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AnatomySpecialSensesEarTasteSmellnew — Transcript

by Dr. Naveen Jalota, M.D. · 9,066 words · 1,572 segments · language en · Watch on YouTube

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  1. 0:00Hello and welcome. Let's talk
  2. 0:04chemical senses. Let's talk chemical
  3. 0:06senses now. Let's go through and we're
  4. 0:08going to look at a couple of different
  5. 0:10senses.
  6. 0:11And here when we go through and we talk
  7. 0:13chemical senses, chemical senses we're
  8. 0:16going to look at are going to include
  9. 0:18the senses
  10. 0:19uh in relation to smell and uh the sense
  11. 0:22taste. So, let's go through and let's
  12. 0:24look at both of these senses there.
  13. 0:26Again, this is the anatomy, so we're
  14. 0:27going to go through and we'll check out
  15. 0:28the anatomy. Uh I'll hit at a little bit
  16. 0:30of the physio there, but it's nothing uh
  17. 0:32uh
  18. 0:33that you have to know or you're going to
  19. 0:34be responsible for knowing about or
  20. 0:36um you'll have to know in great detail.
  21. 0:38Um
  22. 0:38when you get to physio, then obviously
  23. 0:40you'll see that in greater detail when
  24. 0:41you get there.
  25. 0:42So, here let's move through. Let's get
  26. 0:45slideshow opened up. Let's play this
  27. 0:47from the current slide.
  28. 0:49All right. So, here we're going to go
  29. 0:51through and what uh talk about uh this
  30. 0:53first chemical sense, this first
  31. 0:54chemical sense will be uh the chemical
  32. 0:57senses of smell. Uh the the sense of
  33. 1:00smell.
  34. 1:01Now, when we go through and we talk
  35. 1:02about uh
  36. 1:03the sense of smell, the sense of smell
  37. 1:05is going to be elicited thanks to you'll
  38. 1:06see our olfactory epithelium. Thanks to
  39. 1:09our olfactory epithelium. Now, when we
  40. 1:11go through and we talk olfactory
  41. 1:12epithelium, this olfactory epithelium is
  42. 1:15going to be found occupying basically
  43. 1:18the olfactory mucosa. So, when we talk
  44. 1:20olfactory mucosa, the olfactory mucosa
  45. 1:22itself is going to be found now lining
  46. 1:25you'll see the roof. It says the roof of
  47. 1:27the nasal cavity here in your guys'
  48. 1:28slides. Um again now when we go through
  49. 1:31and we talk uh nasal cavity, we're going
  50. 1:33to talk specifically specifically
  51. 1:34speaking, we're going to see it's going
  52. 1:35to be found lining the superior nasal
  53. 1:37conchae on both sides. Lining the
  54. 1:39superior nasal conchae on both sides.
  55. 1:42So, here when we go through and we talk,
  56. 1:45you can see that there in greater detail
  57. 1:47now.
  58. 1:49Here you got the superior nasal conchae.
  59. 1:50We've talked about these nasal conchae
  60. 1:52when we talked bones. We referred to
  61. 1:54them as scroll-like structures. Okay?
  62. 1:57And then they've got meatuses, little uh
  63. 2:00canal-like uh passageways underneath and
  64. 2:02they're going to be involved with
  65. 2:03helping to create turbulence in the air
  66. 2:05that we breathe. So, here when we talk
  67. 2:07uh
  68. 2:08uh conchae, you can see all three
  69. 2:10conchae and we've got the superior
  70. 2:13our reference point for the sense of
  71. 2:15smell now.
  72. 2:17So, again, here we've got what we call
  73. 2:20our olfactory mucosa. The olfactory
  74. 2:21mucosa contains this olfactory
  75. 2:23epithelium. Let's look at this now in
  76. 2:25greater detail. Now, while we're here in
  77. 2:27this image, I want to point out to you
  78. 2:29as well um we're not going to just look
  79. 2:31at this one part and just talk about
  80. 2:32this and just you know leave this alone.
  81. 2:34I want you to look at everything, right?
  82. 2:35There's a picture, so I want you to go
  83. 2:36through the picture and look at
  84. 2:37everything there. Now, the sense of
  85. 2:38smell, the sense of smell is going to
  86. 2:41take place inside the nasal cavity. But
  87. 2:43now here you can see the nerve that's
  88. 2:45making its way to that nasal cavity is
  89. 2:48coming from you can see the cranial
  90. 2:49cavity. So, you've got a cranial cavity
  91. 2:52you can appreciate right in here.
  92. 2:54You've got then the nasal cavity. And
  93. 2:56then here you've got oral cavity. So,
  94. 2:58you got three different cavities I want
  95. 2:59you to be able to uh
  96. 3:01put together there as well. And then
  97. 3:02we're going to go through and we're
  98. 3:03going to look at uh all these other
  99. 3:05structures uh throughout the semester as
  100. 3:06well, but here you can appreciate one
  101. 3:09bone. You should know this bone here.
  102. 3:11Not only that, you should know this bone
  103. 3:12that you have here and you should see
  104. 3:14and be able to identify this bone you
  105. 3:15have here as well. So, not only that,
  106. 3:18but then we've got these bones down
  107. 3:19here. So, these are all going to be
  108. 3:21creating different boundaries. You could
  109. 3:23think of borders from one cavity to
  110. 3:25another. So, here we've got the sphenoid
  111. 3:27bone. Okay, here we've got the frontal
  112. 3:29bone. Between the two you've got the
  113. 3:31ethmoid bone. If you recall, we had the
  114. 3:35name of that
  115. 3:36structure uh that has the openings.
  116. 3:40Very good. I know you're all guessing it
  117. 3:42right. Cribriform plate with the
  118. 3:45olfactory foramina or cribriform
  119. 3:46foramina, right? Now, here you can see
  120. 3:50we've got
  121. 3:52which bone?
  122. 3:53Okay, we all know what bone that is. Uh
  123. 3:55it's got a specific name to it. Okay? Uh
  124. 3:59you would have want to know the name to
  125. 4:00that and then here we're going to have
  126. 4:01another bone that's going to help make
  127. 4:04up then the posterior 1/3 you could
  128. 4:06think of of that hard palate and that's
  129. 4:09going to be I'm 100% sure we all know
  130. 4:11the name of that bone there as well. But
  131. 4:14again, more specifically speaking,
  132. 4:15what's the name of that specific spot of
  133. 4:18that bone?
  134. 4:19Okay? So, here you can see then you've
  135. 4:22got basically that nasal cavity and
  136. 4:25we'll discuss the nasal cavity and its
  137. 4:26boundaries, borders, and all of that in
  138. 4:27greater detail when we get to
  139. 4:30uh respiratory system. So, looking here
  140. 4:33now, you can appreciate that olfactory
  141. 4:34epithelium. Now, this olfactory nerve
  142. 4:38we've got there, we've talked about that
  143. 4:39nerve there as well. We said this is
  144. 4:40cranial nerve number one. Here you can
  145. 4:42see it's got two parts to it. It's got a
  146. 4:44tract and then you can see the bulb
  147. 4:46part. I told you guys before, we'll look
  148. 4:48at the inside and we'll see what that
  149. 4:51is what that create what basically is
  150. 4:53helping to create that bulging part uh
  151. 4:56that bulb part of that nerve there as
  152. 4:58well when we move through
  153. 4:59excuse me through here.
  154. 5:01So, let's zoom in on that. When we zoom
  155. 5:03in on that region there, this is what
  156. 5:04you see.
  157. 5:06So, higher power
  158. 5:08this is what you've got there. Again
  159. 5:10now, let me reorient you to where we're
  160. 5:11at. You've got cranial cavity up in
  161. 5:14here.
  162. 5:15Cribriform plate of the ethmoid bone.
  163. 5:18And then right down here you've got
  164. 5:19nasal cavity.
  165. 5:22So, you can see here
  166. 5:23those tiny openings you've seen them
  167. 5:25when we talked bones and we went through
  168. 5:26all of that at the beginning of the
  169. 5:28semester.
  170. 5:29Let's talk then this olfactory
  171. 5:30epithelium. Now, when we talk olfactory
  172. 5:32epithelium, this olfactory epithelium
  173. 5:34you can see it's made up of a couple of
  174. 5:36different a few different cells. Now,
  175. 5:38the major cell type that we have here
  176. 5:40that we're going to talk about we're
  177. 5:41going to check out is going to be the
  178. 5:42olfactory sensory neurons or you can
  179. 5:45refer to them as the olfactory receptor
  180. 5:48cells. Now, when we talk about these
  181. 5:50olfactory receptor cells or these
  182. 5:52olfactory sensory neurons, you can see
  183. 5:55those cells here very nicely in yellow.
  184. 5:58These cells they're described they're
  185. 6:01described as being bowling pin-shaped
  186. 6:05cells. Bowling pin-shaped cells.
  187. 6:10They're found in that olfactory
  188. 6:12epithelium.
