo to maximize its efficacy.
1:00:45>> That's right. That's what we're doing in
1:00:46Istanbul
1:00:49and and and also in in in Greece. We're
1:00:52doing we're doing those same things. So
1:00:54you you can use this
1:00:55>> when you enter a fasted or ketogenic
1:00:57state. Your healthy cells essentially go
1:00:58into bunker mode. They slow their
1:01:01division, conserve energy, and build up
1:01:02their defenses. Cancer cells, however,
1:01:04do not have this evolutionary off
1:01:06switch. They continue trying to rapidly
1:01:08divide. When the toxic chemotherapy
1:01:09hits, your shielded healthy cells
1:01:11survive it much better. While the
1:01:14exposed rapidly dividing cancer cells
1:01:16take the full hit.
1:01:18>> Yeah.
1:01:18>> Oh, okay. Interesting.
1:01:20>> Yeah. In other words, you make with the
1:01:22tools you have work better. The problem
1:01:24in the field of cancer today is they're
1:01:26not using the tools in the correct way.
1:01:29Now, let me give you another example. If
1:01:31you take imunotherapies, you hear about
1:01:33these things, chimeic acid, G receptor,
1:01:36PDL, PD1, PDL1 inhibitors, they're
1:01:39called precision medicines, right? So
1:01:42look, they're designed
1:01:44to attack a a molecule on the surface or
1:01:48stop that cell from uh being resistant.
1:01:51>> Mhm.
1:01:51>> If you would try to attack and what they
1:01:53do often times, they come at after
1:01:55you've failed chemo and radiation, they
1:01:57then come at you with an imunotherapy.
1:01:59The metabolic pressure shrinks down your
1:02:01tumor, makes it very indolent,
1:02:03>> non-aggressive, and the rest of your
1:02:05body is healthy. You're not going bald.
1:02:06You're not bleeding gums. Your
1:02:08microbiome isn't blown to hell. So, and
1:02:10then you can come in with lowdose chemo
1:02:13imunotherapy because what'sever left in
1:02:15that remaining residual mass, they may
1:02:18all have something in common for having
1:02:20survived all this, right? So now you can
1:02:23come in with a precision medicine and
1:02:24possibly resolution. I thought this was
1:02:27fascinating. It says chemotherapy
1:02:28creates massive oxidative stress, i.e.
1:02:30damage inside the tumor. To repair the
1:02:32damage and survive, the cancer cell
1:02:33requires massive amounts of glucose. So,
1:02:35if the patient is in ketosis, the
1:02:37tumor's glucose supply is essentially
1:02:39cut off. It can't the cancer cell can't
1:02:41repair the DNA damage caused by your
1:02:43chemo, leading to faster tumor death.
1:02:46Um, yeah, interesting.
1:02:48>> Well, don't forget also, listen to this,
1:02:51and there's another thing people go in.
1:02:53What protects the tumor cell from chemo
1:02:55and radiation is the waste products of
1:02:58fermentation. The lactic acid and the
1:03:00suxinic acid that are dumped out of this
1:03:03raging beast prevent these other
1:03:06therapies from working. So if you want
1:03:08your therapy to work, you got to target
1:03:11those two fuels together at the same
1:03:13time. And when you do that now this cell
1:03:16the shield is off. These things are
1:03:18super vulnerable to even low doses of
1:03:20chemo and radiation. And the
1:03:22imunotherapies, look at if you have an
1:03:24imunotherapy, you try to attack the
1:03:27beast when it's at its strongest. H
1:03:28you're not going to win. And this is
1:03:30what happens. You get only partial
1:03:32response. They in the field of cancer
1:03:33today, they think living an extra six
1:03:35months is a major breakthrough. We're
1:03:37talking about living an extra five and
1:03:39six years. This is what's really
1:03:41important. I just um I was reading some
1:03:43research to figure out if oncologists so
1:03:47cancer doctors are currently
1:03:48recommending the ketogenic diet and it
1:03:50says the vast majority of mainstream
1:03:52oncologists do not recommend the
1:03:53ketogenic diet to the to their newly
1:03:55diagnosed patients. Um in fact if a
1:03:58patient brings it up many doctors will
1:03:59actively advise against it and the
1:04:02reasons for that number one is the fear
1:04:04of cacettia. Cexia. Yeah.
1:04:07>> Cexia. Cancer. Cexia is a severe wasting
1:04:10syndrome where patients rapidly lose
1:04:11muscle and fat. It is a massive problem
1:04:13and a leading cause of mortality in
1:04:15cancer patients. Because the ketogenic
1:04:16diet suppresses appetite and often leads
1:04:19to weight loss. Encologists are
1:04:20terrified that a strict keto diet will
1:04:22accelerate cexia and weaken the patient.
1:04:25>> Well, that's because they they have not
1:04:27heard what I just said with respect to
1:04:29the biology and biochemistry. Okay.
1:04:31Cexia there's two ways you can lose in
1:04:34cancer patients. CEXIA is the ability of
1:04:36the tumor cell to mobilize energy out of
1:04:39the muscles. It's taking the glutamine
1:04:41out of your muscles and feeding. This is
1:04:43one of the two fuels that's driving the
1:04:45beast is glutamine. Where are they
1:04:47getting the glutamine from? They're
1:04:48getting the glutamine not only from the
1:04:50bloodstream, but they dissolve your
1:04:51muscles as a uh as part of that part of
1:04:55that process. So, when you put a patient
1:04:58in nutritional ketosis,
1:05:00the weight loss is therapeutic weight
1:05:02loss. CEXIA is pathological weight loss.
1:05:05Now, the only way you can lose weight is
1:05:07you take a high dose of chemotherapy.
1:05:10I travel all the time. So, I made a rule
1:05:12in my life that I'll only travel with a
1:05:14cabin bag. The problem with this is
1:05:15there's not much space. And here's the
1:05:17solution. It is called an extra 1%
1:05:20travel pack. And I teamed up with Extra
1:05:22to make this. Typically, I can only
1:05:24bring some of my black shirts. And it's
1:05:25a trade-off of which black shirt should
1:05:26I bring? How many of these do you think
1:05:28I can get in here? So, let's try 1 2 3 4
1:05:325 6 7 8 9 10 11 12 13 14. Let's try 15.
1:05:4116 17 18 19 20 21 22 23 24.
1:05:46Okay, so that's 24 black t-shirts.
1:05:49Here's where the magic comes in. Zip it
1:05:51up. Make sure it's nice and sealed. And
1:05:52then you use this little contraption.
1:05:55Stick it on there. I can now take more
1:05:57than 20 black shirts with me, which will
1:05:59last me 3 weeks. So, if you travel
1:06:02frequently and you want to get one of
1:06:03these so you can save more space and be
1:06:04away for longer, go to extra.com and use
1:06:07code DOAC for 10% off our collection.
