2025 3MT 2nd place: Ashley Baranczuk | K-State Graduate School — Transcript

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1. 0:02our next presenter is originally from
2. 0:05shaune Kansas she is a PhD student in
3. 0:08kinesiology when she's not busy with her
4. 0:10lab rats she loves spending time with
5. 0:12her adorable guinea pig
6. 0:15Elton Ashley enjoys the outdoors and
7. 0:18never misses a chance to play board
8. 0:20games with her friends this year she's
9. 0:22focused on improving her public speaking
10. 0:24skills and setting realistic goals to
11. 0:27push herself further what a better way
12. 0:29to do that then here at 3mt would you
13. 0:32please welcome Ashley
14. 0:36[Applause]
15. 0:45baranek test again okay every time we
16. 0:49exercise or are Physically Active even
17. 0:52if it's as simple as walking up the
18. 0:54stairs or doing chores around the house
19. 0:56our body has to make physiological
20. 0:58adjustments one of of those adjustments
21. 1:00is an increase in blood pressure this
22. 1:03increase in blood pressure helps to
23. 1:05promote an increase in blood flow to
24. 1:07working skeletal muscle in a healthy
25. 1:09individual a small to moderate increase
26. 1:12in blood pressure is beneficial and
27. 1:14helps us complete daily tasks of living
28. 1:16however and when a cardiovascular
29. 1:18disease patient exercises their increase
30. 1:21in blood pressure is much larger this
31. 1:24exaggerated blood pressure response to
32. 1:26activity puts them at risk for adverse
33. 1:28cardiovascular events such as heart
34. 1:30attack or stroke currently glucagon like
35. 1:34peptide 1 receptor agonists or gp1s such
36. 1:37as OIC are largely prescribed for
37. 1:40diabetes and weight loss however this
38. 1:43class of drugs have also been shown to
39. 1:44benefit cardiovascular health due to
40. 1:47their anti-inflammatory and antioxidant
41. 1:49properties this led us to hypothesize
42. 1:52that gp1s may be used to benefit
43. 1:55cardiovascular disease and blood
44. 1:57pressure control and exercise in a rat
45. 1:59model of cardiovascular disease to do
46. 2:02this we surgically induce peripheral
47. 2:04artery disease or pad in a group of rats
48. 2:08pad is a common form of cardiovascular
49. 2:10disease we also teach these rats to then
50. 2:12run on a treadmill so that we can
51. 2:13measure their blood pressure response to
52. 2:15exercise our lab has previously
53. 2:17demonstrated that this rat model of pad
54. 2:20produces that exaggerated blood pressure
55. 2:22response to activity just like that seen
56. 2:24in pad patients on experiment day our
57. 2:27pad rats complete a control bout of
58. 2:30treadmill exercise and then receive a
59. 2:32single dose of a
60. 2:34gp1 then a second exercise bout is
61. 2:36performed and we can compare that blood
62. 2:38pressure response from the control and
63. 2:41post glp1 bout in order to determine if
64. 2:43there were any effects of the glp1 on
65. 2:46blood pressure incredibly that single
66. 2:49dose of a gp1 was actually able to
67. 2:52decrease that blood pressure response in
68. 2:54our pad rats if glp1 Administration
69. 2:57could improve blood pressure control in
70. 3:00a cardiovascular disease patient this
71. 3:02could reduce their risk for stroke or
72. 3:04heart attack this class of drugs has
73. 3:07already been approved for use in humans
74. 3:08so we are very hopeful that these
75. 3:10results May translate and benefit this
76. 3:12population of patients in the near
77. 3:14future by allowing these patients to
78. 3:16more safely complete daily tasks of
79. 3:18living such as walking up the stairs or
80. 3:20doing chores we hope to both extend and
81. 3:23improve their overall quality of life
82. 3:25thank you
83. 3:27[Applause]