  189. 6:13This olfactory epithelium
  190. 6:17we said is found located high up in that
  191. 6:21nasal cavity in the roof of the nasal
  192. 6:23cavity covering the superior nasal
  193. 6:25conchae on each side of that nasal
  194. 6:26septum.
  195. 6:28So, that epithelium has got one major
  196. 6:30cell type here that we can see and
  197. 6:32that's the olfactory sensory neurons.
  198. 6:35Now, these olfactory sensory neurons
  199. 6:39So again, they're going to be found
  200. 6:40making up that epithelium
  201. 6:41which covers the superior nasal conchae.
  202. 6:44Now, these olfactory receptor cells,
  203. 6:46these olfactory receptor cells
  204. 6:48these cells you'll see they are number
  205. 6:50one, they're unusual bipolar neurons. If
  206. 6:53you recall, we talked about having
  207. 6:55bipolar neurons in a couple of different
  208. 6:57places. A couple of main places where
  209. 6:59I'd like you to know about and we've hit
  210. 7:01that now both of those.
  211. 7:04Next thing you can see each of these
  212. 7:05cells, each
  213. 7:07of these olfactory sensory neurons,
  214. 7:09these receptor cells, they have a thin
  215. 7:13apical dendrite. Here you can appreciate
  216. 7:16that thin apical dendrite. You can see
  217. 7:19that here for this neuron. Same thing
  218. 7:21same thing here for this one. Same thing
  219. 7:23here for this one. Here, here, and here
  220. 7:26as well.
  221. 7:27Now, these
  222. 7:29apical dendrites, these apical dendrites
  223. 7:31they're going to terminate. They
  224. 7:33terminate.
  225. 7:35They terminate as these widened-out
  226. 7:38knob-like structures.
  227. 7:41The dendrites, these thin apical
  228. 7:42dendrites, they're going to terminate as
  229. 7:44these
  230. 7:45widened-out
  231. 7:47knob-like structures you can see right
  232. 7:48here at the end.
  233. 7:50From which you're going to see several
  234. 7:52cilia radiate. From which you can see
  235. 7:55several cilia radiate. Now, this cilia,
  236. 7:59this cilia you'll see is going to be a
  237. 8:02little different from the cilia that
  238. 8:03we've talked about we've mentioned
  239. 8:04throughout the semester. Normally
  240. 8:06speaking, we've seen cilia to be erect.
  241. 8:08Here you see it's not erect. It's found
  242. 8:10lying flat against the epithelium.
  243. 8:13And also epithelia you can see there and
  244. 8:16when we talk cilia, we said cilia is
  245. 8:17going to help to move things along. So,
  246. 8:19here you see it's not helping to move
  247. 8:20things along. Here it's going to serve
  248. 8:22as we'll see here in a few seconds as a
  249. 8:24as basically the receptive area. So,
  250. 8:27let's talk olfactory cilia. That's next
  251. 8:29up on your note taker. Now, when we talk
  252. 8:31olfactory cilia, this olfactory cilia,
  253. 8:34what it does is it increases
  254. 8:37it increases the receptive surface area.
  255. 8:41It increases the receptive surface area.
  256. 8:45And again, like I said, you can see it's
  257. 8:46going to be found lying flat against
  258. 8:49it's found lying flat against that nasal
  259. 8:52epithelium.
  260. 8:57Against those epithelial cells.
  261. 9:00Against that olfactory epithelium.
  262. 9:08Now, here when we go through and we talk
  263. 9:11this cilia, you can see the cilia is
  264. 9:13also coated. It's also covered by a thin
  265. 9:15coat. It's covered by a thin coat of
  266. 9:18mucus.
  267. 9:20This mucus
  268. 9:22is a solvent.
  269. 9:24The mucus is a solvent and what this
  270. 9:26mucus does, it's going to capture it
  271. 9:29captures and it dissolves airborne
  272. 9:32irritants.
  273. 9:33It will capture and it will help
  274. 9:35dissolve airborne irritants.
  275. 9:43Now, when we go through and we talk
  276. 9:45mucus, this mucus is going to come from
  277. 9:48we can see these glands. Here we've got
  278. 9:51olfactory glands. These olfactory
  279. 9:53glands, they're They're to help produce
  280. 9:56the mucus
  281. 9:58along with the supporting cells.
  282. 10:00So, they'll produce the mucus along with
  283. 10:02the supporting cells.
  284. 10:04And these glands, they're found, as you
  285. 10:07can see, in the underlying connective
  286. 10:10tissue.
  287. 10:13They're found,
  288. 10:14excuse me, in the underlying
  289. 10:16connective tissue.
  290. 10:18So, you can see that right underneath
  291. 10:20here. Again, remember we talked
  292. 10:21epithelium, we said epithelium has got
  293. 10:23all these different characteristics. So,
  294. 10:25one of those characteristics is it's
  295. 10:26supported by connective tissue, and
  296. 10:28that's what you got right there.
  297. 10:31Now, here you can appreciate the gland.
  298. 10:34And here you got the the duct of the
  299. 10:37gland.
  300. 10:38And so, allow it to
  301. 10:41introduce its secretions to the surface
  302. 10:43or into a cavity. So, what type of a
  303. 10:45gland are we talking about here?
  304. 10:50Very good. That duct gave it away.
  305. 10:54You're talking about exocrine glands.
  306. 10:56Exocrine glands.
  307. 10:58So, next then let's move and let's talk
  308. 11:01then. The filaments, here you can see
  309. 11:03the filaments of olfactory nerve,
  310. 11:05cranial nerve number one. Here you can
  311. 11:07see now the filaments of cranial nerve
  312. 11:09number one. They're basically these
  313. 11:12slender
  314. 11:13unmyelinated
  315. 11:15axons. They are slender, unmyelinated
  316. 11:19axons
  317. 11:20of the olfactory receptor cells.
  318. 11:24Of the olfactory receptor cells.
  319. 11:28That are going to collect
  320. 11:30that are going to collect.
  321. 11:34You can see here and gather
  322. 11:38before they penetrate
  323. 11:42through the foramina. So, we talk
  324. 11:43filaments, filaments of cranial nerve
  325. 11:46number one, they're slender unmyelinated
  326. 11:49axons of the olfactory receptor cells
  327. 11:54that are going to collect and gather
  328. 12:00right before they penetrate
  329. 12:03through this cribriform plate via those
  330. 12:06olfactory foramina or cribriform
  331. 12:08foramina.
  332. 12:13Now, you can see these fascicles are
  333. 12:15going to these filaments basically,
  334. 12:16they're going to project superiorly.
  335. 12:19So, they project superiorly through
  336. 12:22the openings, through the foramina,
  337. 12:25cribriform foramina on the ethmoid bone.
  338. 12:30Now, I told you that olfactory
  339. 12:34nerve is going to have some subdivisions
  340. 12:36to it. We saw the tract, and then here
  341. 12:37we can see the bulb. Now, the bulb, you
  342. 12:39can see the inside. Now, the bulb is a
  343. 12:41widened out region, and you can see why
  344. 12:42it's widened out. It's widened out
  345. 12:44because you can see here we've got a
  346. 12:46junction.
  347. 12:47We've got a junction between
  348. 12:50the axon of one cell
  349. 12:52and the dendrites of another cell, from
  350. 12:55one neuron to another neuron. So, here
  351. 12:57what we have is we have these
  352. 12:59axodendritic
  353. 13:01synapses.
  354. 13:04Okay? Synapses
  355. 13:06where two cells come together. So, here
  356. 13:07you can see exactly that happening. Now,
  357. 13:10this cell here, multipolar
  358. 13:13cell, multipolar neuron, specifically
  359. 13:15speaking, it's a mitral cell.
  360. 13:18And now, these signals
  361. 13:20are going to be basically traveling
  362. 13:22in between these two cells, you can see.
  363. 13:29So, the olfactory bulb is basically
  364. 13:32found at the distal ends.
  365. 13:35It's the widened distal ends of that
  366. 13:38olfactory nerve, you can see right
  367. 13:39there.
  368. 13:41And then tract, I've given you the
  369. 13:42definition of tract.
  370. 13:45And so, that's exactly what you're
  371. 13:46seeing here.
  372. 13:52Now, we've got supporting cells here.
  373. 13:54These supporting cells are columnar
  374. 13:56cells. They are columnar cells.
  375. 13:59And they make up, you can see, they make
  376. 14:01up the majority.
  377. 14:02They make up the bulk. They make up the
  378. 14:05majority of this
  379. 14:07penny thin
  380. 14:09It's like as as as thin as a penny.
  381. 14:14So, again, they're going to be making up
  382. 14:16the bulk of this penny thin
  383. 14:19epithelial membrane.
  384. 14:21Now, this penny thin epithelial
  385. 14:23membrane.
  386. 14:27And then we can also see their basal
  387. 14:29cells. Basal cells are going to be
  388. 14:30dynamic stem cells.
  389. 14:38And so, here what happens then
  390. 14:40you've got the anatomy laid out here.
