AnatomyUrinary — Transcript
Full transcript
- 0:01hello and welcome let's start talking
- 0:06today let's start talking today about
- 0:12the urinary system now when we talk
- 0:16urinary system the urinary system we'll
- 0:18see is going to be made up of a few
- 0:20different organs here we can see those
- 0:23few different organs being depicted and
- 0:25being depicted in relation to you can
- 0:29see a whole bunch of other organs and
- 0:31structures there as well
- 0:33so here we have a good view and here we
- 0:36also have a very good view also so what
- 0:39we'll do first is we'll go through the
- 0:40different components here and then we'll
- 0:42relate everything to the other
- 0:44structures there as well
- 0:45so we talk urinary system urinary system
- 0:47is made up of you can see your kidneys
- 0:50your two kidneys your urinary bladder
- 0:57do you readers that are found in between
- 1:01the kidneys and the urinary bladder your
- 1:06your readers and your urethra so you've
- 1:11got kidneys two kidneys to your readers
- 1:17leading to one bladder the urinary
- 1:20bladder hoping to basically flow this
- 1:27move this urine forward to then do you
- 1:30read the row which will then we'll see
- 1:32expelled a urine for the body so kidneys
- 1:35your readers bladder and urethra kidneys
- 1:42ureter bladder you may have heard of
- 1:43that with the x-ray KUB kidneys ureter
- 1:46bladder and that's usually what they're
- 1:48looking at in this abdominal kind of
- 1:51pelvic x-ray that don't do there so here
- 1:54now these are the organs again of the
- 1:56urinary system now when we go through we
- 1:57talk you're in a system what we're gonna
- 1:59do is we'll focus on the structures one
- 2:02by one so we'll start off with the
- 2:03kidneys let's start with the kidneys we
- 2:05talked about the kidneys first let's
- 2:06talk function of the kidneys kidneys
- 2:07we'll see you have a few functions okay
- 2:09and we'll go to we'll check those out
- 2:11and here we could see
- 2:13now these kidneys the ureters the
- 2:18bladder and the urethra from an atom an
- 2:22anterior view and here you can see also
- 2:24the suprarenal glands above them okay we
- 2:27would have then the liver up in here
- 2:30right and here you can see the blood
- 2:33vessels we're gonna go to those major
- 2:34blood vessels we've got the abdominal
- 2:36aorta the inferior vena cava and then
- 2:38here we can see some muscles right we've
- 2:40gone to the iliacus and the psoas major
- 2:42muscles here the iliopsoas muscles and
- 2:46here you can appreciate then basically
- 2:49how the bladder is found in that pelvis
- 2:52so from this posterior view now you can
- 2:54appreciate how the kidneys are gonna be
- 2:56found in that I mean basically this
- 2:58lumbar region we're gonna go through
- 3:00we're gonna check out the lower thoracic
- 3:02lumbar and higher lumbar region and then
- 3:04here you can see the bladder and how
- 3:07it's found in the pelvis so two kidneys
- 3:12two you readers bladder and a urethra so
- 3:15I told you kidneys gonna have several
- 3:16functions first function we're gonna go
- 3:18through we're gonna talk about we're
- 3:19gonna check out is urine formation urine
- 3:22formation your information
- 3:25urine your information urine formation
- 3:33is going to occur when the kidneys
- 3:37filter fluid from the blood when the
- 3:42kidneys filter fluid from the blood this
- 3:47is gonna allow them to remove toxins
- 3:51metabolic wastes and even excess ions
- 3:56and this will allow these wastes the
- 4:02metabolic toxins the waste the excess
- 4:06ions to leave the body as urine while
- 4:12the kidneys return needed substances
- 4:15back to the blood so they're going to
- 4:19filter fluid from the blood and this
- 4:21will allow these components to be
- 4:24removed while returning
- 4:27needed substances back to the blood so
- 4:31filter blood plasma and excrete waste we
- 4:33can see there regulate blood volume and
- 4:38blood pressure we've talked about how
- 4:41that happens you should be able to
- 4:43explain that regulate osmolarity we've
- 4:47talked a little bit about that regulate
- 4:50electrolyte and acid-base balance
- 4:53secrete erythropoietin for red blood
- 4:56cell production we've seen that help
- 4:59synthesize vitamin D right we've talked
- 5:01about this along with this there's two
- 5:03other systems that are gonna be involved
- 5:05there as well helps to clear hormones
- 5:09and drugs
- 5:09so basically detoxifying free radicals
- 5:12also and then help support blood glucose
- 5:16levels during starvation so
- 5:19gluconeogenesis producing hormones right
- 5:24erythropoietin green in metabolized