1:06:10And I think some of the background
1:06:12context here is that mainstream oncology
1:06:14operates on the um sort of sematic
1:06:16mutation therapy, which is the belief
1:06:18that cancer is fundamentally a genetic
1:06:20disease driven by DNA mutations. And
1:06:23because their training focuses on
1:06:24genetics, their treatments are designed
1:06:26to target DNA and cell division like
1:06:28heradiation targeted genetic therapies
1:06:30rather than manipulating um cellular
1:06:33metabolism. And lastly, as mentioned, I
1:06:36think we talked about this earlier,
1:06:37mainstream medicine requires massive
1:06:39multic-enter double blind phase 3
1:06:41clinical trials before a protocol
1:06:43becomes the standard of care. So dietary
1:06:45interventions rarely get the level of
1:06:47funding. So on ancologists lack the
1:06:48institutional green light to prescribe
1:06:50them to patients and they tend to say to
1:06:52them eat what you can.
1:06:54>> I I don't blame them. They're good. Many
1:06:56of them are good people. The problem is
1:06:58the system doesn't train them to
1:06:59understand the biology and biochemistry
1:07:01of the disease they're treating. Uh some
1:07:03of them become very resistant to this.
1:07:05They say get angry because if I why
1:07:06didn't I why wasn't I told this? Well,
1:07:09first of all, they're not reading these
1:07:10papers. Uh you ask them about it. They I
1:07:12never read it. Well, how are you going
1:07:13to know anything if you don't read the
1:07:14literature? Um, listen to this. The
1:07:17National Cancer Institute, the NCI, on
1:07:19their website, on their website says
1:07:21cancer is a genetic disease caused by
1:07:23what you just said. Okay, they I well I
1:07:26said why don't they put the articles in
1:07:28there showing all the tumors they can't
1:07:30find any mutations. The somatic mutation
1:07:33theory says that cancer is caused by
1:07:35random genetic mutations. So now new
1:07:39sequencing of normal people like you and
1:07:42me are finding mutations in all these
1:07:44driver genes in cells in our body that
1:07:46aren't in disregulated cell growth. So
1:07:48we're calling them wild type cancers.
1:07:49What do you mean a wild type cancer?
1:07:51>> You lost me.
1:07:52>> Okay. The nucleus of a tumor cell, a
1:07:54raging tumor cell.
1:07:56>> What's causing him that cell to grow? Is
1:07:58it the mitochondria and the cytoplasm or
1:08:00is it the mutations in the nucleus?
1:08:03Okay. So according to the sematic
1:08:05mutation theory, it's the mutations in
1:08:07the nucleus that are causing the
1:08:08disregulated cell growth. You take that
1:08:10nucleus and put it into into a
1:08:13enucleated normal cell.
1:08:15>> Yeah. And there's no cancer.
1:08:16>> No can there's no disregulation.
1:08:18>> There must be something else.
1:08:19>> Then you take the nucleus of the normal
1:08:21cell and put it into the cytoplasm of a
1:08:24tumor cell and you get disregulated cell
1:08:27growth.
1:08:27>> So it must be something other than the
1:08:28nucleus.
1:08:29>> Yes. The mitochondria.
1:08:30>> Interesting. And it says
1:08:31>> so with mitochondria controlling our
1:08:32destiny and and and the the field of
1:08:36cancer has yet to understand it, accept
1:08:40it, and then say, "Well, we can't do any
1:08:42of this until we double the line
1:08:43crossover." That's just what do you
1:08:44mean? The science is telling us this.
1:08:46That's your way of protecting a broken
1:08:48system.
1:08:49>> Are you pissed off about this? Cuz you
1:08:50do seem pissed off about this.
1:08:51>> Well, who wouldn't be,
1:08:54Stephen?
1:08:55There's 1,700
1:08:58people a day in this country dying from
1:09:00cancer. I don't know the English.
1:09:02Listen, that that comes out to 70 an
1:09:04hour. And it gets worse every single
1:09:07year. And the last time I was on the
1:09:08show, you guys use some old data. Look
1:09:11it up today. It's 2026. American Cancer
1:09:14Society says this year in 2026 we will
1:09:18have 626,000
1:09:21souls leave the planet from cancer.
1:09:25Okay, this 2026 and every year it gets
1:09:28worse. So when you hear all the
1:09:30breakthroughs, we have we have
1:09:32television ads in Boston for the cancer.
1:09:35Breakthrough after breakthrough after
1:09:37breakthrough. All these different they
1:09:40come on and and and and all we do is get
1:09:42more dead cancer patients. Raise money
1:09:44for cancer. Where's the where's the
1:09:46accountability for all the money you're
1:09:48raising? When are the work when is the
1:09:49people going to wake up? You don't make
1:09:51someone healthy by irdiating and
1:09:54poisoning them. You've got to understand
1:09:56the biology and the biochemistry of the
1:09:58disease. I have the concepts and the
1:10:00proofs, but the physician who works with
1:10:03the patient on a clinic basis, they're
1:10:05the ones that must apply this to the
1:10:07clinic. So, there's two different things
1:10:08here. There's the hard science that's
1:10:10the that's the bedrock for this and then
1:10:13there's the clinical person who has the
1:10:15practice that practice does that.
1:10:17Together, you get great success or
1:10:19better I say success better than
1:10:20anything that's out there today. The
1:10:22American Cancer Society recently
1:10:23released its latest projections for 25
1:10:26and 26, and the data paints a
1:10:28fascinating dual-sided picture. More
1:10:30people are getting diagnosed with
1:10:31cancer. Um, new cases. The ACS projects
1:10:35over 2.11 million new cancer diagnoses
1:10:38in 2026. This translates roughly to
1:10:415,800 new cases every single day.
1:10:44>> Approximately 626,000 Americans are
1:10:47expected to die from cancer in 2026.
1:10:50>> Right. about 1,700 deaths per day. Lung
1:10:54cancer remains the leading cause of
1:10:55cancer death projected to cause more
1:10:57fatalities than colurectal
1:11:00>> colurectal and pancre pancreatic cancers
1:11:02combined. I also just want wanted to
1:11:04pick a point we were talking about
1:11:05earlier which is about the metabolic
1:11:07approach to cancers.
1:11:08>> It says here and this is going to the
1:11:10point about you know people telling you
1:11:11to just eat whatever you want while
1:11:12you're you know managing cancer. Um
1:11:15because the primary goal of the hospital
1:11:16dietitian is to prevent weight loss
1:11:18during brutal chemotherapy regimes,
1:11:20patients are frequently told to eat
1:11:22whatever they can and eat whatever they
1:11:24can keep down. It is incredibly common
1:11:25for cancer patients to be handed meal
1:11:27replacement shakes which are often
1:11:28packed with corn syrups and refined
1:11:30sugars, ice cream, and high carbohydrate
1:11:32comfort foods just to keep their
1:11:34calorific intake up. From a metabolic
1:11:37perspective, this is a tragedy. While it
1:11:40keeps weight on the patient, it
1:11:41simultaneously floods the bloodstream
1:11:43with glucose and insulin directly
1:11:44feeding the tumor. Um, and while keto is
1:11:47not the standard of care, the landscape
1:11:49is beginning to slowly shift. There is a
1:11:52growing minority of integrative
1:11:54oncologists and specialized metabolic
1:11:56clinicians worldwide that actively
1:11:57prescribe therapeutic ketosis alongside
1:12:01conventional treatments. Those doctors
1:12:03use the keto diet and fasting protocols
1:12:05to protect healthy cells and um and and
1:12:07sanitize tumors before administering
1:12:09lower more targeted doses of chemo.