  391. 14:43What's going to happen is
  392. 14:47uh
  393. 14:48odorants. Odorants are going to come in.
  394. 14:50Excuse me, odorants will come in. And
  395. 14:52when odorants come in, odorants will
  396. 14:54dissolve in this mucus, and they'll go
  397. 14:56and they'll bind to receptors that are
  398. 14:58going to be found on the olfactory
  399. 15:00cilia. So, that's why I told you the
  400. 15:01cilia is a little bit different from the
  401. 15:03cilia that we've described before.
  402. 15:05So, these odorants come and they bind to
  403. 15:08these various receptors. And when they
  404. 15:10bind to the various receptors, then
  405. 15:11they'll excite these cells. These cells
  406. 15:14then will say get excited, they're going
  407. 15:16to start sending
  408. 15:17signals basically to the next cells,
  409. 15:18eventually letting
  410. 15:20the brain know what we have there that
  411. 15:22we're smelling.
  412. 15:24And then physio, you'll see we get into
  413. 15:26it in full on detail where you can
  414. 15:28actually see the receptors and the
  415. 15:31odorants, and you see the connection
  416. 15:32between the two help to activate a whole
  417. 15:35bunch of different uh uh
  418. 15:37you can think of activities inside the
  419. 15:40cell which are going to then allow us to
  420. 15:43be able to smell what we're smelling.
  421. 15:45Not only smell what we're smelling, but
  422. 15:47also to help create adaptation.
  423. 15:50So, you don't just keep smelling the
  424. 15:52same thing with that same intensity over
  425. 15:54and over. Right? If somebody comes
  426. 15:56with this new cologne, after a few
  427. 15:57minutes the initial
  428. 16:00you know, that initial smell is a pretty
  429. 16:02strong smell, but after that
  430. 16:05you know, you stop smelling it.
  431. 16:07And that's going to be due to
  432. 16:07adaptation. And you'll do different
  433. 16:09activities there as well where you'll
  434. 16:11try to see how long it takes for you to
  435. 16:14adapt.
  436. 16:17Next then let's move from
  437. 16:20sense of smell, we'll move to the next
  438. 16:22sense. This will be This will be taste.
  439. 16:24But let me go through the different
  440. 16:25processes that are taking place here.
  441. 16:27You can see now first the odorants will
  442. 16:29come in. The odorants come in and
  443. 16:30they'll bind to the receptor. Once they
  444. 16:32bind to the receptor, what's going to
  445. 16:34happen is they'll activate this G
  446. 16:36protein-linked receptor system which
  447. 16:39you can see here now this GTP gets
  448. 16:42activated. This olfactory protein gets
  449. 16:45basically gets activated, and it's going
  450. 16:47to activate now you can see adenylyl
  451. 16:49cyclase. So, there's an enzyme here.
  452. 16:52This enzyme, what it does then it
  453. 16:54converts ATP
  454. 16:56to cyclic AMP.
  455. 16:58Now, cyclic AMP then what it does, it
  456. 17:00goes and it binds to
  457. 17:03these receptors.
  458. 17:05These channel receptors.
  459. 17:08When it binds to these channel receptors
  460. 17:10now, here you can see what it does, it
  461. 17:11helps to open up that gated cation
  462. 17:15channel.
  463. 17:17And you'll learn and you'll see when
  464. 17:18these ions move across the membrane, if
  465. 17:20you haven't learned in 107, right? When
  466. 17:22you talk action potentials, you'll see
  467. 17:24this in physio and you'll get this down
  468. 17:25there. This will help to create then an
  469. 17:27action potential.
  470. 17:30As you can see here
  471. 17:32leading to the first part,
  472. 17:33depolarization.
  473. 17:35So, the cell depolarizes
  474. 17:38when that sodium is going to rush into
  475. 17:40the cell.
  476. 17:46Now, when we go through and we talk
  477. 17:47about the sense of smell, I want you
  478. 17:49guys to know this uh is one of the
  479. 17:51senses where signals are not going to
  480. 17:54pass through the thalamus.
  481. 17:56They do not pass through the thalamus.
  482. 17:59Okay? Before stimulating the primary
  483. 18:01olfactory cortex. Everything else we've
  484. 18:03seen, we said that the thalamus is going
  485. 18:04to serve as our
  486. 18:07relay station.
  487. 18:09It serves as our relay station. So,
  488. 18:11since it serves as a relay station
  489. 18:13for we said also incoming signals.
  490. 18:16So, here you can see is where one sense
  491. 18:19is not going to be sending in signals
  492. 18:21through the thalamus.
  493. 18:23So, secondary areas are going to include
  494. 18:25then you can see insula
  495. 18:28the orbital frontal cortex, hippocampus,
  496. 18:31amygdala, and the hypothalamus.
  497. 18:39And then here you can see all those
  498. 18:40passageways.
  499. 18:50Let's talk gustation. Let's talk taste.
  500. 18:52Now, when we talk gustation, we talk
  501. 18:54taste. Taste is going to take place
  502. 18:56inside the oral cavity, more
  503. 18:58specifically speaking, on the tongue.
  504. 19:00And we'll see other areas in that oral
  505. 19:02cavity as well. Most we'll say primarily
  506. 19:05inside the on the tongue because on the
  507. 19:07tongue is where we're going to find
  508. 19:09taste buds.
  509. 19:11And that's where the sense of taste is
  510. 19:13going to occur. So, taste buds, tongue
  511. 19:15is going to have most of them. There's
  512. 19:17some that are going to be found in the
  513. 19:18soft palate, the pharynx, the
  514. 19:20epiglottis, and also the cheeks as well.
  515. 19:22So, that's why I said primarily tongue.
  516. 19:26Now, these papillae we're going to go
  517. 19:28through and we're going to check out are
  518. 19:29going to be various papillae. Now,
  519. 19:32they're referred to as your lingual
  520. 19:33papillae.
  521. 19:35They're going to be projections on the
  522. 19:37surface of the tongue. Now, you can see
  523. 19:39there's various types. We have
  524. 19:41fungiform, we have foliate, we have
  525. 19:45vallate or circumvallate,
  526. 19:47and we have filiform.
  527. 19:50Filiform have no buds inside of them.
  528. 19:53They have no taste buds. They're going
  529. 19:54to be involved with basically uh
  530. 19:58we're going to talk about them in
  531. 19:59digestion. Okay, we're going to see that
  532. 20:01they're going to be involved with
  533. 20:02helping to basically uh
  534. 20:05uh give us a little bit of texture kind
  535. 20:07of taste there. And um they'll be
  536. 20:09involved with uh kind of helping to
  537. 20:11manipulate food basically.
  538. 20:13Now, the other three we can see here,
  539. 20:15they're going to have taste buds. The
  540. 20:17foliate, they're going to be basically
  541. 20:20containing buds in children. We can see
  542. 20:22them the fungiform will have buds there
  543. 20:23and then the valley will have buds there
  544. 20:25as well. We're not going to go through
  545. 20:26every single one of them. What we'll do
  546. 20:28then is we'll look at you can see now
  547. 20:30the various types. First here we've got
  548. 20:32the fungiform. Fungiform now we're going
  549. 20:35to see are going to be found scattered
  550. 20:37over the entire tongue surface.
  551. 20:39The fungiform are going to be scattered
  552. 20:42over the entire tongue surface and they
  553. 20:45are mushroom shaped.
  554. 20:48They are mushroom shaped papillae.
  555. 20:57Next up we have our foliate papillae.
  556. 20:59Foliate papillae are going to be found
  557. 21:01on the lateral aspects of the tongue.
  558. 21:03Found on the side walls.
  559. 21:07Found on the side walls.
  560. 21:10And then we have our vallate or
  561. 21:11circumvallate papillae.
  562. 21:14So taste buds
  563. 21:16you can see
  564. 21:18fungiform and foliate and then we said
  565. 21:21here
  566. 21:24fungiform, foliate and then the third
  567. 21:27the vallate or circumvallate they're
  568. 21:28also known as as well. So circumvallate
  569. 21:32found forming an inverted V.
  570. 21:35Found forming an inverted V at the back
  571. 21:38of the tongue.
  572. 21:39There's about 7 to 12 of them. About 7
  573. 21:42to 12 vallate or circumvallate papillae
  574. 21:46found forming an inverted V
  575. 21:51at the back of the tongue.
  576. 21:58So let's look at one one of their
  577. 22:00structures. Here we can see the
  578. 22:02circumvallate.
  579. 22:03So here you can see right on the sides
  580. 22:06you've got these taste buds. So what
  581. 22:08we'll do is we'll look at one of those
  582. 22:09taste buds
  583. 22:13and we'll examine that in greater
  584. 22:14detail. So let's move from this picture
  585. 22:16over to this picture here as well. So
  586. 22:18here now when we look at the structure
  587. 22:19of a taste bud, you can see they're
  588. 22:22going to be made up of gustatory cells
  589. 22:24or your taste cells.
  590. 22:27Now these are types of epithelial cells.