- 5:29vitamin d to its active form right so
- 5:31all these basic functions you've got
- 5:33here now where are these kidneys found
- 5:38you can see they're found located lying
- 5:42in a retroperitoneal position between
- 5:48the dorsal body wall and the parietal
- 5:53peritoneum they're found in the superior
- 5:59lumbar region extending approximately
- 6:04from t12 down to l3 extending
- 6:10approximately from t12 down to l3 you
- 6:14can see the right kidney is slightly
- 6:17lower compared to the left the right
- 6:21kidney is slightly lowered compared to
- 6:25the left and that's going to be because
- 6:26we have our liver found here on the
- 6:31right side that will be occupying a good
- 6:34amount of space there and that causes
- 6:36this kidney to be found in a position
- 6:39slightly lower compared to
- 6:40the left kidney now when we talk about
- 6:44the size in the shape of the kidneys we
- 6:47talk about the size the kidneys weigh
- 6:48about 150 grams about five ounces when
- 6:53you talk about their dimensions the
- 6:54kidneys are going to be about 12
- 6:57centimeters long they're about 12
- 6:59centimeters long they're about 6
- 7:03centimeters wide about 6 centimeters
- 7:08wide and 3 centimeters thick about the
- 7:13size of a large bar of soap about the
- 7:17size of a large bar of soap and when you
- 7:19talk shape they're being shaped their
- 7:22kidney bean-shaped
- 7:23and you can see that they're very nicely
- 7:30now when we talk about the external
- 7:32anatomy of the kidneys the external
- 7:34anatomy you can see here the lateral
- 7:35surfaces convex while the medial surface
- 7:39is concave and the medial surface has a
- 7:44vertical cleft to it and the vertical
- 7:48cleft is called the renal hilum which
- 7:56we'll see is going to lead us to the
- 7:58renal sinus here in this location you
- 8:04can see you have do you readers and the
- 8:08blood vessels entering and exiting
- 8:10basically dorg and kidneys
- 8:15now atop each kidney we can appreciate
- 8:19the adrenal glands so you've got two
- 8:23adrenal glands or Supra renal glands we
- 8:28refer to them as well Supra renal above
- 8:31the kidneys now we talked about the
- 8:35renal hilum so here you'll see it's
- 8:37gonna contain the ureter the renal blood
- 8:39vessels the lymphatics okay in the
- 8:44nerves basically all these important
- 8:45organs we're going to see here in
- 8:46relation to the organs now when we go
- 8:50through and we talk about and we talk
- 8:54about
- 8:54these kidneys here you can appreciate
- 8:57now some supporting tissue in relation
- 9:00to these kidneys as well
- 9:02now the supporting tissue we have here
- 9:05so when we talk about the supporting
- 9:08tissue you can see the supporting tissue
- 9:10is gonna be made up of various factors
- 9:12so here we're able to appreciate that
- 9:14supporting tissue right in this picture
- 9:16here and also right in this picture here
- 9:18what we'll do is we'll move over to this
- 9:20picture here in this picture now we can
- 9:22appreciate the three layers which are
- 9:24going to be surrounding each kidney and
- 9:26make up the supporting tissue first we
- 9:29have here what we call the fibrous
- 9:31capsule the fibrous capsule we talked
- 9:34about the fibrous capsule you can see
- 9:35the fibrous capsule is going to be the
- 9:37innermost layer it's a transparent
- 9:41capsule and it prevents infection from
- 9:44spreading to the kidneys then we have
- 9:49the peri renal fat capsule the peri
- 9:53renal fat capsule is exactly what its
- 9:55name says it's going to be a fatty mass
- 9:58that surrounds and cushions the kidneys
- 10:02against blows then we have the renal
- 10:08fashio the renal fashion now you can see
- 10:11we've got an anterior and a posterior
- 10:15component now there's renal fashio as
- 10:18the outer layer and it's a layer of
- 10:20dense fibrous connective tissue it's a
- 10:23layer of dense fibrous connective tissue
- 10:25and it anchors the kidneys and the
- 10:29adrenal glands to the surrounding
- 10:32structures
- 10:38now in the cats you'll be able to go
- 10:42through basically all of this you can
- 10:46see the peritoneum those layers and
- 10:49you'll be able to appreciate that when
- 10:51we get to the renal system in relation
- 10:54to the cats and that's when you'll be
- 10:56able to remove that you'll be able to
- 10:57actually dissect out the adrenal glands
- 10:59there as well up till now you've just
- 11:02been feeling them and seeing them there
- 11:03and once you actually look at it and you
- 11:06see them you'll see the very very
- 11:08tiny structures so here now when we look
- 11:12at the internal anatomy let's move over
