Addiction I Full Documentary I NOVA I PBS — Transcript
Full transcript
- 0:01♪ ♪
- 0:03NARRATOR: A devastating epidemic...
- 0:05KEN: We just didn't know what to do.
- 0:07We just felt powerless.
- 0:09A parents' worst nightmare,
- 0:12to find my kid not breathing.
- 0:16JAMES WINNEFELD: He was always very good
- 0:17at telling us, "Mom and Dad, everything's going to be fine,"
- 0:20but it wasn't.
- 0:23NARRATOR: Addiction is ruining lives
- 0:25and ending them too soon.
- 0:27(alarm blaring)
- 0:28Overdose is the number one cause of death
- 0:30for people under 50.
- 0:32RAHUL GUPTA: We are racing against time.
- 0:34We have the equivalent
- 0:36of a Boeing 737 crashing every single day.
- 0:39NARRATOR: But what causes addiction?
- 0:42ROBERT MALENKA: Individuals struggling with addiction
- 0:44are actually battling millions of years of evolution,
- 0:48because our brains are exquisitely evolved,
- 0:52to seek rewards.
- 0:54It's those cravings, the inability to stop.
- 0:59NARRATOR: A dangerous cocktail of biology and medicine
- 1:03made deadlier by a drug 100 times more potent
- 1:07than morphine.
- 1:08DARWIN FISHER: Fentanyl is super toxic.
- 1:10So you get a batch that comes on the street
- 1:13that's a little bit hot,
- 1:14and on those days, it's like,
- 1:16bam, somebody's going down.
- 1:18Bam, somebody's going down.
- 1:20Bam!
- 1:22NARRATOR: But can new treatments offer hope?
- 1:25LAURA KEHOE: We have extremely effective medications
- 1:28that are life-saving.
- 1:30This is a very treatable illness.
- 1:32ANNA LEMBKE: The solution to this
- 1:34is for us to embrace addiction as a disease,
- 1:38to bring it within the house of medicine.
- 1:40FISHER: People recover from addiction.
- 1:42Nobody is unreclaimable.
- 1:46The only thing that you can't recover from
- 1:49is death.
- 1:50NARRATOR: "Addiction,"
- 1:52on "NOVA."
- 1:56♪ ♪
- 2:08♪ ♪
- 2:10NARRATOR: McDowell County, West Virginia,
- 2:13feels like a place left behind.
- 2:18Yet its miners helped power America
- 2:21when coal was king.
- 2:26Back then, the largest city, Welch,
- 2:30was a thriving community.
- 2:32But as coal jobs vanished by the 1990s,
- 2:36the poverty rate in the county
- 2:38climbed to 38%.
- 2:43Then investigators found
- 2:45that over a six-year period,
- 2:47drug companies had flooded the state
- 2:49with 780 million highly addictive pain pills.
- 2:53(train horn blaring)
- 2:58(rumbling)
- 3:04JASEN EDWARDS: West Virginia was the perfect storm.
- 3:07The whole state's dominated
- 3:08by one of the hardest and most dangerous jobs
- 3:10in the world.
- 3:11Most of the old timers that work in the mines
- 3:14work with pain.
- 3:15And then pain pills started flooding the community,
- 3:18and people that you used to know
- 3:21weren't the same people that they used to be.
- 3:24I mean, it, it just... it ruined everything.
- 3:28♪ ♪
- 3:30NARRATOR: Jasen Edwards and his two brothers Scott and Mark,
- 3:33grew up in Sophia, West Virginia.
- 3:38The town was near the Winding Gulf coal field.
- 3:42Most of its residents were miners,
- 3:46including the Edwards family.
- 3:49All three sons would struggle with pain pills.
- 3:55Jasen got his first prescription
- 3:57after crushing his leg in a mining accident.
- 4:02They cut my leg off the day after Christmas in 2008,
- 4:07and I was back underground mid-to-late February.
- 4:12First day I went back to work,
- 4:15I had to crawl everywhere or ride everywhere I went,
- 4:19because my stump was still too swollen
- 4:22to put my prosthetic leg on.
- 4:25A man hurts his back,
- 4:27if he is not back to work, they will replace him.
- 4:30And I could not have supported my family on the disability.
- 4:34NARRATOR: Soon, a few pills a day
- 4:37could no longer stop the pain.
- 4:38(drill grinding)
- 4:41But Jasen could easily buy more
- 4:44by visiting doctors and showing his artificial leg.
- 4:50JASEN: The first time I realized that I was in trouble
- 4:53is when I couldn't go to work,
- 4:54because I didn't have any pain pills.
- 4:57And it wasn't because of how bad I was hurting,
- 5:00it was because of the sickness due to detoxing.
- 5:04♪ ♪
- 5:06NARRATOR: Jasen was addicted to a powerful opioid painkiller
- 5:09called OxyContin.
- 5:13Opioids like OxyContin are chemically similar to morphine,
- 5:17found in the opium of the poppy plant.
- 5:20They mimic the body's natural pain relievers,
- 5:25like endorphins,
- 5:26which bind to proteins, called receptors,
- 5:29calming pain and inducing euphoria.
- 5:33Prolonged opioid use can alter the brain
- 5:37and lead to addiction,
- 5:38manifested by cravings and compulsive drug use
- 5:42despite negative consequences.
- 5:45♪ ♪
- 5:49As opioids were aggressively marketed,
- 5:51West Virginia soon had the highest rate of overdose deaths
- 5:54in the U.S.,
- 5:55alarming health commissioner Dr. Rahul Gupta.
- 5:59GUPTA: We were amongst the top states
- 6:02prescribing pain pills in the nation.
- 6:05At the same time,
- 6:07people were losing their employment,
- 6:08they were also losing a way of life.
- 6:11It spelled the perfect conditions under which
- 6:15addiction began to creep in.
- 6:18(indistinct talking)
- 6:21♪ ♪
- 6:26NARRATOR: At Stanford University,
- 6:28psychiatrist Anna Lembke
- 6:30also feared Big Pharma's pressure on doctors
- 6:32was creating an epidemic.
- 6:35When she got access to patients' prescriptions records,
- 6:39her suspicions were confirmed.
- 6:44Many people abusing pain pills
- 6:46were getting them from doctors-- not drug dealers.