  591. 22:31These are types of epithelial cells and
  592. 22:33you can see they're going to be found
  593. 22:34making up the majority of
  594. 22:37these taste
  595. 22:39receptors. These
  596. 22:41taste buds
  597. 22:42we can say there.
  598. 22:45All right, so talking about these
  599. 22:47gustatory cells, you can see these
  600. 22:49gustatory cells are going to be found
  601. 22:51distributed among some supporting cells.
  602. 22:53So some of these cells will be
  603. 22:54supporting cells and other cells will be
  604. 22:56gustatory taste cells.
  605. 22:58Now these gustatory cells or these taste
  606. 23:00cells, they're epithelial cells. They're
  607. 23:03type of epithelial cell and you can see
  608. 23:04they're going to make up the taste bud
  609. 23:05along with supporting cells. Now we
  610. 23:09talked these uh
  611. 23:10gustatory cells. These gustatory cells
  612. 23:12now we can find these uh
  613. 23:15gustatory cells basically you can see
  614. 23:17here and we've got these nerve fibers
  615. 23:19coming in. Then they'll be penetrating
  616. 23:21basically and innervating uh these
  617. 23:25gustatory cells. So whenever those
  618. 23:26gustatory cells get excited, those
  619. 23:28gustatory cells are going to stimulate
  620. 23:29basically those cranial nerve fibers and
  621. 23:31then sending signals to you know, then
  622. 23:34basically to the cortices to just sum
  623. 23:36that up real quick. Now again, I was
  624. 23:38going to say to the different nerves. So
  625. 23:40depending on which part of the tongue
  626. 23:42you're at, so it'll be that specific
  627. 23:43nerve and then eventually making its way
  628. 23:45to the brain. Now
  629. 23:47here when we go through we look at one
  630. 23:48of the
  631. 23:50one taste bud and we look at its
  632. 23:51structure. Now I want you guys to see
  633. 23:53here what we can see is we can see first
  634. 23:55a taste pore.
  635. 23:56Now here we've got a taste pore. The
  636. 23:59taste pore is going to be an opening.
  637. 24:01It's a neck-like opening. It's a
  638. 24:04neck-like opening
  639. 24:05to each of the taste buds and it's going
  640. 24:08to allow now those tastants that are
  641. 24:10going to be coming making their way in
  642. 24:12with saliva basically allowing them to
  643. 24:15make their way into the sensitive the
  644. 24:17receptor portion which we're going to
  645. 24:19see is going to be the gustatory hairs.
  646. 24:23So the taste pore is going to be
  647. 24:24important
  648. 24:26because it's going to allow the tastants
  649. 24:28to make their way
  650. 24:30and come into contact now with those
  651. 24:33gustatory hairs.
  652. 24:35The receptive portion.
  653. 24:38Next in here we also have our gustatory
  654. 24:39hairs. So when we talk gustatory hairs,
  655. 24:41these gustatory hairs are long
  656. 24:44microvilli.
  657. 24:46They're going to be long microvilli.
  658. 24:50And you see the same thing right inside
  659. 24:52of here as well. They are long
  660. 24:54microvilli.
  661. 24:56They're long microvilli that are going
  662. 24:57to be found projecting from the tips
  663. 25:00of all gustatory cells. They're found
  664. 25:04projecting from the tips. You can see of
  665. 25:06all of those gustatory cells.
  666. 25:11Again, they are the sensitive portion.
  667. 25:14They are the sensitive portion. They
  668. 25:16contain basically the receptor membrane.
  669. 25:19So that is
  670. 25:22what the tastants are going to come and
  671. 25:23bind to.
  672. 25:27Then again you can appreciate those
  673. 25:29taste cells.
  674. 25:31And you can see how then they are
  675. 25:32innervated.
  676. 25:35And then as soon as they get excited
  677. 25:37they will then send signals along these
  678. 25:40sensory nerve fibers.
  679. 25:43Then physio you guys will do a lab and
  680. 25:44you'll see the importance of saliva. Now
  681. 25:47without saliva there it takes
  682. 25:49you'll see tasting is close to
  683. 25:51impossible basically because the saliva
  684. 25:54is there to help guide take basically be
  685. 25:56the medium take this tastant to the
  686. 26:00sensitive portion.
  687. 26:03Now again you also have basal cells here
  688. 26:05as well. Again, dynamic stem cells.
  689. 26:10So dynamic stem cells they differentiate
  690. 26:13and divide into new gustatory cells.
  691. 26:17And then taste fibers cranial nerve
  692. 26:18fibers is what you see there and then
  693. 26:20depending on which uh part of the tongue
  694. 26:22you're on, right? Or which part of the
  695. 26:24oral cavity you're at then
  696. 26:26uh because if we talk tongue, you got
  697. 26:28the anterior 2/3, the posterior 1/3 or
  698. 26:30uh the anterior uh
  699. 26:32uh 2/3, posterior 1/3 and then you've
  700. 26:34got the most dorsal portion and the
  701. 26:36pharynx included there as well, the
  702. 26:38epiglottis. Again, that's going to
  703. 26:40contain uh some of these uh taste buds
  704. 26:43there as well.
  705. 26:44So we talk taste
  706. 26:46in the oral cavity.
  707. 26:51Let's move then from taste. Let's move
  708. 26:53over to
  709. 26:55we'll see hearing. Before we jump down
  710. 26:58here you can appreciate the pathway now.
  711. 27:00So here you can see this pathway for the
  712. 27:03sense of taste is going to make its way
  713. 27:06right through the thalamus and then
  714. 27:08eventually to the specific areas of the
  715. 27:11cerebral cortex.
  716. 27:15Now we've talked about those specific
  717. 27:17areas
  718. 27:18already when we talked uh the cortices.
  719. 27:23So let's move then to
  720. 27:25hearing. Here you can see all the
  721. 27:26different nerves I told you you'll be
  722. 27:28responsible for knowing about there as
  723. 27:29well.
  724. 27:33Let's talk hearing. Let's talk ear.
  725. 27:36Now we talk ear. Ear you can see here
  726. 27:38this is a picture depicting the external
  727. 27:40ear or one part of the external ear. Now
  728. 27:43when we go through we talk ear, we'll
  729. 27:45look at the ear in a greater
  730. 27:48uh idea basically we'll get a greater
  731. 27:49greater idea of the ear when we look at
  732. 27:51this picture here. So here you can see
  733. 27:53and appreciate the ear in its entirety.
  734. 27:55Now here we go through we talk about the
  735. 27:57ear. You can see the ear is going to be
  736. 27:58get divided up into three different
  737. 28:00parts. You've got an external ear,
  738. 28:01you've got a middle ear and then you've
  739. 28:02got the internal ear. Now let's go
  740. 28:04through and let's talk each of these
  741. 28:06divisions one by one first. So here
  742. 28:09first we'll start with external ear. Now
  743. 28:11we talk external ear, the external ear
  744. 28:12is going to consist of a couple of major
  745. 28:14parts. You've got first the auricle
  746. 28:17which you can see right outside of here
  747. 28:19and then here we've got the external
  748. 28:20acoustic meatus. So these two main parts
  749. 28:23are going to make up what we call our
  750. 28:25external ear. So again, it consists of
  751. 28:27the auricle and the external acoustic
  752. 28:30meatus.
  753. 28:31First let's talk auricle. When we talk
  754. 28:33auricle, the auricle is what we call the
  755. 28:37ear in layman's terms, right? We say
  756. 28:38ear, we refer to this as the ear.
  757. 28:41Uh now you can see that that's just one
  758. 28:43part of the ear. This auricle is a shell
  759. 28:47shaped projection.
  760. 28:51It's a shell shaped projection.
  761. 28:53It's also known as the pinna. You can
  762. 28:56see here the pinna.
  763. 29:00This shell shaped projection is found
  764. 29:05surrounding the opening. It's found you
  765. 29:09can see surrounding
  766. 29:12the opening
  767. 29:14which is the external acoustic meatus.
  768. 29:18So what this auricle or this pinna does
  769. 29:21is a shell shaped projection. It's going
  770. 29:23to help kind of funnel sound into that
  771. 29:26opening into the external acoustic
  772. 29:28meatus.
  773. 29:30What type of uh
  774. 29:32cartilage are we talking about here?
  775. 29:35Very good. Elastic. Remember it's easy.
  776. 29:38It's elastic. Makes up the ear.
  777. 29:41And
  778. 29:43good job. The epiglottis. Very good.
  779. 29:46So here now when we go through we talk
  780. 29:48uh
  781. 29:49Oracle. You can appreciate that Oracle
  782. 29:51there. Now, in relation to the Oracle
  783. 29:52itself, we've got a few parts, but not
  784. 29:55just to the Oracle, but you can see to
  785. 29:57the external ear there as well. Let's go
  786. 29:59through these different parts here. Here
  787. 30:01you can first appreciate the helix, the
  788. 30:04helix. Now, the helix is the is the is
  789. 30:07is thick. It's the thickened rim you
  790. 30:10could think of. It's the thickened rim
  791. 30:16All right, of that Oracle. It's a
  792. 30:17thickened rim of the Oracle.