- 11:14to then this picture right in here or we
- 11:17can see this picture right in here now
- 11:20here we can see the frontal section this
- 11:23is going to review to us basically three
- 11:27different three distinct regions we can
- 11:31say we've got here first the renal
- 11:33cortex and then we've got the renal
- 11:35medulla and then we've got the renal
- 11:37pelvis so let's go through let's talk
- 11:39first the renal cortex the renal cortex
- 11:41is the most superficial region you can
- 11:45see here it's light in color the most
- 11:47superficial region light in color and it
- 11:51has a granular appearance - it has a
- 11:54granular appearance to it and you'll be
- 11:57able to appreciate that there with the
- 11:59cow kidneys you'll be able to see it
- 12:06very nicely
- 12:07we don't dissect out cat kidneys because
- 12:09the cat kidneys are you know really
- 12:11really small structures and trying to
- 12:13appreciate the internal anatomy inside
- 12:15it's just almost non-existent and so we
- 12:19supplement that with cow kidneys now we
- 12:23can see the renal medulla the renal
- 12:25medulla is the darker reddish brown
- 12:28region you see just deep to the cortex
- 12:32and this renal medulla you can see the
- 12:35zip it's it exhibits cone-shaped tissue
- 12:39masses that we're gonna refer to as
- 12:42renal pyramids these renal pyramids are
- 12:44cone-shaped
- 12:45tissue masses they have a base and they
- 12:48have an apex to them the base is facing
- 12:51the cortex the apex or the papilla you
- 12:55can see is facing then that pelvis now
- 13:03when we talk about the nephrons the
- 13:06nephrons are mostly found in the cortex
- 13:10when we go through we look at the actual
- 13:11nephron we'll be able to appreciate that
- 13:13there you see the majority of the
- 13:14nephron is gonna be found in the cortex
- 13:17and we'll have a couple of parts
- 13:18basically dipping down into you
- 13:21the medulla so then here we've got the
- 13:25renal columns the renal columns are
- 13:27going to be found as in word extensions
- 13:31of cortical tissue you can see that
- 13:34extending downward and the renal columns
- 13:38are found separating the pyramids from
- 13:42one another from then the medulla we can
- 13:47move down into the pelvis now when we
- 13:50talk about the pelvis the renal pelvis
- 13:53is this funnel shaped funnel shaped tube
- 13:58type structure you can see one side of
- 14:03this renal pelvis it's continuous with
- 14:06the ureter and the other side it's
- 14:11continuous with the minor and the major
- 14:14callous ease but which are gonna be
- 14:20found surrounding you can see the
- 14:22papillae and we talked renal pelvis so
- 14:29minor calyx minor calyce's you two to
- 14:35three come together to give rise to one
- 14:37major calyx and then a couple of these
- 14:41major calyxes a few these major calluses
- 14:43will come together and they're gonna
- 14:44give rise then to the pelvis the pelvis
- 14:48then continues as the ureter
- 14:52we saw the ureter in that initial image
- 14:55there and you saw how it's making its
- 14:58way down to the bladder so major kala
- 15:03sees two to three branching extensions
- 15:05of the pelvis and the minor calyce's
- 15:08you can see even more or further
- 15:11branches of the major Calla seized and
- 15:13they're surrounding the papillae
- 15:17so when urine is gonna make its way out
- 15:20its gonna get basically making its way
- 15:21out of this papal are there and then
- 15:24it's gonna get basically dropped into
- 15:25the minor calyx major calyx and then the
- 15:28pelvis and then into the ureter then the
- 15:30buter to bladder urethra and toilet
- 15:35the tree the grass and civilize so here
- 15:43then when we moved through we can see we
- 15:47want to get down to the nephron here now
- 15:48when we talk about the nephron in order
- 15:50for us to reach the nephron we're going
- 15:53to follow the blood supply and the
- 15:57arterial supply basically in and then
- 15:59we'll follow the venous supply all the
- 16:02way out so here when we go through and
- 16:04we talk then here we can use this image
- 16:06here we could use this image right
- 16:08inside of here now here we could see
- 16:10right off the bat
- 16:12we've got first our renal arteries the
- 16:14renal artery now is going to make its
- 16:17way further in to then the kidneys at
- 16:21the renal hilum we said so told you here
- 16:23you can appreciate all of these
- 16:24structures and then we talk nor it--
- 16:27they be found surrounding this artery
- 16:29and basically making their way through
- 16:30and all of that you can check all that