- 6:50♪ ♪
- 6:53I'll never forget when I first looked at the drug database
- 6:56for a patient of mine.
- 6:57I mean, it was just glaringly obvious
- 7:00she'd been doctor shopping,
- 7:01you know, 1,600 pills, I think, in the span of a month.
- 7:04And I think it's important to know
- 7:06that doctors were being sued
- 7:08if they did not do everything within their power
- 7:11to address a patient's pain.
- 7:13So there was a serious problem going on here.
- 7:16NARRATOR: Lembke was also seeing a new type of patient--
- 7:21an "opioid refugee."
- 7:24(dog barking)
- 7:26KEN: How's your chemistry class coming?
- 7:27CASEY: It's fine.
- 7:30What are you guys working on in there?
- 7:31Compounds, chemical compounds,
- 7:33like iron...
- 7:34NARRATOR: Casey leads a protected life.
- 7:36Her father Ken watched drugs destroy his brothers,
- 7:41so he moved his daughters out of the city
- 7:43and put them in private schools.
- 7:49In her teens, Casey stayed busy with sports.
- 7:54But she began having severe muscle cramps.
- 7:58CASEY: I remember one game in particular,
- 8:01all of sudden I just started feeling really shaky
- 8:05and then everything just started hurting.
- 8:07My legs and my arms just cramped up really tight.
- 8:11She fell straight to the ground screaming in pain.
- 8:15It took me and one of her coaches to pick her up,
- 8:17put her in our car, rush her out to Children's.
- 8:21They did a million and one tests,
- 8:22and then they found, you know, an ovarian mass.
- 8:25Well, an ovarian mass in a teen, that's scary.
- 8:28So then that required more medical workup
- 8:31in order to discover that the mass was, in fact, benign,
- 8:34but by then, you know, she had a surgery,
- 8:36it had been removed,
- 8:37and through all of this,
- 8:38she received copious opioids.
- 8:41♪ ♪
- 8:44CASEY: Once I left the hospital,
- 8:45I noticed that I was still having a lot of pain,
- 8:48but it was nowhere near the surgery sites
- 8:51that they had operated on.
- 8:52KEN: We couldn't even touch her,
- 8:55she was in so much pain.
- 8:57She described it as
- 8:58it felt like her bones were being ripped out of her body.
- 9:01Now, the pain she was experiencing
- 9:04was opioid withdrawal pain, but they didn't know.
- 9:06So they whisk her back to the emergency room.
- 9:09"What could this possibly be?
- 9:10She's got terrible pain."
- 9:12And, essentially, every single time
- 9:14the solution was, "Prescribe more opioids."
- 9:17But after a while
- 9:18they didn't help as much anymore,
- 9:20so I started taking way too many.
- 9:24LEMBKE: Until at one point
- 9:25an emergency room doctor realized she's addicted,
- 9:29and what was his reaction?
- 9:30He basically went out and he shamed them.
- 9:32And he's like, "Your daughter's addicted.
- 9:34We never want to see her here again."
- 9:35NARRATOR: Stunned, Ken drove home,
- 9:39with no idea of how to help his daughter.
- 9:43Casey was now an opioid refugee,
- 9:46battling cravings and withdrawal on her own.
- 9:50We just felt powerless.
- 9:53And as a dad, I'm supposed to be her protector,
- 9:56and I just felt like I had, I had completely let her down,
- 10:00that...
- 10:06I just didn't,
- 10:07I mean, I just didn't know what, what to do anymore.
- 10:11♪ ♪
- 10:15LEMBKE: There was implicit trust.
- 10:17"If this medication were dangerous,
- 10:18"they would tell me.
- 10:20"As long as we take it just as prescribed,
- 10:23everything is going to be okay."
- 10:24And that is totally untrue.
- 10:26Casey's a great example.
- 10:29Now, given her family history of addiction,
- 10:31she probably had an underlying vulnerability, right?
- 10:33But what made her addicted
- 10:36was the opioids that she received from her doctors.
- 10:42NARRATOR: Addiction runs in families,
- 10:44and studies suggest
- 10:45that genes play a role in determining one's risk.
- 10:52Addiction is a complex disorder,
- 10:54and as a complex disorder, there's not one addiction gene.
- 10:58It's multiple genes
- 10:59and multiple other factors that interact with your genetics
- 11:03that increases risk.
- 11:06NARRATOR: Over 90% of addiction cases start before age 21,
- 11:11when the brain is still forming.
- 11:15For Jasen's brother Mark,
- 11:16it was a time of impulsive decisions.
- 11:20MARK EDWARDS: I had no idea how dangerous pain medication would be.
- 11:26I never woke up any day and said,
- 11:30"Man, I want to be an addict today."
- 11:33And I asked myself, "How did you end up here?"
- 11:38And I look back on my surroundings
- 11:40and everything that was around me.
- 11:42People everywhere was, was doing this.
- 11:47It was almost like there was nothing else in life.
- 11:51♪ ♪
- 11:53NARRATOR: As doctors prescribed fewer pain pills,
- 11:55drug cartels filled the void by selling heroin,
- 11:59an illegal opioid cheaper than OxyContin.
- 12:05Overdose deaths climbed
- 12:07as heroin, long available in inner cities,
- 12:09turned up in rural communities.
- 12:12♪ ♪
- 12:16In a single year,
- 12:17more than 70,000 Americans died of an overdose.
- 12:25Addiction is America's number one domestic issue today.
- 12:28We have hospitals
- 12:30that are overwhelmed with people who need help.
- 12:34We have a prison system that is filled
- 12:36with people who actually need treatment.
- 12:39We have judges
- 12:41that are often seeing more people with mental diseases
- 12:45than a psychiatrist-- or a primary care physician like me--
- 12:47sees in a day.
- 12:49The entire fabric of our society is being destroyed,
- 12:53as a result of addiction.
- 12:55♪ ♪
- 12:58NARRATOR: Addiction is often viewed as a moral failing--
- 13:02stigmatized by words like "clean," "dirty,"
- 13:06"abuser," "addict."
- 13:09But scientists now know it's a disorder
- 13:12that occurs as the brain changes in response to drugs.