1:12:12Yeah, that's what we developed. That's
1:12:13our that's our plan. That's that's what
1:12:14we're doing. Okay. We we we do that
1:12:17because we understand the biology and
1:12:18biochemistry. And that's why we
1:12:20developed we're developing the new
1:12:22society called more the more alliance
1:12:24metabolic oncology research and
1:12:27education. This is bringing uh together
1:12:29what you just mentioned there in a
1:12:32logical approach to manage cancer. This
1:12:34is a logical approach based on the hard
1:12:37science of decades of research initiated
1:12:40originally by Otter Werberg and then
1:12:42continued by our group at Boston
1:12:44College. The American Cancer Society
1:12:46says that breast cancer is increasing,
1:12:48prostate cancer is increasing,
1:12:49pancreatic cancer, melanoma, HPV
1:12:51associated oral cancers are steadily
1:12:54increasing in the incidence of severe um
1:12:57cancers.
1:12:58>> Yeah, there has been no major advance in
1:13:01managing glyopblast in 100 years.
1:13:04>> What's glyobblasto?
1:13:05>> That's the the the deadly brain cancer.
1:13:08Okay, that killed uh Teddy Kennedy from
1:13:10Massachusetts, Senator Kennedy, John
1:13:12McCain, President Biden's son, Bo Biden.
1:13:16It's killed a lot of various people and
1:13:18it's considered a death sentence. No,
1:13:19no, no, no. We we we're keeping these
1:13:21guys alive. Okay, we're not saying we
1:13:23cure the cancer, but we can certainly
1:13:25keep them alive a lot longer. Pancreatic
1:13:27cancer always considered so bad. We're
1:13:29getting very excellent results in
1:13:31managing pancreatic cancer using
1:13:33metabolic therapies. We know what to do
1:13:35and we know how to do it. I have
1:13:37clinicians that work with me, dieticians
1:13:39that know how to manage cancer
1:13:41effectively. We can do it right now
1:13:44today. If someone were to say, Seaf
1:13:46Freed, get your get your group together.
1:13:48Let me see what you can do. I will put
1:13:50up our metabolic therapy against any
1:13:52trial from any of these pharmaceutical
1:13:54companies. We can keep these people
1:13:55alive a hell of a lot longer to
1:13:57participate in our society. We're not
1:13:59doing that.
1:14:00>> If you were made president today,
1:14:02Thomas,
1:14:03>> of the United States,
1:14:03>> of the United States,
1:14:05>> don't go there. I'm going to go there.
1:14:09>> Those guys are
1:14:12uh not, let's put it this way, they're
1:14:14not scientifically literate. [laughter]
1:14:16>> But I would have to be. Yeah. Right.
1:14:17>> You, Professor Thomas, you're now
1:14:20president of the United States, and your
1:14:21primary objective is to bring down this
1:14:251,700 Americans that are going to get
1:14:27cancer a day.
1:14:30>> Um, is it is it get cancer or die from
1:14:32cancer?
1:14:32>> No, they die from cancer. Okay. 1,700 a
1:14:35day dying from cancer in the United 70
1:14:37an hour. Think about it.
1:14:39>> You you can put in place policies to
1:14:41stop this happening and to also help
1:14:43people manage it better. What is it you
1:14:44do?
1:14:44>> First of all, we wouldn't throw out
1:14:46everything. Just like I said, we have a
1:14:48strategy now to manage cancer
1:14:50effectively.
1:14:51>> Okay. So, you we're not going to get rid
1:14:53of the drugs that are making billions
1:14:55and billions of dollars. We're just
1:14:56going to use them at lower dosages in a
1:14:58different different
1:14:59>> But we also want to prevent it in the
1:15:00first place. Well, preventing it that
1:15:02comes back to our chart.
1:15:03>> I'm going to write down the manifesto.
1:15:05So, what what is what do we do to
1:15:06prevent these 71 people an hour dying of
1:15:08cancer?
1:15:09>> Well, that has to come from government
1:15:10policies.
1:15:11>> Okay. You just got promotion. You're now
1:15:12the king of the United States. So, you
1:15:13don't even need to ask anybody.
1:15:15>> What do you do to prevent the 71 people
1:15:17a day dying of cancer?
1:15:19>> It's going to be education.
1:15:20>> Education number one.
1:15:22>> Education number one.
1:15:23>> Okay.
1:15:23>> You have to let people know that those.
1:15:26And now let me tell you another thing
1:15:28that's really important.
1:15:30It should not be any government or
1:15:32government official telling anyone what
1:15:36they should or should not eat. Okay? The
1:15:39the power of this chart is um personal.
1:15:43You're embolding the patient. They have
1:15:46to know. We're not going to tell
1:15:48somebody, "Oh, if you continue to eat
1:15:51bad food, you're going to have you're at
1:15:53high risk." And that person, I don't
1:15:55care. I'll smoke cigarettes and I'm
1:15:56going to Well, the government's not
1:15:57going to come into this guy's house and
1:15:59take away the bad food. No, no, no, no.
1:16:00That should never happen. Those foods
1:16:02are there because they give us pleasure,
1:16:05but they should be the the knowledgeable
1:16:07person would be to say, I'd like to have
1:16:10it every now and then, but I can't live
1:16:12in that environment. And the other thing
1:16:13we do terribly in this country, the poor
1:16:16people in these food deserts where you
1:16:19only get crap food and and as a tragedy
1:16:23in itself there they to go to whole uh
1:16:25whole foods where they have the
1:16:27expensive ribe eyes and all this stuff
1:16:29that's much more expensive. A lot of
1:16:30people can't afford the kinds of foods
1:16:33that will put them in these better
1:16:34healthy zones.
1:16:35>> So we're going to make food healthy food
1:16:37more cost cost effective cheaper. Those
1:16:40are easy words to say, but in
1:16:42practicality it's not.
1:16:44>> Now, what kinds of foods should people
1:16:45be eating?
1:16:46>> Well, I I think they should just try to
1:16:47avoid the highly processed carbs. Okay.
1:16:49You don't listen to this. You and and
1:16:52exercise. There's a lot of things we can
1:16:55do that would mitigate the the
1:16:59inflammatory conditions put on this
1:17:00chart. The goal here is we know what
1:17:03keeps us healthy. It's the efficiency of
1:17:06that organel. We want to do everything
1:17:08possible to keep that organel healthy.
1:17:11We will reduce dementia. We will reduce
1:17:14diabetes. We will reduce obesity. And
1:17:17they say, "Well, GLP, why don't I why
1:17:19don't do and human beings are are the
1:17:21kind that I want a quick fix for
1:17:22everything?" Right?
1:17:23>> Ampeg. How about some ampeg?
1:17:25>> Is this what is this GLP?
1:17:28>> GLP1.
1:17:28>> Okay. We don't, you know, first of all,
1:17:31we haven't done any research yet to know
1:17:34where a GLP would put you on the chart.