- 16:32out there so here you can see now the
- 16:34renal artery as it makes its way further
- 16:36into the kidneys it's going to start to
- 16:39branch and divide now here when it
- 16:42starts to branch and divide it's going
- 16:44to give rise first to the segmental
- 16:46arteries these segmental arteries then
- 16:49you can see are going to pass and
- 16:51they're going to further divide and
- 16:53they're going to make their way in to
- 16:55the columns and here you can appreciate
- 16:58now those arteries segment arteries are
- 17:01gonna become the inner lobar arteries
- 17:02these interloper arteries now are gonna
- 17:05continue deeper into the kidneys even
- 17:08moving further into the kidneys and as
- 17:10they move further up into the kidneys
- 17:11here you can see they're gonna start to
- 17:13curve and when they occurred now they're
- 17:16going to become known as the arcuate
- 17:19arteries now here you can see the
- 17:22arcuate artery making its way up and
- 17:24again making its way further up into the
- 17:27kidney and here then it's going to
- 17:29become the cortical radiate artery the
- 17:32cortical radiate arteries now are going
- 17:35to have you can tell these branches
- 17:36coming off from them as well making sure
- 17:38that the cortex is fully supplied so
- 17:40here what do we have we said the
- 17:41majority of the nephron is going to be
- 17:42found here now the cortical radiate
- 17:44artery is going to lead us to then you
- 17:49can see the afferent arteriole the
- 17:53afferent arteriole is going to continue
- 17:56on then to form the glomerulus to form
- 18:01the glomerulus here you can appreciate
- 18:03that glomerulus to glomerulus now is
- 18:06going to be in connection with the
- 18:09nephron so here's the initial part of
- 18:12the nephron and here you can see they're
- 18:14in contact with each other we can move
- 18:15over further to this picture in here and
- 18:18you can see blood flow is going to be
- 18:20into that
- 18:22afferent arteriole right in today from
- 18:24our tail then it flows into the
- 18:26glomerulus or whatever needs to be
- 18:27filtered out it's gonna get filtered out
- 18:28in here and whatever gets returned is
- 18:30going to be returned back into the
- 18:31circulation thanks to the afferent
- 18:33arteriole which then is going to collect
- 18:37blood from other arterioles as well the
- 18:40capillaries they're more specifically
- 18:42speaking and here we can see that blood
- 18:45is gonna make its way then back out of
- 18:47the nephron here you can see the rest of
- 18:52those capillaries so once this blood
- 18:55makes its way into the ef'n our children
- 18:57are chills become the peritubular
- 18:58capillaries the Vasa recta peritubular
- 19:01capillaries then and they're all going
- 19:03to then empty you can see here they're
- 19:06all going to empty them and they empty
- 19:09right into the cortical radiate vein now
- 19:14the cortical radiate vein then is going
- 19:17to receive this blood and it's going to
- 19:20circulate that blood then and put it
- 19:23into you can see with the arcuate veins
- 19:25arcueid vein then it's gonna pass this
- 19:27blood back to the heart then on its way
- 19:29back now to the heart it becomes you can
- 19:31see that arcuate is going to become the
- 19:33inner lobar vein the inner lobar vein
- 19:35then continues through the kidneys
- 19:37making its way out and it becomes the
- 19:39renal vein from the renal vein then we
- 19:42go into the inferior vena cava and we'll
- 19:44pick up from there when we get to
- 19:45circulation and we talk cardiovascular
- 19:48system so let's look at what we have
- 19:52then right up in here so this is where
- 19:54all the magic occurs so let's go here
- 19:57you can see one idea of the area there
- 20:00this is all the cortical Reed
- 20:02these are cortical nephrons these are
- 20:04juxta medullary nephrons you can see we
- 20:07have a couple of different types so
- 20:09let's talk nephrons nephrons now are
- 20:11going to be the structure on the
- 20:12functional unit of our kidneys each
- 20:16kidney contains over a million of these
- 20:18tiny blood processing units which are
- 20:22gonna carry out the process that form
- 20:25the processes that are gonna form urine
- 20:31so we saw the glomerulus first here the
- 20:35glomerulus is a tuft of capillaries
- 20:37it's a tuft a bunch of capillaries and
- 20:41then surrounding those capillaries is
- 20:44the you can see the renal corpuscle or
- 20:49basically more specifically speaking
- 20:51we're gonna see the glomerular capsule
- 20:53so again the glomerulus along with this
- 20:56capsule make up what we call the renal