- 13:17MALENKA: Individuals struggling with addiction
- 13:21are actually battling millions of years of evolution,
- 13:24because our brains are exquisitely evolved
- 13:28to seek rewards,
- 13:30to seek reinforcement wherever and whenever we can.
- 13:33♪ ♪
- 13:37NARRATOR: To understand how reward shapes behavior,
- 13:39Robert Malenka simulates a famous experiment.
- 13:44A mouse is attached to a fiber optic cable
- 13:47and placed in a cage with two holes.
- 13:50♪ ♪
- 13:53When the mouse explores the hole on the right,
- 13:55a flash of light sparks a feeling of pleasure
- 13:58in its brain.
- 14:01At the other hole, nothing happens.
- 14:07Yep, there he goes again, right now.
- 14:08(voiceover): We are learning machines.
- 14:12Our brains have evolved to be exquisite reward seekers,
- 14:16and that was important for evolutionary survival.
- 14:19But that came with a price--
- 14:22our susceptibility to developing addictions.
- 14:25NARRATOR: Obsessed with that burst of pleasure,
- 14:30the mouse will probe the hole several thousand times
- 14:33over the next hour.
- 14:35MALENKA: I mean look at this,
- 14:36he's just doing nothing else.
- 14:39NARRATOR: This experiment revealed the reward pathway in the brain,
- 14:44primarily controlled by a chemical messenger
- 14:47called dopamine.
- 14:50Dopamine tells your brain to pay attention,
- 14:53that whatever it just experienced
- 14:55is worth getting more of.
- 14:59It's released by endorphins
- 15:01or when we encounter anything pleasurable or exciting--
- 15:07especially drugs that can push dopamine levels
- 15:10ten times higher than normal.
- 15:13MALENKA: All drugs of abuse cause this unnatural rise of dopamine.
- 15:19And because of that,
- 15:21they're among the most powerful experiences
- 15:24our brains can have.
- 15:25♪ ♪
- 15:27NARRATOR: As drugs raise dopamine levels,
- 15:29they also alter the connections between brain cells,
- 15:33creating memoires of euphoria that trigger fierce cravings.
- 15:40But it's not just about seeking pleasure.
- 15:43People struggling with addiction
- 15:44soon use drugs to avoid the pain of withdrawal.
- 15:50JASEN: Withdrawals will make your bones ache.
- 15:54I couldn't leave the house because I couldn't take a step
- 15:58without soiling myself from the withdrawals.
- 16:02(shattering)
- 16:04You couldn't talk to me,
- 16:06I'd throw something at you or bite your head off.
- 16:10NARRATOR: When opioids are abruptly stopped,
- 16:13stress hormones are released at catastrophic levels.
- 16:18This imbalance triggers the opposite symptoms of opioid use,
- 16:23including shaking, anxiety, pain, and intense dysphoria.
- 16:29Many times I would lay my head on a pillow
- 16:33and think, "I'm done.
- 16:34I can't live like this, I don't want to be this person."
- 16:38And I would wake up the very next day,
- 16:41and I would just do more drugs.
- 16:43I was powerless over my addiction.
- 16:46It consumed me, it owned me,
- 16:49I was a slave to it.
- 16:54♪ ♪
- 16:59NARRATOR: This cycle of addiction, says Dr. Corey Waller,
- 17:03starts as the brain struggles to rebalance
- 17:06as drugs overwhelm it with dopamine.
- 17:09WALLER: When that happens,
- 17:10the body decreases the production of dopamine,
- 17:14and eventually you can't even get enough dopamine produced
- 17:16to get out of bed,
- 17:17let alone produce good relationships
- 17:19and good decision-making.
- 17:21♪ ♪
- 17:23NARRATOR: To understand what happens to dopamine,
- 17:26Dr. Nora Volkow has been imaging the brains
- 17:31of people with and without addiction
- 17:32to search for changes that occur with drug use.
- 17:36♪ ♪
- 17:40VOLKOW: We systematically were investigating
- 17:41individuals addicted to different classes of drugs,
- 17:44and we found that a common change
- 17:46across all of the different types of drug addictions
- 17:49was a reduction in the levels of dopamine D2 receptors.
- 17:54NARRATOR: The number of receptor proteins,
- 17:58seen here as red in the brains of control subjects,
- 18:01are reduced in brains exposed to drugs.
- 18:05Fewer receptors means the brain is starving for dopamine.
- 18:09VOLKOW: Drugs interfere with your motivational drive.
- 18:15So imagine what it means
- 18:16to lose the motivation to do things,
- 18:19to just not have it.
- 18:21WALLER: And so anytime someone hears the term motivation,
- 18:23they should really supplant that with dopamine.
- 18:26Because without dopamine, you don't have motivation.
- 18:29And so, when we look at a person
- 18:30who is in the throes of an addictive disorder,
- 18:33and say, "They just need to motivate!"
- 18:34We're telling them to somehow magically make dopamine.
- 18:38(tumblers spinning)
- 18:40NARRATOR: And it's not just drugs--
- 18:41gambling or eating can also spike dopamine levels
- 18:46and become addictive.
- 18:49Volkow found that people with morbid obesity
- 18:52also have fewer dopamine receptors.
- 18:57VOLKOW: Once those receptors are going down,
- 18:59you are going to have a great difficulty
- 19:04in self-regulating the desire not to eat,
- 19:06because cognitively, your brain is fighting.
- 19:09On the one hand you say, "I, I'm obese,
- 19:11I don't want to eat anymore."
- 19:12And at the same time, there is intense craving.
- 19:15And if your brain is not functioning properly,
- 19:19you cannot win the game.
- 19:22You are going to give in
- 19:24and impulsively and compulsively eat that food.
- 19:28NARRATOR: And drugs can unleash even stronger cravings.
- 19:34JASEN: My wife at the time
- 19:35went and seen her sister for nine days,
- 19:39and I spent $21,000 while she was gone...
- 19:41(chuckles sardonically)
- 19:44on pain medicine.
- 19:46I did lose my job, I didn't care.
- 19:50Only thing I cared about
- 19:53was that magical date on the calendar
- 19:54when I went back to the doctor.
- 19:55WALLER: The body has a drive for dopamine,
- 19:59and that craving flips them into survival mode.