  793. 30:21This helix
  794. 30:22is going to
  795. 30:24project inferiorly
  796. 30:27to give rise to the lobule to the
  797. 30:29earlobe, to the lobule.
  798. 30:35Lobule is the fleshy
  799. 30:38dangling
  800. 30:40structure, fleshy dangling structure,
  801. 30:44and you can see here
  802. 30:46adipose.
  803. 30:49And then connective basically connective
  804. 30:51tissue
  805. 30:52support for the epithelial tissue right
  806. 30:55on top.
  807. 30:59Next here you have your tragus.
  808. 31:03Tragus
  809. 31:04you can see
  810. 31:06is going to help protect
  811. 31:08that external acoustic meatus, that
  812. 31:10opening. It's going to help protect that
  813. 31:11opening.
  814. 31:14Tragus is often pierced.
  815. 31:20And then here across from the tragus, we
  816. 31:22can appreciate the anti-tragus.
  817. 31:26Both again helping to block off that
  818. 31:28entrance into the ear.
  819. 31:33And then we've got the antihelix.
  820. 31:36So, first we talked helix. We can see
  821. 31:39across from the helix we've got our
  822. 31:40antihelix.
  823. 31:44So, anti usually you can see is across
  824. 31:46from the structure it's named for.
  825. 31:50And then here we've got the triangular
  826. 31:52fossa. You can see right above the
  827. 31:54antihelix.
  828. 31:57Triangular fossa.
  829. 32:02And then we've got the concha
  830. 32:04on the other side.
  831. 32:08So, it's when you
  832. 32:10stick your finger into your ear without
  833. 32:12sticking it into the external acoustic
  834. 32:13meatus. So, all of this is all the
  835. 32:16concha.
  836. 32:17The concha.
  837. 32:20You can see that. I don't know why I'm
  838. 32:21showing it to you on me. You can see it
  839. 32:22clearly in the picture.
  840. 32:24Concha.
  841. 32:26And then you got that opening, the
  842. 32:27external acoustic meatus.
  843. 32:30This external acoustic meatus is also
  844. 32:32known as the auditory canal.
  845. 32:35AKA
  846. 32:37auditory canal.
  847. 32:40It's a very short
  848. 32:42curved
  849. 32:44It's a very short curved tube.
  850. 32:49And it's going to extend from the Oracle
  851. 32:52to the eardrum.
  852. 32:56Believe it or not, there's a wrong way
  853. 32:58and a right way to put your stethoscope
  854. 33:00into your ear. If you don't know what
  855. 33:02you're doing and uh you don't uh check
  856. 33:05your uh technique, you can end up
  857. 33:08placing your stethoscope into the
  858. 33:09concha. If you place it in the concha,
  859. 33:12now there's no receptors here for
  860. 33:14hearing.
  861. 33:15So, you have to make sure you push the
  862. 33:17ear buds away from you so that way they
  863. 33:20follow the contour of that external
  864. 33:23acoustic meatus.
  865. 33:26Your teachers can tell just from the way
  866. 33:29you put your stethoscope into your ear
  867. 33:31whether you know what you're doing with
  868. 33:32the stethoscope.
  869. 33:34So, here you can see those sound waves
  870. 33:36are going to get funneled thanks to that
  871. 33:37external acoustic meatus into the
  872. 33:40tympanic membrane.
  873. 33:41So, they're going to pass through that
  874. 33:42external acoustic meatus and they're
  875. 33:45going to come in and they're going to
  876. 33:45stimulate that tympanic membrane.
  877. 33:49So, if you stick that uh stethoscope
  878. 33:51into the concha
  879. 33:53uh it's difficult to hear what you're
  880. 33:55trying to listen to.
  881. 33:56Especially those sounds, the sounds of
  882. 33:58the heart or the sounds of the abdomen
  883. 34:00or the sounds of the lungs already uh
  884. 34:02sometimes pretty faint in some
  885. 34:03individuals.
  886. 34:07So, external acoustic meatus you can
  887. 34:09appreciate there. Now, this external
  888. 34:10acoustic meatus
  889. 34:12is going to lead us to the eardrum as we
  890. 34:14described, to the tympanic membrane.
  891. 34:16Now, within this external acoustic
  892. 34:18meatus you're going to be able to
  893. 34:19appreciate ceruminous glands, right?
  894. 34:21We've talked about these glands before.
  895. 34:23Now, ceruminous glands are going to be
  896. 34:24modified apocrine glands. They are
  897. 34:27modified apocrine glands.
  898. 34:32Modified apocrine sweat glands, you can
  899. 34:35say more specifically.
  900. 34:38Modified apocrine.
  901. 34:44Now, these glands, they're going to
  902. 34:46secrete a yellow-brown
  903. 34:49waxy material called cerumen.
  904. 34:55So, they secrete a yellow-brown waxy
  905. 34:57material called cerumen or earwax.
  906. 35:00And earwax is important. Earwax is
  907. 35:03important because earwax is going to
  908. 35:04provide as a sticky trap.
  909. 35:09It will act as a sticky trap
  910. 35:12and help keep foreign bodies and also
  911. 35:14help repel insects.
  912. 35:17Doesn't always happen. I've removed uh
  913. 35:20cockroaches, toys even from
  914. 35:25people's external acoustic meatus, from
  915. 35:27children to adults.
  916. 35:30And uh wax I can't begin to tell you how
  917. 35:33many times.
  918. 35:38Now, we've got the tympanic membrane
  919. 35:40there next. The tympanic membrane is
  920. 35:41also known as the eardrum. The tympanic
  921. 35:44membrane you can see is going to serve
  922. 35:45as the boundary. It's going to serve as
  923. 35:46the boundary between that external ear
  924. 35:49and the middle ear. So, it's the border
  925. 35:51between the external and the middle ear.
  926. 35:58Let's move then to the middle ear. Here
  927. 36:00you can appreciate the middle ear, but
  928. 36:02what we'll do is we'll zoom in on the
  929. 36:04middle ear. And we zoom in on the middle
  930. 36:06ear, we're going to be able to
  931. 36:07appreciate its structures in greater
  932. 36:10detail. So, here you can appreciate its
  933. 36:11structures then in greater detail. Now,
  934. 36:13here first we've got the middle ear. The
  935. 36:16middle ear I'd like you to know is also
  936. 36:17going to be known as the tympanic
  937. 36:19cavity. AKA tympanic cavity. It's a
  938. 36:22small air-filled It's a very small
  939. 36:26air-filled
  940. 36:29mucosa-lined
  941. 36:32cavity.
  942. 36:35It's found in the petrous portion of the
  943. 36:37temporal bone.
  944. 36:39In that petrous portion of the temporal
  945. 36:41bone.
  946. 36:45Tympanic membrane we've already
  947. 36:46discussed there. You can appreciate now
  948. 36:48a round window and an oval window. The
  949. 36:51round window and the oval window are
  950. 36:53going to be openings.
  951. 36:55They're openings on the bony wall
  952. 36:58that lead us to the internal ear.
  953. 37:01Openings on that bony wall of the middle
  954. 37:04ear
  955. 37:05that will lead us to the internal ear.
  956. 37:09Now, the oval window you can appreciate
  957. 37:11underneath the stapes. So, here you've
  958. 37:13got the stapes, one of the bones, the
  959. 37:16ossicles we'll discuss in the middle ear
  960. 37:17here in a few minutes.
  961. 37:19Round window
  962. 37:21or oval window and round window you can
  963. 37:23see here inferior to the stapes.
  964. 37:28So, right underneath it
  965. 37:30you've got that oval window. So, deep to
  966. 37:33the stapes the oval window. And then
  967. 37:34here you can appreciate just inferior to
  968. 37:36it you've got the round window. So, this
  969. 37:38oval window is covered by the stapes.
  970. 37:39Now, the round window is covered by
  971. 37:42membrane. It's going to be covered by
  972. 37:44membrane. This membrane is going to be
  973. 37:46basically a membrane that's going to act
  974. 37:48like a valve. What's going to happen is
  975. 37:50when the stapes hits up against that
  976. 37:52oval window, that's going to help to
  977. 37:53create a a wave of basically a movement
  978. 37:57of fluid inside that ear. And that
  979. 37:59movement of fluid is going to happen
  980. 38:02efficiently if that round window is
  981. 38:05flexible and if it acts like a valve and
  982. 38:07allows basically that motion within the
  983. 38:11fluid to
  984. 38:12occur, we're going to be able to then
  985. 38:14hear the sound. So, we'll check all that
  986. 38:16out as we progress. So, I want you to
  987. 38:18know there going to be two openings.
  988. 38:20However, they're covered you can see.
  989. 38:25Next that we have our pharyngotympanic
  990. 38:27tube. The pharyngotympanic tube or the
  991. 38:30auditory tube, formerly known as the
  992. 38:33Eustachian tube.