- 20:59corpuscle so here you've got the renal
- 21:01corpuscle and the rest here you can see
- 21:04you've got the tube you'll we've got the
- 21:07renal tubular so let's go through you
- 21:10can see the glomerulus
- 21:12you've got the renal tubules and then
- 21:16the glomerular capsule surrounding that
- 21:20glomerulus so let's talk renal corpuscle
- 21:24when we talk renal corpuscle
- 21:26okay so nephron is going to consist of
- 21:29two major components okay that
- 21:33glomerulus you can see and then
- 21:35basically the capsule along with the
- 21:37tubular component we've got here so here
- 21:41now when we go through and we talked
- 21:43about the renal corpuscle
- 21:44so the renal corpuscle is going to be
- 21:47made up of you can see these two parts
- 21:48where you can see that there and then
- 21:49here we could see that being depicted as
- 21:52well so the renal corpuscle and then the
- 21:57tube you'll major components of the
- 22:00nephron so here then let's talk this GU
- 22:04malar capsule now the glomerular capsule
- 22:06you can see okay it's going to be made
- 22:10up of two parts you're gonna have two
- 22:12parts say you've got a pride of layer
- 22:13and you've got a visceral layer prior to
- 22:15layer and
- 22:16so layer so here the parietal layer
- 22:19right outside you've looked at that in
- 22:20the beginning of the semester and then
- 22:22the visceral layer is gonna be the layer
- 22:23right on top of here and there's that
- 22:27visceral layer in greater detail so here
- 22:32you can see you've got that glomerulus
- 22:34it's got all these little openings in it
- 22:37as well please don't allow these
- 22:39different components to make their way
- 22:40through and we can't just allow any and
- 22:43everything to make its way through so to
- 22:44help prevent that from occurring we've
- 22:46got these little cells on top of them
- 22:49podocytes
- 22:50which have these little foot like
- 22:51processes so here you can see those
- 22:53little sites in greater details same
- 22:55thing being basically you can see now
- 22:58here's another part basically being
- 23:00depicted here that glomerulus in greater
- 23:02detail is what we're looking at here
- 23:04okay so you can't see those photo sites
- 23:06that well that's why you can see them
- 23:07here and that's what you're seeing
- 23:08depicted here in this picture they're
- 23:10all a little like processes all helping
- 23:12to block off those tiny little openings
- 23:14and that's what you're seeing right in
- 23:15here so down here is the basement
- 23:18membrane and on the other side is that
- 23:19fenestrated endothelium of the
- 23:20glomerulus now here you can see
- 23:27everything basically in relation to each
- 23:30segment so you've got to know that
- 23:32histology basically there for each of
- 23:34these different segments as well so you
- 23:36can see we've checked that out we talked
- 23:38PCT proximal convoluted tubule now the
- 23:41next segment we're able to check out so
- 23:44this tubules system now is basically
- 23:46forming and you can see here you got the
- 23:47PCT proximal convoluted tubules and when
- 23:50you talk about the histology you can you
- 23:52can appreciate now here the cells and we
- 23:57move down into the next segment the loop
- 23:59of Henle you can see the loop of Henle
- 24:00has a descending and an a sending limb
- 24:03the descending limb is made up of
- 24:05basically just a thin segment while the
- 24:07ascending limb is made up of a thin and
- 24:09a thick segment so here you can see the
- 24:11thin segment here we can appreciate then
- 24:13you can see very nicely and then as we
- 24:19move back up now we move up this loop of
- 24:21Henle to the DCT the distal convoluted
- 24:23tubules we talk distal convoluted
- 24:25tubules okay here we're gonna be able to
- 24:27appreciate the histology in relation
- 24:30the distal convoluted tubule so you can
- 24:32see we're going to cuboidal columnar
- 24:34alright simple squamous so we're moving
- 24:36all around and then we moved through the
- 24:39DCT we move up into the collecting ducts
- 24:42the collecting ducts you can see receive
- 24:44basically many DC T's we talk about the
- 24:47collecting duct now you can see the
- 24:49structure of the collecting duct very
- 24:51important you understand each segment
- 24:54because that's how you'll be able to
- 24:56understand the physiology so you have to
- 24:58go through every segment and understand
- 24:59that detail there so we've got all the
- 25:05different parts there and then we've got
- 25:10the papillary duct basically that's
- 25:11going to be found as the merger of
- 25:14several collecting ducts so renal