- 20:03If you understand that this is about survival for them,
- 20:05you can understand why they steal $20 out of your wallet,
- 20:10why they hock jewelry from the house.
- 20:13JASEN: My habits was putting my wife and my daughter in danger.
- 20:18Finally, she just done what any mother would do,
- 20:21and they left.
- 20:24♪ ♪
- 20:27NARRATOR: Jasen attempted suicide
- 20:29after his brother Scott died of an overdose
- 20:31on the outskirts of town.
- 20:35For Mark Edwards,
- 20:36it was a moment of reckoning with his own addiction.
- 20:40MARK: I did not want to be that person that was broken.
- 20:44And I wanted to get help,
- 20:47but every place that I called didn't have beds available.
- 20:51I felt like that
- 20:52if I didn't do something,
- 20:54that I would end up dead.
- 20:58♪ ♪
- 21:01NARRATOR: Another drug is making the epidemic even deadlier,
- 21:06especially in Vancouver, Canada.
- 21:11The city has become a gateway for illegal fentanyl,
- 21:14made in China.
- 21:17Normally used for anesthesia, fentanyl is so potent,
- 21:21it's often shipped a few ounces at a time
- 21:24and later mixed with other drugs.
- 21:28Hidden in innocuous-looking packages,
- 21:31much of China's fentanyl is headed for U.S. markets.
- 21:36But it's also devastating Vancouver.
- 21:42FISHER: Fentanyl is a synthetic opiate created in a lab.
- 21:45It is super toxic.
- 21:46So you'll get a batch that comes on the street
- 21:48that's a little bit hot.
- 21:50And on those days, it's like,
- 21:51bam, somebody's going down, bam, somebody's going down,
- 21:53bam!
- 21:57NARRATOR: Up to 50 times stronger than heroin,
- 21:59an amount of fentanyl equal in size
- 22:01to two grains of salt
- 22:03will kill you.
- 22:05(siren blaring)
- 22:09Fentanyl's path of destruction
- 22:11is closely monitored in West Virginia
- 22:14by Dr. Rahul Gupta.
- 22:16Using a digital map,
- 22:20Gupta follows overdoses as they occur.
- 22:23Circles stand for non-lethal incidents.
- 22:28Squares indicate fatal ones.
- 22:31And a spike of deaths in nearby states
- 22:35means fentanyl-tainted drugs may soon show up
- 22:38in West Virginia.
- 22:39♪ ♪
- 22:42GUPTA: On one day, we had 26 overdoses reported to us.
- 22:47It was almost like a communicable disease outbreak.
- 22:50And here's the scariest part.
- 22:51We found that of all of those people who overdosed,
- 22:55none-- no one--
- 22:57was ever admitted into a treatment facility.
- 23:01(radios squawking)
- 23:03NARRATOR: But many people don't survive at all
- 23:06because opioids, if taken in excess,
- 23:08can quickly shut down breathing.
- 23:11Hello?
- 23:12NARRATOR: And because of the potency of fentanyl,
- 23:15the risk of a fatal overdose is high,
- 23:19no matter who you are or where you live.
- 23:23♪ ♪
- 23:31MARY WINNEFELD: Jonathan was a wonderful young man.
- 23:33From a very early age, compassionate, smart, loving.
- 23:39Our family did go through many moves.
- 23:42We lived all over this country, overseas.
- 23:45So that was, I think, tough for Jonathan.
- 23:49NARRATOR: Jonathan Winnefeld was born into an accomplished family.
- 23:57His father James rose through the naval ranks
- 24:00to become the Vice Chairman of the Joint Chiefs of Staff
- 24:03in 2011.
- 24:07By that time, Jonathan was struggling.
- 24:10JAMES: At one point, he was in five different school districts
- 24:14in six years, which is tough for a kid.
- 24:16And so what became apparent to us over time
- 24:19was that Jonathan, as great a kid as he was,
- 24:22was suffering from some form of anxiety and depression.
- 24:27NARRATOR: Unfortunately, Jonathan was misdiagnosed
- 24:29with attention deficit disorder,
- 24:32and prescribed Adderall, a powerful stimulant.
- 24:37Soon, to unwind at night, he began to drink.
- 24:43To calm his anxiety,
- 24:45he used Xanax, a mild tranquilizer,
- 24:48and smoked pot.
- 24:50Then, he experimented with heroin.
- 24:55MARY: So we got him into counseling,
- 24:57and I did what a normal parent would do.
- 25:01I took away the Xbox,
- 25:02I took away his phone, I monitored all of his moves.
- 25:06In retrospect,
- 25:08it was probably the worst thing I could have done for him,
- 25:10because it isolated him even more.
- 25:13(sirens blaring)
- 25:14JAMES: And, ultimately, he tried to take his own life.
- 25:17He ended up wrapping his car around a telephone pole.
- 25:22It was at that point when we realized
- 25:23that we needed to get Jonathan into inpatient treatment
- 25:25or we were going to lose him.
- 25:27(typing on keyboard)
- 25:29MARY: I went on the internet and searched,
- 25:31and it's overwhelming.
- 25:33There are so many different places out there.
- 25:35You don't know who's good, who's bad,
- 25:37who's just trying to make money.
- 25:39Financially, our insurance covered nothing.
- 25:42We really tried to find the best treatment possible out there.
- 25:45But, in America, there's not a lot of support
- 25:48in the mental health
- 25:50and especially in substance abuse.
- 25:55NARRATOR: The Winnefelds found a center in Connecticut
- 25:57to treat Jonathan's addiction and anxiety.
- 26:02Like some 80% of programs,
- 26:03it followed the 12-step model of Alcoholics Anonymous,
- 26:07where patients admit they are powerless over drugs,
- 26:10need help from a higher power, and commit to abstinence.
- 26:16WALLER: If we look at the legacy treatments
- 26:19that've been around for 70 years,
- 26:21they revolve around going to meetings
- 26:22and working through the 12 steps,
- 26:25generally doing that a lot
- 26:27with self-help and group-based therapy,
- 26:29and then maintaining that abstinence
- 26:32by using that alone.
- 26:33NARRATOR: Jonathan's treatment for 15 months
- 26:37cost the Winnefelds hundreds of thousands of dollars,
- 26:41but it seemed worth it.
- 26:46JAMES: Our son came back to us.
