Avoid Metformin For Longevity - Critical Side Effects! — Transcript

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1. 0:00if you are a non-diabetic who is taking
2. 0:02metformin for longevity purposes I
3. 0:04highly recommend you stop immediately
4. 0:06hear me out and at the end of the video
5. 0:07I'll share with you what to do instead
6. 0:09metformin initially held great promise
7. 0:12as a way to extend lifespan we had my
8. 0:14starter published in 2008 showing a 37.8
9. 0:17increase in lifespan and in 2014 we had
10. 0:21an observational human study showing
11. 0:22that diabetics who were taking metformin
12. 0:24appeared to live 15 longer compared to
13. 0:27non-diabetics since that initial promise
14. 0:29though data has steadily trickled in
15. 0:31suggesting that metformin for
16. 0:33non-diabetics probably won't extend
17. 0:35lifespan and actually we've got very
18. 0:37good evidence now that it likely causes
19. 0:39harm so let's go through everything step
20. 0:42by step and then I'll share what to do
21. 0:43instead starting with the 2008 paper
22. 0:46showing a 37.8 increase in mice lifespan
23. 0:49now these mice were shr mice and that
24. 0:52stands for spontaneously hypertensive
25. 0:54rats so these rats are genetically
26. 0:56inbred and they develop high blood
27. 0:58pressure so yes for genetically inbred
28. 1:00mice who develop high blood pressure
29. 1:02metformin is probably a great option but
30. 1:04in 2016 the interventions testing
31. 1:07program trialled normal mice in three
32. 1:09separate Labs at the same time and
33. 1:11Metformin did not extend lifespan so the
34. 1:14pre-clinical my starter it doesn't
35. 1:16really support the idea that metformin
36. 1:18will extend lifespan okay but what about
37. 1:20the human research well taking a closer
38. 1:23look at that 2014 paper showing that
39. 1:25diabetics who were taking metformin
40. 1:26lived 15 percent longer this study is
41. 1:29what's called an observational study
42. 1:31it's looking in the rear view mirror
43. 1:33this means that there's a lot of other
44. 1:34factors that can skew the results but in
45. 1:37October 2021 a prospective
46. 1:39Interventional study was published so
47. 1:41this is a study that actively made a
48. 1:43change and therefore is higher up on the
49. 1:45evidence pyramid compared to that 2014
50. 1:48observational study the new study was
51. 1:50part of the diabetes prevention program
52. 1:52and it examined over 3 000 patients at
53. 1:55high risk for type 2 diabetes so these
54. 1:57were non-diabetics but they were
55. 1:59overweight and had High fasting blood
56. 2:01sugar levels half of them received
57. 2:03metformin and the other half Placebo and
58. 2:05over the 21-year follow-up period there
59. 2:07was no significant differences in death
60. 2:09rates cancer or heart disease so if
61. 2:12metformin didn't provide any benefits
62. 2:14for these high-risk individuals it's
63. 2:16highly unlikely that metformin would
64. 2:18provide any benefits for low-risk people
65. 2:20overall then there's no clear benefit in
66. 2:23either the my starter or the human data
67. 2:25now I want to be clear not a day goes by
68. 2:27at the clinic where I don't prescribe
69. 2:29metformin for my pre-diabetic and type 2
70. 2:31diabetic patients they absolutely should
71. 2:34be on Metformin what I'm talking about
72. 2:35here in this video is non-diabetics
73. 2:38taking metformin for longevity purposes
74. 2:40but you might be asking so what even if
75. 2:43there isn't a clear benefit for
76. 2:44non-diabetics to take Metformin what's
77. 2:47the harm well this significant harm
78. 2:49actually but before we get into that if
79. 2:51you do want to accelerate your longevity
80. 2:53journey and support the channel consider
81. 2:55signing up to my patreon page where all
82. 2:57members get early access to my videos
83. 2:58access to my my five years younger
84. 3:01online program that goes through the
85. 3:02optimal diet exercise sleep and skin
86. 3:05care routine taken directly from the
87. 3:07latest clinical guidelines plus from the
88. 3:09PowerHouse support level and above you
89. 3:11get access to the Discord server where
90. 3:13you can connect with me and other
91. 3:14members where we share the latest
92. 3:16longevity research and answer questions
93. 3:18proceeds go towards funding the
94. 3:20rapamycin clinical study in 2019 a human
95. 3:23study was published examining older
96. 3:25adults at risk for developing type 2
97. 3:27diabetes and they wanted to see what
98. 3:29effect metformin would have on exercise
99. 3:31performance over a 12-week period both
100. 3:34groups performed aerobic exercise
101. 3:35training and half of them took Placebo
102. 3:38and the other half metformin but in the
103. 3:40metformin group their VO2 max which is a
104. 3:43measure of Fitness only went up by half
105. 3:45compared to Placebo meaning that
106. 3:47metformin significantly blunted the
107. 3:49positive effects of exercise these
108. 3:51findings were confirmed by a second
109. 3:53study published in June 2022 showing
110. 3:55that once again metformin reduced the
111. 3:58VO2 max Improvement by half we've also
112. 4:01got very good human research showing
113. 4:03that metformin lowers testosterone
114. 4:04levels in conclusion then the mice and
115. 4:07human data don't show a clear benefit
116. 4:09for non-diabetics instead we've got very
117. 4:11good research showing that metformin
118. 4:13blunts the positive effects of exercise
119. 4:15and lowers testosterone levels at the
120. 4:18end of the day though it's your health
121. 4:19your decision I just think it's
122. 4:21important that you're aware of this
123. 4:23research followers of this channel will
124. 4:25know that I used to take Metformin when
125. 4:27I was initially sucked into the hype I
126. 4:29made the decision to stop about one year
127. 4:31ago and removed all of the videos that
128. 4:33promoted metformin's use so you want to
129. 4:35know what to do instead focus on diet
130. 4:38exercise sleep socializing meditation
131. 4:41and the occasional supplements such as
132. 4:43creatine all of which I go through in
133. 4:45this next video here a massive thank you
134. 4:47to do notage.org for the ten thousand
135. 4:49dollar donation to my rapamycin study
136. 4:52they are a health research organization
137. 4:53and to benefit from the ingredients as
138. 4:55well as the 10 discount code check out
139. 4:58the pinned comment