1:17:36We do know one thing. It lowers blood
1:17:38sugar. How level how high of a level
1:17:40would it bring to ketone? Because it's
1:17:42the ketones that keep the organel
1:17:44healthy. So, I'm lowering blood sugar,
1:17:46but am I raising the ketones that
1:17:48enhance the bioenergetic efficiency of
1:17:50the organel? I don't know what number
1:17:53and hasn't been done yet. I don't I
1:17:54haven't seen any papers coming out.
1:17:56>> Okay. So, we'll keep the zen peek off
1:17:58the table, but you're saying exercise
1:17:59number three. So, I've got I've got
1:18:00education,
1:18:02kill the food deserts so people can get
1:18:04healthy food.
1:18:04>> Yeah. Um, stay away from the ultra
1:18:06processed stuff. Number three, exercise.
1:18:08We're going to give everybody free gym
1:18:09memberships and whatever else they need.
1:18:10>> Reduce stress, emotional stress. You got
1:18:12to you got to do that. And there's a lot
1:18:14of ways. Music therapy. There's a lot of
1:18:15different ways you can meditation,
1:18:17>> friends, happiness, all of those reduce
1:18:20stress. So, I had I had a guy from uh
1:18:22Korea.
1:18:24I think it was Japan or Korea. We did a
1:18:26big meeting one time and he he didn't
1:18:28tell me what to do. He says, "Um, you
1:18:30want to get cancer? If your job and if
1:18:32your goal in life is to get cancer, you
1:18:34got to eat crap food all the time, you
1:18:37have to have terrible sleep, make sure
1:18:39you never unass the couch, sit in front
1:18:41of the TV all day, look at doom
1:18:42scrolling, do all that kind of stuff.
1:18:44Make sure you never exercise, and make
1:18:47sure you don't have any friends or be
1:18:48happy. He says, [laughter]
1:18:50you're on a fast track for for not only
1:18:53cancer, but all these other chronic
1:18:55diseases. So, so that's the what I just
1:18:58said is you need to not do that.
1:19:00you're doing a great job. You know,
1:19:02there's not many people are going to be
1:19:03measuring their GKI every day, but there
1:19:06are people who love to measure that kind
1:19:07of stuff. Um, now I tell you another
1:19:10thing. So, they put these things on your
1:19:12arm, these continuous sugar monitors.
1:19:13They're making continuous glucose ketone
1:19:15monitors. So, apps are coming out now.
1:19:18Believe me, there's apps. I have my
1:19:21Lucas Lou and some others are making
1:19:22these apps in my lab. and and um you can
1:19:25take your cell phone and and photograph
1:19:29a particular food item [laughter]
1:19:32and and the food item immediate you put
1:19:35places you're put the food item on the
1:19:37chart so you'll know eating that will
1:19:39give you what zone you'll be in if you
1:19:40eat it. So um it's really interesting
1:19:43and and these things are coming. We're
1:19:44using AI to so but it's purely patient
1:19:48empowerment. Okay. The patient
1:19:50themselves, the person themselves make
1:19:53the choices. No government president or
1:19:57king or whatever you want to say should
1:19:58ever tell people what and how they
1:20:01should eat. The patients should be
1:20:03familiar with this and have the
1:20:05knowledge to know I'm going to test what
1:20:07I think. So people say to me all the
1:20:09time, "Well, just tell us what you can
1:20:12eat." That's all they say to me. Okay,
1:20:14eat whatever you want. You figure out
1:20:16where on the chart you're going to be
1:20:17and then you'll know. So people say,
1:20:19"Well, I can't eat ketogenic diet."
1:20:20Well, our our group in in Greece, now
1:20:22you tell me. They got the brain cancer
1:20:24tremendous success in keeping brain
1:20:26glyopblastoma guys alive. What was the
1:20:29diet? It was a calorierestricted
1:20:30Mediterranean diet. salmon,
1:20:33sardines,
1:20:35olive oil, avocado, and exercise. That
1:20:39is that like oh man, that that's the
1:20:41worst diet. What about the carnivore
1:20:42diet? What about the the ribeye with a
1:20:45little sauce bernese on top of it? This
1:20:47keeps your your blood sugar low and
1:20:49elevates your ketone. If you want to do
1:20:51it with plants,
1:20:53everything you got fish, plants, you get
1:20:55the vegans and all these kind of people.
1:20:58This is a bioenergetic road map to
1:21:01health.
1:21:01>> Let me just give some specific. So this
1:21:03is amazing. What about high fructose
1:21:05corn syrups and refined?
1:21:06>> Oh man, that's the worst kind of crap.
1:21:07You don't take that.
1:21:08>> What about What about industrial seed
1:21:10oils?
1:21:11>> Well, you know, people talk about seed
1:21:12oils,
1:21:13>> canola and soybeans.
1:21:14>> I DON'T KNOW. BUT every there's another
1:21:16thing too.
1:21:18You and I are different. Uh we have an
1:21:20individual metabolism.
1:21:22uh age, race, sex, all all the religion,
1:21:26all kinds of stuff determine what and
1:21:28how you live. And I can't be sure uh
1:21:32what you eat and what I eat or what you
1:21:34exercise where it's going to put put us
1:21:36on the chart.
1:21:36>> Synthetic pesticides. I was reading here
1:21:38that it's in increases the chance of
1:21:40lymphoma by a staggering 41%.
1:21:42>> They all damage the oxidative
1:21:44phosphorilation, putting the cell at
1:21:46risk for compensatory fermentation,
1:21:48disregulated cell growth. Wow. The
1:21:50problem, the problem. The field doesn't
1:21:52understand what I'm saying with respect
1:21:55to the origin of cancer, how it happens
1:21:57mechanistically, how this organel
1:22:00controls the life of the cell. They
1:22:03don't know enough about the biology and
1:22:05biochemistry of the mitochondria. You
1:22:07ought to get guys on here like Nick
1:22:08Lane, he he from England. I mean, these
1:22:10guys like Doug Wallace and some of these
1:22:13guys, they're mitochondrial biologists.
1:22:15They they they understand this kind of
1:22:17stuff. I want to give people actionable
1:22:18things that they can think about. So, um
1:22:20that's why I was asking you this
1:22:21question about you becoming king.
1:22:23Fasting protocols.
1:22:25>> Well, intermittent fasting.
1:22:27>> Let me let me talk about that just
1:22:28briefly. Do you ever try it?
1:22:30>> Yeah.
1:22:31>> What do you think? You liked it?
1:22:32>> It depends how long you're talking
1:22:34about.
1:22:34>> Okay, let's go a week.
1:22:36>> Oh, I know. I've not fasted for a week
1:22:37before.
1:22:38>> Okay. You know what is the call the
1:22:39wall? This guy, he just sent me his
1:22:40book. It's coming out. Very nice guy.
1:22:42Veral Simck. He say people share things
1:22:45with me. The wall is after about three
1:22:48days of not eating, just drinking water,
1:22:52you hit this wall and it's like, "Oh
1:22:54man, I'm just I can't deal with it
1:22:56anymore. It's just a terrible feeling in
1:22:58my body. I can't sleep at night. I got
1:23:00the Jimmy legs. I got all kinds of
1:23:01problems. Screw it. I'm not doing this."