- 26:49We were able to have a real conversation with him.
- 26:51We saw, about a year into his treatment,
- 26:53that he regained his ambition.
- 26:56♪ ♪
- 26:58NARRATOR: Seeming confident of his recovery,
- 27:00Jonathan enrolled as a freshman at the University of Denver.
- 27:05JAMES: That day we dropped him off at his dorm,
- 27:07he was excited, looking good, fired up,
- 27:11and it was one of the best moments of my life,
- 27:13seeing him doing so well.
- 27:16(phone vibrating)
- 27:20NARRATOR: Three days later,
- 27:22their hopes were shattered.
- 27:25MARY: I was not prepared to get a phone call
- 27:29saying that my son had passed away
- 27:31in his bed, in his dorm room, from heroin and fentanyl.
- 27:36Never, never, never would have guessed that
- 27:39in a million years.
- 27:43♪ ♪
- 27:45NARRATOR: With failure rates nearing 80% to 90%,
- 27:48is the abstinence-based approach to opioid addiction
- 27:52scientifically flawed?
- 27:55Abstinence-based programs really, for opioid use disorder,
- 28:00are setting people up to fail and to relapse.
- 28:02And in the face of this crisis,
- 28:05where we know that every single time
- 28:07that somebody uses an opioid,
- 28:09they are at real risk of overdosing and dying,
- 28:12this should never be recommended as a primary intervention.
- 28:20NARRATOR: In Morgantown, West Virginia,
- 28:22Dr. James Berry also believed abstinence-based treatment
- 28:26was failing his patients with opioid addiction.
- 28:30(nurse talking indistinctly)
- 28:31BERRY: We would get them successfully detoxed,
- 28:34get them exposed to family therapy,
- 28:36group therapy, individual therapy,
- 28:39and we'd find that they would invariably relapse,
- 28:42and they'd just be out there on the streets using again.
- 28:45♪ ♪
- 28:47NARRATOR: Frustrated, Berry considered using methadone,
- 28:49a long-lasting opioid
- 28:51that curbs cravings from heroin and pain pills
- 28:55without causing euphoria.
- 28:57Methadone binds to opioid receptors
- 29:01and normalizes brain functions altered by addiction,
- 29:05including dopamine levels.
- 29:08Here is your medication, sir.
- 29:10NARRATOR: Under current laws,
- 29:11most patients must take it at clinics.
- 29:13Here is your medication, sir.
- 29:15NARRATOR: In 2003, the opioid buprenorphine
- 29:19became available under the brand name Suboxone,
- 29:23which could be taken at home.
- 29:27Less potent than methadone,
- 29:30Suboxone only partially activates opioid receptors
- 29:33to reduce cravings.
- 29:36If taken as prescribed and not misused,
- 29:39both drugs cut mortality by about half.
- 29:43After a year,
- 29:4640% to 90% of patients are in recovery.
- 29:49You feeling better?
- 29:51NARRATOR: Berry began giving patients Suboxone.
- 29:54Oh, yeah, 100%.
- 29:55They started doing well,
- 29:56they started getting their lives back,
- 29:58they started getting to work again.
- 30:00Uh, Lawrence, how are you?
- 30:01Good.
- 30:02And how much time do you got today?
- 30:04I got like 260 or...
- 30:06BERRY: 245 days!
- 30:08245, okay, yeah.
- 30:10Tell us what you have been doing the last two weeks.
- 30:11Work has picked up.
- 30:13I'm about to buy into my boss's business,
- 30:14yeah 35%.
- 30:16He's gonna let me buy in.
- 30:16No kidding!
- 30:17So that will be awesome for me.
- 30:19So you've really showed him what you've been able to do.
- 30:20Yeah, yeah.
- 30:22The main thing that makes Suboxone so effective
- 30:24is it's helping with these cravings
- 30:27that people are experiencing.
- 30:29But it's so hard to break that chain.
- 30:31BERRY: Patient after patient after patient
- 30:34will tell me the same story.
- 30:35"Listen, Doc,
- 30:36"I am not using to get high anymore.
- 30:39I am just using not to be sick anymore."
- 30:41What Suboxone does is
- 30:44it satisfies those cravings
- 30:46in a way that they're under control.
- 30:49It works so much better
- 30:52on calming that demon inside you.
- 30:53If I went home,
- 30:56started doing opiates again,
- 30:58I was going to kill myself.
- 30:59(indistinct talking)
- 31:01NARRATOR: With cravings under control,
- 31:03patients can take advantage of a range of therapies
- 31:06to help them cope and rebuild their lives.
- 31:12LEMBKE: There are fantastic psychosocial interventions
- 31:16like retraining your brain, being mindful,
- 31:19learning more adaptive coping strategies.
- 31:21The night before, I was saying...
- 31:23CARRIE WILKINS: Because it's not just one epiphany moment.
- 31:26It's a learning process.
- 31:27You have to learn to be sober.
- 31:29And it takes practice, it takes trial and error.
- 31:31And you've got to be ready for the ups and downs.
- 31:35♪ ♪
- 31:38NARRATOR: One challenge, according to psychologist Rita Goldstein,
- 31:42are the changes that occur with addiction
- 31:44in the brain's executive control center,
- 31:46the prefrontal cortex.
- 31:49This is the prefrontal cortex, in the front of the brain.
- 31:54And we're looking at gray matter,
- 31:55separating it from the white matter.
- 31:58So you can see,
- 31:59it's actually tinted gray in this scan.
- 32:01♪ ♪
- 32:03NARRATOR: Scans reveal that chronic drug use
- 32:06is associated with reduced grey matter,
- 32:09especially in the prefrontal cortex.
- 32:14GOLDSTEIN: Those regions are essential to make advantageous choices--
- 32:18to make the right decision at the right time.
- 32:21So, the lower the gray matter,
- 32:23the more the decision-making is impaired.
- 32:25You have a decrease
- 32:27in the ability to control your behavior.
- 32:31NARRATOR: Neuroscientist Yasmin Hurd
- 32:34has found another way
- 32:35that chronic drug use impacts the brain.
- 32:39By analyzing the brains of overdose victims,
- 32:43she's discovered that heroin changes the activity
- 32:46of key genes.
- 32:50Heroin changes the way our DNA functions.