  993. 38:35If you're old school, we used to refer
  994. 38:37to it as the Eustachian tube.
  995. 38:41It runs obliquely. It's found running
  996. 38:43obliquely. It runs obliquely downward.
  997. 38:46And it's going to link the middle ear.
  998. 38:49It will link that middle ear cavity you
  999. 38:51can see here.
  1000. 38:53It will link that middle ear cavity to
  1001. 38:56the pharynx.
  1002. 38:57To more specifically speaking, you'll
  1003. 38:58see the nasopharynx.
  1004. 39:01To the nasopharynx. Now, when we get to
  1005. 39:03when we get to digest No, we get to
  1006. 39:05respiratory. We get to respiratory,
  1007. 39:07we're going to look at the other end.
  1008. 39:10We're going to see where it opens up at
  1009. 39:11inside that nasopharynx.
  1010. 39:16So, you can see here when we go up and
  1011. 39:17down the hill, we want to equalize the
  1012. 39:19pressure, right? We'll usually plug our
  1013. 39:20nose and that's what that uh helps us to
  1014. 39:23do basically there.
  1015. 39:26Let's talk then. Next we've got our
  1016. 39:28auditory ossicles. When we talk auditory
  1017. 39:30ossicles, they are three of the smallest
  1018. 39:33bones in the body.
  1019. 39:34They're found in this tympanic cavity.
  1020. 39:38And they're going to be named according
  1021. 39:40to their shape. They will be named
  1022. 39:43according to their shape.
  1023. 39:46And uh question we can formulate here is
  1024. 39:49uh which skeletal division do they
  1025. 39:51belong to?
  1026. 39:54Very good.
  1027. 39:56I know you got that right, axial.
  1028. 40:01So here we can see first we've got the
  1029. 40:03malleus. Malleus is hammer-shaped.
  1030. 40:08Malleus is going to be found you can see
  1031. 40:11one end of it articulating with the
  1032. 40:13tympanic membrane and the other end and
  1033. 40:15you can see articulating with the next
  1034. 40:17bone in line which is going to be the
  1035. 40:20incus. Now the incus is anvil-shaped.
  1036. 40:25It's anvil-shaped.
  1037. 40:28We talk anvil-shaped, you can appreciate
  1038. 40:30that they're very well. It's uh
  1039. 40:32basically the structure that blacksmiths
  1040. 40:35bend metal on and uh do work on.
  1041. 40:38Or a wrestler from WWF if you remember.
  1042. 40:43Next then we have our stapes. The stapes
  1043. 40:46stapes stirrup-shaped
  1044. 40:50stirrup-shaped.
  1045. 40:52And you can see here it's going to be
  1046. 40:53articulating with the incus on one end
  1047. 40:56and then it's covering that oval window
  1048. 40:58on the other end.
  1049. 41:01So three of the smallest bones
  1050. 41:05you'll find in the body.
  1051. 41:08Next then let's move to the internal
  1052. 41:11ear. Let's move to the internal ear. Now
  1053. 41:14when we talk internal ear
  1054. 41:19All right, so here we can see that
  1055. 41:21internal ear. Now we talked this
  1056. 41:23internal ear
  1057. 41:26we can see
  1058. 41:28it's also going to be known now as the
  1059. 41:30labyrinth. Internal ear will also be
  1060. 41:33known as the labyrinth. If you look up
  1061. 41:35the definition labyrinth it's tortuous
  1062. 41:36maze right and so forth. So here when we
  1063. 41:40talk now this labyrinth this internal
  1064. 41:41ear this internal ear is going to be
  1065. 41:43found lying deep. It's found lying deep
  1066. 41:45in the temporal bone behind the eye
  1067. 41:47socket. Found deep in that temporal bone
  1068. 41:52behind the eye socket. Now
  1069. 41:55this internal ear is going to get
  1070. 41:56divided up into two different parts into
  1071. 41:57two different parts. Now to be able to
  1072. 41:59appreciate these two different parts
  1073. 42:00what we'll do is we'll move over to this
  1074. 42:02picture here.
  1075. 42:03Now in this picture here you can
  1076. 42:05appreciate the bony labyrinth and then
  1077. 42:07you can see within the bony labyrinth is
  1078. 42:09the membranous labyrinth. So first off
  1079. 42:12let's talk bony labyrinth. Now when we
  1080. 42:14talk bony labyrinth the bony labyrinth
  1081. 42:16is going to be this tortuous maze type
  1082. 42:19pathway.
  1083. 42:21It's a system you can think of of
  1084. 42:23tortuous channels
  1085. 42:25that's worming
  1086. 42:28through the bone.
  1087. 42:32So it's a
  1088. 42:33you can think of carved out part inside
  1089. 42:35the bone.
  1090. 42:37It's going to be filled with a fluid.
  1091. 42:39The fluid it's going to be filled with
  1092. 42:40is called perilymph.
  1093. 42:43Now this perilymph
  1094. 42:45is a fluid that's going to fill this
  1095. 42:48bony labyrinth. It fills this bony
  1096. 42:50labyrinth and this perilymph is a fluid
  1097. 42:53that's similar to and continuous with
  1098. 42:57CSF.
  1099. 43:03Next we have the vestibule. So here
  1100. 43:05we'll move back. Now we move back here
  1101. 43:08you can actually appreciate the
  1102. 43:09vestibule
  1103. 43:10and coming back here you can see the
  1104. 43:13vestibule then in greater detail.
  1105. 43:16So moving back when we talk vestibule
  1106. 43:18the vestibule is a central egg-shaped
  1107. 43:21cavity of the bony labyrinth.
  1108. 43:26Within the sac within this uh vestibule
  1109. 43:30we're able to appreciate the saccule
  1110. 43:34and the utricle. So here's the utricle
  1111. 43:37and here's the saccule within
  1112. 43:42the vestibule. All within the vestibule.
  1113. 43:44Now
  1114. 43:46why is the saccule and the utricle
  1115. 43:47important? Because we'll see within them
  1116. 43:49are going to be the maculae
  1117. 43:51our maculae and we'll talk about our
  1118. 43:54maculae in a few minutes. So saccule
  1119. 43:57first. Saccule is the membranous
  1120. 44:01labyrinth sack.
  1121. 44:04It's a membranous labyrinth sack.
  1122. 44:10As is the utricle so utricle also a
  1123. 44:15membranous labyrinth sack
  1124. 44:19and they're both suspended
  1125. 44:21in the perilymph.
  1126. 44:24Right? They have perilymph around them.
  1127. 44:26They're suspended within perilymph. And
  1128. 44:28the reason why the saccule and the
  1129. 44:30utricle are important because they
  1130. 44:31contain the maculae. The maculae are
  1131. 44:33going to be equilibrium receptors.
  1132. 44:36They are our equilibrium receptors.
  1133. 44:42Let's move then to the semicircular
  1134. 44:44canals. So here you can appreciate the
  1135. 44:46semicircular canals. And now within
  1136. 44:48those canals you can see are the
  1137. 44:49semicircular ducts.
  1138. 44:52Within the canals are the semicircular
  1139. 44:53ducts.
  1140. 44:54Now when we talk semicircular canals
  1141. 44:57semicircular canals are going to be
  1142. 44:59found lying posterior and lateral to the
  1143. 45:02vestibule.
  1144. 45:04Lying posterior and lateral to the
  1145. 45:07vestibule.
  1146. 45:10And they're important because they
  1147. 45:12contain the semicircular ducts.
  1148. 45:17These ducts now
  1149. 45:19you can see have these ampullae to them.
  1150. 45:22The ampulla.
  1151. 45:24The ampulla is going to be the enlarged
  1152. 45:27swelling.
  1153. 45:30It is the enlarged swelling at the end
  1154. 45:34of the semicircular ducts.
  1155. 45:37So you can see one here for this
  1156. 45:40anterior duct
  1157. 45:42you can see the same thing here for this
  1158. 45:44lateral
  1159. 45:45duct and we're going to have the same
  1160. 45:46thing right back here for this posterior
  1161. 45:48semicircular duct.
  1162. 45:52The ampullae
  1163. 45:53are important because the ampullae are
  1164. 45:54going to be receptors as well. Also
  1165. 45:57equilibrium receptors.
  1166. 46:01So let's discuss the membranous
  1167. 46:03labyrinth now. So we already took care
  1168. 46:05of the bony labyrinth. Now when we talk
  1169. 46:08membranous labyrinth the membranous
  1170. 46:09labyrinth is a continuous
  1171. 46:13series.
  1172. 46:15It's a continuous
  1173. 46:17series
  1174. 46:19of membranous sacks and ducts.
  1175. 46:27Continued within
  1176. 46:30the bony labyrinth.
  1177. 46:32So a continuous series of membranous
  1178. 46:35sacks and ducts
  1179. 46:37continued within the bony labyrinth
  1180. 46:41and following its contours.