1:23:03He found out if you sip just tiny
1:23:05amounts of a grape juice, you can get
1:23:07get through the wall. What we do for the
1:23:08cancer patients in the way we design our
1:23:11clinical procedures with my clinical
1:23:13friends, we do a zero carb diet for
1:23:16about a week uh while the body is
1:23:18readjusting getting getting bringing
1:23:20them out of the red zone getting into
1:23:21the yellow zone. You can't believe the
1:23:24power of glucose as an addictive drug on
1:23:26the brain. It's unbelievable. It's like
1:23:28cocaine. It it's it's and you know that
1:23:30when you start you start shaking and you
1:23:32go. So, but if you don't eat carbs and
1:23:34just eat meat or whatever to keep you in
1:23:36a low GKI, um then when you jump off to
1:23:40the water only fasting, it's much less
1:23:42traumatic to the brain. You've gone
1:23:43through the wall of the gate, so to
1:23:44speak. So, once you know how to get
1:23:46through the gate, you make this whole
1:23:48process a lot a lot easier. And that
1:23:50helps people enormously, especially
1:23:53those people that want to get rid of
1:23:55their chronic disease. Okay? Because or
1:23:57some, you know, we have a lot of people
1:23:59out there that just like to do all this
1:24:00stuff. You know, you got these these
1:24:02people that go overboard on everything.
1:24:03But, you know, right now we have an
1:24:06obesity, chronic epid cancer epidemic.
1:24:09All of these epidemics are the result of
1:24:11an abuse of that organel in one way or
1:24:13another. And we have a pl a plan to
1:24:16mitigate that abuse and at least people
1:24:18have an at least they're empowered to do
1:24:20it with the help of knowledgeable
1:24:22physicians.
1:24:23>> I want to just keep on this point of
1:24:24actionable feedback. So, um Dr. Valter
1:24:26Longos Dr. His extensive research
1:24:28clinical trials prove that fasting
1:24:30mimicking diets drastically lower IGF-1
1:24:34which triggers cellular autophagy and
1:24:36actually makes standard cancer therapies
1:24:37up to three times more effective by
1:24:39removing the metabolic shield of cancer
1:24:42cells.
1:24:42>> Yeah. Which is the gluc the waste
1:24:44[clears throat] products of of of gluc
1:24:45which is the lactic acid and the suxenic
1:24:47acid that all goes down.
1:24:49>> Would you recommend again if you're king
1:24:51would you recommend that
1:24:52>> I would never recommend any I have to
1:24:54just give them the knowledge. Then the
1:24:55person has to make the decision
1:24:57themselves.
1:24:57>> Do you think it could be beneficial?
1:24:59>> Of course,
1:24:59>> if you were king to um have everybody
1:25:02wear a CGM, one of those continuous
1:25:05glucose monitors, at least once.
1:25:06>> No.
1:25:07>> Never.
1:25:08>> No. I I think if you have cancer and you
1:25:11really want to stay in this green zone
1:25:12to know, right? Listen, I was down in
1:25:15Mexico not long ago. I was talking to
1:25:16one of the head physicians down there.
1:25:18He wore one of these things, right?
1:25:20>> He said, "Every time I wanted to go out
1:25:22and have a party, have a good time, this
1:25:23damn thing would be beeping." So what do
1:25:25you ripped it off and threw it in the
1:25:26trash? So [laughter] that you don't want
1:25:29somebody barking in your ear when you're
1:25:31having a good time. That's why what
1:25:32you're doing right now with this, you're
1:25:34choosing to prick your finger.
1:25:37>> You're the one making that decision.
1:25:38There's not something on your arm
1:25:40saying, "Stephen, don't do that. Don't
1:25:41do that."
1:25:42>> But you know what? It was useful to wear
1:25:43it once or twice because it even I could
1:25:46I suddenly realized that things I put in
1:25:48my mouth
1:25:49>> had an impact on my blood sugar and my
1:25:51blood which [clears throat] and also I
1:25:53realized that it had an impact in 10
1:25:54minutes.
1:25:55>> Yeah.
1:25:55>> And I thought and then and then also
1:25:57when my blood sugar came back down and
1:25:58crashed
1:25:59>> I thought oh gosh I feel
1:26:01>> I could suddenly pair my behavior to my
1:26:04feelings.
1:26:04>> Yes. Well, that that now I'm not I I no
1:26:08I I' I've seen that. And not only that,
1:26:10uh Andrew Scarboro from England who who
1:26:12has been doing this for for the stage
1:26:14three go uh he's like 15 years out. He's
1:26:18done this so many times with the finger
1:26:20prick and all this. He knows now already
1:26:22when his body is in these zones from the
1:26:24feeling that you just described. But for
1:26:27the people at the beginning and who are
1:26:29given a terminal diagnosis, they want to
1:26:31get into these green zones and they want
1:26:33to use the things that are going to keep
1:26:34them alive on the planet for a longer
1:26:36period of time with a higher quality of
1:26:38life. That is important. That thing on
1:26:41your arm can help you stay in that zone
1:26:44until you have this thing managed at
1:26:46which time you can choose when to do
1:26:48that. So there's flexibility in this
1:26:50whole process. It's not one like for
1:26:52example we have the standard of care
1:26:54which is written in granite for crying
1:26:56out loud. They get all they they if you
1:26:58do anything different from the standard
1:26:59of care you could lose your license as a
1:27:01physician. Metabolic therapy is is
1:27:04patient driven. It's driven on the
1:27:06patient.
1:27:06>> What about hyperbaric oxygen? Yeah.
1:27:08There was a study in 2013 that
1:27:11demonstrated that while the ketogenic
1:27:12diet alone significantly slowed tumor
1:27:14growth in systemic metastic cancer mouse
1:27:16models, combining the diet with
1:27:18hyperbaric oxygen therapy elicited a
1:27:20profound synergetic decrease in tumor
1:27:23growth and drastically increase survival
1:27:24times.
1:27:25>> Yeah, we published that paper with
1:27:26Dominic D. Augustino. So we we put my So
1:27:29uh listen, hyperbaric oxygen will create
1:27:32oxidative stress in cells that do not
1:27:35have efficient oxidative
1:27:36phosphorilation. uh cancer cells.
1:27:38>> Cancer cells. So you can kill cancer
1:27:40cells by oxidative stress by irdiating
1:27:42or poisoning them or you can put a
1:27:44patient in in nutritional ketosis and
1:27:47then put them in hyperbaric oxygen and
1:27:49the cancer cells are selectively killed.
1:27:52When you irdiate somebody, you're
1:27:54damaging the whole body with all kinds
1:27:55of stuff. And there's another thing,
1:27:57Stephen, you got to listen to this and
1:27:58you listen carefully. when you go to
1:28:00these treat these standard of care
1:28:04>> standard when you use standard of care
1:28:05radiation chemo whatever they give
1:28:07imunotherapies or whatever so the
1:28:09patient comes in and he says I've been
1:28:10really working hard on this the doctor
1:28:12says oh no that doesn't work right gives
1:28:14you some radiation or gives you
1:28:16[laughter] flying up into the red zone
1:28:18the treatment itself puts so much stress
1:28:20on the body that the body itself starts
1:28:23going you go into the red zone from the
1:28:24very treatments that you're giving to
1:28:26the patient which is making
1:28:28strengthening the tumor else.