- 25:19corpuscle now we can see from here the
- 25:23peritubular capillaries the peritubular
- 25:25capillaries they arise from the e ffred
- 25:28arteriole they arise from the efferent
- 25:30arteriole that's draining the glomerular
- 25:35and these capillaries they cling you can
- 25:39see closely to these adjacent renal
- 25:42tubules they're gonna empty into nearby
- 25:47venules as I mentioned and then we've
- 25:54got basically the different segments
- 25:56that we talked about as well so coming
- 26:01nice view here we can appreciate now
- 26:05next what we call the juxtaglomerular
- 26:07apparatus this juxtaglomerular apparatus
- 26:11is going to be found you can see here
- 26:15where you have one segment of the
- 26:18nephron loop coming into contact now you
- 26:23can see here weird our glomerulus right
- 26:31and then basically the vessels that are
- 26:33feeding the glomerulus and emptying the
- 26:36glomerulus so let's look at this
- 26:37juxtaglomerular apparatus in greater
- 26:39detail it's made up of three parts you
- 26:41got the macula densa cells you can see
- 26:44you're gonna be able to appreciate the
- 26:45juxtaglomerular cells surrounding that
- 26:49afferent arteriole there smooth muscle
- 26:52cells and then mesangial cells so we
- 26:54talked mesangial cells you're going to
- 26:56be able to appreciate the mesangial
- 26:57cells now here in between those two
- 26:59cells here you can appreciate that
- 27:05juxtaglomerular apparatus in greater
- 27:08detail now again so macula densa cells
- 27:11we can see here right we saw the same
- 27:15thing right inside of there extra
- 27:19glomerular mesangial cells
- 27:22okay the extra column Aylor mesangial
- 27:24cells mostly in between the two and then
- 27:28here you can see your granular cells so
- 27:34I want you to understand the function of
- 27:36each of these cells and how they're
- 27:38going to be involved in relation to
- 27:39blood pressure and how they're involved
- 27:43in relation to blood pressure
- 27:46next in here when we talk this segment
- 27:49right inside here and more specifically
- 27:50speaking you can see this segment is the
- 27:53ascending limb of the loop of Henle you
- 27:56have to make sure you understand that
- 27:57there as well and also just by looking
- 28:00you can appreciate the size difference
- 28:02between the two vessels there as well
- 28:03and that's telling you more blood is
- 28:05gonna make its way in versus the amount
- 28:06that's gonna be making its way out and
- 28:08that's gonna help to create a higher
- 28:10pressure gradient inside which is going
- 28:12to favor filtration the process of
- 28:14moving things out moving those
- 28:16substances out into you can see that
- 28:18capsular space so from this capsular
- 28:22space whatever gets filtered out is
- 28:26going to be passed then into you can see
- 28:28in detail now that PCT the PCT is
- 28:32considered the workhorse of the kidney
- 28:34the PCT has the ability to reabsorb 50
- 28:38to 60% of the components that get
- 28:41filtered right out of here
- 28:45so from that PCT those substances are
- 28:48going to be then passed along if they
- 28:50don't get reabsorbed by the peritubular
- 28:52capillaries are gonna be passed along to
- 28:54the loop the same thing if things don't
- 28:57get reabsorbed
- 28:57or other things aren't getting added
- 28:59back in this will continue the spilt
- 29:02rate will continue to you can see the
- 29:04ascending limb and then making its way
- 29:06forward there's gonna be basically
- 29:08things that are gonna be happening to it
- 29:10all the way through moving forward to
- 29:12the DCT and from the DCT we saw right
- 29:14into the collecting ducts so as this
- 29:21filtrate is making its way through you
- 29:23can see how concentrated it gets when it
- 29:25makes its way down here towards that
- 29:29apex you can see the osmolarity there is
- 29:32going to become about twelve hundred
- 29:33million dollars and the physiology is
- 29:39going to explain that but you have to go
- 29:41there with this basic knowledge of
- 29:42understanding what's happening there so
- 29:45has this filtrate passes through the
- 29:48osmolarity there you can see is about
- 29:50300 milliosmoles gets a little bit more
- 29:52concentrated a little bit more constant
- 29:53even further concentrate even further
- 29:54concentrated and then you can see it
- 29:56becomes less concentrated as it makes
- 29:57its way back up then you have to be able
- 30:01to explain that with the physiology when
- 30:03you talk renal physiology so let's move
- 30:10then to let's make sure you've got
- 30:13everything taken care of here two