  1181. 46:49Now when we talk about this um
  1182. 46:51membranous labyrinth you'll see this
  1183. 46:53membranous membranous labyrinth is going
  1184. 46:55to be filled with a fluid as well. This
  1185. 46:56fluid here is going to be called
  1186. 46:58endolymph.
  1187. 47:05Endolymph.
  1188. 47:07Now endolymph is going to be chemically
  1189. 47:09similar to
  1190. 47:11potassium-rich
  1191. 47:13intracellular fluid.
  1192. 47:17Similar to
  1193. 47:19potassium-rich intracellular fluid. And
  1194. 47:21now this endolymph this endolymph is
  1195. 47:23going to be found in the interior of the
  1196. 47:25membranous labyrinth.
  1197. 47:28It's found in the interior of the
  1198. 47:31membranous labyrinth.
  1199. 47:33So here what we're going to do is we're
  1200. 47:34going to look at
  1201. 47:38this
  1202. 47:40cochlea we'll go into first.
  1203. 47:44And we'll look at the cochlea first and
  1204. 47:46then we'll jump into equilibrium. So
  1205. 47:47let's look at the cochlea here first.
  1206. 47:49Let's grab this part first and here
  1207. 47:54we can appreciate that cochlea.
  1208. 47:57So here you can see what they're doing
  1209. 48:00in this picture in this image is they're
  1210. 48:01going to do a nice L cut basically to
  1211. 48:04this cochlea. Now here with this cut
  1212. 48:07what this going to allow us to do is
  1213. 48:08it's going to allow us to appreciate
  1214. 48:10basically the coils all the way through.
  1215. 48:12So here what you really have is you have
  1216. 48:15one
  1217. 48:16cochlea
  1218. 48:18you can see here
  1219. 48:20that's continuous
  1220. 48:22all the way through
  1221. 48:26all the way
  1222. 48:30to the end.
  1223. 48:33So here now you can see each of these
  1224. 48:37regions of that cochlea
  1225. 48:40themselves are divided up you can see
  1226. 48:42into three different parts.
  1227. 48:44So inside here you have three parts. You
  1228. 48:46can have one part on the top you can see
  1229. 48:48up here
  1230. 48:49one part in the middle which we see
  1231. 48:51right here and then the third part on
  1232. 48:52the bottom which you would got right
  1233. 48:54there.
  1234. 48:55So let's unwind this cochlea. Let's grab
  1235. 48:59it let's unwind it and then we'll do one
  1236. 49:00cut right through. We're going to do one
  1237. 49:02cut right through this is what you're
  1238. 49:03going to have.
  1239. 49:06Coming back so let's unwind this snail
  1240. 49:10looking structure. You completely unwind
  1241. 49:12it pull it all the way open.
  1242. 49:14Okay? So if you were to pull it all the
  1243. 49:16way open this is what we're going to
  1244. 49:17have.
  1245. 49:18You're going to have something that's
  1246. 49:19going to look now like this.
  1247. 49:26Does that make sense?
  1248. 49:27Right? That's what you have here. Unwind
  1249. 49:30it this is what we're going to have. And
  1250. 49:31now within it within it
  1251. 49:34Okay? So let's continue here.
  1252. 49:37Pen color, let me switch to blue.
  1253. 49:41Just to depict the membranous labyrinth.
  1254. 49:48You'll have something looking like this.
  1255. 49:53Okay?
  1256. 49:56So, this is going to be segment one.
  1257. 49:59Here is
  1258. 50:01region two.
  1259. 50:03And then down here we have three, right?
  1260. 50:06So, unwinding this
  1261. 50:08in here would be like one, number two,
  1262. 50:10and then number three. So, let's do
  1263. 50:12this. Let's move over here.
  1264. 50:14Here you've got one. Here you got two.
  1265. 50:16Here you have three. So, number one is
  1266. 50:18known as the scala vestibuli.
  1267. 50:20Scala vestibuli, in the middle you got
  1268. 50:22scala media.
  1269. 50:25And then here on the bottom, scala
  1270. 50:26tympani.
  1271. 50:29Scala tympani.
  1272. 50:31Now, scala media is important because we
  1273. 50:32can see here is where we're going to
  1274. 50:34find the receptor organ for hearing.
  1275. 50:36This is the spiral organ.
  1276. 50:38The receptor organ for hearing.
  1277. 50:40So, moving back
  1278. 50:42this is our image.
  1279. 50:44That spiral organ receptor hearing is
  1280. 50:46all
  1281. 50:48right in here.
  1282. 50:51You basically like you can think of
  1283. 50:53right in here.
  1284. 50:58All right in here.
  1285. 51:03Okay?
  1286. 51:05So,
  1287. 51:07you can see there, scala vestibuli,
  1288. 51:09scala tympani, in the middle, scala
  1289. 51:11media. And then right here we've got the
  1290. 51:13spiral organ,
  1291. 51:14organ of Corti,
  1292. 51:16the sensitive uh
  1293. 51:18receptor region.
  1294. 51:20So, here on the outside we're going to
  1295. 51:22have fluid, right? The bony labyrinth is
  1296. 51:24what we described here. That's going to
  1297. 51:25have perilymph,
  1298. 51:27and then we said endolymph,
  1299. 51:29and then perilymph. So, you see that
  1300. 51:30same thing being described here.
  1301. 51:32Perilymph,
  1302. 51:33perilymph.
  1303. 51:35In the middle you got endolymph.
  1304. 51:38Now, look at here.
  1305. 51:41These parts are continuous with each
  1306. 51:42other.
  1307. 51:44This is the apex.
  1308. 51:50Right here.
  1309. 51:51Apex.
  1310. 51:53At the apex is found at the helicotrema.
  1311. 51:57Right? This area here is the
  1312. 51:59helicotrema, and this is where you find
  1313. 52:01the apex.
  1314. 52:07So, now here
  1315. 52:08let's continue to add in here. Here we
  1316. 52:10have the round window,
  1317. 52:15covered by membrane. Now, you understand
  1318. 52:16why I said this is a valve.
  1319. 52:18Does that make sense now?
  1320. 52:20The fluid inside is what's going to be
  1321. 52:22jiggling.
  1322. 52:23And what do we say is going to be up
  1323. 52:25here?
  1324. 52:26So, here we're going to have I'm going
  1325. 52:27to draw a little bit weird, but here's
  1326. 52:29the stapes.
  1327. 52:33Right? And then here we have the
  1328. 52:36anvil,
  1329. 52:38incus.
  1330. 52:40Here we have the malleus,
  1331. 52:45tympanic membrane,
  1332. 52:48and then the rest of the ear.
  1333. 52:53Right? And then the lobe and
  1334. 52:56all of that is right out here.
  1335. 52:59So, when we talk sound, sound is
  1336. 53:01vibrations of the air. These vibrations
  1337. 53:04of the air are going to make their way
  1338. 53:05into we said
  1339. 53:08that ear.
  1340. 53:11Eventually helping to get that tympanic
  1341. 53:12membrane moving. When the tympanic
  1342. 53:14membrane vibrates, the tympanic membrane
  1343. 53:16is going to get the malleus to move.
  1344. 53:18Malleus will hit up against the incus,
  1345. 53:20which will hit up against the stapes,
  1346. 53:21which is going to hit up against that
  1347. 53:22oval window,
  1348. 53:23which will then get the fluid inside of
  1349. 53:25here to eventually start moving.
  1350. 53:27You see it's like a domino effect is
  1351. 53:29what we're trying to get.
  1352. 53:31So, now here if we're going to see if
  1353. 53:33sounds are of low intensity, those
  1354. 53:36sounds are going to make their way
  1355. 53:37through. They're going to come all the
  1356. 53:38way through to the apex, and then all
  1357. 53:40the way around.
  1358. 53:42They don't ever stimulate
  1359. 53:44the spiral organ, that's why you don't
  1360. 53:45hear them.
  1361. 53:47But now if we talk sounds of higher
  1362. 53:49intensity, those sounds they're not
  1363. 53:51going to be making their way all the way
  1364. 53:52to the back. They're just going to come
  1365. 53:54right through in here, and when they
  1366. 53:55come in here they're just going to get
  1367. 53:57all of this in here to start vibrating.
  1368. 54:00Now, why do we need all this here to
  1369. 54:01vibrate? Because we're going to see that
  1370. 54:03in a few seconds. Let's move over then
  1371. 54:05to this picture here. So, here you can
  1372. 54:07appreciate the spiral organ. Look at the
  1373. 54:09spiral organ, you got the nerve. You've
  1374. 54:10got these important cells in here, and
  1375. 54:12then some supporting cells there. And
  1376. 54:14look at here, you've got a membrane on
  1377. 54:17top and a membrane on bottom. You've got
  1378. 54:18a tectorial membrane right here on top,
  1379. 54:20and we've got a basilar membrane right
  1380. 54:22down here. So, you can see here that
  1381. 54:24spiral organ is sandwiched in between
  1382. 54:26those two membranes.
  1383. 54:28So, let's zoom in on that then.
  1384. 54:31This is what you see.