1:28:30>> You're not against chemotherapy, though.
1:28:31Are you?
1:28:32>> No. I'm I'm I'm positive about it, but
1:28:34it has to be used in the right context.
1:28:38>> It has to be used when your body is in
1:28:40this state of nutrition. And you can use
1:28:42low doses so you don't force the tumor
1:28:45cell to become even more resistant to
1:28:47the treatment.
1:28:49>> The next thing which is actionable is
1:28:51what you talked about earlier, which is
1:28:52these microplastics and forever
1:28:54chemicals. In late 2023, the
1:28:55International Agency of Research on
1:28:56Cancer officially upgraded these forever
1:28:59chemicals which are used in non-stick
1:29:00pans and food packaging to a grade one
1:29:03carcinogen
1:29:05>> in humans, cancer causing in humans
1:29:07based on strong mechanistic evidence
1:29:08that it induces epigenetic which is gene
1:29:12alterations and suppresses the immune
1:29:14system. So you ban the forever
1:29:15chemicals.
1:29:16>> Okay, this is a beautiful paper. I went
1:29:19back and I took what all of Otto Werberg
1:29:21meticulously went through all of his
1:29:23work showed where he was absolutely
1:29:25correct and where he just didn't have
1:29:26the the new information that would make
1:29:28him I talked about the forever chemicals
1:29:30microplastics guess what they damage the
1:29:34organel they get into they break they
1:29:36cause rosin damage they it reduce the
1:29:39efficiency of oxidative phosphorilation
1:29:42causing a compensatory increase in the
1:29:46utilization of glucose and glutamine and
1:29:47disregul related cell growth. Everything
1:29:49comes back to this organel. Chron all
1:29:52chronic diseases and cancer are the
1:29:53result of damage to this organel. That's
1:29:56why having this little thing here is so
1:29:58important. It's a great prop. I got to
1:30:01get one for my class.
1:30:02>> You can keep it. Um the next thing is
1:30:05purifying the water supply. Um heavy
1:30:07metals are found in local water supplies
1:30:09to run off and ultimately are
1:30:11carcinogenic in some cases. The IARC
1:30:15classifies arsenic and cacadium as group
1:30:18one on carctogenics and they're
1:30:20frequently found in unfiltered public
1:30:22water infrastructure. So you clean out
1:30:25the water supply as well.
1:30:26>> Yeah.
1:30:27>> You know all this stuff is coming into
1:30:29our water supplies. People flushing down
1:30:31all these chemicals into the into the
1:30:33which then leech back into the water
1:30:35supply. And every one of the chemicals
1:30:37that we have looked at that has been
1:30:38linked to oncology or disregulated cell
1:30:41growth all damage the oxidative
1:30:43phosphorilation chronically. So we're
1:30:45bringing the entire focus back to things
1:30:49what can I do to keep this organel
1:30:52healthy uh even if I'm exposed to these
1:30:55chemicals if I can do get into these
1:30:58zones like you're trying to do. So even
1:31:00if you are exposed to these, this
1:31:02organel has an incredible healing power
1:31:04in itself.
1:31:06>> What is the most important thing we
1:31:07haven't talked about that we should have
1:31:08talked about, Professor Thomas?
1:31:09>> Well, I mean, you've covered a lot. One
1:31:11of the things I I want to talk about uh
1:31:13is metastasis.
1:31:14>> What's that?
1:31:15>> That's the spread of the tumor
1:31:16throughout the body.
1:31:18>> Okay. So if you were to have a cancer
1:31:20that's just localized in one spot,
1:31:23>> you know, the probability of developing
1:31:25a therapy that would be um long term is
1:31:29highly increased. The problem that kills
1:31:32people is the spread. So if the tumor is
1:31:35in the breast and it spreads to the
1:31:36liver and the lungs and the brain, you
1:31:38know, you've got a problem. Lung cancer
1:31:40spreads to the brain, the liver. Most of
1:31:42these cancers that spread to the brain
1:31:44or other organs become difficult and
1:31:47that's why you use systemic chemotherapy
1:31:49you're trying to stop. What we have
1:31:51found is that you have a a stem cell
1:31:55people love stem cells. If you ever hear
1:31:57the term stem cell tumor wow stem cell
1:31:59tumor stem cell tumors cannot
1:32:01metastasize how do I know because I have
1:32:03stem cell tumors diagnosed as stem cell
1:32:06tumors with stem cell markers. I've
1:32:07grown them. They grow very angry. They
1:32:09get a lot of blood vessels, but they
1:32:11can't spread. Okay, how do you get
1:32:14spreading tumor cells in your body? The
1:32:16immune system comes in, recognizes that
1:32:19as an unhealed wound, and then fuses
1:32:21with the stem cells, and then you have
1:32:23these hybrid cells. They are programmed
1:32:26to move around your body. So, they are a
1:32:29macroofagage tumor cell hybrid. So, and
1:32:33they're very hard to kill, but we found
1:32:35they're remarkably sensitive. They're
1:32:37glutamine driven. So we know they're
1:32:40glutamine driven and they need the
1:32:42glucose and that why that's why
1:32:44metabolic therapy done the right way can
1:32:47nail nail those metastatic cancer cells
1:32:50purging them with a little little bit of
1:32:52imunotherapy to go along with it. You
1:32:54might be able to to get what we call
1:32:56resolution. Don't forget my colleagues
1:32:58and I do Diagto Joe Maroon we built the
1:33:01press pulse therapeutic strategy. I
1:33:03mentioned that on your previous show.
1:33:05That's the way you you you press down
1:33:08the glucose of the tumor and then you
1:33:10pulse to kill the glutamine which will
1:33:11which will target the metastatic cancer
1:33:13cells enhancing the health and vitality
1:33:16of the organs already infiltrated by the
1:33:18tumor.
1:33:18>> I looked on our previous conversation
1:33:20doc professor Thomas and um it's quite
1:33:24heartbreaking because the comments
1:33:25sections are all people that are e
1:33:27either struggling themselves with cancer
1:33:29or a loved one of theirs their wife
1:33:31their husband has just been diagnosed
1:33:33with cancer. Is there anything for those
1:33:36people that have clicked on this video
1:33:37because I imagine they are in the
1:33:38millions.
1:33:39>> Yeah.
1:33:40>> That you want them to hear.
1:33:41>> Well, the thing of it is is why Well,
1:33:44this is a bigger issue. When you have
1:33:46the science and you have the strategy to
1:33:48manage cancer effectively with minimal
1:33:51toxicity, not to say we can cure, but to
1:33:53say we can manage it. Why is it not
1:33:56being done?
1:33:57That's the question. But to them to them
1:34:00who've tuned in.
1:34:01>> Okay. So these kinds of conversations
1:34:04that we have are allowing the
1:34:07populations to realize that there is
1:34:11their loved ones do not need to be
1:34:14sacrificed
1:34:16for the good of industries that are
1:34:19generally considered profitable. They in
1:34:22other words the profitability of the
1:34:24industries are based on your sickness.