- 32:52It turns on genes that should not be on.
- 32:56And turns off genes that should be on.
- 32:58And so that imbalance changes the brain function.
- 33:02♪ ♪
- 33:05NARRATOR: The genes most affected
- 33:06regulate the brain's key chemical messenger,
- 33:08called glutamate,
- 33:11which is essential for sending signals between neurons,
- 33:13making thinking, memory, and learning possible.
- 33:20HURD: It's not that addiction completely takes away
- 33:22every aspect of your cognitive function.
- 33:25In fact, you have to work even harder.
- 33:27So I think people need to understand
- 33:29that people with these disorders
- 33:30are actually fighting a very strong battle.
- 33:35NARRATOR: But is this a battle that can be fought and won?
- 33:40Opioids are still being studied,
- 33:42but scans reveal
- 33:44that dopamine receptors reduced by other addictive drugs
- 33:48can come back with recovery.
- 33:52Rita Goldstein has seen evidence that grey matter can increase.
- 33:58The ability of the brain to heal and to recover is amazing.
- 34:01So definitely there is a lot of hope.
- 34:04HURD: The question is,
- 34:06"How long does it take?"
- 34:07And everyone's brain is different.
- 34:10(siren blaring)
- 34:14NARRATOR: Yet most people don't have access
- 34:16to effective treatment,
- 34:18especially medications for opioid addiction.
- 34:21♪ ♪
- 34:23For Dr. Corey Waller,
- 34:25the problem is that addiction is not handled
- 34:27like other diseases.
- 34:29WALLER: If a patient comes into an emergency department
- 34:32with chest pain,
- 34:33we have a pretty standard set of approaches.
- 34:35We evaluate whether or not the heart's being injured.
- 34:38We look at an E.K.G. that tells me,
- 34:40"Do they need to get something done quickly?"
- 34:43And no matter what the answer is,
- 34:44we actually have a place for them to go.
- 34:48NARRATOR: For overdose victims, the focus is mainly on revival.
- 34:55These are patients who are basically dead.
- 34:57They're not breathing.
- 34:58They are this close to being dead forever.
- 35:01WALLER: Let's give the Narcan real quick.
- 35:02NARRATOR: The drug naloxone,
- 35:04sold under the brand name Narcan,
- 35:06can reverse an overdose
- 35:08by pulling opioids off receptors in the brain.
- 35:11You all right?
- 35:12Good.
- 35:15WALLER (voiceover): And in most emergency departments around the country,
- 35:16that's the extent of the intervention.
- 35:19Check the box, sign the chart, discharge the patient.
- 35:22Unfortunately, we discharge them back out into the wilderness,
- 35:25where there is no consolidated, appropriate care for them.
- 35:29Big, deep breaths.
- 35:30NARRATOR: Although Narcan saves lives,
- 35:33it can also put patients into acute withdrawal.
- 35:37Without medications to control cravings,
- 35:41many will overdose again.
- 35:45WOMAN: Oh, my God.
- 35:48(child crying)
- 35:52KEHOE: This human tragedy really is a human rights issue.
- 35:58The last thing we should be doing
- 35:59is kicking people out of care.
- 36:00That's when they're in crisis.
- 36:01♪ ♪
- 36:04NARRATOR: Massachusetts General Hospital
- 36:06runs one of the few programs in the U.S.
- 36:09that immediately offers overdose patients medications
- 36:12to control cravings.
- 36:16KEHOE: This is a treatable illness.
- 36:19We have to have people in that moment
- 36:21who can say, "Hey, I'm here to help you.
- 36:24"Are you interested in engaging in care?
- 36:26We have Suboxone we can start you on right away."
- 36:31We're seeing people come that day
- 36:32and engage in care,
- 36:33and the vast majority of them, 75% to 80%,
- 36:37are returning.
- 36:38♪ ♪
- 36:40What's going on here? Did we tolerate it?
- 36:42NARRATOR: Since effective treatment is hard to find,
- 36:44the costs of the epidemic continue to rise.
- 36:49In Charleston, West Virginia,
- 36:52Dr. Stefan Maxwell cares for babies born dependent on drugs.
- 36:56(baby wailing)
- 36:58MAXWELL: It's a withdrawal syndrome.
- 37:01They have vomiting, diarrhea.
- 37:04Frantic behavior, they may scratch themselves.
- 37:06These babies may go for many days without sleeping
- 37:11or eating.
- 37:12And symptoms may last up to three months.
- 37:16NURSE: I know, baby, I know.
- 37:17NARRATOR: Babies in acute withdrawal are weaned off opioids
- 37:21by giving them smaller and smaller doses.
- 37:25I just gave her a methadone about five minutes ago.
- 37:30NARRATOR: Every 25 minutes,
- 37:32somewhere in the U.S.,
- 37:34a baby is born dependent on opioids.
- 37:38Many will become wards of the state.
- 37:44We have amongst the highest number of foster children
- 37:47in the nation per capita.
- 37:48We're having difficulty finding parents
- 37:51and providing services.
- 37:53In fact, we believe it cost
- 37:55over a million dollars per child additionally
- 37:58if they're born dependent on drugs.
- 38:02♪ ♪
- 38:04NARRATOR: Many parents with addiction are also facing challenges
- 38:08like poverty and trauma.
- 38:12BESSEL VAN DER KOLK: Trauma is an experience that overwhelms you,
- 38:16that leaves you bereft, paralyzed,
- 38:19and with no way out.
- 38:21And it can come in many different contexts.
- 38:24It can be physical, verbal, sexual abuse,
- 38:28childhood neglect.
- 38:29And these problems early in life
- 38:32put you at risk later in life.
- 38:35NARRATOR: Studies show experiencing a combination
- 38:38of five adverse events
- 38:40can increase the risk of addiction tenfold.
- 38:45Trauma can cause long-lasting changes in the brain,
- 38:49leaving sufferers like Marie
- 38:50also vulnerable to depression and anxiety.
- 38:56We had somewhat of a decent family life, you know,
- 38:59but I watched my dad beat my mom my whole life, you know.
- 39:02My dad was an alcoholic.
- 39:04They finally divorced,
- 39:06and me and my mom moved out here.
- 39:07And my mom kind of lost it.