  1385. 54:33You got your tectorial membrane,
  1386. 54:35and then down here you got the basilar
  1387. 54:36membrane.
  1388. 54:38So, here you can see sandwiched in
  1389. 54:40between them is two rows of cells.
  1390. 54:42You've got
  1391. 54:43one
  1392. 54:45row of inner hair cells and three rows
  1393. 54:47of outer hair cells.
  1394. 54:49So, here what happens now is when sound
  1395. 54:53comes in, now you can see here to each
  1396. 54:55of these hair cells you've got hair
  1397. 54:56bundles. Those hair bundles are embedded
  1398. 54:58within the tectorial membrane.
  1399. 55:01So, here what happens is now when sound
  1400. 55:04comes in
  1401. 55:05So, when sound comes in, sound is going
  1402. 55:07to come in we said it's going to go
  1403. 55:08right through here. It's going to get
  1404. 55:09that basilar membrane vibrating. Now,
  1405. 55:12when that basilar membrane starts to
  1406. 55:13move, here you'll see it's going to get
  1407. 55:16these cells' hairs to bend. And when
  1408. 55:19those hairs bend, this will start to
  1409. 55:23generate signals in the nerves, and
  1410. 55:25letting then the ear know this is what's
  1411. 55:27going on.
  1412. 55:30So, that's how
  1413. 55:33hearing is done.
  1414. 55:36Next then let's talk equilibrium. So, we
  1415. 55:39make sure I've got everything with that
  1416. 55:40cochlea.
  1417. 55:41Coachella. One way you guys like to
  1418. 55:43remember that. Hear sound, Coachella,
  1419. 55:46cochlea.
  1420. 55:48So, yeah. We've got everything there.
  1421. 55:51Let's talk then equilibrium.
  1422. 55:55So, we talk equilibria then
  1423. 55:57let's talk
  1424. 56:00So, this is basically everything we just
  1425. 56:02went through. You can kind of go through
  1426. 56:03that.
  1427. 56:05Okay. Talking about the bending of the
  1428. 56:07stereocilia, how it's going to open up
  1429. 56:10ion channels, helping to trigger
  1430. 56:13electrical signals.
  1431. 56:23And then again the pathway you can
  1432. 56:24appreciate there as well.
  1433. 56:27Let's talk then equilibrium. So,
  1434. 56:30equilibrium then we'll see is going to
  1435. 56:31be a sense
  1436. 56:33that not only depends on input from the
  1437. 56:35internal ear. So, it's a sense that's
  1438. 56:37not only going to depend on input from
  1439. 56:38the internal ear, but also it's going to
  1440. 56:40depend on information from vision,
  1441. 56:44and it's going to depend on information
  1442. 56:45coming from stretch receptors
  1443. 56:50in relation to our muscles and our
  1444. 56:51tendons.
  1445. 56:54And also from our stretch receptors in
  1446. 56:56relation to our muscles and tendons.
  1447. 56:59Now, here we have first
  1448. 57:02our maculae. Our maculae are described
  1449. 57:05as sensory receptors for static
  1450. 57:08equilibrium.
  1451. 57:09Sensory receptors for static
  1452. 57:11equilibrium. When you talk about their
  1453. 57:13function, their function is that they
  1454. 57:15monitor the position of the head in
  1455. 57:17space.
  1456. 57:19They will monitor the position of the
  1457. 57:20head in space.
  1458. 57:22They also play a key role in posture.
  1459. 57:29Where are they found? They're going to
  1460. 57:30be found as we described, one
  1461. 57:33in each saccule
  1462. 57:36and utricle wall.
  1463. 57:41One in each saccule and utricle wall.
  1464. 57:48Utricle.
  1465. 57:54Now here when you look at the position,
  1466. 57:55you can see how each of them are going
  1467. 57:57to be found. One is
  1468. 57:59vertically placed, one is a little bit
  1469. 58:01more horizontally placed.
  1470. 58:03So, here now what happens is like we
  1471. 58:04described, they're going to monitor the
  1472. 58:07position of the head in space.
  1473. 58:09But not only the monitor not only
  1474. 58:10monitoring position of the head in
  1475. 58:11space,
  1476. 58:13also linear acceleration
  1477. 58:15we'll see there as well.
  1478. 58:18Linear acceleration, let's say you're
  1479. 58:19standing here and all of a sudden you
  1480. 58:20start to move forward fast.
  1481. 58:22Right? This is linear acceleration. Even
  1482. 58:24elevators, right? Moving up and down in
  1483. 58:26elevator. Okay, vertical acceleration
  1484. 58:29you've got happening there, but that's
  1485. 58:30not that common. More is this
  1486. 58:32uh
  1487. 58:33you can see this linear acceleration.
  1488. 58:37Next then here when we go through and we
  1489. 58:38talk uh
  1490. 58:39maculae, now what happens here when we
  1491. 58:41look at their structure, you can see
  1492. 58:42here in greater detail the maculae are
  1493. 58:45made up of also supporting cells and
  1494. 58:47hair cells. Now, these hair cells have
  1495. 58:49these hair bundles. Those hair bundles
  1496. 58:52have you'll see now a whole bunch of
  1497. 58:55stereocilia
  1498. 58:57and
  1499. 58:58a kinocilium.
  1500. 59:01Stereocilia and a kinocilium. So, that
  1501. 59:04makes up a hair bundle. Those hair
  1502. 59:05bundles themselves now are embedded
  1503. 59:08within this otolithic membrane, this
  1504. 59:11rocky membrane you see there. Otolithic,
  1505. 59:15rocky membrane. So, you can see that
  1506. 59:16membrane is going to cover all of those
  1507. 59:19hair bundles. So, here now what happens
  1508. 59:22is as soon as you have the position of
  1509. 59:24the head start to change, what this does
  1510. 59:27it's going to get those stereocilia
  1511. 59:30and the kinocilium to start to bend. It
  1512. 59:32gets those hair bundles to bend. So,
  1513. 59:34when those hair bundles start to bend,
  1514. 59:36now depending on whether they're bending
  1515. 59:38towards or away from the kinocilium,
  1516. 59:41this will trigger then
  1517. 59:43action potentials or signals along these
  1518. 59:45nerves, letting then the brain know
  1519. 59:47what's going on.
  1520. 59:52So, you can see exactly that happening.
  1521. 59:53Here, this individual goes from the
  1522. 59:55seated position to where they put their
  1523. 59:57head down a bit, and this gets this
  1524. 59:59otolithic membrane membrane to start
  1525. 1:00:01moving.
  1526. 1:00:04Next then, we have our cristae
  1527. 1:00:06ampullaris.
  1528. 1:00:08Now, the cristae ampullaris are going to
  1529. 1:00:10be receptors for dynamic equilibrium.
  1530. 1:00:13Receptors for dynamic equilibrium.
  1531. 1:00:16Their function is that they get
  1532. 1:00:18stimulated by head movements. Now, they
  1533. 1:00:21get stimulated by head movements, but in
  1534. 1:00:23this case, you'll see the majority the
  1535. 1:00:26major stimulus are going to be rotary or
  1536. 1:00:29angular head movements. Rotary or
  1537. 1:00:32angular head movements.
  1538. 1:00:36Where are these receptors found? These
  1539. 1:00:38receptors are going to be found
  1540. 1:00:40in the ampulla of each semicircular
  1541. 1:00:42canal as we described.
  1542. 1:00:44In the ampulla of each semicircular
  1543. 1:00:45canal.
  1544. 1:00:47Now, here what we have is we'll move
  1545. 1:00:49over to this picture. Here what we have
  1546. 1:00:50is you can appreciate now
  1547. 1:00:53hair cells again, hair bundles. Okay?
  1548. 1:00:56Again, supporting cells there as well.
  1549. 1:00:58Now, here you have a cupula on top. Here
  1550. 1:01:00you have a cupula
  1551. 1:01:03enclosing all those hair bundles. So,
  1552. 1:01:05now here what happens is you can see
  1553. 1:01:08when we have these rotary movements.
  1554. 1:01:11Okay? These rotary movements are going
  1555. 1:01:13to cause this endolymph
  1556. 1:01:17to start to turn in the opposite
  1557. 1:01:19direction.
  1558. 1:01:20So, here what happens is you can see
  1559. 1:01:22now, if we're going to be moving in one
  1560. 1:01:24direction, this fluid is going to be
  1561. 1:01:26moving in the opposite direction. And
  1562. 1:01:28what that does, it gets basically this
  1563. 1:01:29cupula to start to bend, and that's
  1564. 1:01:31going to get those, again, same concept,
  1565. 1:01:34hair cells,
  1566. 1:01:36their bundles, the hair bundles, to
  1567. 1:01:37bend, and that's going to start then
  1568. 1:01:39sending signals to the brain, letting
  1569. 1:01:41the brain know, "Hey, we've got these
  1570. 1:01:43rotary movements occurring."
  1571. 1:01:47So, that there then is equilibrium as
  1572. 1:01:49well.

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