ADVERSE EFFECTS OF TRANSFUSION : IRON OVERLOAD — Transcript
Full transcript
- 0:00okay the other quite important
- 0:03complication
- 0:04of blood consumption is iron overload
- 0:07we must remember one pint of red cell
- 0:10back contain around 200 to 250 milligram
- 0:14of iron
- 0:16so if we repeatedly transfuse a patient
- 0:20with
- 0:21red blood cells there will be a
- 0:23deposition of iron
- 0:25occurring in the body
- 0:27at first
- 0:28the iron will be deposited in the
- 0:30reticular endothelial system or
- 0:32reticular endothelial tissue such as
- 0:35spleen
- 0:37but over many years the deposition of
- 0:40blood
- 0:40can occur in the liver
- 0:43in the myocardium which is the heart
- 0:45muscle and also the endocrine glands
- 0:48and this will cause damage to all these
- 0:51major organs after many years sometimes
- 0:54they present
- 0:56with hepatic or cardiac failure diabetes
- 0:59because their pancreas has been damaged
- 1:02and also thyroid abdominalities because
- 1:04a thyroid gland also has been damaged
- 1:07how do you want to treat this patient
- 1:10currently we have iron chelators ion
- 1:13chelators are a drugs that can chelate
- 1:16the iron
- 1:18bind to the iron and also get rid of the
- 1:21iron wire urine
- 1:23and also for the prevention we need to
- 1:26practice judy's transfusion meaning that
- 1:28we need to really weigh the benefit
- 1:32against the risk of transmission
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