- 39:11That's when I started
- 39:12really, just, you know, going wild.
- 39:14VAN DER KOLK: What you're left with as a kid,
- 39:17is these heartbreaking feelings
- 39:19of "I'm no good" and "The world is a terrible place."
- 39:23Somebody says to you,
- 39:25"Here is something that will make these feelings go away."
- 39:29And so, people take drugs
- 39:30because they can't stand the way they feel.
- 39:33NARRATOR: After Marie had her first child,
- 39:37she became addicted to OxyContin.
- 39:41Child Protective Services took custody of her son
- 39:44until she could pass her drug tests.
- 39:48For a while, things went well.
- 39:53But Marie began struggling
- 39:55after giving birth to her second child.
- 39:59MARIE: I went home to see my first son,
- 40:01you know, because I hadn't been spending time with him.
- 40:04And then I got a phone call,
- 40:05and CPS said, "Get ready,
- 40:07"'cause we got to meet you in Charleston
- 40:08to take your kids."
- 40:12NARRATOR: During her pregnancy,
- 40:14Marie had been given methadone for free.
- 40:17But after her delivery,
- 40:19she had to pay for her treatment.
- 40:24With no money or insurance, she relapsed.
- 40:28It's a reality faced by countless people
- 40:31without resources.
- 40:33MARIE: By that time
- 40:35I owed the methadone clinic over $600 and some, you know.
- 40:39And, of course, when you go back, you know,
- 40:40they wouldn't see you no more
- 40:41because I owed them too much money.
- 40:43So I couldn't, I couldn't dose no more,
- 40:45so here I am back at it again, you know.
- 40:48(sniffles)
- 40:50MARY PRICE: She needed services that were lacking
- 40:53here in rural West Virginia.
- 40:56She needed those to be available for her,
- 40:58and they're not.
- 41:00And that saddens me, because...
- 41:04because I know...
- 41:07that the mom's hearts break.
- 41:12(radio squawking)
- 41:13MARIE: I'll never forget that whole scene in my life.
- 41:18they surrounded us with cops,
- 41:19and that was not needed, you know.
- 41:21And my three-year-old said, "Mommy,
- 41:23hold my hat while I'm gone."
- 41:26(voice breaking): And...
- 41:27they took him away.
- 41:34WALLER: People always want to talk about,
- 41:36"How do we stop the cycle?"
- 41:39That's how we stop the cycle.
- 41:40You don't stop the cycle by pulling the baby
- 41:42because mom took drugs.
- 41:45We just need to see it and treat it
- 41:46like it's any other disease.
- 41:48You get the mom stable, you get baby stable,
- 41:51and you go home with a family.
- 41:53♪ ♪
- 41:57NARRATOR: Back in Vancouver,
- 41:59the opioid epidemic spurred the city to take bold steps,
- 42:03even before fentanyl tainted the drug supply.
- 42:08In 2003 it sanctioned the first legal site in North America
- 42:13where people could inject illegal drugs
- 42:16under medical supervision.
- 42:19Called Insite,
- 42:21the program provides clean needles
- 42:23to prevent the spread of infectious diseases,
- 42:25drugs to reverse overdoses,
- 42:28and help accessing services,
- 42:29like medically assisted treatment.
- 42:34FISHER: When people come to Insite,
- 42:36often the first thing that they're thinking is,
- 42:38"I need a safer place to use.
- 42:40"I don't want to die in the alley.
- 42:42"I'm tired of living in, essentially,
- 42:43what are Third World conditions."
- 42:45So what we're doing is we're saying,
- 42:47"Come on in to First World health care."
- 42:49And in the years since Insite's opened,
- 42:52overdoses in the area have gone down,
- 42:54and our H.I.V. rate in Vancouver has plummeted dramatically.
- 42:57NARRATOR: Insite's success bolstered other efforts.
- 43:02At the Overdose Prevention Society,
- 43:06Sarah Blythe helps people test their drugs for fentanyl.
- 43:11But that's not the only contaminant
- 43:13she's worried about.
- 43:16BLYTHE: Because we've seen everything
- 43:17from cement filler to Comet to pig de-wormer,
- 43:22like, you name it,
- 43:23anything that they can put in there,
- 43:25they do, and it's dangerous.
- 43:27NARRATOR: A pink stripe indicates the presence of fentanyl.
- 43:31It's now found in 88% of illegal opioids here.
- 43:38Like many longtime users,
- 43:40Daniel knows he's injecting fentanyl,
- 43:45but the fear of dying
- 43:46isn't as powerful as his cravings.
- 43:52He first took opioids in prison to calm his anxiety.
- 43:58There's always a fear
- 44:00of something horrible about to happen.
- 44:02There's going to be somebody getting stabbed,
- 44:04a fight's going to break out.
- 44:05And so when I did that first hit,
- 44:08it was the first time I felt like I could relax
- 44:12and not have to worry.
- 44:13♪ ♪
- 44:17FISHER: To my mind,
- 44:18obviously the most important thing
- 44:20about supervised injection sites
- 44:22is that it implicitly says that,
- 44:24"These lives are worth saving,
- 44:26these people are valuable to us."
- 44:28What's really important about it as well
- 44:29is that it's a space of connection.
- 44:31That's the space that people are going to ask for help from.
- 44:37NARRATOR: Supervised injection sites are illegal in the U.S.,
- 44:42but in Canada, the controversy is waning.
- 44:46For 22 years, Bill Spearn has walked the streets
- 44:51of the downtown east side.
- 44:54Although drugs are still here,
- 44:56overdose deaths decreased 35%
- 44:59after Insite opened.
- 45:04Once a skeptic of supervised injection sites,
- 45:07today he's not.
- 45:10SPEARN: Does it increase crime?
- 45:12Does it encourage drug use?
- 45:14Is Insite a big magnet that attracts drug users
- 45:17from all over the world?
- 45:18And the answer is no, it doesn't.
- 45:21And I think that harm reduction
- 45:23is something that every city should consider,
- 45:26because it keeps people alive.
- 45:29FISHER: It actually saves taxpayers dollars.
- 45:31The most expensive housing that we have in this society?
- 45:37Emergency rooms and jail cells.
- 45:40We need to quit putting people in those
- 45:42and start putting people in more compassionate spaces
- 45:45like supervised injection sites.