1:34:28Uh and and a lot of those comments came,
1:34:30oh, you can't you can't do anything.
1:34:31Yes, you can do something about it. When
1:34:33you're armed with the knowledge and
1:34:36people ignore the knowledge, then
1:34:37there's a problem.
1:34:38>> Do people need to sort of self advocate
1:34:40to some degree?
1:34:41>> I think so.
1:34:42>> With with uh care providers, what do
1:34:44they
1:34:45>> Yeah. I I think that's a very delicate
1:34:47question.
1:34:47>> Yeah.
1:34:48>> That the oncologists never heard of this
1:34:49stuff.
1:34:50>> They have never read these papers. They
1:34:52were never trained in medical school to
1:34:54know the biology and biochemistry of
1:34:56cancer. It was told to be a genetic
1:34:58disease. Theories are so important in
1:35:01science. For 1,800 years, people thought
1:35:05the work of Aristotle, his comments and
1:35:07the mathematics of Claudius Talami said
1:35:10that the earth was the center of the
1:35:12solar system and all the planets uh and
1:35:16sun revolved around the earth. The
1:35:18geocentric theory, right? Capernicus
1:35:21struggled with the talami mathematics
1:35:23and realized that if he put the the sun
1:35:26in the center of the solar system and
1:35:28made earth just another planet, a lot of
1:35:30the mathematics made sense. Kepler comes
1:35:32in and says these aren't circles,
1:35:34they're ellipticals. Galileo takes the
1:35:36telescope, sees the moon's interpreter
1:35:37and was able to look at and quantify
1:35:40where where predict where planets would
1:35:42be at a certain period of time. Then
1:35:44they took poor Gillodono Bruno. You know
1:35:47about this guy Bruno? Oh, there Steven.
1:35:49You got to know Bruno. Your job is to
1:35:50know about the poor Bruno who was burned
1:35:52alive by the Catholic Church for
1:35:54challenging the the the geocentric
1:35:57theory. And he became a martyr of
1:35:59science. So when you have established
1:36:01power structure, whether it's a religion
1:36:04or whether it's an industry or whatever,
1:36:06challenging that can be very very
1:36:07hazardous.
1:36:08>> Has it been hazardous for you?
1:36:10>> Listen, no. I mean, I do what I do
1:36:13because I like I just collect more and
1:36:15more data to support. Hazardous for me
1:36:17would be getting blindsided. Blindsided
1:36:19would be somebody coming at me with a
1:36:21piece of new data that I have never
1:36:23considered. I don't sleep. I I think
1:36:25about this stuff all the time to avoid
1:36:26the blind side. My students are on the
1:36:29on the alert for any paper that comes
1:36:31out that says cancer oh cancer cells can
1:36:33burn fatty acids and ketone bodies. Oh,
1:36:35really? Let's go back through and
1:36:38dissect out their control experiments
1:36:40and you find in every case there was
1:36:41always some glucose and glutamine in the
1:36:43media making it look like the fatty
1:36:44acids. So, so that's what bothers me.
1:36:47What bothers me is getting hit with a
1:36:49piece of data that undermines what we're
1:36:52what we our knowledge base is. And so
1:36:54far we haven't had that. Okay, it's
1:36:56we're standing on the shoulders of Otto
1:36:58Warberg, a giant in the field of
1:37:00biochemistry. He was thrown under the
1:37:02bus when everybody thought cancer was a
1:37:03genetic disease. My this paper goes back
1:37:06and shows exactly where Warberg made his
1:37:08mistakes and where we have rectified
1:37:10some of that. Bringing the whole field
1:37:11back on where it should be. It is a
1:37:14mitochondrial metabolic disorder and we
1:37:17can account for all of the phenotypes
1:37:18and characteristics of that disease
1:37:20knowing that now with that knowledge
1:37:23logical people and people interested in
1:37:25helping others will will uh take
1:37:28advantage of that. We're not throwing
1:37:30out all these toxic chemicals. We're
1:37:32learning how to use them in a different
1:37:33way and that's where the success is
1:37:35going to come. So let's con let's
1:37:37conclude with a a actionable takeaway
1:37:40for people who are suffering themselves
1:37:41with with cancers um or have someone in
1:37:44their family right now that is suffering
1:37:46from cancers. What is the actionable
1:37:48takeway?
1:37:49>> Well, I think the action will take once
1:37:50this paper comes out they can start
1:37:52taking action if they are motivated
1:37:53enough.
1:37:54>> They can read about this. they can read
1:37:56about it and then try to like just like
1:37:58you're doing no different
1:37:59>> get into these zones and then work with
1:38:03their oncologists, knowledgeable people
1:38:05to to to treat them with standards of
1:38:08care. Yeah. As long as they can remain
1:38:10and then we do non-invasive imaging, PET
1:38:13scans, see MRIs.
1:38:14>> Okay. So, specifically what what you're
1:38:16saying is this paper, I will link it
1:38:18below in the comment section for anyone
1:38:19that wants to read it. This graph will
1:38:21be on the screen throughout this episode
1:38:22anyway, so people can screenshot it if
1:38:23they want to have a look. And the way
1:38:25that they test whe what what their GKI
1:38:28index is is they can buy one of these
1:38:30Keto Mojo things which you can get on
1:38:32Amazon for $ 20 $30.
1:38:33>> You prick your finger. It gives you the
1:38:36glucose reading. Yeah.
1:38:37>> You divide it by 18.
1:38:38>> No, no. The new machines have the
1:38:40button. You So even the people only have
1:38:42to do that.
1:38:42>> Okay. Fine. And as you can see on here,
1:38:44this is an interesting way to sort of
1:38:48increase your your management improve
1:38:51your management of of some of these.
1:38:53>> Yeah. And then there's a challenge
1:38:55to get into those zones. Um, you know,
1:38:58I'm not saying this is easy stuff.
1:39:01GLP1 inhibitor, man, that's a hell of a
1:39:03lot easier than than than doing this.
1:39:06>> And I should probably say always consult
1:39:08with a medical professional.
1:39:09>> Yeah. Um, I I think uh because you know,
1:39:12a lot of people they have a lot of
1:39:14coorbidities. They have diabetes, high
1:39:17blood pressure, hypertension, cancer.
1:39:19They have a it's not a perfectly healthy
1:39:21person with cancer.
1:39:22>> Mhm. So before you go in to challenge
1:39:25that, you need to have what you look
1:39:26like you you might look, you know, you
1:39:28might have to be adjusted in some way.
1:39:30That's why the people who the physicians
1:39:32that are working with this can do all
1:39:34that. I I'm I'm not in the clinical
1:39:35thing.
1:39:36>> And there are some people who respond
1:39:37poorly to the ketogenic diet is high
1:39:40states of ketosis because I've I've
1:39:41received DMs before from a woman who
1:39:44said, "My my husband did ketosis and he
1:39:46collapsed unconscious. He took him to
1:39:47the hospital. He had some coorbidity."
1:39:49>> Yeah. Yeah. Yeah. Oh, the other thing
1:39:50too is you got to be some people have
1:39:52carnitine deficiencies. Carnitine
1:39:54prevents fatty acids from being made
1:39:55into ketone bodies.