- 30:15different types of nephrons
- 30:19juxtaglomerular apparatus make sure you
- 30:23got that distal layer there down as well
- 30:27all right so let's move forward then
- 30:31let's move forward now let's talk about
- 30:32the e-readers now when we talk about the
- 30:35you readers there you readers are
- 30:36slender tubes their slender tubes
- 30:39they're a continuation of the renal
- 30:41pelvis and their function is that they
- 30:44convey urine from the kidneys to the
- 30:47bladder they convey urine from the
- 30:50kidneys to the bladder their location
- 30:53they are going to be found they begin
- 30:59around the level of l2 they begin around
- 31:02the level of l2 and they're going to
- 31:05descend behind the peritoneum they
- 31:09descend behind the peritoneum they
- 31:10extend for about 20
- 31:1135 centimeters from the kidneys to the
- 31:15bladder behind the peritoneum okay you
- 31:27can see all that retroperitoneal talk
- 31:30I've been doing they're going to be
- 31:35running obliquely through to enter into
- 31:41the kidneys from the posterior inferior
- 31:46bladder wall and we can appreciate that
- 31:52then right inside of here very nicely so
- 31:58right here you can see how they make
- 31:59their way down so I was drawn here
- 32:01you've got to be able to understand
- 32:03they're coming down and when they're
- 32:05coming down right they're continuing
- 32:07right down in here to come in and enter
- 32:13that we said coming in to enter right
- 32:19here at the posterior inferior bladder
- 32:21wall let's look at the internal anatomy
- 32:25of the your readers the internal anatomy
- 32:27you'll see is made up of three layers
- 32:29here we can appreciate the three layers
- 32:31you've got first of mukou so we've
- 32:33talked about the mucosa you should know
- 32:35everything about that mucosa we did that
- 32:36in the beginning of the semester if you
- 32:38don't recall we talked about
- 32:40transitional epithelium there and that's
- 32:42what you're able to appreciate this
- 32:44transitional fidelium is continuous with
- 32:46the kidney pelvis superiorly and the
- 32:50bladder on its inferior medial aspect
- 32:56and then we can appreciate the lamina
- 33:00propria connective tissue support and
- 33:07then underneath there we've got the
- 33:08muscularis muscularis is typical by
- 33:12layered you've got a longitudinal and
- 33:13you've got a circular layer longitudinal
- 33:20on inside circular here on the outside
- 33:21and then we've got the adventitia
- 33:25right out here external to the
- 33:29muscularis mucosae
- 33:42continuing forward then so that been
- 33:45tisha covers the you readers external
- 33:46surface and it's typical fibrous
- 33:48connective tissue okay so make sure you
- 33:51know the differences in the different
- 33:53connective tissues there as well then
- 33:57we've got the urinary bladder so let's
- 33:58move over to the urinary bladder nice
- 34:00view here a little better view here we
- 34:02can talk
- 34:03you're very bladder you can see it's a
- 34:04smooth collapsible muscular sac it's a
- 34:10smooth collapsible muscular sac when we
- 34:15talk about the urinary bladder its
- 34:16function is that it stores urine
- 34:19temporarily have that students ask me if
- 34:23they hold their urine will they get more
- 34:24nutrients no no urine formation all that
- 34:29happened already in the kidneys here
- 34:31it's just all in the process of removing
- 34:32it so when you talk function of the
- 34:34bladder it stores urine temporarily the
- 34:38location it's found in for a para
- 34:41Tonioli in for a para Tony Lee on the
- 34:45pelvic floor and here you can see that
- 34:46peritoneum in for peritoneal e on the
- 34:51pelvic floor just posterior to the pubic
- 34:54symphysis just posterior to the pubic
- 34:57symphysis no ii not when you look at and
- 34:59you talk about the internal anatomy here
- 35:00you can see this internal anatomy of the
- 35:04bladder it has basically three openings
- 35:07it has openings for both of the you
- 35:10readers number one we saw one making its
- 35:12way down this way the other one does the
- 35:13exact same way so you got the two
- 35:15ureteric offices the openings for the
- 35:18you readers and then here you can see
- 35:20that bladder neck the opening basically
- 35:21for the urethra and then here you've got
- 35:28two truther muscle the detrusor muscle
- 35:31is all smooth muscle it's the muscular
- 35:33layer of this urinary bladder so that
- 35:37detrusor muscle the muscular layer
- 35:39consists of intermingled smooth muscle
- 35:41fibers
- 35:47the bladder leads us then to the urethra
- 35:49when we talk urethra it's a thin walled