- 45:46♪ ♪
- 45:51NARRATOR: Meanwhile in West Virginia,
- 45:53heath commissioner Dr. Rahul Gupta,
- 45:56is also trying to reverse
- 45:58the soaring number of overdose deaths.
- 46:02Today he's traveling with a volunteer medical team
- 46:05to bring free health care to McDowell County
- 46:08and take steps to stop preventable deaths.
- 46:16GUPTA: This is naloxone.
- 46:18NARRATOR: Because overdose fatalities here
- 46:21are seven times the national average,
- 46:23Gupta and his colleagues are trying to get naloxone,
- 46:26the overdose reversal drug,
- 46:28to as many people as possible.
- 46:30That's how this drug works to save your life,
- 46:33okay?
- 46:34But after that you've got to get help as well.
- 46:37I don't look at this as a single epidemic.
- 46:39I look at this as multiple epidemics
- 46:41coming together and evolving in real time.
- 46:44NARRATOR: Gupta is worried
- 46:47about the huge spike in hepatitis
- 46:49and the rising number of H.I.V. cases.
- 46:52Patients are offered free testing
- 46:56to see if they need treatment.
- 46:58VOLUNTEER: It just takes 20 minutes.
- 47:01Now, I also want to talk to you about a needle exchange,
- 47:03are you okay with that? Okay.
- 47:05NARRATOR: McDowell is one of the few counties
- 47:09that allows needles to be handed out to prevent infections.
- 47:12Okay?
- 47:13The idea here is to have your own set.
- 47:16NARRATOR: According to Gupta's analysis,
- 47:19every dollar spent on harm reduction
- 47:21saves up to seven dollars in medical costs
- 47:24and steers people towards treatment.
- 47:27...when you do want to get help,
- 47:29whether it's counseling or any other aspect,
- 47:31we're here to help you.
- 47:32♪ ♪
- 47:34The cost are really unsustainable
- 47:36if we continue this path,
- 47:38losing over half a trillion dollars a year
- 47:40for multiple years in our economy.
- 47:43We've got to be smart about addressing addiction.
- 47:47We have to find ways
- 47:49to prevent it from happening in the first place.
- 47:51VOLKOW: As a country,
- 47:53we have neglected it,
- 47:55and we have stigmatized it, and we have criminalized it,
- 47:58and that has not solved the problem.
- 48:00In fact, it has made it worse.
- 48:02NARRATOR: But America's addiction crisis is not just limited to opioids.
- 48:09Each year over 80,000 people die from excessive drinking.
- 48:15Smoking is responsible for over 400,000 deaths.
- 48:23And so if we don't build a stabilized, appropriate,
- 48:27evidenced-based treatment system for addiction,
- 48:29then the reason that medicine gets so costly every year
- 48:34is because what we're trying to do
- 48:36is not intervene on the front end,
- 48:39we're trying to fix everything that's broken on the back end.
- 48:41The solution to this
- 48:43is for us to embrace addiction as a disease,
- 48:47to bring it within the house of medicine,
- 48:48so that anybody struggling with addiction
- 48:51can walk into an emergency room,
- 48:53or a pediatrician's office,
- 48:55say, "I'm having a problem with drugs or alcohol,
- 48:58will you help me?"
- 49:00And that the answer is an enthusiastic "Yes!"
- 49:03(turn signal ticking)
- 49:06NARRATOR: Today most people struggling with opioid addictions
- 49:08cannot access medications
- 49:10or treatments proven to be effective.
- 49:17Some people recover on their own,
- 49:19but it's rare.
- 49:23Jasen is one who beat the odds.
- 49:26He is remarried
- 49:28and delivers cars for his brother Mark's business.
- 49:32♪ ♪
- 49:33JASEN: I am not the man that I want to be,
- 49:37but I'm not the man I used to be, thank God.
- 49:39I try to become better every day.
- 49:43Sometimes I fail, sometimes I succeed.
- 49:46But I keep trying.
- 49:47(cooing)
- 49:49NARRATOR: Mark recovered after five years of methadone treatment,
- 49:53followed by a faith-based program.
- 49:56MARK: And that love began to change me
- 50:00in a way that I didn't think would ever be possible.
- 50:03Shoot!
- 50:05Oh, good shot!
- 50:09NARRATOR: Casey is now on Suboxone
- 50:11and studying to become a doctor.
- 50:15Her muscle cramps have been diagnosed
- 50:17as fibromyalgia
- 50:19and rheumatoid arthritis.
- 50:23To control her symptoms,
- 50:25she takes 11 other medications,
- 50:28but none are opioids.
- 50:31Happy...
- 50:33(voiceover): Recovery is definitely possible.
- 50:35It might take years or months or however long,
- 50:39but it is possible.
- 50:40♪ ♪
- 50:44NARRATOR: Marie is on Suboxone and getting group therapy,
- 50:48paid for by Medicaid.
- 50:51Today, she is going to see her youngest son,
- 50:54who lives with a foster family.
- 50:59Bubby, come here.
- 51:02What are you doing?
- 51:05Get me in!
- 51:06Come here and give me a hug, Booga!
- 51:09Mmm, I love you.
- 51:12(voiceover): That baby means so much to me.
- 51:15Now that I'm getting it together,
- 51:17I hope that as time goes by,
- 51:19they'll see a difference in me, you know.
- 51:21NARRATOR: As long as Marie is in recovery,
- 51:24she can visit her children.
- 51:25Ready?
- 51:26I want to go with you.
- 51:28I wish you could go with me, Bubby.
- 51:30I want you to go with me, if you only knew.
- 51:34If you only knew.
- 51:36FISHER: People recover from addiction.
- 51:38They need basic stability, stability of relationships,
- 51:43they need housing,
- 51:44they need that sense of a future that they can look forward to.
- 51:49When we offer people things like that,
- 51:51they get better.
- 51:52They are better.
- 51:54Nobody is unreclaimable.
- 52:01♪ ♪
- 52:17♪ ♪
- 52:32To order this "NOVA" program on DVD,
- 52:35visit ShopPBS or call 1-800-PLAY-PBS.
- 52:40This program is also available on Amazon Prime Video.
- 52:45♪ ♪
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