1:39:57>> So, so, so they can be carnitine
1:39:59supplementation can help them, but you
1:40:01need a physician to know this.
1:40:04>> We have a closing tradition where the
1:40:05last leader question for the next and a
1:40:07question left for you is on the subject
1:40:08of energy. What in your life has brought
1:40:10you the most energy and what was the
1:40:14biggest energy drain you've ever
1:40:16experienced? Well, this is bringing me
1:40:18the biggest energy. This [laughter]
1:40:21>> well not this the whole concept. The
1:40:23idea that you have found
1:40:27uh mother nature has allowed you to look
1:40:30into the depths of of of what we
1:40:33consider the biology and biochemistry of
1:40:36how bodies work. and knowing how to take
1:40:39that and apply it to people that are
1:40:41suffering from all these different
1:40:43chronic diseases and giving them the
1:40:45opportunity to change that because
1:40:48before that it was mysterious. Oh, I'm
1:40:51do I'm in keto. What's your GK? I I
1:40:54don't know. Well, now you have a
1:40:56quantitative opportunity that gets us.
1:40:58So, we have a lot of evidence. I think
1:41:00people should be feel encouraged. I
1:41:03think we have given hope to the hopeless
1:41:06and and I think that's empowering and
1:41:08the goal here is not to make a billion
1:41:11dollars. It's just to know that you've
1:41:12kept all these poor souls alive longer
1:41:14than they were projected to be to be.
1:41:16And I think this power and that keeps us
1:41:18going because when we see more and more
1:41:20people coming to me, I get emails back
1:41:22from people three or four years ago and
1:41:23I said, "Gee, I thought you were a
1:41:24goner." And he says, "I'm doing really
1:41:26well. Just came back from a vacation
1:41:28with my wife." Well, that's empowering.
1:41:30I said, "Well, that's good. And don't
1:41:31forget, Stephen, all of our research
1:41:34money comes from private foundations and
1:41:35philanthropy.
1:41:37>> So,
1:41:37>> so is that a way that people can help?
1:41:39>> Yeah.
1:41:39>> And where do they go to help?
1:41:40>> Oh, Travis Kristopherson's foundation.
1:41:43So, we in my papers that we have the
1:41:46foundations that support our work,
1:41:48private foundations. So, I'll link
1:41:49>> and there are occasionally, yes, please
1:41:51link. There are occasionally people I
1:41:53know and I when I give kits of
1:41:55information to people uh I say please
1:41:58consider making a donation only if it
1:42:00works for you. Yeah. Don't charge them
1:42:02anything or ask them to pay something if
1:42:05it's not going to help them. If you were
1:42:07told to be dead in 6 months and six
1:42:10years later you're alive. Maybe you
1:42:11throw us a few shekels into the private
1:42:13found into the foundation supporting our
1:42:15work.
1:42:15>> I'll link that foundation below in the
1:42:17comments section. Yeah, we have a couple
1:42:18on breast cancer on on on general
1:42:20general uh um support on the metabolic
1:42:23approach that we have. So, we have a lot
1:42:25going. We're very excited. You can see
1:42:27all the papers we've published. Uh and
1:42:29it's not like um uh some of these are in
1:42:32top journals, some of them are in new
1:42:34journals, but but the issue is we're
1:42:36we're we're we're
1:42:38publishing this.
1:42:39>> My thing is, you know, I great great
1:42:41great respect for science and doctors in
1:42:43the medical profession. Go go go get
1:42:44your information. Speak to your medical
1:42:46provider. There's so many tools out
1:42:47there now. Go and check for yourself.
1:42:48>> Yeah. Well, I think in the oncology
1:42:50field, that's where we have this vast
1:42:51wasteland of misinformation or
1:42:53misunderstanding, let's put it that way.
1:42:55They don't understand these concepts
1:42:57where, you know, people who have done
1:42:59heart work and bone work and
1:43:00replacements, those people are at the
1:43:01state-of-the-art with this kind of
1:43:03stuff.
1:43:03>> Well, the last conversation we had, it's
1:43:04reached about 15 million people. So, on
1:43:06YouTube, it's got 10 million views and
1:43:08then across audio platforms, it's got
1:43:09another five or so million views. Yeah.
1:43:22>> practitioner about, but also it actually
1:43:25just creates a community of people in
1:43:26the comment section where, you know,
1:43:28this is a community of people that are
1:43:29searching for hope.
1:43:30>> Yeah.
1:43:31>> And as some of them read through the
1:43:32comment sections, they actually
1:43:33commented saying, "It was so nice to to
1:43:35speak to other people in the comment
1:43:36sections about what I'm going through
1:43:38and how it feels from an emotional
1:43:39level." So, this is something I actually
1:43:41wanted to say in this episode was if
1:43:42you're if you're listening to this
1:43:44conversation now and you've gotten to
1:43:45this point, do feel free to go into the
1:43:47comment section and just offer some
1:43:49support and some love to other people um
1:43:52who are struggling because you know it
1:43:54can be a very lonely experience the
1:43:56minute you find out you've got a
1:43:57diagnosis and off you go into the
1:43:58internet into podcasts into AI to try
1:44:00and figure out what you can do. So,
1:44:02yeah, do share things that have helped
1:44:03you point at different resources that
1:44:05are rigorous and offer emotional support
1:44:07to those that are in the comments
1:44:08section. and that would be a wonderful
1:44:09thing. Thomas, thank you so much for all
1:44:12that you do. Um, you're you're an
1:44:14absolute worrier for pushing science,
1:44:16the science into the world and for
1:44:19fighting for these people that don't
1:44:20have the tools. And if you I mean, I
1:44:22don't think I've ever seen a comment
1:44:23section quite like it in terms of the
1:44:25gratitude that people have for the work
1:44:26that you're doing. It is remarkable
1:44:28work. Long may you continue to do it.
1:44:29>> Well, thank you very much. and you you
1:44:31know you play a very important part on
1:44:32this because this information is not
1:44:34disseminated to the the population and
1:44:37it's the population of people that will
1:44:39eventually make the change. So they're
1:44:41going to want this especially when we
1:44:42keep publishing more and more case
1:44:44reports of successful cases and the ch
1:44:48the system will change and we just have
1:44:50to modify what we have to make it better
1:44:51and I think that's what keeps us going.
1:44:53So I have no plans of stopping this
1:44:55anytime soon. My students are all
1:44:57excited about this. they they're
1:44:58learning about it at Boston College. So,
1:45:01this is a big emphasis that we have and
1:45:03we continue to do it. Again, scientific
1:45:05literacy is so important uh for uh how
1:45:09you um navigate through life and um
1:45:13thank you very much for your show and
1:45:14we'll we'll keep uh pushing this as as
1:45:17hard as we can.
1:45:18>> Thank you. YouTube have this new crazy
1:45:20algorithm where they know exactly what
1:45:22video you would like to watch next based
1:45:24on AI and all of your viewing behavior.
1:45:26And the algorithm says that this video
1:45:29is the perfect video for you. It's
1:45:31different for everybody looking right
1:45:32now.

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