- 35:53muscular tube it's lined by
- 35:58pseudostratified columnar epithelium
- 36:05near the bladder
- 36:07it's transitional and near the external
- 36:13opening become stratified squamous so
- 36:17you can see it all changes as it makes
- 36:20its way through now when we talk about
- 36:26the function of the urethra the function
- 36:28of the urethra is that it drains urine
- 36:31it will drain urine and drains urine
- 36:35from the bladder and it'll convey this
- 36:37urine out of the body now when you talk
- 36:43location it's the Lehrer is going to be
- 36:45found located you can see right after
- 36:48the bladder that's in both females and
- 36:51in males now here let's talk first
- 36:53female you read throughout the female
- 36:56urethra is smaller in size compared to
- 36:59the male urethra it's about one and a
- 37:02half inches long and it's tightly bound
- 37:05to the anterior vaginal wall it's
- 37:09tightly bound to the anterior vaginal
- 37:11wall the location of the urethra and the
- 37:16size of the urethra we believe all
- 37:19increase the chances of UTI is here in
- 37:23the female compared to the male so when
- 37:27we get to reproductive we'll talk more
- 37:29about the location you'll be able to see
- 37:31the close proximity in relation to
- 37:34basically the anus the anus now when we
- 37:42talk male urethra we'll check out there
- 37:44as well but the female you reach I want
- 37:45you to be able to appreciate the
- 37:46external urethral orifice the external
- 37:48urethral orifice is going to be the
- 37:50external opening it's the external
- 37:52opening and it's lying anterior to the
- 37:56vaginal opening it's lying anterior to
- 38:00the vaginal opening
- 38:01and posterior to the clitoris so
- 38:06anterior to the vag an opening and
- 38:07posterior to the clitoris to give you a
- 38:09full an idea of exactly where that's
- 38:11going to be found again you'll be able
- 38:12to see that in the next video when we
- 38:14get into reproductive now we talk male
- 38:18urethra the male urethra is longer in
- 38:23size has three different regions to it
- 38:30it gets divided into three different
- 38:32regions you have first week what we call
- 38:33the prostatic urethra the prosthetic
- 38:37urethra is the region of the urethra
- 38:39that's running through the prostate
- 38:41gland then we have the membranous
- 38:48urethra the membranous urethra then is
- 38:51the sequence of us it's a segment that
- 38:54runs through the urogenital diaphragm
- 39:03excuse me so it runs through the
- 39:12urogenital diaphragm and it's gonna
- 39:24extend for a few centimeters it extends
- 39:28for a few centimeters from that
- 39:30prostatic urethra
- 39:31to where the penis is going to begin
- 39:34then so next and we have the spongy
- 39:37urethra the spongy urethra is the
- 39:41segment of the urethra that's going to
- 39:43be found excuse me that's going to be
- 39:46found running through the penis runs
- 39:49through the penis and opens at its tip
- 39:54here we have the external urethral
- 39:56orifice as well the external urethral
- 39:58orifice is opening at the tip of the
- 39:59penis it's the opening at the tip of the
- 40:02penis now we talk external Anatomy here
- 40:06we've got now a couple of sphincters I'd
- 40:09like you to know about first we're able
- 40:10to appreciate now what we call the
- 40:12internal urethral
- 40:13sinter the internal urethral sphincter
- 40:16is going to be found at the bladder you
- 40:19read through a junction it's found at
- 40:21the bladder you read through Junction
- 40:24and you can see that right inside of
- 40:25here that's the internal urethral
- 40:28sphincter here with the male and then
- 40:31we've got the same thing here we've got
- 40:33the internal urethral sphincter with the
- 40:35female as well so it's at the bladder
- 40:38you read through a junction and it's a
- 40:39thickening of the detrusor smooth muscle
- 40:42it's a thickening of the detrusor smooth
- 40:46muscle so smooth muscle you should be
- 40:50able to understand what type of control
- 40:51it's under and then we have the external
- 40:54urethral sphincter we talk external
- 40:56urethral sphincter you can appreciate
- 40:57that there with the female surrounds the
- 40:59urethra as it passes through the
- 41:02urogenital diaphragm same thing here
- 41:06with the male external urethral
- 41:10sphincter the external urethral
- 41:14sphincter is gonna be formed by skeletal
- 41:16muscle by skeletal muscle it's the same
- 41:20thing you should know the control there
- 41:26alright that concludes the urinary
- 41:30system
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